Full Text - Science and Education Publishing
... step of cell wall biosynthesis by cross-linking two strands of peptidoglycan, or DD-peptidases [29]. This agrees with that many ESBLs TEM genes evolved from one or more amino acid substitution around the active site [30]. This mutation increased protein isoelectric point from pI; 5.32 to pI; 5.44, t ...
... step of cell wall biosynthesis by cross-linking two strands of peptidoglycan, or DD-peptidases [29]. This agrees with that many ESBLs TEM genes evolved from one or more amino acid substitution around the active site [30]. This mutation increased protein isoelectric point from pI; 5.32 to pI; 5.44, t ...
Genetics in Primary Care - Jude Hayward
... melanomas, association with CML / renal cell carcinoma ...
... melanomas, association with CML / renal cell carcinoma ...
Primary cilia in energy balance signaling and
... Moreover, metabolic disorders are interrelated diseases exemplified by the association of obesity with insulin resistance, leading to development of type II diabetes (2). Genetic factors for obesity are poorly understood, and recent progress by genome-wide association studies support the notion of p ...
... Moreover, metabolic disorders are interrelated diseases exemplified by the association of obesity with insulin resistance, leading to development of type II diabetes (2). Genetic factors for obesity are poorly understood, and recent progress by genome-wide association studies support the notion of p ...
New Insights into Polycistronic Transcripts in Eukaryotes
... RT-PCR analyses suggested that it must be transcribed as a polycistronic transcript. These receptor genes span 11 kb of genomic DNA and encode gustatory receptors of sucrose, maltose, glucose, arabinose, trehalose, and glycerol. (4) In addition to the results of RT-PCR, the fact that the adjacent re ...
... RT-PCR analyses suggested that it must be transcribed as a polycistronic transcript. These receptor genes span 11 kb of genomic DNA and encode gustatory receptors of sucrose, maltose, glucose, arabinose, trehalose, and glycerol. (4) In addition to the results of RT-PCR, the fact that the adjacent re ...
Solid Tumour Section Soft tissue tumors: Dermatofibrosarcoma protuberans Atlas of Genetics and Cytogenetics
... is the transcriptional up-regulation of the PDGFB gene. The associated COL1A1-PDGFbeta fusion protein is posttranslationally processed to a functional PDGFbeta and results in PDGFbeta-mediated autocrine and/or paracrine activation of platelet-derived growth factor receptor-beta (PDGFBB). ...
... is the transcriptional up-regulation of the PDGFB gene. The associated COL1A1-PDGFbeta fusion protein is posttranslationally processed to a functional PDGFbeta and results in PDGFbeta-mediated autocrine and/or paracrine activation of platelet-derived growth factor receptor-beta (PDGFBB). ...
The Tel-PDGFRß fusion gene produces a chronic
... with the transmembrane and tyrosine kinase domains of platelet-derived growth factor receptor  (PDGFR) gene. To investigate the role of this fusion protein in the pathogenesis of CMML, we expressed the Tel-PDGFR fusion cDNA in hematopoietic cells of transgenic mice under the control of the human ...
... with the transmembrane and tyrosine kinase domains of platelet-derived growth factor receptor  (PDGFR) gene. To investigate the role of this fusion protein in the pathogenesis of CMML, we expressed the Tel-PDGFR fusion cDNA in hematopoietic cells of transgenic mice under the control of the human ...
11.4 How Is The Information In A Gene
... 11.5 How Is The Information In Messenger RNA Translated Into Protein? mRNA, with a specific base sequence, is used during translation to direct the synthesis of a protein with the amino acid sequence encoded by the mRNA. • Decoding the base sequence of mRNA is the job of tRNA and ribosomes in the ...
... 11.5 How Is The Information In Messenger RNA Translated Into Protein? mRNA, with a specific base sequence, is used during translation to direct the synthesis of a protein with the amino acid sequence encoded by the mRNA. • Decoding the base sequence of mRNA is the job of tRNA and ribosomes in the ...
Genetic susceptibility to Hodgkin`s lymphoma and to secondary
... reversible. Long-term follow-up of the stem-cell donors may, therefore, be required. The significance of these preliminary findings has yet to be elucidated. ...
... reversible. Long-term follow-up of the stem-cell donors may, therefore, be required. The significance of these preliminary findings has yet to be elucidated. ...
Ch11_lecture - Dr Owen class material
... 11.5 How Is The Information In Messenger RNA Translated Into Protein? mRNA, with a specific base sequence, is used during translation to direct the synthesis of a protein with the amino acid sequence encoded by the mRNA. • Decoding the base sequence of mRNA is the job of tRNA and ribosomes in the ...
... 11.5 How Is The Information In Messenger RNA Translated Into Protein? mRNA, with a specific base sequence, is used during translation to direct the synthesis of a protein with the amino acid sequence encoded by the mRNA. • Decoding the base sequence of mRNA is the job of tRNA and ribosomes in the ...
Attanasio et al.
... as causing an NPHP-like phenotype in humans and mice, using positional cloning and mouse transgenics, respectively. Kidneys of Glis2 mutant mice show severe renal atrophy and fibrosis starting at 8 weeks of age. Differential gene expression studies on Glis2 mutant kidneys demonstrate that genes prom ...
