Segway: simultaneous segmentation of multiple functional genomics
... expands beyond a sequence of nucleotides occasionally annotated with discrete features to a collection of numerical data tracks defined at almost every part of every chromosome. At the same time, we have moved beyond treating the cellular state determined by functional genomics experiments as consti ...
... expands beyond a sequence of nucleotides occasionally annotated with discrete features to a collection of numerical data tracks defined at almost every part of every chromosome. At the same time, we have moved beyond treating the cellular state determined by functional genomics experiments as consti ...
Relative Rates of Nucleotide Substitution in Frogs
... mtDNA substitution rates to a greater extent than scnDNA substitution rates (Rand 1994). Alternatively, the ratio of substitution rates may be more or less constant across divergent taxa, implying that evolution has arrived at some fundamental constant determined by the balance between error minimiz ...
... mtDNA substitution rates to a greater extent than scnDNA substitution rates (Rand 1994). Alternatively, the ratio of substitution rates may be more or less constant across divergent taxa, implying that evolution has arrived at some fundamental constant determined by the balance between error minimiz ...
Mining External Resources for Biomedical IE
... • how to use other texts • which texts to use Note: some systems (MaxEnt for instance) can easily and successfully integrate a huge number of features ...
... • how to use other texts • which texts to use Note: some systems (MaxEnt for instance) can easily and successfully integrate a huge number of features ...
Comparative Bacterial Genomics Genome Databases
... In bioinformatics, FASTA format is a text-based format for representing either nucleotide sequences or peptide sequences, in which nucleotides or amino acids are represented using single-letter codes. The format also allows for sequence names and comments to precede the sequences. The format origina ...
... In bioinformatics, FASTA format is a text-based format for representing either nucleotide sequences or peptide sequences, in which nucleotides or amino acids are represented using single-letter codes. The format also allows for sequence names and comments to precede the sequences. The format origina ...
A gene dosage map of Chromosome 18
... We hypothesize that most genes on Chromosome 18 are actually haplosufficient. This is supported by the data regarding PMP22 discussed earlier. In addition, it has been estimated that 90% of mutations are recessive to wild type in Drosophila.10 This leads us to hypothesize that relatively few genes ( ...
... We hypothesize that most genes on Chromosome 18 are actually haplosufficient. This is supported by the data regarding PMP22 discussed earlier. In addition, it has been estimated that 90% of mutations are recessive to wild type in Drosophila.10 This leads us to hypothesize that relatively few genes ( ...
No Slide Title
... established genetic markers that aid in the identification of loci affecting quantitative traits and/or disease in wide variety of eukaryote species. In addition, SNPs have been used extensively in efforts to study the evolution of microbial populations. Such efforts have largely been confined to mu ...
... established genetic markers that aid in the identification of loci affecting quantitative traits and/or disease in wide variety of eukaryote species. In addition, SNPs have been used extensively in efforts to study the evolution of microbial populations. Such efforts have largely been confined to mu ...
Bacteriophage-mediated nucleic acid immunisation
... V-HBsAg phage i.m. in either saline bu¡er, oil adjuvant or in association with liposomes. Recombinant phage were also administered nasally after association with the mucosal adjuvant chitosan [18] and by gene gun after freeze drying. Control mice were immunised with unmodi¢ed V-gt11 phage (i.m. in b ...
... V-HBsAg phage i.m. in either saline bu¡er, oil adjuvant or in association with liposomes. Recombinant phage were also administered nasally after association with the mucosal adjuvant chitosan [18] and by gene gun after freeze drying. Control mice were immunised with unmodi¢ed V-gt11 phage (i.m. in b ...
Convergent evolution of antifreeze glycoproteins in
... AFGP genes are transcribed and translated into large polyproteins that are posttranslationally cleaved. The near-identical AFGP protein structures from the two fishes have led to suggestions of a common ancestor (18), and the apparent similarities in their AFGP genes appear to support such an argume ...
... AFGP genes are transcribed and translated into large polyproteins that are posttranslationally cleaved. The near-identical AFGP protein structures from the two fishes have led to suggestions of a common ancestor (18), and the apparent similarities in their AFGP genes appear to support such an argume ...
