![PINK1- and Parkin- mediated mitophagy at a glance](http://s1.studyres.com/store/data/022456941_1-3b56697987be30cdcbb9ced164d53141-300x300.png)
PINK1- and Parkin- mediated mitophagy at a glance
... would be located either on the OMM or in the cytosol. For Parkin, as suggested above, it has not been fully elucidated how many proteins are subject to ubiquitylation, and subsequently degradation, in a manner mediated by its ubiquitin ligase activity, and whether any of these substrates are crucial ...
... would be located either on the OMM or in the cytosol. For Parkin, as suggested above, it has not been fully elucidated how many proteins are subject to ubiquitylation, and subsequently degradation, in a manner mediated by its ubiquitin ligase activity, and whether any of these substrates are crucial ...
Novel targets for tuberculosis drug discovery
... M. tuberculosis [46]. Three crystal structures of ternary complexes of M. tuberculosis dihydrofolate reductase with NADP and three different inhibitors (methotrexate, trimethoprim and WR99210) were determined, as well as the binary complex with NADP [47]. Pantothenate (vitamin B5) is involed in CoA ...
... M. tuberculosis [46]. Three crystal structures of ternary complexes of M. tuberculosis dihydrofolate reductase with NADP and three different inhibitors (methotrexate, trimethoprim and WR99210) were determined, as well as the binary complex with NADP [47]. Pantothenate (vitamin B5) is involed in CoA ...
Adenosine triphosphate Adenosine triphosphate Adenosine
... NADH and NAD+. Instead of transferring the generated NADH, a malate dehydrogenase enzyme converts oxaloacetate to malate, which is translocated to the mitochondrial matrix. Another malate dehydrogenase-catalyzed reaction occurs in the opposite direction, producing oxaloacetate and NADH from the newl ...
... NADH and NAD+. Instead of transferring the generated NADH, a malate dehydrogenase enzyme converts oxaloacetate to malate, which is translocated to the mitochondrial matrix. Another malate dehydrogenase-catalyzed reaction occurs in the opposite direction, producing oxaloacetate and NADH from the newl ...
Type I Factor XI11 Deficiency Is Caused By a
... Insertion of U triplet AAC i n exon III of the gene , f . r the b subunit. Six pairs of specific amplification primers were employed for in vitro amplification of all 12 exons andtheir boundaries of the gene for theb subunit (Fig 2) in the DNA of theproband’ssister (11-1 in Fig 1). Pairs 1-6 produce ...
... Insertion of U triplet AAC i n exon III of the gene , f . r the b subunit. Six pairs of specific amplification primers were employed for in vitro amplification of all 12 exons andtheir boundaries of the gene for theb subunit (Fig 2) in the DNA of theproband’ssister (11-1 in Fig 1). Pairs 1-6 produce ...
The Boron Efflux Transporter ROTTEN EAR Is
... “rotten” appearance at the tip and sterile tassels were designated as rotten ear (rte) (Figure 1). Detailed phenotypic characterization of both tassel and ear was performed on two rte alleles (hereafter referred to as rte-1 and rte-2) and in different genetic backgrounds, revealing a range of phenot ...
... “rotten” appearance at the tip and sterile tassels were designated as rotten ear (rte) (Figure 1). Detailed phenotypic characterization of both tassel and ear was performed on two rte alleles (hereafter referred to as rte-1 and rte-2) and in different genetic backgrounds, revealing a range of phenot ...
Biology 30 January 1998 Grade 12 Diploma Examination
... Stressful situations trigger the release of hormones such as cortisol. Recent studies have found that some forms of depression cause a similar hormonal response that lasts much longer than the normal stress response. This unregulated release of stress hormones may result in reduced appetite, an unre ...
... Stressful situations trigger the release of hormones such as cortisol. Recent studies have found that some forms of depression cause a similar hormonal response that lasts much longer than the normal stress response. This unregulated release of stress hormones may result in reduced appetite, an unre ...
Nutrient Sensing through the Plasma Membrane of Eukaryotic Cells
... transporter [42], is induced only by low levels of glucose because its promoter has binding sites for the Mig1 glucose repressor, which represses transcription when glucose levels are high (Figure 3) [43]. By contrast, expression of HXT1, which encodes a low-affinity glucose transporter [42], is ind ...
... transporter [42], is induced only by low levels of glucose because its promoter has binding sites for the Mig1 glucose repressor, which represses transcription when glucose levels are high (Figure 3) [43]. By contrast, expression of HXT1, which encodes a low-affinity glucose transporter [42], is ind ...
Spring 2005 - AT Children`s Project
... the rat, which may possess neurological abnormalities similar to those seen in patients. For years mice have been genetically manipulated in order to gain a better understanding of human disease. For example, researchers have added genes to the mouse’s already existing genetic repertoire, creating s ...
