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13059_2007_1664_MOESM13_ESM
13059_2007_1664_MOESM13_ESM

... Visually, gene a, b, and c share similar profile of terms. Gene e, f, and g have common profile. Gene d could be in either groups. Gene h (yellow) is an outlier not closely associating with any of the groups. Therefore, there are two major gene groups (blue and red), and gene d (green) could belong ...
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... • A site in the genome where individual members of a species differ in a single base pair • Haplotype: the specific set of SNPs and other genetic variants observed on a chromosome • Linkage disequilibrium • Tag SNPs • Genome-wide association studies ...
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... Spontaneous Mutations – a mistake in base pairing during DNA replication. It occurs at random or at any ...
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... sequence is directly displaced by another sequence. The enzyme continues to exchange sequences until a promoter is found. ...
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... • DNA composition: “Chargaff’s rules” – varies from species to species – all 4 bases not in equal quantity – bases present in characteristic ratio • humans: A = 30.9% T = 29.4% G = 19.9% C = 19.8% ...
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... Recombinant DNA refers to DNA of one organism inserted into the DNA of another. A Transformation refers to the process of creating recombinant DNA. The major tools of recombinant DNA technology are bacterial enzymes called restriction enzymes. Each enzyme recognizes a short, specific nucleotide sequ ...
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... Mutations are a result in a change in DNA sequence – A protein with a different AA sequence could be produced. – Germ Cell - If mutations occur in sex cells they may be passed on to the next generation. – Somatic- A mutation occurring only in body cells may be a problem for the individual but will n ...
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Leukaemia Section t(4;21)(q31;q22) Atlas of Genetics and Cytogenetics in Oncology and Haematology

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... may also express small peptide hormones such as gastrin-releasing peptide, calcitonin and serotonin. As significant differences exist in the treatment of SCLC and NSCLC, the distinction of SCLC from other neuroendocrine lesions (such as large cell neuroendocrine carcinoma) is important. No premalign ...
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19-7-SA-V1-S1__mcq_a..

... 1. Who proposed the structure of of nucleic acid? 2. Which are the three covalently bound parts of nucleotides? 3. What are the sugars of nucleic acid? 4. Which are the bases of nucleic acid? 5. How nucleotides polymerize to form nucleotides? 6. What are the features of nucleic acid defined by Watso ...
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BTCH Reg Course Rev Sem2

... intron ...
< 1 ... 953 954 955 956 957 958 959 960 961 ... 1621 >

Vectors in gene therapy

Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).
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