lecture1
... small nuclear RNA (snRNA). DNA transcription of the genes for mRNA, rRNA, and tRNA produces large precursor molecules ("primary transcripts") that must be processed within the nucleus to produce the functional molecules for export to the cytosol. Some of these processing steps are mediated by snRNAs ...
... small nuclear RNA (snRNA). DNA transcription of the genes for mRNA, rRNA, and tRNA produces large precursor molecules ("primary transcripts") that must be processed within the nucleus to produce the functional molecules for export to the cytosol. Some of these processing steps are mediated by snRNAs ...
BCH-201:Nucleotides and Nucleic acids
... small nuclear RNA (snRNA). DNA transcription of the genes for mRNA, rRNA, and tRNA produces large precursor molecules ("primary transcripts") that must be processed within the nucleus to produce the functional molecules for export to the cytosol. Some of these processing steps are mediated by snRNAs ...
... small nuclear RNA (snRNA). DNA transcription of the genes for mRNA, rRNA, and tRNA produces large precursor molecules ("primary transcripts") that must be processed within the nucleus to produce the functional molecules for export to the cytosol. Some of these processing steps are mediated by snRNAs ...
Methods to analyze RNA expression - RNA
... Initially each library is analyzed separately except for the two files of each library if paired ends sequencing was done. 1) The short reads are aligned on the reference genome if available 2) The transcript(s) from each gene are reconstructed. At that point the analysis is done with all the librar ...
... Initially each library is analyzed separately except for the two files of each library if paired ends sequencing was done. 1) The short reads are aligned on the reference genome if available 2) The transcript(s) from each gene are reconstructed. At that point the analysis is done with all the librar ...
Homework 1 / Introduction General questions Programming tasks
... name in the beginning as the author of the script. Make a clear distinction between the exercises and format the output in a clear and understandable way. If for some reasons some of the exercises are not completed, write to the output: "5. Task not completed due to ..." and you can also describe wh ...
... name in the beginning as the author of the script. Make a clear distinction between the exercises and format the output in a clear and understandable way. If for some reasons some of the exercises are not completed, write to the output: "5. Task not completed due to ..." and you can also describe wh ...
Slides PPT
... material, stored as DNA. • The nuclear genome refers to the DNA in the chromosomes contained in the nucleus; in the case of humans the DNA in the 46 chromosomes. It is the nuclear genome that defines a multicellular organism; it will be the same for all (almost) cells of the organism. ...
... material, stored as DNA. • The nuclear genome refers to the DNA in the chromosomes contained in the nucleus; in the case of humans the DNA in the 46 chromosomes. It is the nuclear genome that defines a multicellular organism; it will be the same for all (almost) cells of the organism. ...
No Slide Title
... The RNA is typically converted to cDNA, labeled with fluorescence (or radioactivity), then hybridized to microarrays in order to measure the expression levels of thousands of genes. ...
... The RNA is typically converted to cDNA, labeled with fluorescence (or radioactivity), then hybridized to microarrays in order to measure the expression levels of thousands of genes. ...
PHAR2811 Dale`s lecture 7 The Transcriptome Definitions: Genome
... exons (each of on average about 300bp in length, with the final exon often being considerably longer) spanning 9 introns (which may vary from a few hundred bps to many kilobases or 100s of kilobases in ...
... exons (each of on average about 300bp in length, with the final exon often being considerably longer) spanning 9 introns (which may vary from a few hundred bps to many kilobases or 100s of kilobases in ...
No Slide Title
... Regulatory regions=300 Mbp? •Only 5-10% of human genome codes for genes - function of other DNA (mostly repetitive sequences) unknown but it might serve structural or regulatory roles ...
... Regulatory regions=300 Mbp? •Only 5-10% of human genome codes for genes - function of other DNA (mostly repetitive sequences) unknown but it might serve structural or regulatory roles ...
Barbara McClintock
... • Encode the enzyme Protein Transposase • This is required for excision (cut) and insertion (paste) • Move on their own (no intermediaries) ...
... • Encode the enzyme Protein Transposase • This is required for excision (cut) and insertion (paste) • Move on their own (no intermediaries) ...
The Central Dogma of Molecular Biology - APBiology2010-2011
... the direction of DNA • Transcription produces messenger RNA (mRNA) • Translation is the synthesis of a polypeptide, which occurs under the direction of mRNA • Ribosomes are the sites of translation ...
... the direction of DNA • Transcription produces messenger RNA (mRNA) • Translation is the synthesis of a polypeptide, which occurs under the direction of mRNA • Ribosomes are the sites of translation ...
What happens to our genes in the twilight of death?
... complex chain of reactors linked together by a mul3tude of control networks that normally determine its func3onality. Most disaster-like processes involve a sequence of events that occurs due to the availability of residual energy and materials. Understanding this p ...
... complex chain of reactors linked together by a mul3tude of control networks that normally determine its func3onality. Most disaster-like processes involve a sequence of events that occurs due to the availability of residual energy and materials. Understanding this p ...
Gene, Protein Synthesis & Gene Regulation
... • The end products of protein synthesis is a primary structure of a protein. • A sequence of amino acid bonded together by peptide bonds. ...
... • The end products of protein synthesis is a primary structure of a protein. • A sequence of amino acid bonded together by peptide bonds. ...
lec07
... B. DNA, RNA, and the Flow of Information • RNA differs from DNA in three ways: It is single-stranded, its sugar molecule is ribose rather than deoxyribose, and its fourth base is uracil rather than thymine. • The central dogma of molecular biology is DNA RNA protein. Unidirectional when genes a ...
