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... Microarray has become a popular biotechnology in biological and medical research. However, systematic and stochastic variabilities in microarray data are expected and unavoidable, resulting in the problem that the raw measurements have inherent “noise” within microarray experiments. Currently, logar ...
... Microarray has become a popular biotechnology in biological and medical research. However, systematic and stochastic variabilities in microarray data are expected and unavoidable, resulting in the problem that the raw measurements have inherent “noise” within microarray experiments. Currently, logar ...
The Humanized Fly - Barbara J. Culliton
... Flies age and die, faster than human beings, to be sure, but their aging appears to be under the control of similar genes. (Drosophila’s prodigious reproduction, coupled with their short life span is what makes them ideal or "model organisms" for laboratory research.) Flies have genes for apoptos ...
... Flies age and die, faster than human beings, to be sure, but their aging appears to be under the control of similar genes. (Drosophila’s prodigious reproduction, coupled with their short life span is what makes them ideal or "model organisms" for laboratory research.) Flies have genes for apoptos ...
Mutations - GK-12 Program at the University of Houston
... on its location. If the mutation occurs in a gene, the result will be an altered protein, but the mutation can also occur in a nongenic region of the DNA. In the latter case, the mutation will have no effect on the organism. Large-Scale Mutation Effects The effects of large-scale mutations are more ...
... on its location. If the mutation occurs in a gene, the result will be an altered protein, but the mutation can also occur in a nongenic region of the DNA. In the latter case, the mutation will have no effect on the organism. Large-Scale Mutation Effects The effects of large-scale mutations are more ...
Online Repository - Nederlands Tweelingen Register
... used for analysis. A file containing independent eQTLs for each gene, and their respective proxy SNPs, is required to run EUGENE and is available at https://genepi.qimr.edu.au/staff/manuelF. Files containing eQTLs in tissues relevant for other diseases or traits are also available but were not anal ...
... used for analysis. A file containing independent eQTLs for each gene, and their respective proxy SNPs, is required to run EUGENE and is available at https://genepi.qimr.edu.au/staff/manuelF. Files containing eQTLs in tissues relevant for other diseases or traits are also available but were not anal ...
Transvection, nuclear structure, and chromatin proteins.
... For instance, the evidence for nuclear compartmentalization (for example, see Carter et al., 1991; Leonhardt et al., 1992 and references within; reviewed by Manuelidis, 1990; Jackson, 1991) and the restriction of transcripts to nuclear '~racks" (Xing and Lawrence, 1991) lend plausibility to a propos ...
... For instance, the evidence for nuclear compartmentalization (for example, see Carter et al., 1991; Leonhardt et al., 1992 and references within; reviewed by Manuelidis, 1990; Jackson, 1991) and the restriction of transcripts to nuclear '~racks" (Xing and Lawrence, 1991) lend plausibility to a propos ...
PCR: an outstanding method
... Soon after its discovery the PCR method was refined in several ways. One of the first modifications of the original protocol concerned the polymerases used. Like all enzymes, polymerases function best at the body temperature of the organism in which they originate – 37°C in the case of polymerases ...
... Soon after its discovery the PCR method was refined in several ways. One of the first modifications of the original protocol concerned the polymerases used. Like all enzymes, polymerases function best at the body temperature of the organism in which they originate – 37°C in the case of polymerases ...
Genome assemblies
... A whole genome shot gun sequence assembly of Chinese Spring was carried out using nested long mate-pair libraries alongside a modified version of the DISCOVAR algorithm for assembly. This method created an assembly of total length 13.4 Gb, with approximately 10x longer N50 than the CSS and W7984 ass ...
... A whole genome shot gun sequence assembly of Chinese Spring was carried out using nested long mate-pair libraries alongside a modified version of the DISCOVAR algorithm for assembly. This method created an assembly of total length 13.4 Gb, with approximately 10x longer N50 than the CSS and W7984 ass ...
Supplementary Information
... showing less than 0.5 (log2) differential mean expression in patients with versus without progression. We also excluded 5 probesets associated with sex origin (XIST probeset 214218_s_at and 4 probesets corresponding to genes located on chromosome Y). A list of 42 probesets, corresponding to 32 disti ...
