91.510_ch06 - Computer Science
... If the odds of being sampled from the background are low (i.e., much less than 1), then they are approximately equal to the P-value of the MSP having been created from the background distribution. Low P-values do not necessarily mean the score is biologically significant, only that the MSP was more ...
... If the odds of being sampled from the background are low (i.e., much less than 1), then they are approximately equal to the P-value of the MSP having been created from the background distribution. Low P-values do not necessarily mean the score is biologically significant, only that the MSP was more ...
Topic guide 12.4: Analysis methods
... an initial set of amino acid sequences, which are believed to represent a given protein family (for example, the prion proteins: http://www.bioinf.manchester.ac.uk/cgi-bin/dbbrowser/ALIGN/ PRINTShtmlalign.cgi?align=PRION); she examines the alignment to discover the most conserved regions or motifs. ...
... an initial set of amino acid sequences, which are believed to represent a given protein family (for example, the prion proteins: http://www.bioinf.manchester.ac.uk/cgi-bin/dbbrowser/ALIGN/ PRINTShtmlalign.cgi?align=PRION); she examines the alignment to discover the most conserved regions or motifs. ...
The nuclear envelope in genome organization, expression and
... Perinuclear proteins in silencing. DNA-tagging methods have been used to assess the extent of perinuclear DNA positioning on a genome-wide scale. One such method is DNA adenine methyltransferase identification (DamID), which can detect loci located near the nuclear periphery by identifying DNA that ...
... Perinuclear proteins in silencing. DNA-tagging methods have been used to assess the extent of perinuclear DNA positioning on a genome-wide scale. One such method is DNA adenine methyltransferase identification (DamID), which can detect loci located near the nuclear periphery by identifying DNA that ...
BLAST: Basic Local Alignment Search Tool Meng Cao, Arthur Lee
... In order to find similar sequences, BLAST first finds the highest scoring pair of sequences, or the maximal segment pair (MSP), and in one version of BLAST, matching DNA nucleotides are given a score of +5, while mismatches are assigned -4 (as outlined in the flowchart). In order to more directly ap ...
... In order to find similar sequences, BLAST first finds the highest scoring pair of sequences, or the maximal segment pair (MSP), and in one version of BLAST, matching DNA nucleotides are given a score of +5, while mismatches are assigned -4 (as outlined in the flowchart). In order to more directly ap ...
MyTaxa: an advanced taxonomic classifier for genomic and
... approaches (19). The main limitation of the homology-based approaches is the lack of a comprehensive database of reference genome sequences. Accordingly, query sequences representing novel taxa provide only low-identity matches or no matches to the reference sequences and, in a typical metagenomic s ...
... approaches (19). The main limitation of the homology-based approaches is the lack of a comprehensive database of reference genome sequences. Accordingly, query sequences representing novel taxa provide only low-identity matches or no matches to the reference sequences and, in a typical metagenomic s ...
Robust Genome Editing in Stem Cells Using CRISPR
... attractive tool for large-scale genome engineering in a wide variety of hosts. We have developed various CRISPR-Cas9 formats that can be used to edit genomes in a wide variety of cell types, including stem cells. Using these formats we have achieved greater than 50% target-specific DNA cleavage in m ...
... attractive tool for large-scale genome engineering in a wide variety of hosts. We have developed various CRISPR-Cas9 formats that can be used to edit genomes in a wide variety of cell types, including stem cells. Using these formats we have achieved greater than 50% target-specific DNA cleavage in m ...
c-fos Protein Can Induce Cellular Transformation: A Novel
... protein, the results suggest that the transforming activity of fos is unaffected by the large out of frame deletion in vfos which results in an altered C terminus. This conclusion is supported by the observation that, like VVV, VMV also induces transformation (Table 1 A). Taken together these result ...
... protein, the results suggest that the transforming activity of fos is unaffected by the large out of frame deletion in vfos which results in an altered C terminus. This conclusion is supported by the observation that, like VVV, VMV also induces transformation (Table 1 A). Taken together these result ...
File
... Transcription factors recognize the promoter and regulatory sequences to control transcription mRNA sequences such as the ribosomal-binding site and codons direct translation Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ...
... Transcription factors recognize the promoter and regulatory sequences to control transcription mRNA sequences such as the ribosomal-binding site and codons direct translation Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ...
Evolution Expression Level, and Interactivity Are Correlated in
... lost. However, the one/zero scoring scheme for gene loss and preservation in different lineages does not reflect the time during which a particular gene was lost or preserved. This time can be different for different lineages, which renders the binary measure inaccurate. In our reconstruction of the ...
... lost. However, the one/zero scoring scheme for gene loss and preservation in different lineages does not reflect the time during which a particular gene was lost or preserved. This time can be different for different lineages, which renders the binary measure inaccurate. In our reconstruction of the ...
DYNAMIC BLOCK ALLOCATION FOR BIOLOGICAL SEQUENCES
... present two versions of this algorithm, namely DBFA (Double Brute Force Algorithm) and MBFA (Multi Brute Force Algorithm). A series of tests were performed, mostly related to integer numbers where blocking and block size planning was used. Comparisons made between these two versions of the algorithm ...
... present two versions of this algorithm, namely DBFA (Double Brute Force Algorithm) and MBFA (Multi Brute Force Algorithm). A series of tests were performed, mostly related to integer numbers where blocking and block size planning was used. Comparisons made between these two versions of the algorithm ...