... the rat, which may possess neurological abnormalities similar to those seen in patients. For years mice have been genetically manipulated in order to gain a better understanding of human disease. For example, researchers have added genes to the mouse’s already existing genetic repertoire, creating s ...
The Wnt code: cnidarians signal the way
... libraries) RNAi, morpholinos, transient and stable transfection are available or under optimization procedure. The introduction of transgenic approaches to the field of cnidarian biology was a major breakthrough. Wittlieb et al. (2006) succeeded in producing the first stable transgenic Hydra by using ...
... libraries) RNAi, morpholinos, transient and stable transfection are available or under optimization procedure. The introduction of transgenic approaches to the field of cnidarian biology was a major breakthrough. Wittlieb et al. (2006) succeeded in producing the first stable transgenic Hydra by using ...
MOLECULAR BIOLOGY OF FRUIT MATURATION AND
... A clarification of the common genetic regulatory elements that are shared among climacteric and non-climacteric species is central to a full understanding of fruit ripening. Such primary regulators of fruit maturation might be shared by, or at least related to, those that regulate maturation of dehi ...
... A clarification of the common genetic regulatory elements that are shared among climacteric and non-climacteric species is central to a full understanding of fruit ripening. Such primary regulators of fruit maturation might be shared by, or at least related to, those that regulate maturation of dehi ...
General introduction - University of Amsterdam
... clades, but no correlation has been found between host factors such as sex and age and strain type (143). C. albicans multiplies primarily in clonal mode of reproduction (44, 92) and relative high levels of non-homologous mitotic recombination, translocation and aneuploidy are observed (21). However ...
... clades, but no correlation has been found between host factors such as sex and age and strain type (143). C. albicans multiplies primarily in clonal mode of reproduction (44, 92) and relative high levels of non-homologous mitotic recombination, translocation and aneuploidy are observed (21). However ...
Full-Text PDF
... Interestingly, the TP53 induced glycolysis regulatory phosphatase (TIGAR) shows sequence homology to the phosphatase domain of PFKFB proteins [40]. TIGAR is induced upon acute activation of p53 in response to DNA damage. This blocks PFK1 activity by reducing Fru-2,6-BP levels. As a consequence, G6P ...
... Interestingly, the TP53 induced glycolysis regulatory phosphatase (TIGAR) shows sequence homology to the phosphatase domain of PFKFB proteins [40]. TIGAR is induced upon acute activation of p53 in response to DNA damage. This blocks PFK1 activity by reducing Fru-2,6-BP levels. As a consequence, G6P ...
Virp1 Is a Host Protein with a Major Role in Potato - IMBB
... Viroids are small, circular, single-stranded RNA molecules that, while not coding for any protein, cause several plant diseases. Viroids rely for their infectious cycle on host proteins, most of which are likely to be involved in endogenous RNA-mediated phenomena. Therefore, characterization of host ...
... Viroids are small, circular, single-stranded RNA molecules that, while not coding for any protein, cause several plant diseases. Viroids rely for their infectious cycle on host proteins, most of which are likely to be involved in endogenous RNA-mediated phenomena. Therefore, characterization of host ...
Supporting document 1 Safety assessment
... The csr1-2 gene expression cassette in CV127 is identical in sequence to the transforming plasmid DNA except for three point mutations, one of which occurred in the AHAS coding sequence, resulting in a conservative amino acid change. This mutation does not affect the function or activity of the AHAS ...
... The csr1-2 gene expression cassette in CV127 is identical in sequence to the transforming plasmid DNA except for three point mutations, one of which occurred in the AHAS coding sequence, resulting in a conservative amino acid change. This mutation does not affect the function or activity of the AHAS ...
HLA-A, -B
... A*0101, *0301, Cw*0701,*0702, B*0702,*0801, DRB1*0301,*1501, DQA1*0501,*0102, DQB1*0201,*0602 composed from 2 haplotypes from the parents: A*0101 : Cw*0701 : B*0801 : DRB1*0301 : DQA1*0501 : DQB1*0201 (by serotyping A1-Cw7-B8-DR3-DQ2) A*0301 : Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602 (by ...
... A*0101, *0301, Cw*0701,*0702, B*0702,*0801, DRB1*0301,*1501, DQA1*0501,*0102, DQB1*0201,*0602 composed from 2 haplotypes from the parents: A*0101 : Cw*0701 : B*0801 : DRB1*0301 : DQA1*0501 : DQB1*0201 (by serotyping A1-Cw7-B8-DR3-DQ2) A*0301 : Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602 (by ...
Chapter 4
... been built with as main purpose the automatic checking disambiguation and correction of variant descriptions. In [Vis et al., 2015] an efficient algorithm for automated DNA/RNA variant description extraction is presented. Here, we propose an extension of this algorithm which provides the automated d ...