Rotavirus future surveillance activities and nested studies:
... vaccines are in use, to develop more robust data collection and analysis protocols and mechanisms. A control group consisting of countries without rotavirus vaccination is provided by EuroRotaNet in order to identify the emergence of unusual strains and zoonotic introductions in the absence of vacci ...
... vaccines are in use, to develop more robust data collection and analysis protocols and mechanisms. A control group consisting of countries without rotavirus vaccination is provided by EuroRotaNet in order to identify the emergence of unusual strains and zoonotic introductions in the absence of vacci ...
File S1.
... Identifying possible small RNAs: Overview At this step of the pipeline, we mapped reads to their corresponding position on the L. monocytogenes genome. The next task is to identify expressed regions of interest, i.e. those regions harboring potentially regulatory sRNAs. In order to do so, we first r ...
... Identifying possible small RNAs: Overview At this step of the pipeline, we mapped reads to their corresponding position on the L. monocytogenes genome. The next task is to identify expressed regions of interest, i.e. those regions harboring potentially regulatory sRNAs. In order to do so, we first r ...
Cloning, DNA nucleotide sequence and distribution
... pellet was redissolved in 4 pl distilled water. Sequencing reactions were done in accordance with the manufacturer’s recommendations. Primers for sequencing were synthesized on an ABI PCR-mate following the maker’s recommendations and were designed to give overlapping readings on both strands. The n ...
... pellet was redissolved in 4 pl distilled water. Sequencing reactions were done in accordance with the manufacturer’s recommendations. Primers for sequencing were synthesized on an ABI PCR-mate following the maker’s recommendations and were designed to give overlapping readings on both strands. The n ...
Evolution Expression Level, and Interactivity Are Correlated in
... between PGL and gene dispensability and interactivity is much stronger than that for sequence evolution rate. Thus, propensity of a gene to be lost during evolution seems to be a direct reflection of its biological importance. Lineage-specific gene loss is one of the major evolutionary processes tha ...
... between PGL and gene dispensability and interactivity is much stronger than that for sequence evolution rate. Thus, propensity of a gene to be lost during evolution seems to be a direct reflection of its biological importance. Lineage-specific gene loss is one of the major evolutionary processes tha ...
Development of a codominant PCR-based marker for the wheat Wx
... expected PCR products were amplified from all wheat cultivars. However, cultivars carrying the null Wx-B1 allele did not produce an amplification product corresponding to fragment 3’-3 (Fig. 1). This indicated that a deletion breakpoint was located in the region between primers 3’-F3 and 3’-F4. Next ...
... expected PCR products were amplified from all wheat cultivars. However, cultivars carrying the null Wx-B1 allele did not produce an amplification product corresponding to fragment 3’-3 (Fig. 1). This indicated that a deletion breakpoint was located in the region between primers 3’-F3 and 3’-F4. Next ...
ika1 and rag1 as Markers for the Development of
... embryos are clear and develop outside of the mother, facilitating easy screening for visual abnormalities that might occur during development. Therefore, zebrafish are good organisms for genetics, including screens for mutations in genes affecting development. Genetic tricks such as the creation of ...
... embryos are clear and develop outside of the mother, facilitating easy screening for visual abnormalities that might occur during development. Therefore, zebrafish are good organisms for genetics, including screens for mutations in genes affecting development. Genetic tricks such as the creation of ...
The DNA repair helicase UvrD is essential for replication
... • RecG and RecA likely act independently of each other • RecG doesn't like free Mg • …because free cations freeze Holliday junction geometry? • RecG can work on fully duplex 3-stranded structures, but RecA cannot • (since RecA requires ssDNA for nucleation) • Why is the RecG reaction unidirectional? ...
... • RecG and RecA likely act independently of each other • RecG doesn't like free Mg • …because free cations freeze Holliday junction geometry? • RecG can work on fully duplex 3-stranded structures, but RecA cannot • (since RecA requires ssDNA for nucleation) • Why is the RecG reaction unidirectional? ...
- Murdoch Research Repository
... B. hyodysenteriae has been shown to contain an unusual prophage-like agent named VSH-1 (virus of Serpulina hyodysenteriae) that is involved in natural gene transfer and recombination within the species (Humphrey et al., 1997 and Matson et al., 2007). This agent is in a state of permanent lysogeny an ...