... as causing an NPHP-like phenotype in humans and mice, using positional cloning and mouse transgenics, respectively. Kidneys of Glis2 mutant mice show severe renal atrophy and fibrosis starting at 8 weeks of age. Differential gene expression studies on Glis2 mutant kidneys demonstrate that genes prom ...
PPT presentation
... there in similarity. • While it is presumed that the homologous sequences have diverged from a common ancestral sequence through iterative molecular changes we do not actually know what the ancestral sequence was. ...
... there in similarity. • While it is presumed that the homologous sequences have diverged from a common ancestral sequence through iterative molecular changes we do not actually know what the ancestral sequence was. ...
Ontologies - Buffalo Ontology Site
... Common standards are required Ontologies must be interoperable and logically well-formed Ontologies should be developed collaboratively ...
... Common standards are required Ontologies must be interoperable and logically well-formed Ontologies should be developed collaboratively ...
Document
... majority of ALL samples (grey squares) and cluster A2 contains the majority of AML samples (black circles). (B) Prediction strength (PS) distributions. The scatterplots show the distribution of PS scores for class predictors. The first two plots show the distribution for the predictor created to cla ...
... majority of ALL samples (grey squares) and cluster A2 contains the majority of AML samples (black circles). (B) Prediction strength (PS) distributions. The scatterplots show the distribution of PS scores for class predictors. The first two plots show the distribution for the predictor created to cla ...
Microbiota: the human body is a home for bacteria
... organisms, which all together are identified as the human microbiota. The human microbiota consists of organisms that come from all taxa, but in this article we will focus only on bacteria. According to some recent studies, the amount of "good" bacteria that colonises our body amounts to approx. one ...
... organisms, which all together are identified as the human microbiota. The human microbiota consists of organisms that come from all taxa, but in this article we will focus only on bacteria. According to some recent studies, the amount of "good" bacteria that colonises our body amounts to approx. one ...
Full Text - The International Journal of Developmental Biology
... use a netrin source for proper orientation (Kolodziej et al., 1996). ...
... use a netrin source for proper orientation (Kolodziej et al., 1996). ...
CH 8. DNA: The Universal Molecule of Life
... The chromosome number is more or less than that in the normal diploid or haploid cell. Results in the addition or loss of whole chromosomes from a cell. Normally in meiosis, homologous chromosomes come together and then segregate into separate cells, so that the gametes finish up with only one ...
... The chromosome number is more or less than that in the normal diploid or haploid cell. Results in the addition or loss of whole chromosomes from a cell. Normally in meiosis, homologous chromosomes come together and then segregate into separate cells, so that the gametes finish up with only one ...
Mammals Differences between the Chicken and Antagonist in the
... (13). Third, icIL-1RN isoforms may be released from cells and act in a similar way to sIL-1RN by antagonizing membrane-bound IL-1RI (14–17). Other, more recently discovered IL-1 family members (IL-1F5– F11) have been less extensively studied. However, functional roles for most of these are beginning ...
... (13). Third, icIL-1RN isoforms may be released from cells and act in a similar way to sIL-1RN by antagonizing membrane-bound IL-1RI (14–17). Other, more recently discovered IL-1 family members (IL-1F5– F11) have been less extensively studied. However, functional roles for most of these are beginning ...
Gene Set Testing
... not have stronger association with the subject condition than the other genes. Self-contained null hypothesis: The genes in the gene set do not have any association with the subject condition (i.e., no gene in the set is differentially expressed). We do not care about what the genes outside the set ...
... not have stronger association with the subject condition than the other genes. Self-contained null hypothesis: The genes in the gene set do not have any association with the subject condition (i.e., no gene in the set is differentially expressed). We do not care about what the genes outside the set ...
Gene Name
... hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in tra ...
... hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in tra ...
KiCS and PROFYLE: Precision Medicine Initiatives
... cancer, and Director of the national multi-institutional TFRI Precision Oncology For Young People (PROFYLE) initiative which is establishing a pipeline for incorporation of next generation sequencing and variant modeling to incorporation of novel clinical trials for children and young adults with ha ...
... cancer, and Director of the national multi-institutional TFRI Precision Oncology For Young People (PROFYLE) initiative which is establishing a pipeline for incorporation of next generation sequencing and variant modeling to incorporation of novel clinical trials for children and young adults with ha ...
DNA Content of Nuclei andChromosome
... Chromosome counts were made from acetic orcein prepara tions (3). In a few cases, the frequency of metaphases of the .< and 2s types was estimated from the relative sizes of the metaphase plates. Such estimates were in reasonable agreement with more exact counting methods. Feulgen determinations wer ...
... Chromosome counts were made from acetic orcein prepara tions (3). In a few cases, the frequency of metaphases of the .< and 2s types was estimated from the relative sizes of the metaphase plates. Such estimates were in reasonable agreement with more exact counting methods. Feulgen determinations wer ...
Tumors with microsatellite instability: many mutations, targets and
... This is important because it addresses the problematic issue of establishing the relevancy of the absence of an event rather than its presence. It could be viewed as a situation equivalent to the insightful Sherlockian conclusion (in the ‘Adventure of Silver Blaze’) that the relevant incident was th ...
... This is important because it addresses the problematic issue of establishing the relevancy of the absence of an event rather than its presence. It could be viewed as a situation equivalent to the insightful Sherlockian conclusion (in the ‘Adventure of Silver Blaze’) that the relevant incident was th ...