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Recommendations for the development of rare disease drugs using
Recommendations for the development of rare disease drugs using

... those situations in which timely standard approval via a clinical endpoint is unlikely or impossible due to practical, scientific, or ethical reasons. The use of biomarkers in the AA pathway is not intended to substitute for clinical endpoint-based studies in diseases with sufficient patients and re ...
Carotid Sheath Abscess Caused by a Tooth Decay Infection on the
Carotid Sheath Abscess Caused by a Tooth Decay Infection on the

... The patient was hospitalized in pediatrics clinic because of a lack of oral intake. Intravenous ceftriaxone and metronidazole medications were started at the first day of hospitalization. As the patient consulted otolaryngologist, in spite of impaired mouth opening abscess formation and purulent sec ...


... to report our clinical experience on the relationship between eosinophils and asthma. In our study the link between eosinophil counts and asthma control is significant but not so strong, which is in keeping with the concept of concordant and discordant disease when relating symptoms to inflammation ...
DYSFUNCTIONAL UTERINE BLEEDING (DUB) The gynaecological
DYSFUNCTIONAL UTERINE BLEEDING (DUB) The gynaecological

... abnormalities Dysfunctional uterine bleeding (DUB) is a common disease comprising about 15% - 20% of new patients attending the hospital. In every case primary fault lies in the in-appropriate hormone production. DEFINITION Dysfunctional uterine bleeding (DUB) is defined as abnormal bleeding from th ...
Guidance for national tuberculosis programmes on the
Guidance for national tuberculosis programmes on the

... specific challenges of TB in children and an increased recognition of its importance as a global public health challenge. Although most children with TB may not be responsible for widespread transmission of the disease in the community, TB is an important contributor to maternal and child morbidity ...
Comprehensive Guideline Summary - AIDS Education and Training
Comprehensive Guideline Summary - AIDS Education and Training

... Testing for Drug Resistance  Before initiation of ART:  Transmitted resistance in 6-16% of HIV-infected patients  In absence of therapy, resistance mutations may decline over time and become undetectable by current assays, but may persist and cause treatment failure when ART is started  Identif ...
An approach to paediatric asthma: the role of the community pharmacist ReView
An approach to paediatric asthma: the role of the community pharmacist ReView

... market. However, they are not easy to use, as they require good patient co-ordination between inhalation and activation of the device. This is rarely perfect in children. Giraud has demonstrated that 71% of patients misuse MDIs, and that 47% of patients could not co-ordinate activation and inspirati ...
PDF - American Society of Mammalogists
PDF - American Society of Mammalogists

your life matters
your life matters

... individuals to know if they have hepatitis B before they start PrEP. For some people with active hepatitis B, taking Truvada (Viread+Emtriva) may be inadequate at controlling the virus and could eventually cause drug resistance to occur. Further, stopping these drugs during undiagnosed hep B disease ...
Nutrition and HIV/AIDS
Nutrition and HIV/AIDS

... Eng J Med 336 (15): 1072-1078. World Health Organization. 1997. Weekly Epidemiological Record 72: 81-88. Geneva. ———. 1990. Weekly Epidemiological Record 65: 221-228. Geneva. ...
Strategic Policy Plan RIVM-Centre for Infectious Disease Control
Strategic Policy Plan RIVM-Centre for Infectious Disease Control

... theme leaders will be given a greater role in prioritisation and accounting. The intention is that the research programmes should more closely reflect the relative importance of infections. In the future, the RIVM-CIb wishes to place greater emphasis on the pooling of information about infectious di ...
HIV/AIDS Care and Treatment Plan, 2003-2008
HIV/AIDS Care and Treatment Plan, 2003-2008

... every corner of the country, and all aspects of its economic and social life. This plan is best seen as an effort to take that struggle to a new level, offering the hope of comprehensive care and treatment to an extensive segment of the affected populace. The HIV/AIDS Care and Treatment Plan replace ...
Questionnaires, spirometry and PEF monitoring in epidemiological
Questionnaires, spirometry and PEF monitoring in epidemiological