... showing less than 0.5 (log2) differential mean expression in patients with versus without progression. We also excluded 5 probesets associated with sex origin (XIST probeset 214218_s_at and 4 probesets corresponding to genes located on chromosome Y). A list of 42 probesets, corresponding to 32 disti ...
... information for the entire living organisms except RNA viruses. Along with RNA and proteins it is one of the three major macromolecules. The first DNA isolation was performed by a Swiss physician (1869) and according to James Watson and Francis Crick (1953), this polynucleotide chain is accepted as ...
Leveraging additional knowledge to support coherent bicluster
... To exceed this limitation, biclustering approaches have been proposed [25]. They examine gene and sample dimensions simultaneously, enabling the discovery of coherent and meaningful biclusters, i.e., potentially overlapping groups of genes showing similar activity patterns under a specific subset of ...
... To exceed this limitation, biclustering approaches have been proposed [25]. They examine gene and sample dimensions simultaneously, enabling the discovery of coherent and meaningful biclusters, i.e., potentially overlapping groups of genes showing similar activity patterns under a specific subset of ...
Full Paper - Biotechniques.org
... Although both aliquots had the same genotype richness and dominant genotype, the community compositions of the two aliquots were significantly different. This difference could be due to slight differences in aliquot storage. Aliquot A was frozen only once before DNA extraction, while Aliquot B was f ...
... Although both aliquots had the same genotype richness and dominant genotype, the community compositions of the two aliquots were significantly different. This difference could be due to slight differences in aliquot storage. Aliquot A was frozen only once before DNA extraction, while Aliquot B was f ...
Extent of Gene Duplication in the Genomes of
... mutation rates in these three organisms and using the estimated rate in Drosophila (15.6 substitutions per site per 109 years; Li 1997, p. 191), we calculated the recent gene duplication rates in the three organisms (table 5). The recent gene duplication rate was found to be more than 10-fold lower ...
... mutation rates in these three organisms and using the estimated rate in Drosophila (15.6 substitutions per site per 109 years; Li 1997, p. 191), we calculated the recent gene duplication rates in the three organisms (table 5). The recent gene duplication rate was found to be more than 10-fold lower ...
Animals and plants manage to make copies of themselves from one
... 1923, he tried this dye on thin slices of living cells. The dye poisoned the cells, but it combined with material in some parts of the cell while leaving other parts untouched. Wherever it combined, DNA had to be present, and there would be a deep red stain in that spot, while everything else remain ...
... 1923, he tried this dye on thin slices of living cells. The dye poisoned the cells, but it combined with material in some parts of the cell while leaving other parts untouched. Wherever it combined, DNA had to be present, and there would be a deep red stain in that spot, while everything else remain ...
Punnett Square Practice
... A Punnett square is a chart which shows/predicts all possible gene combinations in a cross of parents (whose genes are known). Punnett squares are named for an English geneticist, Reginald Punnett. He discovered some basic principles of genetics. He worked with the feather color traits of chickens i ...
... A Punnett square is a chart which shows/predicts all possible gene combinations in a cross of parents (whose genes are known). Punnett squares are named for an English geneticist, Reginald Punnett. He discovered some basic principles of genetics. He worked with the feather color traits of chickens i ...
Document
... 58 million bp (0.38% of the total DNA in a human cell) 86 genes, which code for 23 proteins in mammals, gene SRY (Sex-determining Region on Y, for testis development, thus determining sex) and other genes for production of sperma ...
... 58 million bp (0.38% of the total DNA in a human cell) 86 genes, which code for 23 proteins in mammals, gene SRY (Sex-determining Region on Y, for testis development, thus determining sex) and other genes for production of sperma ...
Document
... The strand of DNA that would produce a mirror image (antisense) messenger RNA that is opposite in sequence to one directing protein synthesis. Antisense technology is used to selectively turn off production of certain proteins. Antiserum. Blood serum containing specific antibodies against an antigen ...
