Genome-Wide Identification of Allelic Expression in Hypertensive
... crosses between SHR-A3 and SHR/N and between SHR-A3 and SHR-C.9 –11 In each case, blood pressure was measured by tail cuff, a method no longer recommended in the present context12 that can contribute to relatively large within group variances that reduce statistical power and can lead to type II err ...
... crosses between SHR-A3 and SHR/N and between SHR-A3 and SHR-C.9 –11 In each case, blood pressure was measured by tail cuff, a method no longer recommended in the present context12 that can contribute to relatively large within group variances that reduce statistical power and can lead to type II err ...
Genome-Wide Identification of Allelic Expression in Hypertensive Rats
... of sequence variation between SHR-A3 and WKY. Among the 36 genes and ESTs surveyed, 21 have been found to be polymorphic between SHR-A3 and WKY. Genotyping assays were developed and used to determine which of these 21 genes share the same allele in all SHR lines (SHR-A3, -B2, -C, and SHR/N), but con ...
... of sequence variation between SHR-A3 and WKY. Among the 36 genes and ESTs surveyed, 21 have been found to be polymorphic between SHR-A3 and WKY. Genotyping assays were developed and used to determine which of these 21 genes share the same allele in all SHR lines (SHR-A3, -B2, -C, and SHR/N), but con ...
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... We created several transgenic lines expressing the H19 RNA under the control of the necdin (Ndn) gene promoter. Ndn is expressed in some non-neural tissues (somites, tongue, axial muscles), with a more specific expression in most postmitotic neurons of the central and peripheral nervous systems (And ...
... We created several transgenic lines expressing the H19 RNA under the control of the necdin (Ndn) gene promoter. Ndn is expressed in some non-neural tissues (somites, tongue, axial muscles), with a more specific expression in most postmitotic neurons of the central and peripheral nervous systems (And ...
HW4_final
... This is an open research question; you are requested only to write your research plan (as described below) and not conduct the research!!! As we discussed in class it has been proposed that long non coding RNAs (lncRNAs) can bind Transcription Factors (which usually bind double-stranded DNA) and com ...
... This is an open research question; you are requested only to write your research plan (as described below) and not conduct the research!!! As we discussed in class it has been proposed that long non coding RNAs (lncRNAs) can bind Transcription Factors (which usually bind double-stranded DNA) and com ...
Network properties of human disease genes with pleiotropic effects
... profiles with their interactors could be explained by different biological functions. Hence, we used Gene Ontology (GO) to functionally characterize the essential and phenodiv genes for their cellular component, molecular function and biological process (Additional files 1 and 2). GO analysis of ess ...
... profiles with their interactors could be explained by different biological functions. Hence, we used Gene Ontology (GO) to functionally characterize the essential and phenodiv genes for their cellular component, molecular function and biological process (Additional files 1 and 2). GO analysis of ess ...
Molecular Design of Expression Systems
... the cloned promoter-operator is lost as the vector copy number increases. For case 11, in which repressor is obtained from constitutive expression of a repressor gene included in the expression plasmid, the transcription efficiency decreases as a function of the vector copy number. Different relatio ...
... the cloned promoter-operator is lost as the vector copy number increases. For case 11, in which repressor is obtained from constitutive expression of a repressor gene included in the expression plasmid, the transcription efficiency decreases as a function of the vector copy number. Different relatio ...
Mutations at the Darkener of apricot Locus Modulate Transcript
... ZACHAR and BINGHAM1987; FRIDELL,PRET and SEARLES1990; GEYERet al. 1991 ; MITCHELSONet al. 1993; ZACHAR, CHoU and BINGHAM1987). In general, the products of second-site modifier loci play a role in the expression of the mutation-causing transposable element, and in modifying its activity, result in an ...
... ZACHAR and BINGHAM1987; FRIDELL,PRET and SEARLES1990; GEYERet al. 1991 ; MITCHELSONet al. 1993; ZACHAR, CHoU and BINGHAM1987). In general, the products of second-site modifier loci play a role in the expression of the mutation-causing transposable element, and in modifying its activity, result in an ...
Relationships Between RNA Polymerase II Activity and Spt
... yeast genome and many of these exhibit modulation by many factors (Martens et al. 2004, 2005; Hainer et al. 2011; Bird et al. 2006). Furthermore, widespread antisense transcription is being revealed as a mechanism for shaping gene regulation in a number of ways, including transcription over promoter ...
... yeast genome and many of these exhibit modulation by many factors (Martens et al. 2004, 2005; Hainer et al. 2011; Bird et al. 2006). Furthermore, widespread antisense transcription is being revealed as a mechanism for shaping gene regulation in a number of ways, including transcription over promoter ...
