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Odorant binding proteins and olfactory receptors
Odorant binding proteins and olfactory receptors

... For many of us the five senses have been of philosophical and scientific interest for as long as we can remember. Through our senses we are able to interact with our environment and respond to cues which, most of the time, are not visible to our consciousness. Unlike touch, vision and hearing; taste ...
Two groups of human herpesvirus 6 identified by sequence
Two groups of human herpesvirus 6 identified by sequence

... studies of this virus DNA have shown that the organization of conserved genes and their encoded amino acid sequences are more related to those of human cytomegalovirus (HCMV) than those of the other human herpesviruses (Lawrence et al., 1990; Neipel et aL, 1991). However, these viruses are distant r ...
Chromosome structure and mutations
Chromosome structure and mutations

... DNA polymerase can assemble new DNA at a rate of about 50 nucleotides per second Many origins of replication are required to complete the task of copying the DNA in a genome In mammals, there are 10,000 origins of replication Origins of replication are scattered throughout the ...
(2013). Nothing in genetics makes sense except in light of genomic
(2013). Nothing in genetics makes sense except in light of genomic

... in ZZ/ZW species. The same logic would apply to a similar mutation in a vertically transmitted cytoplasmic endosymbiont (e.g., Wolbachia) that is propagated only through the matriline. Next, suppose that A and B are two alleles at a single locus. If A increases because (a) it was favored by selectio ...
pdf
pdf

... Free duplex DNA will not stick to a nitrocellulose membrane, but a protein-DNA complex will bind. 2. To what sequence in the probe DNA is the protein binding? The presence of a protein will either protect a segment of DNA from attack by a nuclease or other degradative reagent, or in some cases will ...
Evaluation of the phylogenetic position of the planctomycete
Evaluation of the phylogenetic position of the planctomycete

... ancestor simply does not apply in the world of prokaryotes, where each protein has its own history. In this regard, the tree of life is a complex network of vertical and horizontal inheritance. While LGT is not specifically problematic for the phylogeny of closely related species, it becomes more se ...
Gene Annotation Naming Guidelines
Gene Annotation Naming Guidelines

... I. INTRODUCTION This document provides background information and guidelines for microbial annotation. The most accurate annotation comes from experimental work done on the particular protein and genome being annotated. Unfortunately, this level of certainty is almost never available to annotators. ...
The role of duplications in the evolution of genomes highlights the
The role of duplications in the evolution of genomes highlights the

... distinction between mutational generation (duplication), fixation and maintenance has critical implications for genome-scale studies as highlighted by experimental works. For instance, Davis and Petrov [15] investigated which types of genes are likely to generate functional and persistent duplicates ...
BIO 160 - Lake Land College
BIO 160 - Lake Land College

... At the end of this chapter, students should have an understanding of: a. the role of mutation in generating genetic diversity. b. the effects of drift and selection on changing gene frequencies. c. the effects of human activities such as migration, mate selection, and diet on gene frequencies. d. ge ...
Slide 1
Slide 1

... – Variable CNE boundaries for each species ...
Extent of Gene Duplication in the Genomes of
Extent of Gene Duplication in the Genomes of

... (Ohno 1970, p. 72). With the availability of complete genome sequences, it has become possible to study the extent of gene duplication on a genome-wide scale. Block duplications in Drosophila, yeast, and Caenorhabditis elegans have been studied in detail by using genomic data (Wolfe and Shields 1997 ...
Genetic Inversion: Relationships Among Species
Genetic Inversion: Relationships Among Species

... the most important events occur in sex cells (sperm or egg cells). These changes exhibit their full effect on any offspring formed from these inverted sperm or egg chromosomes. In other words, an inversion that occurs in a skin cell only affects that skin cell and its descendants, but the other tril ...
Molecualr Biology and Evolution
Molecualr Biology and Evolution

... for horizontal transfer: the FrankialAnabaena branch restriction map was made of pAR2 and used to generate lies within the proteobacterial clade with bootstrap sup- smaller subclones of the n$K region in pUCl19. port of 80%. Normand et al. ( 1992) provided an additional test of the horizontal transf ...
Module 7 – Microbial Molecular Biology and Genetics
Module 7 – Microbial Molecular Biology and Genetics

... like transcription factors that can bind to specific sequences in double-stranded DNA usually make contacts to the sides of the bases exposed in the major groove. In a DNA double helix, each type of nucleobase on one strand normally interacts with just one type of nucleobase on the other strand. Thi ...
Specific biomolecules serve various functions in the body.
Specific biomolecules serve various functions in the body.

