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Measles infection of the central nervous system
Measles infection of the central nervous system

... measles are serious and often fatal. In spite of functional cell-mediated immunity and high antiviral antibody titers, an immunological control of the CNS infection is not achieved in patients suffering from subacute sclerosing panencephalitis (SSPE). The known cellular receptors for measle virus (M ...
23_T-cell development_LA
23_T-cell development_LA

Innate immune response in avian macrophages elicited by
Innate immune response in avian macrophages elicited by

... mRNA-fold change of 0. A significant upregulation of the expression of the caspase-1, LITAF , MIF, IL-12p35, IL-10 and GM-CSF genes was observed towards 12 hours p.i., the beginning of the mid-cycle period. Regarding the caspase-1, LITAF , MIF, IL12p35, IL-10 and GM-CSF genes, the upregulation of ge ...
Mapping the histone code at hMLH1. - JScholarship
Mapping the histone code at hMLH1. - JScholarship

... Laird, 1999). Two models have been proposed for the mechanism of DNA hypermethylation associated silencing. The first model suggests that DNA hypermethylation directly prevents sequence specific transcription factors from binding to the DNA (Robertson and Jones, 2000). The second model proposes that ...
Microbial Genetics - MyCourses
Microbial Genetics - MyCourses

... operator, preventing transcription • In the presence of lactose, lactose (inducer) binds to the repressor; the repressor cannot bind to the operator and transcription occurs ...
obstructive sleep Apnea and the immune system
obstructive sleep Apnea and the immune system

... in patients with cardiovascular risk factors.13 Findings from several studies have provided evidence for a link between sleep and immune-related factors, particularly with regard to the regulation of sleep. For example, experimental challenge tests have shown that bacterial products and particular i ...
Biosafety Form - University of Idaho
Biosafety Form - University of Idaho

... Yes No - Is from a Risk Group 3 agent. Yes No - Is from a Risk Group 4 agent. Yes No - Is a “Select Agent and Toxin” or other restricted agent. Yes No - Represents more than two-thirds of the genome of a Risk Group 1 or 2 organism. Yes No - Encodes a known oncogene. Yes No - Encodes a control elemen ...
What is the T-cell receptor (TCR)? (abridged
What is the T-cell receptor (TCR)? (abridged

B antigen
B antigen

... • ABO subgroups differ in the amount of antigen present on the red blood cell membrane – Subgroups have less antigen • Subgroups are the result of less effective enzymes. They are not as efficient in converting H antigens to A or B antigens (fewer antigens are present on the RBC) • Subgroups of A ar ...
microbial genetics
microbial genetics

... Plasmids with larger copy number are more useful for gene cloning experiments. (d) Classification on the basis of intrinsic properties A better plasmid classification system uses intrinsic properties such as transfer, replication, maintenance mechanisms, and drug resistance and colicin production. ...
Technologies to keep an eye on: alternative hosts for protein
Technologies to keep an eye on: alternative hosts for protein

The role of gut-associated lymphoid tissues and mucosal defence
The role of gut-associated lymphoid tissues and mucosal defence

... and sustainment of intestinal defences. For example, probiotics can stimulate the synthesis and secretion of polymeric IgA, the antibody that coats and protects mucosal surfaces against harmful bacterial invasion. In addition, appropriate colonization with probiotics helps to produce a balanced T he ...
Linking immune defenses and life history at the
Linking immune defenses and life history at the

... and understanding such trade-offs, however, is complicated by the complexity of the immune system. The measurement of multiple immune indices in studies of “eco-immunology” has only recently become more common, but has great potential for furthering an understanding of the ecological and evolutionar ...
Pathogenic antibodies to coagulation factors. Part one: Factor VIII
Pathogenic antibodies to coagulation factors. Part one: Factor VIII

M201_Asthma_03
M201_Asthma_03

... and I have shown that large numbers of the people have been transferred from the country to the workshops and mills of the towns, and have thus been placed in circumstances where the predisposition to hay-fever would be most rapidly developed in those who rise to a place amongst the educated class. ...
How Aluminum in Vaccines Affects Your Health
How Aluminum in Vaccines Affects Your Health

... It is critical for EVERYONE to get involved now in standing up for the legal right to make voluntary vaccine choices in America because those choices are being threatened by lobbyists representing drug companies, medical trade associations, and public health officials, who are trying to persuade leg ...
Recognition of an organism from fragments of its complete genome
Recognition of an organism from fragments of its complete genome

... length sequences has been discussed 关24兴. The multifractal analysis for these length sequences was done in Ref. 关25兴. Although statistical analysis performed directly on DNA sequences has yielded some success, there has been some indication that this method is not powerful enough to amplify the diff ...
Innate and adaptive immune responses in the lungs
Innate and adaptive immune responses in the lungs

... system such as TLR2 signalling and alveolar epithelial cells type II (AEC II) in the immune responses against mycobacterial infections. Since TLR2 has been shown to be important in the defense against mycobacterial infections; in paper I we investigated the role of TLR2 to generate acquired immune r ...
Temperature-sensitive control of protein activity by conditionally
Temperature-sensitive control of protein activity by conditionally

CpG Mutation Rates in the Human Genome Are
CpG Mutation Rates in the Human Genome Are

... whose sequences had more than one polymorphic position or more than two possible bases at the polymorphic position. A total of 23,208 human SNPs passed all of these tests and, thus, had an unambiguously orthologous sequence in Pan troglodytes. We chose to discard repetitive sequences because it woul ...
Passive vs active & vaccines
Passive vs active & vaccines

... Natural immunity: active and passive • An infection is an example of acquiring natural immunity. It is called ACTIVE as your body needs to work to produce the necessary antibodies • When a mother breast feeds her baby she passes antibodies to it. This is a way of acquiring PASSIVE immunity as it is ...
Invertebrate Immune Systems
Invertebrate Immune Systems

... Paenibacillus alvei and Paenibacillus larvae, or saline (23). Either 8 or 22 days later the insects were given a secondary homologous or heterologous exposure, and their survival and ability to clear the three different species of bacteria from the blood was determined. This approach convincingly de ...
Innate immune responses in hepatitis B virus (HBV
Innate immune responses in hepatitis B virus (HBV

... Other cytokines have also been reported to control HBV replication in the transgenic mouse model, including interleukin 12 (IL-12) [22] and IL-18 [23], the effect being mediated by induction of IFN-γ and IFNα/β respectively. Injection of HBV transgenic mice with CD40 ligand to induce maturation of a ...
Micro Chapter 42 [4-20
Micro Chapter 42 [4-20

... o Expression of latent membrane proteins LMP1 and LMP2a, provides growth signals to infected cells that drive cell proliferation o A small # of viral genes and small RNAs are expressed in long-lived nondividing B cells, which serve as a reservoir for EBV in the normal host o By restricting expressio ...
Immunology and Blood Groups
Immunology and Blood Groups

... Acquired active immunity - This is achieved by injecting small amounts of antigen - the vaccine - into the body of an individual. The whole process is called vaccination or immunisation. The small dose of antigen is usually safe because the pathogen is either killed or attenuated (= crippled). This ...
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DNA vaccination



DNA vaccination is a technique for protecting an animal against disease by injecting it with genetically engineered DNA so cells directly produce an antigen, resulting in a protective immunological response. Several DNA vaccines have been released for veterinary use, and there has been promising research using the vaccines for viral, bacterial and parasitic diseases, as well as to several tumour types. Although only one DNA vaccine has been approved for human use, DNA vaccines may have a number of potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types.
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