Virp1 Is a Host Protein with a Major Role in Potato - IMBB
... Received 6 May 2007/Accepted 16 September 2007 ...
... Received 6 May 2007/Accepted 16 September 2007 ...
Extensive tRNA gene changes in synthetic Brassica
... genome have been identified (Sarilar et al. 2013). Despite the bulk of evidence for other kinds of genomic change in synthetic polyploids, how tRNA gene sequences change and function during the process of polyplodization has yet to be investigated in detail. Is variation in tRNA gene sequences durin ...
... genome have been identified (Sarilar et al. 2013). Despite the bulk of evidence for other kinds of genomic change in synthetic polyploids, how tRNA gene sequences change and function during the process of polyplodization has yet to be investigated in detail. Is variation in tRNA gene sequences durin ...
Figures and figure supplements
... Figure 2—figure supplement 4. ChIP-seq profiles of H3K4me3 and total histone H3 across high-variance and low-variance genes. (A) Developmental expression profile, from early cleavage to adult, of the highly expressed high-variance genes (n = 1066). Expression levels were measured by CEL-seq and resc ...
... Figure 2—figure supplement 4. ChIP-seq profiles of H3K4me3 and total histone H3 across high-variance and low-variance genes. (A) Developmental expression profile, from early cleavage to adult, of the highly expressed high-variance genes (n = 1066). Expression levels were measured by CEL-seq and resc ...
Mendelian and Non-Mendelian Regulation of Gene Expression in
... based analysis of transcriptomic variation in 21 maize elite inbred lines found that a substantial number of genes showed presence/ absence expression patterns [34]. Genetical genomics or expression quantitative trait loci (eQTL) mapping is an efficient method for understanding the genetic basis of ...
... based analysis of transcriptomic variation in 21 maize elite inbred lines found that a substantial number of genes showed presence/ absence expression patterns [34]. Genetical genomics or expression quantitative trait loci (eQTL) mapping is an efficient method for understanding the genetic basis of ...
The amphioxus hairy family: differential fate after duplication.
... cells in the central nervous system (Moore et al., 2000). In Tribolium, the hairy gene also functions during segmentation, but is not involved in nervous system development (Sommer and Tautz, 1993). The nematode gene lin-22 is more closely related to the hairy family than to other families of bHLH p ...
... cells in the central nervous system (Moore et al., 2000). In Tribolium, the hairy gene also functions during segmentation, but is not involved in nervous system development (Sommer and Tautz, 1993). The nematode gene lin-22 is more closely related to the hairy family than to other families of bHLH p ...
Two distinct teleost hepatocyte nuclear factor 1 genes, hnf1a/tcf1
... 2.3. HNF1 transcripts detection by two-step RT-PCR Total RNAs from various tissues of adult zebrafish and developmental stages of zebrafish embryo were prepared by using TRIZOL reagent (Invitrogen). Using 1 Ag of total RNA, the first-strand cDNAs (20 Al) were synthesized with oligo(dT) by SUPERSCRIP ...
... 2.3. HNF1 transcripts detection by two-step RT-PCR Total RNAs from various tissues of adult zebrafish and developmental stages of zebrafish embryo were prepared by using TRIZOL reagent (Invitrogen). Using 1 Ag of total RNA, the first-strand cDNAs (20 Al) were synthesized with oligo(dT) by SUPERSCRIP ...
Genome-wide characteristics of sequence coverage by next
... • Majority of the data can be dominated by a small number of highly abundant transcripts • Ability to observe transcripts of smaller abundance is dependent upon sequence ...
... • Majority of the data can be dominated by a small number of highly abundant transcripts • Ability to observe transcripts of smaller abundance is dependent upon sequence ...
The trp Operon - aandersonbiology
... is a region of a chromosome or DNA to which the repressor binds when the operon is turned off and not producing a protein product. The area of the operon called the promoter indicates to the enzyme, RNA polymerase, where to bind to make mRNA during the process of transcription. The repressor is a pr ...
... is a region of a chromosome or DNA to which the repressor binds when the operon is turned off and not producing a protein product. The area of the operon called the promoter indicates to the enzyme, RNA polymerase, where to bind to make mRNA during the process of transcription. The repressor is a pr ...
Integrated genome sequence and linkage map of physic nut
... and 0.746 Mbp, respectively, which are approximately 1.8 and 46.8 times longer, respectively, than the reported physic nut genome (Hirakawa et al., 2012). As the result of short contigs and scaffolds, too many predicted genes in their study were fragmented. Only 17 Mbp (6%) of their assembly (but ab ...
