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Case Report Section
Case Report Section

... the karyotype 46,Y,t(X;11)(q22;q23) in 25 out of 30 metaphases. Fluorescence in situ hybridization study showed rearrangement of the MLL gene in interphase and metaphase cells revealing that the break-apart 5'MLL segment is translocated to the derivative X chromosome. The patient achieved a complete ...
Dominant
Dominant

... Individuals homozygous for HbS/HbS often die in childhood. Yet, the frequency of the HbS allele is quite high in some regions of the world. In parts of Africa frequencies of 20% to 40% are often found for the HbS allele. It was found however that in areas in which there was a high HbS allelic freque ...
Educator Guide - Cheryl Bardoe
Educator Guide - Cheryl Bardoe

Frequent Loss of Heterozygosity at the TEL Gene Locus
Frequent Loss of Heterozygosity at the TEL Gene Locus

... of the t(12;21)(p13;q22) associated with childhood pre-B ALL.’’ AMLl is the DNA-binding subunit of core binding factor (CBF), and has also been implicated in the pathogenesis of myeloid leukemias.“ TEL is a putative transcription factor belonging to the ETS family of DNA-binding proteins, and was in ...
Pathway and Gene Set Analysis of Microarray Data
Pathway and Gene Set Analysis of Microarray Data

... are series of chemical reactions occurring within a cell. In each pathway, a principal chemical is modified by chemical reactions.” These pathways describe enzymes and metabolites ...
38891
38891

... Figure 2. Four data sets clustered using k-means, hierarchical, and selforganized map algorithms. The horizontal axis shows the number of clusters desired, and the vertical axis shows z-scores. Data sets are (a) Cho, (b) CJRR, (c) Gasch, and (d) Spellman. ...
Solid Tumour Section Angiomatoid fibrous histiocytoma (AFH) Atlas of Genetics and Cytogenetics
Solid Tumour Section Angiomatoid fibrous histiocytoma (AFH) Atlas of Genetics and Cytogenetics

... histiocytoma is made on the basis of histopathology and immunohistochemical studies. Three microscopic findings are characteristic of AFH: (1) solid arrays or nests of histiocyte-like cells, (2) hemorrhagic cyst-like spaces, and (3) aggregates of chronic inflammatory cells. Multifocal recent and old ...
Decreased Expression of the p16/MTS1 Gene without
Decreased Expression of the p16/MTS1 Gene without

... described here is useful in detecting p16 gene abnormalities of any origin. Decreased expression of the p16 gene despite a lack of point mutations has also been reported for nasopharyngeal carcinomas (26) and high grade gliomas (27). Loss of p16 function is very likely to cause deregulation of G1/S ...
oL-Amylase of Clostridium thermosulfurogenes EMi:
oL-Amylase of Clostridium thermosulfurogenes EMi:

... Sequence comparisons with all respective data from EMBL and GenBank were performed with the Wisconsin Genetics Computer Group sequence analysis software package Version 6.0 (Genetics Computer Group, University of Wisconsin Biotechnology Center, Madison). Preparation of E. coli fractions. E. coli HB1 ...
The Gene Gateway Workbook
The Gene Gateway Workbook

... the Human Genome Landmarks poster, but it can be used to investigate any gene or genetic disorder of interest. Many guides to genome Web resources are designed for bioscience researchers and are too technical for non-experts. This workbook and other Gene Gateway resources target a more general audie ...
Genetics
Genetics

... • Homologous pairs –matching genes – one from female parent and one from male parent • Example: Humans have 46 chromosomes or 23 One set from dad – 23 in sperm . One set from mom – 23 in egg . ...
Genotype–phenotype associations and human eye color
Genotype–phenotype associations and human eye color

... does not follow the classical paths of inheritance. Eye color phenotypes demonstrate both epistasis and incomplete dominance. Although there are about 16 different genes responsible for eye color, it is mostly attributed to two adjacent genes on chromosome 15, hect domain and RCC1-like domain-contai ...
Enterococcus Faecium
Enterococcus Faecium

... I’m known to cause harm in humans I also possess the ability to produce antibacterial peptides bacteriocins, which can be used in fermenting foods such as cheese and vegetables. I can also be used as a probiotic to out-compete deleterious bacteria in the gastrointestinal tract. ...
Genetics
Genetics

... • The genes are symbolized by the first letter of the dominant gene. • The letter for the dominant gene is always capitalized. • The letter for the recessive trait is always lower case (make sure you can tell the difference between the two) • Wild Type is the typical form of the organism, strain, or ...
Human Genetics
Human Genetics

... • Explain how a gene alone usually does not solely determine a trait • Distinguish between autosomal recessive and autosomal dominant inheritance • Explain how Mendel’s experiments followed the inheritance of more than one gene • Explain how the law of independent assortment reflects the events of m ...
Gene Flow Gene Flow Between Two Demes
Gene Flow Gene Flow Between Two Demes

... • Many other population genetic distances are available, but all measure the degree of difference between two gene pools • Another type of genetic distance is a molecule genetic distance that measures the difference between two molecules of DNA; e.g., the number or percent of nucleotide differences ...
Document
Document

