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Virulence gene regulation in Salmonella enterica
Virulence gene regulation in Salmonella enterica

Gene Annotation Naming Guidelines
Gene Annotation Naming Guidelines

... PARALOG_DOMAIN: a region shared by members of a family that are all drawn from the same (or very closely related) genome. SUBFAMILY: formally, a branch of a superfamily. Subfamilies often include fairly closely related proteins with functional heterogeneity. In practical terms, this iso_type is warn ...
Characterization of Deletions in the LDL Receptor Gene in Patients
Characterization of Deletions in the LDL Receptor Gene in Patients

Matthew Kwong - GEP Community Server
Matthew Kwong - GEP Community Server

... the way that the amino acid sequences are conserved from one exon to the next. There are often many possible candidates for donor sites (and sometimes acceptor sites as well). One considers all donor sites until the nearest stop codon for that frame. The best candidate is the one that matches the ac ...
No Slide Title
No Slide Title

... – can target recombination to specific tissues and times – can study genes that are embryonic lethal when disrupted – can use for marker eviction – can study the role of a single gene in many different tissues with a single mouse line – can use for engineering translocations and inversions on chromo ...
Chapter 20
Chapter 20

... Plasmid (1,000,000’s in a small volume of aqueous solution in tiny Eppendorf tube) ...
Gene tree reconstruction and orthology analysis based on
Gene tree reconstruction and orthology analysis based on

... and reconciliation, are problems important in multigenomebased comparative genomics and biology in general. In the present paper, we advance the frontier of these areas in several respects and provide important computational tools. First, exact algorithms are given for several probabilistic reconcil ...
The influence of low-molecular-weight heparin (LMWH
The influence of low-molecular-weight heparin (LMWH

... changed prenatal diagnostics in the past three years. Hundreds of thousands of these tests have been performed annually in that time. The level of cell-free fetal DNA (cffDNA level, fetal fraction) in the maternal blood plasma has been evaluated in this process to date as one of the most important c ...
Cloning and functional analysis of the chitinase gene promoter in
Cloning and functional analysis of the chitinase gene promoter in

... been widely used to drive the expression of transferred exogenous genes in all tissues and at all developmental stages of transgenic plants. The sustained expression of foreign genes, however, can suppress plant growth and development and can cause the accumulation of toxic substances in the plants ...
This document - streptomyces.org.uk
This document - streptomyces.org.uk

... This document describes how you may access the data behind StrepDB from your scripts and programs. All you need is some familiarity with SQL and a knowledge of structures of the tables behind StrepDB. Since StrepDB provides access to information about more than one species of Streptomyces, the organ ...
Wide-spread polyploidizations during plant evolution Dicot
Wide-spread polyploidizations during plant evolution Dicot

... Figure 3. Progression of rearrangem ent s and chromoso me fusions leading t o t he loss of a cent romere in Z. rouxii. Two non-reciprocal telomeric translocations and a telomere-to-telomere fusion gave rise to the extant chromosome structures in Z. rouxii. Chromosomes in green boxes are those that u ...
Development of novel computational tools based on
Development of novel computational tools based on

... gene transfer, defined as a mechanism that promotes the transfer of foreign genomic segments between lineages was found to be relatively common in prokaryotes and less common in higher-order organisms. This mechanism effectively contributes to the evolution and diversity of bacterial species by the ...
The double helix: a tale of two puckers
The double helix: a tale of two puckers

... second strand of poly(U) could be taken into the helix to make a triple helix of one poly(A) plus two poly(U)8. Because there was no increase in the diameter of the helix, we suggested that the additional uracil residue was bound by two hydrogen bonds to the amino group and N7 of adenine. This inter ...
Towards an accurate identification of mosaic genes and
Towards an accurate identification of mosaic genes and

... transgenic DNA into human cell, antibiotic-resistant genes spreading to pathogenic bacteria, and disease-associated genes spreading and recombining to create new viruses and bacteria (4). Two models of HGT have been considered in the literature (5). First, and the most popular of them, is the tradit ...
Identification of Saccharomyces cerevisiae DNA ligase IV
Identification of Saccharomyces cerevisiae DNA ligase IV