... and 0.746 Mbp, respectively, which are approximately 1.8 and 46.8 times longer, respectively, than the reported physic nut genome (Hirakawa et al., 2012). As the result of short contigs and scaffolds, too many predicted genes in their study were fragmented. Only 17 Mbp (6%) of their assembly (but ab ...
Gene density and transcription influence the localization of
... null hypothesis that the location of a distal 11p15.5 probe (e.g., cI-11p15-25) was the same as cq26 in 11p15.3, was rejected using a 2 sample t-test, P 0.000, but cI-11p15-25 has the same location as an adjacent probe cI-11p15-46, P 0.43. Volpi et al. (2000) similarly observed a high proportion ...
... null hypothesis that the location of a distal 11p15.5 probe (e.g., cI-11p15-25) was the same as cq26 in 11p15.3, was rejected using a 2 sample t-test, P 0.000, but cI-11p15-25 has the same location as an adjacent probe cI-11p15-46, P 0.43. Volpi et al. (2000) similarly observed a high proportion ...
Epigenetic inheritance of acquired traits through sperm RNAs and
... obese humans48, suggesting that sperm tsRNAs can function as sensitive markers of environmental exposure. Further functional evidence obtained by injecting tsRNA-enriched RNA fragments from the sperm of mice fed a HFD into zygotes indicated that tsRNAs could induce metabolic disorders in offspring, ...
... obese humans48, suggesting that sperm tsRNAs can function as sensitive markers of environmental exposure. Further functional evidence obtained by injecting tsRNA-enriched RNA fragments from the sperm of mice fed a HFD into zygotes indicated that tsRNAs could induce metabolic disorders in offspring, ...
Thesis-1965R-K29r
... RNA in the nucleolus is generally accepted. The types are not agreed on. The transfer of RNA to the cytoplasm seems probable but the method is not apparent. Protein synthesis within the nucleolus is I ittle, if any. Considering the conflicting information obtained, it is evident that nucleolar resea ...
... RNA in the nucleolus is generally accepted. The types are not agreed on. The transfer of RNA to the cytoplasm seems probable but the method is not apparent. Protein synthesis within the nucleolus is I ittle, if any. Considering the conflicting information obtained, it is evident that nucleolar resea ...
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... H3K27me3 mark targets both, genes and repetitive elements and is anti-correlated with transcriptional activity. We show that H3K27me3 distribution over its targets is not uniform, but can be grouped into several different clusters that correlate with different levels of repression. Furthermore, we d ...
... H3K27me3 mark targets both, genes and repetitive elements and is anti-correlated with transcriptional activity. We show that H3K27me3 distribution over its targets is not uniform, but can be grouped into several different clusters that correlate with different levels of repression. Furthermore, we d ...
The murine homologue of HIRA, a DiGeorge
... We examined the evolutionary conservation of HIRA by hybridization of radiolabeled probe hD (from the 4 kb insert of one of our human HIRA cDNA clones) (Fig. 1B) to a blot containing EcoRI digested genomic DNA from various species. The probe hybridizes to homologous sequences in the DNA of all menti ...
... We examined the evolutionary conservation of HIRA by hybridization of radiolabeled probe hD (from the 4 kb insert of one of our human HIRA cDNA clones) (Fig. 1B) to a blot containing EcoRI digested genomic DNA from various species. The probe hybridizes to homologous sequences in the DNA of all menti ...
Abundant RNA editing sites of chloroplast protein
... and it mostly converts C to U, although hornwort and fern have abundant U to C editing. Moreover, the editing events have also been detected in tRNAs, introns and the untranslated regions [19, 20]. RNA editing is essential for the normal development of plant and is involved in a wide variety of biol ...
... and it mostly converts C to U, although hornwort and fern have abundant U to C editing. Moreover, the editing events have also been detected in tRNAs, introns and the untranslated regions [19, 20]. RNA editing is essential for the normal development of plant and is involved in a wide variety of biol ...
Cold-induced silencing by long antisense transcripts of an
... demethylase activity of FLOWERING LOCUS D (FLD)5,6. FLC is also repressed by prolonged cold and epigenetically silenced by a Polycomb mechanism involving a PHD–PRC2 (plant homeodomain–Polycomb repressive complex 2) complex2, in a process known as vernalization3,7. To understand the roles of non-codi ...
... demethylase activity of FLOWERING LOCUS D (FLD)5,6. FLC is also repressed by prolonged cold and epigenetically silenced by a Polycomb mechanism involving a PHD–PRC2 (plant homeodomain–Polycomb repressive complex 2) complex2, in a process known as vernalization3,7. To understand the roles of non-codi ...