... 2. RNA molecules use instruction from DNA to assemble proteins. There are three types of RNA molecules: mRNA, rRNA and tRNA. What specific function does mRNA perform in the process of making proteins? a. It brings instructions from DNA in the cell nucleus to the cytoplasm. b. It clamps onto messenge ...
Risks from GMOs due to Horizontal Gene Transfer
Risks from GMOs due to Horizontal Gene Transfer

... by reproduction (Babić et al., 2008). Consequently, experimental screening for HGT has relied on testing organisms such as bacteria and viruses that can be cultivated in vast numbers and have short generation times. In addition, powerful selection methods such as the use of antibiotics have been us ...
Protein Synthesis - Napa Valley College
Protein Synthesis - Napa Valley College

... Figure 17.17a ...
Slides
Slides

... Yeast genome has 6000 genes Select 50 genes believed to be co-regulated by a common TF Found a motif for these 50 genes It appeared in 20 out of these 50 genes In the whole genome, 100 genes have this motif ...
Full text in pdf - International Microbiology
Full text in pdf - International Microbiology

... no significant identity match with phosphorylating GAPDHs. Both non-phosphorylating GAPDH and phosphorylating GAPDHs showed high specificity towards D-glyceraldehyde3-phosphate [13,18], which suggested that substrate specificity of the two GAPDH forms emerged by convergent evolution along independen ...
19.1 Somatostatin Was the First Human Peptide Hormone Produced
19.1 Somatostatin Was the First Human Peptide Hormone Produced

... secretion of a number of other hormones, including growth hormone, insulin, and glucagon. Somatostatin was not chosen for its commercial potential. Instead, it was chosen because the researchers thought it would be technically less difficult than other hormones. Somatostatin is very small (only 14 a ...
Amphioxus
Amphioxus

... expression pattern) and protein level (i.e. isoform metal binding preferences) [7]. Avian MTs, the closest mammalian relatives, exhibit less polymorphism, with two isoforms identified in chicken [8]. Their genes share the same exon/intron structure as mammalian MTs, and they are regulated by similar ...
Molecular Cloning of engrafted: A Gene Involved in the
Molecular Cloning of engrafted: A Gene Involved in the

... cloned sequences by physically mapping DNA rearrangements that disrupt engrailed function. A number of chromosomal rearrangements with engrailed phenotypes have been isolated in screens for new engrailed alleles (Kornberg, 1981a; Eberlein and Russell, 1983). To map the positions of these rearrangeme ...
LESSON 4 Using Bioinformatics to Analyze Protein
LESSON 4 Using Bioinformatics to Analyze Protein

... When genetic researchers study genes, they often do not write down the complementary DNA sequence, the mRNA sequence, and the tRNAs. They use a “short cut.” Because the coding sequence of the DNA and the sequence of the mRNA are the same (except for the thymines instead of uracils), you can predict ...
Soft inheritance: Challenging the Modern Synthesis
Soft inheritance: Challenging the Modern Synthesis

... of the epimutations found in plants have appeared under conditions of genomic or chemical stress (Jablonka and Lamb, in press). Animals, too, provide good examples of epigenetic inheritance. For example, Vastenhouw and colleagues found that feeding Caenorhabditis elegans with bacteria expressing dou ...
Stochastic processes and Markov chains (part II)
Stochastic processes and Markov chains (part II)

... Application: motifs The binding sites of a transciption factor (that may regulate multiple genes) share certain sequence patterns, motifs. p factors and motifs are known. Hence,, a Not all transcription high occurrence of a particular sequence pattern in the upstream regions of a gene may indicate ...
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Genomics

Genomics is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyze the function and structure of genomes (the complete set of DNA within a single cell of an organism). Advances in genomics have triggered a revolution in discovery-based research to understand even the most complex biological systems such as the brain. The field includes efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome's networks.
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