... B. DNA, RNA, and the Flow of Information • RNA differs from DNA in three ways: It is single-stranded, its sugar molecule is ribose rather than deoxyribose, and its fourth base is uracil rather than thymine. • The central dogma of molecular biology is DNA RNA protein. Unidirectional when genes a ...
Have a go at our V(D)J recombination jigsaw game. How many
... how the 3D architecture of antibody genes influence V(D)J recombination. In particular we have found that these genes make a lot of non-coding RNA. Non-coding RNA doesn’t make protein and 98% of the RNA in our body is non-coding. We are trying to understand how non-coding RNA influences V(D)J recomb ...
... how the 3D architecture of antibody genes influence V(D)J recombination. In particular we have found that these genes make a lot of non-coding RNA. Non-coding RNA doesn’t make protein and 98% of the RNA in our body is non-coding. We are trying to understand how non-coding RNA influences V(D)J recomb ...
Yeast whole-genome analysis of conserved regulatory motifs
... The NF-κB motif is enriched in H3K4me2 regions found uniquely in GM12878 cells It is likewise enriched in the uniquely bound regions for other active marks Conversely, it is enriched in the uniquely unbound regions for the repressive mark H3K27me3 We find that NF-κB is also over expressed in GM12878 ...
... The NF-κB motif is enriched in H3K4me2 regions found uniquely in GM12878 cells It is likewise enriched in the uniquely bound regions for other active marks Conversely, it is enriched in the uniquely unbound regions for the repressive mark H3K27me3 We find that NF-κB is also over expressed in GM12878 ...
Genomics - WHAT IF server
... • Small distance between adjacent genes • Co-orientation (lie on the same strand) • More reliability when these features are conserved in different species Additional arguments: • Similar functional annotations of adjacent genes • Observed co-expression • Known average operon length ...
... • Small distance between adjacent genes • Co-orientation (lie on the same strand) • More reliability when these features are conserved in different species Additional arguments: • Similar functional annotations of adjacent genes • Observed co-expression • Known average operon length ...
D. melanogaster
... discovery. For the moment, at least, that should be sufficient. At some point we will inevitably emerge into a clearing where principles and patterns in the organization and evolution of the genome are evident. Until then, let us be thankful that the pleasures of the forest are so numerous and diver ...
... discovery. For the moment, at least, that should be sufficient. At some point we will inevitably emerge into a clearing where principles and patterns in the organization and evolution of the genome are evident. Until then, let us be thankful that the pleasures of the forest are so numerous and diver ...
The History of RNAi
... • Attempts to overexpress a gene (chalcone synthase) by inserting multiple copies of that gene into the plant’s genome. • Purple plants should become purpler... ...
... • Attempts to overexpress a gene (chalcone synthase) by inserting multiple copies of that gene into the plant’s genome. • Purple plants should become purpler... ...
LUCA - University of Washington
... our spliceosomes: bacteria have no introns and thus no need for spliceosomes. The most convincing part of Forterre's case is an argument developed by three New Zealanders: Anthony Poole, Daniel Jeffares, and David Penny, all at Massey University. They point out that a great many of the special featu ...
... our spliceosomes: bacteria have no introns and thus no need for spliceosomes. The most convincing part of Forterre's case is an argument developed by three New Zealanders: Anthony Poole, Daniel Jeffares, and David Penny, all at Massey University. They point out that a great many of the special featu ...
Chapter 17
... deletions of more than or fewer than 3 nucleotide pairs results in a change of the reading frame. This changes the identity of all the amino acids downstream of the insertion/deletion. ...
... deletions of more than or fewer than 3 nucleotide pairs results in a change of the reading frame. This changes the identity of all the amino acids downstream of the insertion/deletion. ...
Genomics Post-ENCODE
... • Hunting for genetic variants that influence gene expression Linking genetic variants to changes in gene expression – regulatory variants or “expression quantitative trait loci” (eQTL) These will be different between tissues ...
... • Hunting for genetic variants that influence gene expression Linking genetic variants to changes in gene expression – regulatory variants or “expression quantitative trait loci” (eQTL) These will be different between tissues ...
Print edition PDF
... The lncRNAs are pieces of RNA over 200 nucleotides long The result is a complete sequence that don’t encode proteins but instead appear to regulate transcription and translation in multiple ways. In large-scale of the cells’ transcriptomes. sequencing projects, scientists have estimated that the hum ...
... The lncRNAs are pieces of RNA over 200 nucleotides long The result is a complete sequence that don’t encode proteins but instead appear to regulate transcription and translation in multiple ways. In large-scale of the cells’ transcriptomes. sequencing projects, scientists have estimated that the hum ...
Defining Genes in the Era of Genomics
... The boundary between living and dead genes is often not sharp. A pseudogene in one individual can be functional in a different isolate of the same species; for example, FLO8 is active in one strain of yeast but inactive in another (18). Thus, technically it is only a gene in one strain. Moreover, ps ...
... The boundary between living and dead genes is often not sharp. A pseudogene in one individual can be functional in a different isolate of the same species; for example, FLO8 is active in one strain of yeast but inactive in another (18). Thus, technically it is only a gene in one strain. Moreover, ps ...