... The strand of DNA that would produce a mirror image (antisense) messenger RNA that is opposite in sequence to one directing protein synthesis. Antisense technology is used to selectively turn off production of certain proteins. Antiserum. Blood serum containing specific antibodies against an antigen ...
Transformation Lab
... The concept of cell transformation raises the following questions, among others: To transform an organism to express new genetic information, do you need to insert the new gene into every cell in a multicellular organism or just one? For laboratory study, which organism is best suited for total ...
... The concept of cell transformation raises the following questions, among others: To transform an organism to express new genetic information, do you need to insert the new gene into every cell in a multicellular organism or just one? For laboratory study, which organism is best suited for total ...
summary of the current status of development of non
... response element (receptor dimer binding site) located upstream of the estrogen receptor target gene and activates the target gene so as to express hormone effects. The reporter gene assay is an in vitro assay for measuring the transcription activity of the ligand (hormone) dependent target gene, wh ...
... response element (receptor dimer binding site) located upstream of the estrogen receptor target gene and activates the target gene so as to express hormone effects. The reporter gene assay is an in vitro assay for measuring the transcription activity of the ligand (hormone) dependent target gene, wh ...
Karyotyping, FISH and CGH array
... Cytogenetics is the study of genetic material at the cellular level; molecular genetics studies the structure and function of genes at a molecular level (DNA). The various techniques used vary in their clinical application. This article is a brief summary of the indications for the most commonly-use ...
... Cytogenetics is the study of genetic material at the cellular level; molecular genetics studies the structure and function of genes at a molecular level (DNA). The various techniques used vary in their clinical application. This article is a brief summary of the indications for the most commonly-use ...
Myriad - Tech Transfer Central
... Goes back to first principles, relating to whether what is claimed is an abstract idea that preempts every use thereof ...
... Goes back to first principles, relating to whether what is claimed is an abstract idea that preempts every use thereof ...
presentation source (powerpoint)
... First we took the RNA from two mice, a healthy one and a diseased one. We then proceeded to use the RNA to make cDNA, an exact copy of the RNA except that it is in DNA form. Afterwards we embarked on the journey of cleaning the cDNA and inserting it into bacteria. ...
... First we took the RNA from two mice, a healthy one and a diseased one. We then proceeded to use the RNA to make cDNA, an exact copy of the RNA except that it is in DNA form. Afterwards we embarked on the journey of cleaning the cDNA and inserting it into bacteria. ...
PowerPoint - Isaac Newton Institute
... Even if theoretical null N(0,1) is correct for an individual zj of a null gene, the zj’s for the null genes may not behave as N(0,1) variates in the ensemble of z1,…,zN. If they don’t, then the Benjamini-Hochberg procedure will break down using P-values based on theoretical null. ...
... Even if theoretical null N(0,1) is correct for an individual zj of a null gene, the zj’s for the null genes may not behave as N(0,1) variates in the ensemble of z1,…,zN. If they don’t, then the Benjamini-Hochberg procedure will break down using P-values based on theoretical null. ...
Detection of Protein Coding Sequences Using a Mixture Model for
... on knowledge of many different sequence features which are presumably recognized by the transcription/translation machinery of the cell. As biological studies elucidate these mechanisms, computer programs incorporating the new insights will hopefully become increasingly more accurate at predicting w ...
... on knowledge of many different sequence features which are presumably recognized by the transcription/translation machinery of the cell. As biological studies elucidate these mechanisms, computer programs incorporating the new insights will hopefully become increasingly more accurate at predicting w ...
Cloning and characterisation of a cysteine proteinase gene
... In order to clone a complete copy of Llacys1 gene, a cDNA library from L. (L.) amazonensis amastigotes was constructed in lZipLox vector and screened with Llacys1 gene as a probe. Two clones were isolated and sequenced, one of 1.6 kb (2A1) and another of 2.4 kb (3A4). They showed an ORF encoding cys ...
... In order to clone a complete copy of Llacys1 gene, a cDNA library from L. (L.) amazonensis amastigotes was constructed in lZipLox vector and screened with Llacys1 gene as a probe. Two clones were isolated and sequenced, one of 1.6 kb (2A1) and another of 2.4 kb (3A4). They showed an ORF encoding cys ...