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How Exercise Changes Fat and Muscle Cells
How Exercise Changes Fat and Muscle Cells

... Less obviously, but perhaps even more consequentially, they also had altered the methylation pattern of many of the genes in their fat cells. In fact, more than 17,900 individual locations on 7,663 separate genes in the fat cells now displayed changed methylation patterns. In most cases, the genes h ...
No Slide Title
No Slide Title

... • Highly acetylated histones are associated with actively transcribed chromatin – Increasing histone acetylation can turn on some genes. – Immunoprecipitation of DNA cross-linked to chromatin with antibodies against Ac-histones enriches for actively transcribed genes. ...
Nature Rev.Mol.Cell Biol
Nature Rev.Mol.Cell Biol

... from Lodish et al., Molecular Cell Biology, 6th ed. Fig 6-28 ...
neural plasticity
neural plasticity

... • Genetic manipulations can increase the survival of newly generated neurons in the dentate, resulting in improved performance. • These animals showed enhanced hippocampal LTP, which was expected since ...
Nature Rev.Mol.Cell Biol
Nature Rev.Mol.Cell Biol

... AP substrate results in the formation of an insoluble precipitate at the site of hybridization from Lodish et al., Molecular Cell Biology, 6th ed. Fig 6-44 ...
國立嘉義大學九十七學年度
國立嘉義大學九十七學年度

... (i) Restriction endonucleases cut DNA at specific sites that always located between genes. (ii) DNA migrates toward the positive electrode during electrophoresis. (iii) DNA ligase can join two DNA fragments with protruding end on one fragment and blunt end on the other. (iv) In situ hybridization ca ...
here - IMSS Biology 2014
here - IMSS Biology 2014

... plasticity by natural selection (and other mechanisms). ...
Obesity caused BBC tumors to form at a faster rate compared to lean
Obesity caused BBC tumors to form at a faster rate compared to lean

... For most genes, researchers found no correlation between gene expression and methylation ...
Slide 1
Slide 1

... - the goal of this course is to present you the latest original information on epigenetics, to give you some idea on how is such information obtained and to make you a better scientist. - this course is designed for advanced students, particularly for those who consider career in science. The course ...
Unpacking the Epigen..
Unpacking the Epigen..

... Brian Strahl, Ph.D., a professor of biochemistry and biophysics at the University of North Carolina School of Medicine, is addressing several intriguing issues that surround the mechanisms by which distinct chromatin structures are established and maintained, as well as how the underlying DNA is mad ...
Chapter 16: The Molecular Basis of Inheritance
Chapter 16: The Molecular Basis of Inheritance

... 11. What does “semi-conservative” replication mean? 12. What are the functions of primase? DNA polymerase? Ligase? 13. What is the difference between the 5’ and 3’ ends of the DNA molecule? Where are the 5’ and 3’ ends on opposite strands of the double helix? 14. What is the difference between the l ...
DNA Paper Model Activity Try to attach and mode the Gene Reading
DNA Paper Model Activity Try to attach and mode the Gene Reading

... DNA ribbon that is not spooled around a histone or covered by a methyl. Can the machinery read any significant stretch of DNA? No, it cannot. 2. Refer to question 1, would this be an active or inactive gene? Explain. It’s inactive, because the methyl groups make the DNA inaccessible. 3. Try to attac ...
Human gene expression and genomic imprinting
Human gene expression and genomic imprinting

... • TATA box, usually found at a position about 25 bp upstream (25) from the transcriptional start; it is typically found in genes which are actively transcribed by RNA pol II • GC box found in a variety of housekeeping genes, it appears to function in either orientation • CAAT box often located at po ...
Chapter 11: Organization of DNA in Eukaryotes 11.2: mtDNA
Chapter 11: Organization of DNA in Eukaryotes 11.2: mtDNA

... Describe the Endosymbiotic hypothesis. Essentially, modern cells are a product of ancient eukaryotes engulfing free-living mitochondria and/or chloroplasts, allowing these (believed to be) prokaryotes to reside inside of the cytoplasm in a symbiotic relationship. After some time, these mitochondria ...
mc2 Chromatin - WordPress.com
mc2 Chromatin - WordPress.com

... AP substrate results in the formation of an insoluble precipitate at the site of hybridization from Lodish et al., Molecular Cell Biology, 6th ed. Fig 6-44 ...
Gender and epigenetics - Association for Contextual Behavioral
Gender and epigenetics - Association for Contextual Behavioral

... and voluntary exercise, enhances long-term potentiation (LTP) not only in these enriched mice but also in their future offspring through early adolescence, even if the offspring never experience EE. In both generations, LTP induction is augmented by a newly appearing cAMP/p38 MAP kinase-dependent si ...
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... CA1 OGI Reversibly Interferes with Remote Fear Memory Recall ...
Epigenetics seminar 9-7-2014
Epigenetics seminar 9-7-2014

... were once thought of as ‘junk’, but it is now found to have important roles in regulating how, where, & when genes are expressed. •An NIH study found large number of disease-associated GWAS variants located in regulatory DNA regions that are active during foetal development suggesting that environme ...
Long-term memory
Long-term memory

... and retrieval of information. • All animals learn things from their interaction with the environment • Human brain forms memories more effectively than others • Maximum behavioural flexibility and most efficiently adaptation to environment. ...
RNA Polymerase II mediated modifications
RNA Polymerase II mediated modifications

... • HP1 protein binds di and tri-methyl H3K9 and takes a part in gene silencing • In Mammals, 3 types of HP1 are found: HP1α HP1β and HP1 ...
Eukaryotic Gene Expression ppt
Eukaryotic Gene Expression ppt

... Have a nuclear envelope Many are multicellular with specialized cells All cells have full sets of chromosomes Not all genes need to be turned on (expressed) ...
What is memory? - Randolph College
What is memory? - Randolph College

... mental process used to acquire (learn), store, or retrieve (remember) information ...
ppt - Chair of Computational Biology
ppt - Chair of Computational Biology

... unstructured histone tails through acetylation, methylation and phosphorylation. DNA methylation occurs at 5-position of cytosine residues within CpG pairs in a reaction catalyzed by DNA methyltransferases (DNMTs). Together, these modifications provide a unique epigenetic signature that regulates ch ...
Brain Jeopardy Game
Brain Jeopardy Game

... This is where the brain takes multiple items and considers them a single entity (as a way of bypassing the limitations of working memory). ...
PowerPoint-Präsentation
PowerPoint-Präsentation

... found 4.624 genes, which showed differences in gene expression and 19.261 different DNA methylation sites. Between closer related cells like naive and activated/memory cells of the same lymphocyte subtype (CD4+ T-cells) the number decrease to 638 genes and 9.412 sites. Comparing monocytes against T- ...
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Epigenetics in learning and memory

While the cellular and molecular mechanisms of learning and memory have long been a central focus of neuroscience, it is only in recent years that attention has turned to the epigenetic mechanisms behind the dynamic changes in gene transcription responsible for memory formation and maintenance. Epigenetic gene regulation often involves the physical marking (chemical modification) of DNA or associated proteins to cause or allow long-lasting changes in gene activity. Epigenetic mechanisms such as DNA methylation and histone modifications (methylation, acetylation, and deacetylation) have been shown to play an important role in learning and memory.
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