Drug-induced psychomimetic effects as a model for psychosis
... of both dopaminergic and serotonergic receptors. Administration of mescaline primarily leads to disturbances of perception -predominantly visual hallucinations- and was considered an excellent model for psychosis at the time. When Albert Hofmann discovered the psychomimetic effects of lysergic acid ...
... of both dopaminergic and serotonergic receptors. Administration of mescaline primarily leads to disturbances of perception -predominantly visual hallucinations- and was considered an excellent model for psychosis at the time. When Albert Hofmann discovered the psychomimetic effects of lysergic acid ...
Schizophrenia and other psychotic disorders of early onset
... e-Textbook of Child and Adolescent Mental Health. Geneva: International Association for Child and Adolescent Psychiatry and Allied ...
... e-Textbook of Child and Adolescent Mental Health. Geneva: International Association for Child and Adolescent Psychiatry and Allied ...
Indications for Psychotropic Medication Use
... evaluation must be exercised. This becomes increasingly more difficult with more significant developmental disabilities and problems with speech, motor performance, cognitive ability and sensory integration interfere with standardized testing and mental status exams. We expect this problem to dimini ...
... evaluation must be exercised. This becomes increasingly more difficult with more significant developmental disabilities and problems with speech, motor performance, cognitive ability and sensory integration interfere with standardized testing and mental status exams. We expect this problem to dimini ...
CYP2D6 - PGXL Laboratories
... CYP2C9 Poor Metabolizer (PM): This patient’s genotype is consistent with significantly reduced CYP2C9 enzymatic activity. Reduced CYP2C9 activity leads to lower dose requirement (e.g., warfarin) due to decreased clearance, increased elimination half-life, and increased time to reach steady-state blo ...
... CYP2C9 Poor Metabolizer (PM): This patient’s genotype is consistent with significantly reduced CYP2C9 enzymatic activity. Reduced CYP2C9 activity leads to lower dose requirement (e.g., warfarin) due to decreased clearance, increased elimination half-life, and increased time to reach steady-state blo ...
644.3 Bipolar Disorder
... to give up the highs associated with the manic phase. 2. Bipolar disorder is not the same thing as a mood disorder. 3. Some individuals with bipolar disorder suffer mood swings numerous times in a day or a week. 4. Bipolar disorder can lead to psychosis, but not obsessive-compulsive disorder. 5. The ...
... to give up the highs associated with the manic phase. 2. Bipolar disorder is not the same thing as a mood disorder. 3. Some individuals with bipolar disorder suffer mood swings numerous times in a day or a week. 4. Bipolar disorder can lead to psychosis, but not obsessive-compulsive disorder. 5. The ...
Antipsychotic Use in the Elderly
... antipsychotic agents (namely: risperidone, quetiapine, olanzapine, aripiprazole) when compared to placebo among patients with dementia and BPSD. Additionally, in elderly patients with dementia and BPSD, none of the atypical antipsychotics showed significant symptom improvements when compared to each ...
... antipsychotic agents (namely: risperidone, quetiapine, olanzapine, aripiprazole) when compared to placebo among patients with dementia and BPSD. Additionally, in elderly patients with dementia and BPSD, none of the atypical antipsychotics showed significant symptom improvements when compared to each ...
Bipolar Disorder Practice Guidelines for Adults
... Lithium, lamotrigine, valproate, olanzapine, quetiapine, aripiprazole, risperidone long-acting injection and adjunctive ziprasidone continue to be first-line options for maintenance treatment of Bipolar Disorder. Lithium or olanzapine should be considered as first-line maintenance treatment for adul ...
... Lithium, lamotrigine, valproate, olanzapine, quetiapine, aripiprazole, risperidone long-acting injection and adjunctive ziprasidone continue to be first-line options for maintenance treatment of Bipolar Disorder. Lithium or olanzapine should be considered as first-line maintenance treatment for adul ...
Preventing overuse of antipsychotic drugs in nursing home care
... hospitalist at Brigham and Women's Hospital. His research focuses on the use of medications to treat common chronic conditions. Dr. Choudhry has no relevant financial relationships to disclose. Michael Fischer, M.D., M.S. is an Associate Professor of Medicine at Harvard Medical School and a primary ...
... hospitalist at Brigham and Women's Hospital. His research focuses on the use of medications to treat common chronic conditions. Dr. Choudhry has no relevant financial relationships to disclose. Michael Fischer, M.D., M.S. is an Associate Professor of Medicine at Harvard Medical School and a primary ...
Psychotic Symptoms in the Elderly
... not warrant a diagnosis of dementia; they may be the result of normal age-related changes in frontal lobe function rather than a neurodegenerative process. Mild cognitive impairment, which may represent a pre-dementia state, refers to memory loss greater than that expected from normal aging in the a ...