... Since its introduction in clinical practice, measurements of lung volumes and related indices have played a central role in the objective assessment of most respiratory diseases. Among various parameters, forced expiratory volume in one second (FEV1) is strongly recommended as an index of choice for ...
General Findings from the four situational - MeSH
General Findings from the four situational - MeSH

... Various programmes and projects within the Ministry of Health and Social Welfare (MoHSW) also have their own reporting mechanisms, including the prevention of mother-to-child transmission (PMTCT) and the care and treatment clinic (CTC) programmes within the HIV sector. Many facilities report individ ...
Communicable Disease Control
Communicable Disease Control

... communicable disease control course, and whose interest and participation have sustained my motivation during the arduous writing of this material. I would like to express my deep appreciation to Dr. Tadesse Anteneh for his advice, encouragement, and support in the preparation of this lecture note. ...
Task 2
Task 2

... HIV.Classification of immunotropic drugs, their mechanism of action . The principles of clinical application of immunotropic drugs , indications and contraindications for the purpose, dose determination and immunological monitoring of therapeutic effectiveness : immunosuppresive preparations; immune ...
HIV in prisons: a reader with particular relevance to the newly
HIV in prisons: a reader with particular relevance to the newly

... Prisons are among the most unhealthy places in our societies. In them, people are not only deprived of their freedom but they are also exposed to threats such as violence, addiction and infectious diseases, while at the same time their own capacity to manage these risks is severely constrained. Pris ...
GAO
GAO

WHO recommended strategies for the prevention and control of
WHO recommended strategies for the prevention and control of

... This document is not a formal publication of the World Health Organization (WHO), and all rights are reserved by the Organization. The document may, however, be freely reviewed, abstracted, reproduced or translated, in part or in whole, but not for sale or for use in conjunction with commercial purp ...
Review Article: Respiratory diseases in pregnancy
Review Article: Respiratory diseases in pregnancy

... early diagnosis of TB in pregnancy. Xpert MTB/RIF is being explored for early diagnosis of TB especially in the areas of high HIV prevalence.16 ...
FORM 6-K - corporate
FORM 6-K - corporate

... therapy technology platform for multiple targets in cardiovascular diseases. The collaboration includes uniQure’s proprietary gene therapy program for congestive heart failure that is intended to restore the heart’s ability to synthesize S100A1, a calcium sensor and master regulator of heart functio ...
the ethics of poverty alleviation
the ethics of poverty alleviation

... (Article 2). Attempts by natural and social scientists to identify dangerous climate change have failed to appreciate that danger in this context is a normative concept. Climate change is risky, but that which is dangerous is that which we have good reason to avoid. Because climate change and energy ...
Tobacco Free Environments
Tobacco Free Environments

... According to the EPA, between 200,000 and 1,000,000 kids with asthma have their condition worsened by second hand smoke every year. Also, passive smoking may also be responsible for thousands of new cases of asthma every year Chronic respiratory symptoms such as cough and wheezing may be attributed ...
HIV History NSW Perspective
HIV History NSW Perspective

... • Industrialisation and Urbanisation. The move of people from relatively sparse rural populations towards much more densely populated centres following industrialisation certainly increases the opportunities for risk contacts for many diseases including HIV. In Central Africa for example in 1931, on ...
The BlueBook - German Doctors eV
The BlueBook - German Doctors eV

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Diseases of poverty

Diseases of poverty is a term sometimes used to collectively describe diseases, disabilities, and health conditions that are more prevalent among the poor than among wealthier people. In many cases poverty is considered the leading risk factor or determinant for such diseases, and in some cases the diseases themselves are identified as barriers to economic development that would end poverty. These diseases are in contrast to so-called ""diseases of affluence"", which are diseases thought to be a result of increasing wealth in a society. Diseases of poverty are often co-morbid and ubiquitous with malnutrition.
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