... Note:- Genetics as a separate subject should be introduced like Botany, Zoology and Chemistry etc. There will be followed four papers in the B.Sc. (Pass) for qualifying the subject of Genetics: 1) Principles of Genetics 2) Biochemistry and Quantitative Genetics, 3) Microbial and Molecular Genetics, ...
Natural infection of Run1-positive vines by naïve genotypes of
Natural infection of Run1-positive vines by naïve genotypes of

Determining the cause of patchwork HBA1 and HBA2 genes
Determining the cause of patchwork HBA1 and HBA2 genes

... gene expression from the α121 and α212 alleles is undefined at present. Although the majority of individuals who were positive for the α121 or α212 alleles were asymptomatic and had borderline low MCV (Table 1), this could simply be due to the fact that only asymptomatic individuals with borderline ...
Regulation of metabolic products and gene expression in Fusarium
Regulation of metabolic products and gene expression in Fusarium

... of DON (Jiao et al. 2008; Gardiner et al. 2009). In polyamine biosynthesis, agmatine, a cationic compound derived from decarboxylation of the amino acid arginine that serves as the precursor of three major polyamines—putrescine, spermidine, and spermine—has been identified as a strong inducer of DON ...
Document
Document

... Mendel’s work led him to the understanding that traits such as plant height are carried in pairs of information not by single sets of information. ...
by ODRIOZOLA
by ODRIOZOLA

... an intensely black tip, a sub-apical band of yellow, and below that a dull black base. The ventral areas of the coat are lighter, often lacking the black hair tips, resulting in a whitish yellow belly color and tail white underneath as in the cotton-tail rabbit. This is a very effective concealing p ...
Historical Development of the Concept of the Gene
Historical Development of the Concept of the Gene

... other hand, we cannot observe transmission without gene function. According to the so-called classical view of the gene, which prevailed during the 1910s and 1930s, all four criteria led to one and the same unit. According to the classical view, the gene was the smallest indivisible unit of transmis ...
3 The Pathogenesis of Neurofibromatosis 1 and Neurofibromatosis 2
3 The Pathogenesis of Neurofibromatosis 1 and Neurofibromatosis 2

... not contain all the necessary “ingredients” and functions poorly. At other times the protein cannot be made at all, or contains the wrong amino acid. Researchers working on the Human Genome Project estimate that people have a total of 30,000 to 40,000 genes.9 Because people inherit two copies of eac ...
Protein Nanocages - Nanyang Technological University
Protein Nanocages - Nanyang Technological University

... has led to the expansion of their functions beyond the natural ones. There are three surfaces that can be engineered: the internal surface, the external surface, and the interface between the subunits.[5] The internal surface of a protein nanocage does not naturally carry any therapeutic cargo. Howe ...
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Gene nomenclature

Gene nomenclature is the scientific naming of genes, the units of heredity in living organisms. An international committee published recommendations for genetic symbols and nomenclature in 1957. The need to develop formal guidelines for human gene names and symbols was recognized in the 1960s and full guidelines were issued in 1979 (Edinburgh Human Genome Meeting). Several other species-specific research communities (e.g., Drosophila, mouse) have adopted nomenclature standards, as well, and have published them on the relevant model organism websites and in scientific journals, including the Trends in Genetics Genetic Nomenclature Guide. Scientists familiar with a particular gene family may work together to revise the nomenclature for the entire set of genes when new information becomes available. For many genes and their corresponding proteins, an assortment of alternate names is in use across the scientific literature and public biological databases, posing a challenge to effective organization and exchange of biological information. Standardization of nomenclature thus tries to achieve the benefits of vocabulary control and bibliographic control, although adherence is voluntary. The advent of the information age has brought gene ontology, which in some ways is a next step of gene nomenclature, because it aims to unify the representation of gene and gene product attributes across all species.Gene nomenclature and protein nomenclature are not separate endeavors; they are aspects of the same whole. Any name or symbol used for a protein can potentially also be used for the gene that encodes it, and vice versa. But owing to the nature of how science has developed (with knowledge being uncovered bit by bit over decades), proteins and their corresponding genes have not always been discovered simultaneously (and not always physiologically understood when discovered), which is the largest reason why protein and gene names do not always match, or why scientists tend to favor one symbol or name for the protein and another for the gene. Another reason is that many of the mechanisms of life are the same or very similar across species, genera, orders, and phyla, so that a given protein may be produced in many kinds of organisms; and thus scientists naturally often use the same symbol and name for a given protein in one species (for example, mice) as in another species (for example, humans). Regarding the first duality (same symbol and name for gene or protein), the context usually makes the sense clear to scientific readers, and the nomenclatural systems also provide for some specificity by using italic for a symbol when the gene is meant and plain (roman) for when the protein is meant. Regarding the second duality (a given protein is endogenous in many kinds of organisms), the nomenclatural systems also provide for at least human-versus-nonhuman specificity by using different capitalization, although scientists often ignore this distinction, given that it is often biologically irrelevant.Also owing to the nature of how scientific knowledge has unfolded, proteins and their corresponding genes often have several names and symbols that are synonymous. Some of the earlier ones may be deprecated in favor of newer ones, although such deprecation is voluntary. Some older names and symbols live on simply because they have been widely used in the scientific literature (including before the newer ones were coined) and are well established among users.
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