... not warrant a diagnosis of dementia; they may be the result of normal age-related changes in frontal lobe function rather than a neurodegenerative process. Mild cognitive impairment, which may represent a pre-dementia state, refers to memory loss greater than that expected from normal aging in the a ...
Psychotropic Medication in Foster Youth
... – Over the past decade, nearly 15% of Calif. foster youth were given at least 1 psychotropic – In 2013, of Calif. Foster youth taking a psychotropic, 12% received more than 1 at a time. – Nearly ¼ of Calif. Foster youth received at least one psychotropic = 3.5 x the rate for adolescents ...
... – Over the past decade, nearly 15% of Calif. foster youth were given at least 1 psychotropic – In 2013, of Calif. Foster youth taking a psychotropic, 12% received more than 1 at a time. – Nearly ¼ of Calif. Foster youth received at least one psychotropic = 3.5 x the rate for adolescents ...
Bipolar Disorder - University of Colorado Denver
... • 33 year old single female, presents with chronic depression. – Depressed for 15 years – Current symptoms: hypersomnic, eating more, craves carbohydrates/sweets, feels like she is “nailed to the bed in the mornings,” crying spells, not suicidal but sometimes “prays she will not wake up,” irritable, ...
... • 33 year old single female, presents with chronic depression. – Depressed for 15 years – Current symptoms: hypersomnic, eating more, craves carbohydrates/sweets, feels like she is “nailed to the bed in the mornings,” crying spells, not suicidal but sometimes “prays she will not wake up,” irritable, ...
(Dosing, switching, and other practical information).
... Concomitant antipsychotics should be avoided. Caution should be also exercised when prescribing amisulpride to patients with Parkinson’s disease since it may cause worsening of the disease. Amisulpride should be used only if antipsychotic treatment ...
... Concomitant antipsychotics should be avoided. Caution should be also exercised when prescribing amisulpride to patients with Parkinson’s disease since it may cause worsening of the disease. Amisulpride should be used only if antipsychotic treatment ...
Antipsychotic response in delusional disorder and schizophrenia: a
... factors: positive, negative, excitement, depressive/anxiety and cognitive. The PSP scale is a valid and reliable instrument used to evaluate personal and social functioning in patients with schizophrenia. It consists of four sub-dimensions or domains: patient self-care, usual social activities inclu ...
... factors: positive, negative, excitement, depressive/anxiety and cognitive. The PSP scale is a valid and reliable instrument used to evaluate personal and social functioning in patients with schizophrenia. It consists of four sub-dimensions or domains: patient self-care, usual social activities inclu ...
Treatment guidelines for bipolar disorder: A critical review
... Discussion: Despite supposedly being evidence-based, guidelines for the treatment of bipolar disorder vary significantly across committees or working groups. Overall, however, at the first stage of the mania/hypomania algorithm, monotherapy with lithium, divalproex sodium or olanzapine is generally ...
... Discussion: Despite supposedly being evidence-based, guidelines for the treatment of bipolar disorder vary significantly across committees or working groups. Overall, however, at the first stage of the mania/hypomania algorithm, monotherapy with lithium, divalproex sodium or olanzapine is generally ...
Atypical Antipsychotics Induced Chronic Akathisia: A Case Report
... restlessness. The four subtypes of akathisia are as follows: acute, tardive, withdrawal and chronic akathisia. Standardized titration and use of second generation antipsychotics are successful approaches of prevention from drug-induced akathisia. On the other hand, it is possible that atypic antipsy ...
... restlessness. The four subtypes of akathisia are as follows: acute, tardive, withdrawal and chronic akathisia. Standardized titration and use of second generation antipsychotics are successful approaches of prevention from drug-induced akathisia. On the other hand, it is possible that atypic antipsy ...
Quetiapine and extrapyramidal effects
... Up to December 2005, the Netherlands Pharmacovigilance Centre Lareb received, besides several reports on tardive dyskinesia, ten other reports of extrapyramidal effects in association with quetiapine (table 1). In three cases, a contribution of concomitant medication to the symptoms cannot be exclud ...
... Up to December 2005, the Netherlands Pharmacovigilance Centre Lareb received, besides several reports on tardive dyskinesia, ten other reports of extrapyramidal effects in association with quetiapine (table 1). In three cases, a contribution of concomitant medication to the symptoms cannot be exclud ...
product monograph - Eli Lilly Canada
... ZYPREXA (olanzapine) is indicated for the acute treatment of manic or mixed episodes in bipolar I disorder. Olanzapine may be used as monotherapy or cotherapy with agents commonly used in the treatment of acute bipolar disorder (e.g., lithium or divalproex sodium). The efficacy of ZYPREXA as monothe ...
... ZYPREXA (olanzapine) is indicated for the acute treatment of manic or mixed episodes in bipolar I disorder. Olanzapine may be used as monotherapy or cotherapy with agents commonly used in the treatment of acute bipolar disorder (e.g., lithium or divalproex sodium). The efficacy of ZYPREXA as monothe ...
