... activation of the paternal Kcnq1 allele was accompanied by an increase in total Kcnq1 RNA abundance, quantitative (q)PCR on total RNAs from these stages was performed. Whereas the transition from monoallelic to biallelic expression is expected to double RNA abundance, the total cellular RNA levels i ...
Pharmacogenomics: Analyzing SNPs in the CYP2D6 Gene Using
... polymorphisms (SNPs) within an individual’s CYP2D6 gene, functionality problems ranging from overly active metabolism to complete loss of function may result. Therefore, for the purpose of safety, it is necessary to identify these problems before prescribing drugs. Thus far there have been various m ...
... polymorphisms (SNPs) within an individual’s CYP2D6 gene, functionality problems ranging from overly active metabolism to complete loss of function may result. Therefore, for the purpose of safety, it is necessary to identify these problems before prescribing drugs. Thus far there have been various m ...
PDF
... complement the homoeotic phenotype of trx1, as well as each others lethality. Genetic analysis suggests that all three alleles abolish most, if not all, of the wildtype function of the trx locus (Ingham, 1981); in addition, there is some evidence that trx3 may have an antimorphic component (unpublis ...
... complement the homoeotic phenotype of trx1, as well as each others lethality. Genetic analysis suggests that all three alleles abolish most, if not all, of the wildtype function of the trx locus (Ingham, 1981); in addition, there is some evidence that trx3 may have an antimorphic component (unpublis ...
Genetics of host response in leprosy
... (vii) BCG protection rates are highly variable among different populations; (viii) complex segregation analyses have suggested a predominant genetic rather than environmental model for associations in leprosy. During the natural course of the disease some steps can be clearly identified. Thus, lepro ...
... (vii) BCG protection rates are highly variable among different populations; (viii) complex segregation analyses have suggested a predominant genetic rather than environmental model for associations in leprosy. During the natural course of the disease some steps can be clearly identified. Thus, lepro ...
IMGT-ONTOLOGY and IMGT databases, tools and Web
... name and classify IG and TR genes in lMGT. (A) Concepts of classification and their relations. (B) Examples of instances: for each concept of classification is shown the instance which allows the classification of the human IGLV2-1 1∗ 02 allele. ...
... name and classify IG and TR genes in lMGT. (A) Concepts of classification and their relations. (B) Examples of instances: for each concept of classification is shown the instance which allows the classification of the human IGLV2-1 1∗ 02 allele. ...
Comparative analysis of two-component signal transduction systems
... one HK and one RR gene were considered to encode functional HKRR gene pairs and were thus considered to encode a specific TCS. Single HK and RR genes were categorized as ‘orphans’. The definition of a gene cluster was set as follows: intergenic distances within a cluster had to be less than 300 bp a ...
... one HK and one RR gene were considered to encode functional HKRR gene pairs and were thus considered to encode a specific TCS. Single HK and RR genes were categorized as ‘orphans’. The definition of a gene cluster was set as follows: intergenic distances within a cluster had to be less than 300 bp a ...
alignable - gobics.de: Department of Bioinformatics
... P(f) = probability of finding a fragment “like f” by chance in random sequences with same length as input sequences w(f) = -log P(f) (“weight score” of f) ”like f” means: at least same # matches (DNA, RNA) or sum of similarity values (proteins) ...
... P(f) = probability of finding a fragment “like f” by chance in random sequences with same length as input sequences w(f) = -log P(f) (“weight score” of f) ”like f” means: at least same # matches (DNA, RNA) or sum of similarity values (proteins) ...
Chaperone-dependent gene expression of organic
... 3.7. Phylogenetic analysis of S5 lipase The G + C content of a gene encoding a protein may reveal the origin of the protein. The G + C content was calculated using FramePlot 2.3.2 software available at http://www.watson.nih.go.jp. The G + C content of this organic solvent-tolerant lipase gene was 65 ...
... 3.7. Phylogenetic analysis of S5 lipase The G + C content of a gene encoding a protein may reveal the origin of the protein. The G + C content was calculated using FramePlot 2.3.2 software available at http://www.watson.nih.go.jp. The G + C content of this organic solvent-tolerant lipase gene was 65 ...
Direct and indirect consequences of meiotic recombination
... the direct effects of recombination (further details are presented in Box 1 and Figure 1). Although one of the advantages of the indirect effects of recombination is the efficient removal of deleterious alleles from a population, its direct effects may sometimes themselves be harmful. In particular, ...
... the direct effects of recombination (further details are presented in Box 1 and Figure 1). Although one of the advantages of the indirect effects of recombination is the efficient removal of deleterious alleles from a population, its direct effects may sometimes themselves be harmful. In particular, ...
