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A novel C. elegans zinc finger transcription factor, lsy
A novel C. elegans zinc finger transcription factor, lsy

... al., 1999; Johnston and Hobert, 2003) (R.J.J. and O.H., unpublished), we examined this genomic region for the presence of predicted gene regulatory factors. We noted one predicted protein, the F49H12.1 protein (Fig. 2), which contains a nuclear localization sequence and five zinc finger domains of t ...
MiRNA_GO_Meeting_August2015
MiRNA_GO_Meeting_August2015

... When annotating a miRNA we should minimally aim to capture the following: 1. The miRNA’s main role in gene silencing and its target(s); gene silencing by miRNA negative regulation of gene expression mRNA binding involved in post-transcriptional gene silencing by miRNA target mRNA indicated in the an ...
Microsoft Word 97
Microsoft Word 97

... However, Mendel felt that reproduction and the passing on of characteristics was carried out by special cells or gametes in all sexually reproducing organisms. Accordingly, he felt that either animals or plants could be used in investigating different ideas. Mendel's breeding experiments were carrie ...
Genome Analysis of Cyanobacteria
Genome Analysis of Cyanobacteria

... group of prokaryotes. Although their phylogenetic position in the bacterial kingdom is still uncertain, cyanobacteria are believed to be genetically related to gram-positive bacteria. Cyanobacteria are capable of photosynthesis but are distinct from other photosynthetic bacteria, such as purple and ...
Population Differences in Transcript
Population Differences in Transcript

... address the problem on a systems biology level. In other words, on a genome-wide scale, simultaneously model the expression of genes that are downstream targets (DSTs) of a transcript-regulator (TR) (Figure 1). A TR can be a TF, a cofactor, a complex, a microRNA or combination of these which are inv ...
Mammals Differences between the Chicken and Antagonist in the
Mammals Differences between the Chicken and Antagonist in the

... component of the functional IL-1R (3). The two ligands have extremely potent biological activity and therefore their production at both mRNA and protein levels is precisely controlled. Additionally, a naturally occurring antagonist, IL-1R antagonist (IL1RN), reduces the IL-1 effects by physically oc ...
A series of promoters for constitutive expression of heterologous
A series of promoters for constitutive expression of heterologous

... expression vectors, and its transcription level was compared with that of the nmt1 promoter in some experiments (reviewed by Siam et al., 2004)). Although its expression is thought to be constitutive, it is not fully known how much its transcriptional activity varies among different media. Furthermo ...
Specific Combinations of Zein Genes and Genetic Backgrounds
Specific Combinations of Zein Genes and Genetic Backgrounds

... lines, the following can be deduced. The pattern of each o2 genotype is different in respect to the one of the corresponding GB with an O2 allele and all together show a wide spectrum of combinations while considering the relative abundance of the H1 and H2 bands. In some cases, as in Xo2R and Ro2R, ...
Mitosis in Drosophila development - Journal of Cell Science
Mitosis in Drosophila development - Journal of Cell Science

... the unreplicated chromatin condenses and lamin staining becomes weak, diffuse and cytoplasmic (Fig. 2). There seems therefore to be no absolute requirement for the correct completion of S phase in order for both nuclear and cytoplasmic events of M phase to take place. This is not to say that some cr ...
New Construct Approaches for Efficient Gene Silencing in Plants
New Construct Approaches for Efficient Gene Silencing in Plants

... double-transformed tobacco plants displayed a reduced level of gus expression (Table I). The stability of pSIM717-mediated gene silencing was assessed by assaying groups of approximately 25 T1 and T2 plants derived from three randomly chosen double transformants that segregated for single loci carry ...
- Repository of the Academy`s Library
- Repository of the Academy`s Library

... Comparative gene expression profiling of tobacco egg cells, one- and two-celled zygotes ...
Appendix APPENDIX
Appendix APPENDIX

... that chemically modifies histones. Transcription often involves modifying histones so that the chromosomes decondense or “loosen up” and allow RNA polymerase to access the target genes. The BRCA2 protein contains several copies of a 70 amino acid sequence called the BRC motif, which functions by bin ...
Understanding the Basis for Down Syndrome Phenotypes
Understanding the Basis for Down Syndrome Phenotypes