... However, ligase II is induced in response to alkylation damage (Creissen and Shall, 1982), suggesting a role in DNA repair. Similarly, the elevation in levels of a splice variant of ligase III (ligase III-β) in spermatocytes undergoing meiotic recombination (Chen et al., 1995; Husain et al., 1995; M ...
MUTATIONS Introduction Natures intention is that the exact genetic
MUTATIONS Introduction Natures intention is that the exact genetic

... lesion in one specific step of an enzymatic pathway. For bacteria, biochemical mutants need to be grown on a media supplemented with a specific nutrient. Such mutants are called auxotrophs. Often though, morphological mutants are the direct result of a mutation in a biochemical pathway. In humans, a ...
Geuvadis Analysis Meeting
Geuvadis Analysis Meeting

... “28.7% LoF events in a single individual affect only a subset of the known transcripts from the affected gene, Emphasizing the need to consider alternative splicing” [MacArthur et al. 2012] ...
The Development of a Genetic Marker for Resistance to Fescue
The Development of a Genetic Marker for Resistance to Fescue

... Fescue Toxicosis. Recently, our lab has discovered a sequence variation in the DRD2 gene sequence which may serve as a marker for susceptibility to Fescue Toxicosis. The sequence variation was an intronic A→G single nucleotide polymorphism (SNP) that was found in the region of the DRD2 gene, creatin ...
RNA and Protein Synthesis
RNA and Protein Synthesis

... mRNA helps get DNA’s message out to the ...
Modular proteins I
Modular proteins I

... Modular assembly by intronic recombination Discovery of introns provided potential new mechanisms for protein evolution: Gilbert suggested that recombination within introns could assort exons independently Idea of rapid construction of novel genes from parts of old ones led to the formulation of th ...
Nuclear DNA Content Estimates in Green Algal Lineages
Nuclear DNA Content Estimates in Green Algal Lineages

... † Background and Aims Consensus higher-level molecular phylogenies present a compelling case that an ancient divergence separates eukaryotic green algae into two major monophyletic lineages, Chlorophyta and Streptophyta, and a residuum of green algae, which have been referred to prasinophytes or mic ...
PCR for TOPO Cloning
PCR for TOPO Cloning

... Then I prepared a gel and loaded in the middle with Joey’s sample on one side and the 100bp standard on the other. Unfortunately, none of our samples showed up, the red oval below indicates the position of around 1000 bp where the band should have been. So Dr. Ju said that that might have been cause ...
Educator's Resource Guide 4226  Biology 1 s 4-5
Educator's Resource Guide 4226 Biology 1 s 4-5

... The Experiments of Gregor Mendel The delivery of characteristics from parents to offspring is heredity. The scientific study of heredity is genetics. Gregor Mendel founded modern genetics with his experiments on a convenient model system, pea plants: ▶ Fertilization is the process in which reproduct ...
Sex determination in Bombyx mori
Sex determination in Bombyx mori

... Bombyx homologues of doublesex and other sex-determining genes in Drosophila Outline of the genetic cascade for sex determination in Drosophila The sexual differentiation of vertebrates is strongly controlled by sex hormones circulating in blood. The sex hormones are steroids secreted from gonads. I ...
1. The PERL script to
1. The PERL script to

... The Gene Ontology (GO) Database search Introduction Microarray results were analysed for pathway information in the KEGG database using gene names of genes on the microarray. Genes may be known with different names. Therefore, the Gene Ontology database was searched before the KEGG database to colle ...
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Helitron (biology)

A helitron is a transposon found in eukaryotes that is thought to replicate by a so-called ""rolling-circle"" mechanism. This category of transposons was discovered by Vladimir Kapitonov and Jerzy Jurka in 2001. The rolling-circle process begins with a break being made at the terminus of a single strand of the helitron DNA. Transposase then sits at this break and at another break where the helitron targets as a migration site. The strand is then displaced from its original location at the site of the break and attached to the target break, forming a circlular heteroduplex. This heteroduplex is then resolved into a flat piece of DNA via replication. During the rolling-circle process, DNA can be replicated beyond the initial helitron sequence, resulting in the flanking regions of DNA being ""captured"" by the helitron as it moves to a new location.
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