... been built with as main purpose the automatic checking disambiguation and correction of variant descriptions. In [Vis et al., 2015] an efficient algorithm for automated DNA/RNA variant description extraction is presented. Here, we propose an extension of this algorithm which provides the automated d ...
The effecT of chlorinaTion of nucleoTide bases on The
... the second group), in which neither the twist of phosphate group, nor the turn of nucleotide bases around the C1′ – N1 glycoside bond or change of the sugar conformation were not the cause which significantly influenced the change of the conformational parame ters of the molecule. The example of th ...
... the second group), in which neither the twist of phosphate group, nor the turn of nucleotide bases around the C1′ – N1 glycoside bond or change of the sugar conformation were not the cause which significantly influenced the change of the conformational parame ters of the molecule. The example of th ...
Biology II Final Exam Practice
... 113. In fruit flies, the allele for normal body (H) is dominant to the allele for hairy body (h), and the allele for red eye color (B) is dominant to the allele for brown (b). Use a Punnett square to determine the possible phenotypes and frequencies of the offspring from the cross Hhbb hhBb. 114. ...
... 113. In fruit flies, the allele for normal body (H) is dominant to the allele for hairy body (h), and the allele for red eye color (B) is dominant to the allele for brown (b). Use a Punnett square to determine the possible phenotypes and frequencies of the offspring from the cross Hhbb hhBb. 114. ...
8 VARIATION IN CHROMOSOME STRUCTURE AND NUMBER
... similar sequences. These are called repetitive sequences because they occur multiple times. An example of repetitive sequences are transposable elements, which are described in Chapter 17. In Figure 8.5, the repetitive sequence on the right (in the upper chromatid) has lined up with the repetitive s ...
... similar sequences. These are called repetitive sequences because they occur multiple times. An example of repetitive sequences are transposable elements, which are described in Chapter 17. In Figure 8.5, the repetitive sequence on the right (in the upper chromatid) has lined up with the repetitive s ...
What is Biology? Biology and Biologists: Overview What is Biology
... Organic Molecules: Overview Organic Chemistry Food Energy Molecules Nitrogen Containing Compounds Organic Molecules: Summary Macromolecules: Overview Structure and Function of Polysaccharides Structure and Function of Fats Structure and Function of Proteins Macromolecules: Summary ...
... Organic Molecules: Overview Organic Chemistry Food Energy Molecules Nitrogen Containing Compounds Organic Molecules: Summary Macromolecules: Overview Structure and Function of Polysaccharides Structure and Function of Fats Structure and Function of Proteins Macromolecules: Summary ...
Exclusion of known corneal dystrophy genes in an autosomal
... underlying causative genetic mechanism in a three-generation pedigree affected with a unique anterior membrane corneal dystrophy characterized by early onset recurrent corneal erosions, small discrete focal opacities at the level of Bowman layer and anterior stroma, anterior stromal flecks, and prom ...
... underlying causative genetic mechanism in a three-generation pedigree affected with a unique anterior membrane corneal dystrophy characterized by early onset recurrent corneal erosions, small discrete focal opacities at the level of Bowman layer and anterior stroma, anterior stromal flecks, and prom ...
Large-scale Analysis of Pseudogenes in the Human Genome
... It is a little surprising that the total numbers of human pseudogenes reported by the three research groups are quite different. Much of the discrepancy can be attributed to the different criteria used by individual groups. Ohshima et al [11] applied the stringiest criteria in their procedures as th ...
... It is a little surprising that the total numbers of human pseudogenes reported by the three research groups are quite different. Much of the discrepancy can be attributed to the different criteria used by individual groups. Ohshima et al [11] applied the stringiest criteria in their procedures as th ...
Osteon-Mimetic Nanocomposite Materials For Bone Regeneration
... Figure 2.4 Schematic of the electrospinning process ........................................................20 Figure 2.5 SEM micrographs of (a) random and (b) aligned fibers, electrospun from 9.0 wt % PLLA in HFIP solvent. ............................................................................ ...
... Figure 2.4 Schematic of the electrospinning process ........................................................20 Figure 2.5 SEM micrographs of (a) random and (b) aligned fibers, electrospun from 9.0 wt % PLLA in HFIP solvent. ............................................................................ ...
Foundations of Biology
... What Is Pharming? Pharming is the use of recombinant domestic animals to produce proteins and other bioactive compounds One of the most common strategies in pharming involves engineering mammals to produce desired proteins in their milk This strategy was first used to produce t-PA in the milk of go ...
... What Is Pharming? Pharming is the use of recombinant domestic animals to produce proteins and other bioactive compounds One of the most common strategies in pharming involves engineering mammals to produce desired proteins in their milk This strategy was first used to produce t-PA in the milk of go ...