... However, small coincident or additive effects of the many genes over-expressed in every trisomic cell may also contribute to trisomic phenotypes. Recent observations confirm that transcript levels are elevated about 1.5-fold for the majority of trisomic genes in a few tissues from humans with trisomy ...
Glutathione S-transferase copy number variation alters lung gene expression M.W. Butler*
Glutathione S-transferase copy number variation alters lung gene expression M.W. Butler*

... as xenobiotics present in tobacco smoke, as well as other carcinogens and pesticides, and their isoforms are divided into seven classes: a (GSTA), m (GSTM), p (GSTP), h (GSTT), f (GSTZ), s (GSTS) and v (GSTO) [29–34]. Alhough cytosolic GST enzymes are a central part of the lung’s molecular detoxific ...
Personalis®: POSTER | A Negative Result on Exome Sequencing
Personalis®: POSTER | A Negative Result on Exome Sequencing

... missed. In addition, it is important to account for the variation in coverage for a particular gene from sample to sample. If this variance is great, there is a chance that a gene with good average coverage across the gene may still not be well covered in your patient’s sample (FIGURE 1A). A better ...
Transcriptional Repression of Hox Genes by C. elegans HP1/HPL
Transcriptional Repression of Hox Genes by C. elegans HP1/HPL

... Linker histone (H1) and heterochromatin protein 1 (HP1) play central roles in the formation of higher-order chromatin structure and gene expression. Recent studies have shown a physical interaction between H1 and HP1; however, the biological role of histone H1 and HP1 is not well understood. Additio ...
PDF
PDF

... modern vertebrate clusters apparently arose by serial duplication of a 13 member cluster with subsequent deletions. As a result, the homologous genes in different clusters (referred to as paralogues) are more similar to each other than they are to adjacent genes in the same cluster. Paralogous genes ...
BiGCaT
BiGCaT

... Use Mathematica procedure to proces QTL locations and overlaps ...
video slide - Mrs. H-D
video slide - Mrs. H-D

... 2 Entry of phage DNA and degradation of host DNA. The sheath of the tail contracts, injecting the phage DNA into the cell and leaving an empty capsid outside. The cell’s DNA is hydrolyzed. ...
Keywords : LGMD2I, FKRP gene, novel mutations
Keywords : LGMD2I, FKRP gene, novel mutations

... classified as LGMD were analyzed in the present study. The only family with a more severe course included 3 sisters where the two oldest one showed a Duchenne-like progression, with wheelchairconfinement at age 11 and 12 and death of respiratory/cardiac failure at age 14 and 15, respectively. This f ...
New Certation Gene on the First Linkage Group Found
New Certation Gene on the First Linkage Group Found

... If the hybrid semi-sterility is observed in an F, plant of the cross of Japanese tester with a foreign variety and there is the linkage between its causal gene so-called complementary fertility genes and a genetic marker gene, the segregation of the marker would be distorted. In the present study, a ...
SVD and PCA
SVD and PCA

... PCA for DNA Microarrays • PCA shows patterns of correlated activation – Genes with same pattern might have similar function ...
BIOL 106 Introduction to Cell Biology
BIOL 106 Introduction to Cell Biology

... Apply the principles of gene regulation to explain how cells become specialized and how cellular activity leads to a better understanding of development, cancer, and many forms of disease. Learning Objectives Explain how DNA packing influences gene expression. Explain how transcription is usually in ...
Heredity The passing of traits from parent to offspring
Heredity The passing of traits from parent to offspring

... So… the death rate due to malaria is lower where the sickle-cell trait is higher. Since less malaria exists in those area more people live to pass on the sickle-cell trait to their offspring. Consequently, sickle cell continues to increase in Africa. ...
A CONTRIBUTION TO AN UNDERSTANDING OF CROSSING
A CONTRIBUTION TO AN UNDERSTANDING OF CROSSING

... with balanced lethals, following certain specific crossover percentages. (It is assumed that crossing over occurs at the four strand stage. If it takes place at the two strand stage, only one-half the amount of crossing over will be necessary to produce a given percentage of segregation after selfin ...
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Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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