06&07 Drugs used in epilepsy(2nd yr CNS block).
... Transient hair loss, with re-growth of curly hair Thrombocytopenia Hepatotoxicity Teratogenicity ...
... Transient hair loss, with re-growth of curly hair Thrombocytopenia Hepatotoxicity Teratogenicity ...
Slide 1
... transaminase and increases the concentration of inhibitory neurotransmitter GABA at its receptors. Valproic acid has t1/2 13 h and 90% bound to plasma albumin. It is a nonspecific inhibitor of metabolism, and inhibits its own metabolism, and that of lamotrigine, phenobarbital, phenytoin and carbamaz ...
... transaminase and increases the concentration of inhibitory neurotransmitter GABA at its receptors. Valproic acid has t1/2 13 h and 90% bound to plasma albumin. It is a nonspecific inhibitor of metabolism, and inhibits its own metabolism, and that of lamotrigine, phenobarbital, phenytoin and carbamaz ...
qa-lamotrigine-in-breastfeeding
... Lamotrigine is an anti-epileptic drug (AED) used as adjunctive or monotherapy of partial seizures and generalised seizures, including tonic-clonic seizures, and for seizures associated with LennoxGastaut syndrome. It is also used in the treatment of bipolar disorder (1). The National Institute for H ...
... Lamotrigine is an anti-epileptic drug (AED) used as adjunctive or monotherapy of partial seizures and generalised seizures, including tonic-clonic seizures, and for seizures associated with LennoxGastaut syndrome. It is also used in the treatment of bipolar disorder (1). The National Institute for H ...
Lithium Adverse Effects
... • No specific plasma concentration monitoring • Other common monitoring parameters: Cr at baseline; ophthal. exams if prolonged tx; s/sx depression, suicidality, clinical worsening if bipolar disorder, and/or unusual behavior changes ...
... • No specific plasma concentration monitoring • Other common monitoring parameters: Cr at baseline; ophthal. exams if prolonged tx; s/sx depression, suicidality, clinical worsening if bipolar disorder, and/or unusual behavior changes ...
Epilepsy update
... One seizure or two? (24-64% 2 year risk of recurrence) Benefits of treatment vs natural history ...
... One seizure or two? (24-64% 2 year risk of recurrence) Benefits of treatment vs natural history ...
epilepsy
... secondary generalisation in patients from 16 years of age Adjunctive therapy for partial onset seizures with or without secondary generalisation in adults and children from 4 years of age Adjuctive therapy for myoclonic seizures in adults and adolescents from 12 years of age with JME Adjunctive ther ...
... secondary generalisation in patients from 16 years of age Adjunctive therapy for partial onset seizures with or without secondary generalisation in adults and children from 4 years of age Adjuctive therapy for myoclonic seizures in adults and adolescents from 12 years of age with JME Adjunctive ther ...
Антиепилептични лекарства
... transaminase and increases the concentration of inhibitory neurotransmitter GABA at its receptors. Valproic acid has t1/2 13 h and 90% bound to plasma albumin. It is a nonspecific inhibitor of metabolism, and inhibits its own metabolism, and that of lamotrigine, phenobarbital, phenytoin and carbamaz ...
... transaminase and increases the concentration of inhibitory neurotransmitter GABA at its receptors. Valproic acid has t1/2 13 h and 90% bound to plasma albumin. It is a nonspecific inhibitor of metabolism, and inhibits its own metabolism, and that of lamotrigine, phenobarbital, phenytoin and carbamaz ...
Algorithm for adding lamotrigine to valproate
... Lamotrigine metabolism is inhibited by valproate and serum concentrations will be higher and increase more rapidly at a given dose or change in dose than when added to other AEDs lamotrigine (Lamictal) Initiate dose at 25mg/every other day if on concomitant valproate (monitor CBC and for rash) for t ...
... Lamotrigine metabolism is inhibited by valproate and serum concentrations will be higher and increase more rapidly at a given dose or change in dose than when added to other AEDs lamotrigine (Lamictal) Initiate dose at 25mg/every other day if on concomitant valproate (monitor CBC and for rash) for t ...
Lamotrigine
Lamotrigine /ləˈmoʊtrɨˌdʒiːn/, marketed in most of the world as Lamictal /ləˈmɪktəl/ by GlaxoSmithKline, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is also used off-label as an adjunct in treating clinical depression. For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Like many other anticonvulsant medications, lamotrigine also seems to act as an effective mood stabilizer, and has been the first US Food and Drug Administration (FDA)-approved drug for this purpose since lithium, a drug approved almost 30 years earlier. It is approved for the maintenance treatment of bipolar type I.Chemically unrelated to other anticonvulsants (due to lamotrigine being a phenyltriazine), lamotrigine has many possible side-effects. Lamotrigine is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs, but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and carbamazepine and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties. Lamotrigine is inactivated by glucuronidation in the liver.