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nucleic acid
nucleic acid

... are organized in an antiparallel arrangement: the two strands run in opposite directions, one strand is oriented 5’→3’ and the other is oriented 3’ →5’. (2) The bases on the inside and the sugar-phosphate backbones in the outside. (3) The diameter of the double helix is 2 nm, the distance between tw ...
Chapter 9 DNA: THE Genetic Material
Chapter 9 DNA: THE Genetic Material

... errors sometime occur with wrong nucleotide added DNA polymerases “proofreading role” – can backtrack and correct Proofreading reduces errors – DNA replication about one error per 1 billion nucleotides ...
Genetics Quiz – 18 October 2005
Genetics Quiz – 18 October 2005

... 9. DNA is a double stranded helical polynucleotide True 10. Alleles are the genetic code for a character (example hair color), found on both strands of the DNA and on specific locations on the homologous chromosomes False 11. we need one copy of a gene (i.e. its allele) to have that character False ...
cell division notes -
cell division notes -

... Turner's syndrome (45, X0) (learn more about the disorder) Klinefelters syndrome (47, XXY) Down's syndrome (trisomy 21) (learn more about the disorder) - p. 145 other abnormalities related to XY and gender: Animations on sex determination | Gender testing of female athletes | sex unknown: NOVA websi ...
Different microarray applications
Different microarray applications

... Time series (with and without a given treatment) Patterns of gene activity (healthy vs. control) Predicting disease by gene patterns – Predict outcome of AML disease – MammaPrint (breast cancer prognosis) ...
Application of Microarray- Based Genomic Technology to Mutation
Application of Microarray- Based Genomic Technology to Mutation

... • Use nonporous surface for fabrication and fluorescencebased detection. • Miniaturized microarray. • Bacterial artificial chromosomes (BAC)-based cloning ...
Programming Gene Expression
Programming Gene Expression

N N N N N N H purine pyrimdine Chapter 3 Nucleotides and Nucleic
N N N N N N H purine pyrimdine Chapter 3 Nucleotides and Nucleic

... The entire DNA content of an organism is known as its genome, and in humans is contained in 46 chromosomes per cell, or 23 equivalent pairs (diploid). RNA, because of steric hindrance originating from the OH at the 3' position (replaced by H in DNA), does not typically form double-stranded structure ...
From DNA to Proteins
From DNA to Proteins

... for a transmembrane protein that acts as an ion pump. The CFTR gene is found on chromosome 7. It codes for 1480 amino acids. There are over 1000 known mutations, which can affect the function of the CFTR gene in different ways. In around 70% of cases CF is caused by a triplet deletion, resulting in ...
CHAPTER 12
CHAPTER 12

... • The Role of Transcription Factors in Regulating Gene Expression – Transcription factors are the proteins that either acts as transcription activators or transcription inhibitors. • A single gene can be controlled by different regulatory proteins. • A single DNA-binding protein may control the expr ...
Exam #1 Slides
Exam #1 Slides

... Involved in Cystic Fibrosis ...
lecture1-3smster
lecture1-3smster

... • A more global perspective in experimental design (from “one scientist = one gene/protein/disease” paradigm to whole organism consideration). • Data mining - functional/structural information is important for studying the molecular basis of diseases (and evolutionary patterns). ...
olivia.judson.nyt.a.random.analysis.pdf
olivia.judson.nyt.a.random.analysis.pdf

... animals with backbones is thought to have experienced at least one, perhaps two, genome duplications, allowing for an explosion of diversity in complexity and form. So understanding the mutational spectrum — which mutations are more likely and why — is essential for estimating the odds of particular ...
Genes get around
Genes get around

...  Find early signs of cancer  Find genetic defects in human embryos  Examine the DNA of ancient organisms ...
A1981MD68300002
A1981MD68300002

... after operon, only to discover that a single eukaryotic gene may, in some instances, be as large and complex as several operons or even an entire viral chromosome. "I believe this paper is frequently cited because it reported one of the most direct measures of gene size and number in a eukaryote. It ...
L04_Public_Resources_Luke_Durban_2015
L04_Public_Resources_Luke_Durban_2015

... variation within and across human populations - ~2M single nucleotide polymorphisms (SNPs) genotyped in ~1000 individuals from 11 populations ...
Chapter 4 - WordPress.com
Chapter 4 - WordPress.com

... Chapter 4 Cell Metabolism ...
Research Focused Undergraduate Education - GCG-42
Research Focused Undergraduate Education - GCG-42

... Reasons for Plant Gene Transfer  Golden Rice  Grains such as rice, produce all but two of the enzymes needed to produce beta carotene (vit A precursor)  Rice feeds half the world’s population  Vit A deficiencies are associated with blindness, night blindness, diabetes, anemia and easy infection ...
Discussion of control of the lac operon and mutational analysis
Discussion of control of the lac operon and mutational analysis

... Let review a few terms and then look at the lab problem (table) on page 3-24 important terms of DNA control. ...
Analytical and Chromatography - Sigma
Analytical and Chromatography - Sigma

From DNA to Protein
From DNA to Protein

DNA replication - Understanding Evolution
DNA replication - Understanding Evolution

... Students will understand that 1) molecular mechanisms that preserve the fidelity of the genetic sequence have been favored by natural selection, 2) some entities, such as HIV, lack some of these mechanisms and so have a higher rate of mutation and evolution, and 3) many challenges posed to medical s ...
Ch. 18 Regulation of Gene Expression
Ch. 18 Regulation of Gene Expression

... ­found in clusters that have their own promoter  and individually transcribed ­some are found on different chromosomes ­expression depends on a combination of   elements that recognize control elements        and bind to them, so all genes are        transcribed at the same time ...
E. Coli - mrkeay
E. Coli - mrkeay

... Restriction Endonuclease Cut Sites ...
Protein Synthesis
Protein Synthesis

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Non-coding DNA

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