... B. hyodysenteriae has been shown to contain an unusual prophage-like agent named VSH-1 (virus of Serpulina hyodysenteriae) that is involved in natural gene transfer and recombination within the species (Humphrey et al., 1997 and Matson et al., 2007). This agent is in a state of permanent lysogeny an ...
Transgenic and gene disruption techniques from a concept to a tool
... by these method, including oncogenes and the growth hormone gene. By adding the regulatory sequences along with the coding region of interest, expression of the gene may be limited to specific tissues or periods of development. A more complicated method has been developed to replace a functjonal gen ...
... by these method, including oncogenes and the growth hormone gene. By adding the regulatory sequences along with the coding region of interest, expression of the gene may be limited to specific tissues or periods of development. A more complicated method has been developed to replace a functjonal gen ...
CHARACTERlZATION OF THE ~ 0 CHONDRIA . L DNA MOLECULE
... throuph oxidative phosphorylation. Oxidative phosphorylation is a cornplex biochemical mechanism that involves the conversion of potential energy from electron gradients into chernical energy. Each mitochondrion contains its own genetic code. However, the mitochondria do not encode al1 of the protei ...
... throuph oxidative phosphorylation. Oxidative phosphorylation is a cornplex biochemical mechanism that involves the conversion of potential energy from electron gradients into chernical energy. Each mitochondrion contains its own genetic code. However, the mitochondria do not encode al1 of the protei ...
Adenine - One of the four bases in DNA tha make up the letters
... alleles produce variation in inherited characteristics such as hair color or blood type. In an individual one form of the allele (the dominant one) may be expressed more than another form (the recessive one). ...
... alleles produce variation in inherited characteristics such as hair color or blood type. In an individual one form of the allele (the dominant one) may be expressed more than another form (the recessive one). ...
Heredity Notes
... These characteristics are called traits. Traits depend on the types of proteins that the 4 bases (A,C,G,T) make up. Parents pass on copies of their DNA to their offspring. The DNA from each parent combines to form the DNA of the offspring. How the offspring develops depends on the instructions ...
... These characteristics are called traits. Traits depend on the types of proteins that the 4 bases (A,C,G,T) make up. Parents pass on copies of their DNA to their offspring. The DNA from each parent combines to form the DNA of the offspring. How the offspring develops depends on the instructions ...
Comprehensive Cardiomyopathy Panel
... sites or untranslated regions of the genes listed in the panel, as well as 22 reported non-coding region mutations in DMD, are enriched from the patient’s genomic DNA and sequenced using a solid-state sequencing-by-synthesis process. DNA sequences are assembled and compared to the published genomic ...
... sites or untranslated regions of the genes listed in the panel, as well as 22 reported non-coding region mutations in DMD, are enriched from the patient’s genomic DNA and sequenced using a solid-state sequencing-by-synthesis process. DNA sequences are assembled and compared to the published genomic ...
Vertebrate DNA Transposon as a Natural Mutator
... heritable phenotypes and new mutant genes that carry different excision footprint sequences. The phenotypic mutation rate is as high as 2% per gamete, representing a 1000-fold increase from spontaneous mutation rates so far determined with the same organism. With mutations caused by insertion, and t ...
... heritable phenotypes and new mutant genes that carry different excision footprint sequences. The phenotypic mutation rate is as high as 2% per gamete, representing a 1000-fold increase from spontaneous mutation rates so far determined with the same organism. With mutations caused by insertion, and t ...
5. Harmful mutations
... 1956 - Francis Crick and George Gamov worked out the "Central Dogma" to explain protein synthesis from DNA: the DNA sequence codes for amino acid sequences and genetic information flows in one direction - from DNA to mRNA to protein 1959 - Francois Jacob and Jacques Monod discovered an important mec ...
... 1956 - Francis Crick and George Gamov worked out the "Central Dogma" to explain protein synthesis from DNA: the DNA sequence codes for amino acid sequences and genetic information flows in one direction - from DNA to mRNA to protein 1959 - Francois Jacob and Jacques Monod discovered an important mec ...
The Gene Gateway Workbook
... - Gene sequences are transcribed into messenger RNA intermediates (mRNA). - mRNA intermediates are translated into proteins that perform most life functions. ...
... - Gene sequences are transcribed into messenger RNA intermediates (mRNA). - mRNA intermediates are translated into proteins that perform most life functions. ...