Bio-session package - Social Science Genetic Association Consortium
... with SNPs that are genotyped on ‘‘SNP chips.’’ Because there are many more segregating variants in the population than those genotyped in GWASs, it is unlikely, but not impossible, that a mutation is genotyped itself, and so its effect usually will be detected through an association with a genotyped ...
... with SNPs that are genotyped on ‘‘SNP chips.’’ Because there are many more segregating variants in the population than those genotyped in GWASs, it is unlikely, but not impossible, that a mutation is genotyped itself, and so its effect usually will be detected through an association with a genotyped ...
Proceedings as -file
... Comparison test: Comments from Duty Laboratory South Africa; Comments from Computing Laboratory The Netherlands; Discussion ISAG panels: Do they work well? How many laboratories are using these panels in the routine? Do we need changes? Standard / Reference samples? • Nomenclature: Is there a ne ...
... Comparison test: Comments from Duty Laboratory South Africa; Comments from Computing Laboratory The Netherlands; Discussion ISAG panels: Do they work well? How many laboratories are using these panels in the routine? Do we need changes? Standard / Reference samples? • Nomenclature: Is there a ne ...
Conjugative plasmids: vessels of the communal gene pool
... ‘deletion bias’ towards small genome sizes exists (Lawrence et al. 2001; Mira et al. 2001; Ochman & Davalos 2006). Furthermore, in prokaryotes, evolution has favoured clustering of cooperating genes, in many cases as ‘selfish’ operons (Lawrence 2003). These two factors, compactness and gene clusteri ...
... ‘deletion bias’ towards small genome sizes exists (Lawrence et al. 2001; Mira et al. 2001; Ochman & Davalos 2006). Furthermore, in prokaryotes, evolution has favoured clustering of cooperating genes, in many cases as ‘selfish’ operons (Lawrence 2003). These two factors, compactness and gene clusteri ...
Conjugative plasmids: vessels of the communal gene pool
... ‘deletion bias’ towards small genome sizes exists (Lawrence et al. 2001; Mira et al. 2001; Ochman & Davalos 2006). Furthermore, in prokaryotes, evolution has favoured clustering of cooperating genes, in many cases as ‘selfish’ operons (Lawrence 2003). These two factors, compactness and gene clusteri ...
... ‘deletion bias’ towards small genome sizes exists (Lawrence et al. 2001; Mira et al. 2001; Ochman & Davalos 2006). Furthermore, in prokaryotes, evolution has favoured clustering of cooperating genes, in many cases as ‘selfish’ operons (Lawrence 2003). These two factors, compactness and gene clusteri ...
Probable presence of an ubiquitous cryptic mitochondrial gene on
... potentially functional gau regions have been found in nuclear genomes. However, a recent bioinformatics study showed that several hypothetical overlapping mt genes could be predicted, including gau; this involves the possible import of the cytosolic AGR tRNA into the mitochondria and/or the expressi ...
... potentially functional gau regions have been found in nuclear genomes. However, a recent bioinformatics study showed that several hypothetical overlapping mt genes could be predicted, including gau; this involves the possible import of the cytosolic AGR tRNA into the mitochondria and/or the expressi ...
as a PDF - CiteSeerX
... B-DNA versus non-B-DNA (51), and organization, can affect homologous recombination and is also likely to affect recombination between diverged DNAs. For example, altered semiconservative replication in yeast DNA polymerase mutants can increase homologous recombination severalfold in a variety of sys ...
... B-DNA versus non-B-DNA (51), and organization, can affect homologous recombination and is also likely to affect recombination between diverged DNAs. For example, altered semiconservative replication in yeast DNA polymerase mutants can increase homologous recombination severalfold in a variety of sys ...
Chapter 2
... The common management strategy has been to replace cultivars when their resistance is no longer effective ( Wolf, 1984, Leath & Heun, 1990). Molecular markers, tightly linked to disease resistance genes, can provide breeders with a tool for marker-assisted selection of resistance gene in plants (Stu ...
... The common management strategy has been to replace cultivars when their resistance is no longer effective ( Wolf, 1984, Leath & Heun, 1990). Molecular markers, tightly linked to disease resistance genes, can provide breeders with a tool for marker-assisted selection of resistance gene in plants (Stu ...
Recurrent Pregnancy Loss and Its Relation to Combined Parental
... CONCLUSION Current results showed the maternal mutated thrombophilic genes’ profiles mainly have a potential risk for RPL but paternal mutation profiles in specific genes may also have a combined effect on RPL phenomenon. Study of mutations in a wide range of thrombophilic genes associated with t ...