Plant centromeres: structure and control Eric J Richards and R Kelly
... that microinjection of arrays of the alphoid class of human centromeric repeats (plus telomeres and a selectable marker) into cultured cells can lead to the formation of centromere-containing microchromosomes [54]. These data strongly suggest that simple centromere repeats are sufficient for chromos ...
... that microinjection of arrays of the alphoid class of human centromeric repeats (plus telomeres and a selectable marker) into cultured cells can lead to the formation of centromere-containing microchromosomes [54]. These data strongly suggest that simple centromere repeats are sufficient for chromos ...
PHYS 4xx Intro 2 1 PHYS 4xx Intro 2
... Panel (a) shows the molecule as a linear chain. Five of the oxygens are part of -OH groups while the sixth is double-bonded as an aldehyde. The double-bonded oxygen can be placed at one of several different positions on the chain, each corresponding to an inequivalent, yet related, molecule. The cha ...
... Panel (a) shows the molecule as a linear chain. Five of the oxygens are part of -OH groups while the sixth is double-bonded as an aldehyde. The double-bonded oxygen can be placed at one of several different positions on the chain, each corresponding to an inequivalent, yet related, molecule. The cha ...
How to measure chromatin modifications
... although other high-throughput sequencing techniques would also work in principle. The first step is the purification of modified chromatin by immunoprecipitation using an antibody that is specific to a particular histone modification (shown in green). The ChIP DNA ends are repaired and ligated to a ...
... although other high-throughput sequencing techniques would also work in principle. The first step is the purification of modified chromatin by immunoprecipitation using an antibody that is specific to a particular histone modification (shown in green). The ChIP DNA ends are repaired and ligated to a ...
Risks from GMOs due to Horizontal Gene Transfer
... Horizontal gene transfer (HGT) is the stable transfer of genetic material from one organism to another without reproduction or human intervention. Transfer occurs by the passage of donor genetic material across cellular boundaries, followed by heritable incorporation to the genome of the recipient o ...
... Horizontal gene transfer (HGT) is the stable transfer of genetic material from one organism to another without reproduction or human intervention. Transfer occurs by the passage of donor genetic material across cellular boundaries, followed by heritable incorporation to the genome of the recipient o ...
Tatiana Rosenblatt - Cockayne Syndrome
... followed by progressive intellectual and behavioral decline. If those two major criteria are present in an infant or toddler, then a diagnosis of CS type I can be made, especially if the toddler also shows strong photosensitivity. In order to make a diagnosis of CS type I in an older child, in addit ...
... followed by progressive intellectual and behavioral decline. If those two major criteria are present in an infant or toddler, then a diagnosis of CS type I can be made, especially if the toddler also shows strong photosensitivity. In order to make a diagnosis of CS type I in an older child, in addit ...
Pfx50™ DNA Polymerase - Thermo Fisher Scientific
... components of the product in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The buyer cannot sell or otherwise transfer (a) this product (b) its components or (c) materials made using this product or its components to a third party or otherwise use this prod ...
... components of the product in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The buyer cannot sell or otherwise transfer (a) this product (b) its components or (c) materials made using this product or its components to a third party or otherwise use this prod ...
tRNA and Translation
... 1. What is the structure and function of transfer RNA? (MCA-II science standard) 2. How does translation work? (MCA-II science standard) 3. What is evolution? (MCA-II science standard) INTRODUCTION DNA, the molecule which provides the blueprint for life, is located in the nucleus of cells. mRNA, whi ...
... 1. What is the structure and function of transfer RNA? (MCA-II science standard) 2. How does translation work? (MCA-II science standard) 3. What is evolution? (MCA-II science standard) INTRODUCTION DNA, the molecule which provides the blueprint for life, is located in the nucleus of cells. mRNA, whi ...
number of fifty human tumours
... The relation between DNA content and chromosome number Considering first the main group of 30 tumours on which substantial numbers of chromosome counts were made, it is evident that except for Tumour No. 29 there is quite good agreement between basic DNA content and chromosome number. For Tumour No. ...
... The relation between DNA content and chromosome number Considering first the main group of 30 tumours on which substantial numbers of chromosome counts were made, it is evident that except for Tumour No. 29 there is quite good agreement between basic DNA content and chromosome number. For Tumour No. ...
Functional analysis of plastid DNA replication origins in tobacco by
... replication origin (confusingly named oriB in Oenothera) was mapped in this region by electron microscopic analysis of displacement loops (Chiu and Sears, 1992). The sequence differences are caused by repetition and variation of short DNA elements. In tobacco, the corresponding region consists of no ...
... replication origin (confusingly named oriB in Oenothera) was mapped in this region by electron microscopic analysis of displacement loops (Chiu and Sears, 1992). The sequence differences are caused by repetition and variation of short DNA elements. In tobacco, the corresponding region consists of no ...
New scientific and technological developments relevant
... Since the completion of the Human Genome Project, systems biology, a busy field of the life sciences, has been developing rapidly. In particular, the international 1000 Genomes Project will provide a map of variations in human DNA at unprecedentedly high resolution, helping to reveal population-spec ...
... Since the completion of the Human Genome Project, systems biology, a busy field of the life sciences, has been developing rapidly. In particular, the international 1000 Genomes Project will provide a map of variations in human DNA at unprecedentedly high resolution, helping to reveal population-spec ...