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DNA, RNA and Protein Synthesis
DNA, RNA and Protein Synthesis

... ii. Unlike DNA replication transcription uses only a specific region (a gene) on one of the two DNA strands to serve as the template. c. As RNA polymerase moves past the separated DNA strand rewinds. 3. Step 3 a. During this step RNA polymerase reaches a terminal signal i. Terminal signals are a spe ...
Overview of splicing relevant databases - Stamm
Overview of splicing relevant databases - Stamm

... Most alternative splicing databases are based on the same strategy: the exon content of transcripts is retrieved by aligning sequence of these transcripts together or against the corresponding genomic sequence. Transcript sequences are downloaded from publicly available databanks: EMBL, GenBank and ...
Introduction to Genetics
Introduction to Genetics

... = roan cow (pinkish brown  RW) • ex: Sickle-Cell anemia ...
2012_ISCBAsia_IRRI
2012_ISCBAsia_IRRI

... imposed by the algorithm • Designed for and best suited for analysis of population samples with high diversity or for the use of a divergent proxy reference sequence for species which have no adequate reference of their own • Fast execution even when there is high divergence between the sample and t ...
Characterization of PIR1, a GATA family transcription factor involved
Characterization of PIR1, a GATA family transcription factor involved

... the reference gene employed for normalization, using the formula previously described (Livak and Schmittgen, 2001). Levels of mRNA from the glyceraldehyde-3-phosphate dehydrogenase (gapdh) gene were used for normalization, as previously described (Canessa et al., 2008). Under the culture condition t ...
Genetics
Genetics

... To learn more about how genetic traits are inherited, you will analyze a specific question: If each parent has one A allele and one a allele (i.e. both parents are Aa), what different combinations of A and/or a alleles would you expect to observe in the children of these parents? To answer this ques ...
Lecture 10 Beyond Mendel 1
Lecture 10 Beyond Mendel 1

... two alleles, one of which is completely dominant to the other. However, in early twenty century, geneticists trying to determine of Mendel’s principles apply to all traits in all organisms were faced with the following dilemma. – In Anthirrinum (Snapdragons), when two pure lines, red and white, are ...
Genetics
Genetics

... 2. Next, model fertilization, using the model chromosome for each type of sperm to fertilize each type of egg. Write the genetic makeup of the resulting zygotes in the chart. To answer the following questions, remember that each zygote undergoes repeated mitosis to become a child, so the child will ...
Yr 10 inheritance notes
Yr 10 inheritance notes

... We have looked at both genes having an effect. We say that both are being expressed. We called that intermediate inheritance. Now, when only one gene is being expressed at the expense of the other, we call that dominant inheritance. The dominant gene ‘hides’ the effect of the other gene for that cha ...
The causes and molecular consequences of polyploidy in
The causes and molecular consequences of polyploidy in

... from polyploidization have a number of distinguishing characteristics compared to genes that ...
Understanding the Basis for Down Syndrome Phenotypes
Understanding the Basis for Down Syndrome Phenotypes

... attenuated) when they occur within the same biochemical pathway. Possible trisomy 21 effects on a number of pathways have been posited [20], prioritizing them as targets for molecular analysis. However, the functions and interactions of most Hsa21 (and other) genes are not catalogued to this level. ...
Presentation
Presentation

... • Built-in access to Glimmer 3.02 gene finder • The labelled boxes are anchors for sequence analysis • Segments of DNA can also be marked as a Feature for further analysis ...
Gene Section SIL (SCL/TAL1 interrupting locus) Atlas of Genetics and Cytogenetics
Gene Section SIL (SCL/TAL1 interrupting locus) Atlas of Genetics and Cytogenetics

... T-cell ALL. This TAL1-SIL fusion transcript is found in approximately 25% of T-ALL patients. Cytogenetics Normal karyotype. Hybrid/Mutated Gene The promoter region of the SCL gene, a hematopoietic transcription factor, and the coding region of the SIL gene are deleted. The molecular result of this S ...
1st set of Journal Clubs this Wednesday!
1st set of Journal Clubs this Wednesday!