Plastic Surgery for the General Surgeon
... years are at a considerably increased risk of developing fatal hepatotoxicity, especially those on multiple anticonvulsants… Pancreatitis:Cases of life-threatening pancreatitis have been reported in both children and adults receiving valproate. ...
... years are at a considerably increased risk of developing fatal hepatotoxicity, especially those on multiple anticonvulsants… Pancreatitis:Cases of life-threatening pancreatitis have been reported in both children and adults receiving valproate. ...
Reynolds-Psych-Panels-11-20-12
... THERAPEUTIC IMPLICATIONS (adapted from published resources) Decreased serotonin transporter expression expected. Risk of decreased response to SSRI-based therapies and increased risk of adverse events. Consider non-SSRI antidepressant therapies, such as SNRIs or tricyclic antidepressants alternative ...
... THERAPEUTIC IMPLICATIONS (adapted from published resources) Decreased serotonin transporter expression expected. Risk of decreased response to SSRI-based therapies and increased risk of adverse events. Consider non-SSRI antidepressant therapies, such as SNRIs or tricyclic antidepressants alternative ...
Psychiatric Essentials 31 August 2012 Presented By
... to 0.5 mg bd to tds luteal phase only Buspirone : 2 small RCTs at up to 60 mg divided dose/day Spironolactone: 100mg daily for 8 days premenstrually Calcium: 1200 mg/day Complex carbohydrate suppl. for affective PMS symptoms Soy supplementation for physical but not mood symptoms Vit B6 – 80 mg/day, ...
... to 0.5 mg bd to tds luteal phase only Buspirone : 2 small RCTs at up to 60 mg divided dose/day Spironolactone: 100mg daily for 8 days premenstrually Calcium: 1200 mg/day Complex carbohydrate suppl. for affective PMS symptoms Soy supplementation for physical but not mood symptoms Vit B6 – 80 mg/day, ...
1
... Use of SYMBYAX with Other MAOIs such as Linezolid or Methylene Blue Do not start SYMBYAX in a patient who is being treated with linezolid or intravenous methylene blue because there is an increased risk of serotonin syndrome. In a patient who requires more urgent treatment of a psychiatric condition ...
... Use of SYMBYAX with Other MAOIs such as Linezolid or Methylene Blue Do not start SYMBYAX in a patient who is being treated with linezolid or intravenous methylene blue because there is an increased risk of serotonin syndrome. In a patient who requires more urgent treatment of a psychiatric condition ...
Symbyax - Eli Lilly and Company
... Adults — Administer SYMBYAX once daily in the evening, generally beginning with the 6 mg/25 mg (mg olanzapine/mg equivalent fluoxetine) capsule. While food has no appreciable effect on the absorption of olanzapine and fluoxetine given individually, the effect of food on the absorption of SYMBYAX has ...
... Adults — Administer SYMBYAX once daily in the evening, generally beginning with the 6 mg/25 mg (mg olanzapine/mg equivalent fluoxetine) capsule. While food has no appreciable effect on the absorption of olanzapine and fluoxetine given individually, the effect of food on the absorption of SYMBYAX has ...
抗精神失常药
... - increasing NE and 5-HT release; stimulating postsynaptic 1 receptors on serotonergic cell bodies - increasing the firing rate of serotonergic neurons potently blocking postsynaptic 5-HT2A, 5-HT2C and 5-HT3 receptors – attenuating 5-HT2C-mediated anxiety The net outcome of these effects is i ...
... - increasing NE and 5-HT release; stimulating postsynaptic 1 receptors on serotonergic cell bodies - increasing the firing rate of serotonergic neurons potently blocking postsynaptic 5-HT2A, 5-HT2C and 5-HT3 receptors – attenuating 5-HT2C-mediated anxiety The net outcome of these effects is i ...
The Glycine Transporter-1 Inhibitor SSR103800 Displays a
... Schizophrenia has been initially associated with dysfunction in dopamine neurotransmission. However, the observation that antagonists of the glutamate N-methyl-D-aspartate (NMDA) receptor produce schizophrenic-like symptoms in humans has led to the idea of a dysfunctioning of the glutamatergic syste ...
... Schizophrenia has been initially associated with dysfunction in dopamine neurotransmission. However, the observation that antagonists of the glutamate N-methyl-D-aspartate (NMDA) receptor produce schizophrenic-like symptoms in humans has led to the idea of a dysfunctioning of the glutamatergic syste ...
Olanzapine
Olanzapine (originally branded Zyprexa) is an atypical antipsychotic. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia and bipolar disorder.Olanzapine is structurally similar to clozapine and quetiapine, but is classified as a thienobenzodiazepine. The olanzapine formulations are manufactured and marketed by the pharmaceutical company Eli Lilly and Company; the drug went generic in 2011. Sales of Zyprexa in 2008 were $2.2B in the US, and $4.7B worldwide.