... CONCLUSION Current results showed the maternal mutated thrombophilic genes’ profiles mainly have a potential risk for RPL but paternal mutation profiles in specific genes may also have a combined effect on RPL phenomenon. Study of mutations in a wide range of thrombophilic genes associated with t ...
Journal of Bacteriology
... transposon had inserted in a dnaK homologue which is located downstream of grpE and upstream of dnaJ. Analysis of putisolvin production and expression studies indicate that dnaK, together with the dnaJ and grpE heat shock genes, takes part in the positive regulation (directly or indirectly) of putis ...
... transposon had inserted in a dnaK homologue which is located downstream of grpE and upstream of dnaJ. Analysis of putisolvin production and expression studies indicate that dnaK, together with the dnaJ and grpE heat shock genes, takes part in the positive regulation (directly or indirectly) of putis ...
Full Text
... al., 2001) in several bi-parental mapping populations, the number and effect of these QTL’s vary greatly. Hence, it is important to adopt other mapping strategies that can exploit all the existing allelic diversity for these traits. In this regard, an excellent alternative to traditional linkage map ...
... al., 2001) in several bi-parental mapping populations, the number and effect of these QTL’s vary greatly. Hence, it is important to adopt other mapping strategies that can exploit all the existing allelic diversity for these traits. In this regard, an excellent alternative to traditional linkage map ...
Mechanisms of translational regulation in bacteria
... the growing peptide chain is determined by triplets of nucleotides, so called codons. However, there are only 20 amino acids but 64 different triplets of nucleotides encoding them. Consequently, the genetic code is degenerate: Except for tryptophan and methionine, the amino acids are encoded by two, ...
... the growing peptide chain is determined by triplets of nucleotides, so called codons. However, there are only 20 amino acids but 64 different triplets of nucleotides encoding them. Consequently, the genetic code is degenerate: Except for tryptophan and methionine, the amino acids are encoded by two, ...
phylogenetic analysis of the rompb genes of rickettsia felis and
... and outer membrane location and the strong immune response observed after infection, suggesting an important yet undefined function under evolutionary selective pressure.1,2 Although the rOmpB encoding gene (rompB) is present in both spotted fever group (SFG) and typhus group (TG) rickettsiae, it ha ...
... and outer membrane location and the strong immune response observed after infection, suggesting an important yet undefined function under evolutionary selective pressure.1,2 Although the rOmpB encoding gene (rompB) is present in both spotted fever group (SFG) and typhus group (TG) rickettsiae, it ha ...
SNP discovery
... all’Adige, Trento, Italy, 4 Laboratory for Fruit Breeding and Biotechnology, Department of Biosystems, Katholieke Universiteit Leuven, Heverlee, Leuven, Belgium, 5 USDA-ARS, National Clonal Germplasm Repository, Corvallis, Oregon, United States of America, 6 Illumina Inc., Hayward, California, Unite ...
... all’Adige, Trento, Italy, 4 Laboratory for Fruit Breeding and Biotechnology, Department of Biosystems, Katholieke Universiteit Leuven, Heverlee, Leuven, Belgium, 5 USDA-ARS, National Clonal Germplasm Repository, Corvallis, Oregon, United States of America, 6 Illumina Inc., Hayward, California, Unite ...
Genetic diversity and epidemiology of infectious hematopoietic
... 6 or 7 d post-inoculation. Infected cells and media for each virus isolate were centrifuged and 1.0 m1 aliquots of supernatant were frozen at -7O0C. These served as the virus stock used in the study. The reference virus strain, RB1, isolated in 1975 from steelhead Oncorhynchus mykiss at the Round Bu ...
... 6 or 7 d post-inoculation. Infected cells and media for each virus isolate were centrifuged and 1.0 m1 aliquots of supernatant were frozen at -7O0C. These served as the virus stock used in the study. The reference virus strain, RB1, isolated in 1975 from steelhead Oncorhynchus mykiss at the Round Bu ...
Cloning and Sequence Analysis of the xylL Gene Responsible for
... recommended by the supplier (Posco Co., Seoul, Korea). The pCS1 and pCSP21 carrying the xylL gene were previously cloned from the chromosomal DNA of Pseudomonas sp. S-47 (9). In this study, a 3.0 kb fragment of pCSP21 digested with ClaI was introduced into the polyclonal region of pBluescript II SK( ...
... recommended by the supplier (Posco Co., Seoul, Korea). The pCS1 and pCSP21 carrying the xylL gene were previously cloned from the chromosomal DNA of Pseudomonas sp. S-47 (9). In this study, a 3.0 kb fragment of pCSP21 digested with ClaI was introduced into the polyclonal region of pBluescript II SK( ...