... 1. There are two key control elements of the operon: the repressor gene and the operator to which the repressor gene product binds. 2. There is a specific interaction between the inducer and repressor that prevents the repressor from binding to the operator. 3. All three lac genes are clustered unde ...
Paper 16-LSPT 409-BIOINFORMATICS THEORY Marks: 100 Unit 1
Paper 16-LSPT 409-BIOINFORMATICS THEORY Marks: 100 Unit 1

... Introduction, Branches of Bioinformatics, Aim, Scope and Research areas of Bioinformatics. Unit 2. Databases in Bioinformatics (Ch 3 Ghosh and Mallick / Ch 2 Pevsner) (5 Periods) Introduction, Biological Databases, Classification format of Biological Databases, Biological Database Retrieval System. ...
"Regulation of Prokaryotic Gene Expression". In: Microbial
"Regulation of Prokaryotic Gene Expression". In: Microbial

... The product of the lacZ gene, ß-galactosidase, cleaves the ß-1,4 linkage of lactose, releasing the free monosaccharides. The enzyme is a tetramer of four identical subunits, each with a molecular weight of 116,400. Entrance of lactose into the cell requires the lac permease (46,500), the product of ...
Chapter 10
Chapter 10

... the 45S pre-rRNA is transcribed, it is immediately bound by nucleolar proteins in preparation for cleavage and base modification. However, it is primarily the small nuclelolar RNAs (snoRNAs), not the proteins, that determine the position of the modifications. The primary modifications are 2’-hydroxy ...
Rabbit Coat Color Biochemistry
Rabbit Coat Color Biochemistry

... pheomelanin creates the yellow pigment. Both of these pigments are created from the same biochemical pathway that branches. Tyrosine changes via the enzyme Tyronease into Dopaquinone. It is from this that the eumelanin and pheomelanin pathways branch out. The Agouti (A) Locus On a Chestnut Agouti’s ...
Mutated DNA
Mutated DNA

... will have a base (or bases) missing, added or exchanged in a codon. ...
Use case flow for use case: 2
Use case flow for use case: 2

... 10. The biomedical researcher uses the location information to determine the relative position of the SNP and the expression. Proposed State Use Case Flow (Semantic Web) Actors: Biomedical Researcher Gene database SNP database The System/Biomedical Research Portal 1. The biomedical researcher choose ...
(I) u--- ---d - uchicago hep
(I) u--- ---d - uchicago hep

... Ease of observation ...
013368718X_CH11_159
013368718X_CH11_159

... In cases of incomplete dominance, neither allele is completely dominant over the other. The phenotype is a blend of the two homozygous phenotypes. In cases of codominance, both alleles in the heterozygous genotype are expressed in the phenotypes. Genes with multiple alleles have more than two forms ...
Identically Different: Why You Can Change Your Genes
Identically Different: Why You Can Change Your Genes

... through to a similar effect lasting for three or more generations. Although Spector doesn’t make this differentiation and makes the unproven assumption of a pre-gestational influence on the epigenetics of the next generation in humans, it is highly unlikely that examples of such effects are yet to b ...
X inactivation Xplained
X inactivation Xplained

... see how to discriminate between different models if not by analysis of molecular components. XCI starts with the accumulation of Xist along the future inactive X chromosome. Recent work indicates that Xist up-regulation is the consequence of sex-specific induction of Xist transcription on the future ...
Genomic disorders: structural features of the genome can lead to
Genomic disorders: structural features of the genome can lead to

... disease, and with Ingram’s demonstration of a specific chemical difference between the hemoglobins of normal and sickled human red blood cells. During the four decades that followed, investigations have focused on the gene – how mutations specifically alter DNA and how these changes affect the struc ...
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RNA-Seq



RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.
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