Care Working Group - Osteoporosis Canada
... Long-term or repeated systemic glucocorticoid use (oral or parenteral) that does not meet the conventional criteria for recent prolonged systemic glucocorticoid use (i.e., > 3 months cumulative during the preceding year at a prednisone equivalent dose > 7.5 mg daily) Recurrent falls defined as falli ...
... Long-term or repeated systemic glucocorticoid use (oral or parenteral) that does not meet the conventional criteria for recent prolonged systemic glucocorticoid use (i.e., > 3 months cumulative during the preceding year at a prednisone equivalent dose > 7.5 mg daily) Recurrent falls defined as falli ...
The Missing Vitamin: Vitamin D
... indoors, cured with cod-liver oil 1923- skin precursor identified 1930’s – chemistry determined ...
... indoors, cured with cod-liver oil 1923- skin precursor identified 1930’s – chemistry determined ...
Board Pearls in Endocrinology Part 2
... kyphosis, a small firm goiter, and diffuse muscle weakness. Bone densitometry confirms low bone mass in her spine (T-score −2.9) and the unaffected hip (T-score −3.4). Labs: CBC normal, calcium 8.6 mg/dL, phosphorus 2.4 mg/dL, alkaline phosphatase165 U/L, TSH 21 µU/mL. Which serum tests would be mos ...
... kyphosis, a small firm goiter, and diffuse muscle weakness. Bone densitometry confirms low bone mass in her spine (T-score −2.9) and the unaffected hip (T-score −3.4). Labs: CBC normal, calcium 8.6 mg/dL, phosphorus 2.4 mg/dL, alkaline phosphatase165 U/L, TSH 21 µU/mL. Which serum tests would be mos ...
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sodium metabolism and hypertension 2[Autosaved]
... when the plasma Ca2+ level is high ,PTH secretion is inhibited and the Ca2+ is deposited in bones. When it is low, secretion is increased and Ca2+ is mobilized from the bones . ...
... when the plasma Ca2+ level is high ,PTH secretion is inhibited and the Ca2+ is deposited in bones. When it is low, secretion is increased and Ca2+ is mobilized from the bones . ...
B2B Endocrinology Review Thyroid, pituitary, adrenal
... Prolonged glucocorticoid use Use of other high-risk medications Parental hip fracture Vertebral # or osteopenia on X-ray Current smoking or high EtOH intake Low weight (< 60kg) or wt loss (>10% of weight at age 25 yr) Rheumatoid arthritis Other disorder strongly associated with osteoporosis CMAJ 201 ...
... Prolonged glucocorticoid use Use of other high-risk medications Parental hip fracture Vertebral # or osteopenia on X-ray Current smoking or high EtOH intake Low weight (< 60kg) or wt loss (>10% of weight at age 25 yr) Rheumatoid arthritis Other disorder strongly associated with osteoporosis CMAJ 201 ...
Hypovitaminosis D and Pain in Cystic Fibrosis
... infection; cytokines having been shown to modulate pain perception both peripherally and centrally [9]. Therefore, although the threshold for optimum vitamin D status is known to be considerably higher than that required to prevent osteomalacia, it is still important to establish the risk of pain ac ...
... infection; cytokines having been shown to modulate pain perception both peripherally and centrally [9]. Therefore, although the threshold for optimum vitamin D status is known to be considerably higher than that required to prevent osteomalacia, it is still important to establish the risk of pain ac ...
USMLE Step 1 Web Prep — Hormonal Control of Calcium and
... When the product is below the solubility product, bone is resorbed [Ca++] x [PO4] < solubility product = bone resorption kidney is damping significant PO4 in urine= low plasma PO4= Ca*PO4< sol. prod = CaPO4in the solution- raise free Ca plasma What is regulated so precisely is free Ca++, not phospha ...
... When the product is below the solubility product, bone is resorbed [Ca++] x [PO4] < solubility product = bone resorption kidney is damping significant PO4 in urine= low plasma PO4= Ca*PO4< sol. prod = CaPO4in the solution- raise free Ca plasma What is regulated so precisely is free Ca++, not phospha ...
No Slide Title
... – increases intestinal absorption and absorption from the skeleton – increases stem cell differentiation into osteoclasts – promotes urinary reabsorption of calcium ions ...
... – increases intestinal absorption and absorption from the skeleton – increases stem cell differentiation into osteoclasts – promotes urinary reabsorption of calcium ions ...
metabolic disease
... erosions (phalanges),pathological fractures. Calcification of soft tissues Blood results calcium, PTH, phosphate, alk. phosp. N/( increased with osteitis fibrosa Treatment ...
... erosions (phalanges),pathological fractures. Calcification of soft tissues Blood results calcium, PTH, phosphate, alk. phosp. N/( increased with osteitis fibrosa Treatment ...
Disorders of Ca/phosphate homeostatsis: Hyper
... Osteoporosis A systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. ...
... Osteoporosis A systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. ...
PTH (1-34) Human|HOPS-297
... polypeptide containing 84 amino acids. It acts to increase the concentration of calciumin the blood, whereas calcitonin (a hormone produced by the parafollicular cells of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acti ...
... polypeptide containing 84 amino acids. It acts to increase the concentration of calciumin the blood, whereas calcitonin (a hormone produced by the parafollicular cells of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acti ...
PDF Version - US Preventive Services Task Force
... osteoporosis reduces fracture-related morbidity or mortality, studies of long-term health outcomes of screened and nonscreened population groups are important. Research is needed to test the effectiveness of drug therapies for osteoporosis in men who do not have a history of fractures. The results o ...
... osteoporosis reduces fracture-related morbidity or mortality, studies of long-term health outcomes of screened and nonscreened population groups are important. Research is needed to test the effectiveness of drug therapies for osteoporosis in men who do not have a history of fractures. The results o ...
Endocrinology Review: Adrenal, thyroid & bone
... Prolonged glucocorticoid use Use of other high-risk medications Parental hip fracture Vertebral # or osteopenia on X-ray Current smoking or high EtOH intake Low weight (< 60kg) or wt loss (>10% of weight at age 25 yr) Rheumatoid arthritis Other disorder strongly associated with osteoporosis CMAJ 201 ...
... Prolonged glucocorticoid use Use of other high-risk medications Parental hip fracture Vertebral # or osteopenia on X-ray Current smoking or high EtOH intake Low weight (< 60kg) or wt loss (>10% of weight at age 25 yr) Rheumatoid arthritis Other disorder strongly associated with osteoporosis CMAJ 201 ...
Back_to_Basics-thyroid^Jpituitary^Jadrenal^Jbone2016
... Use of other high-risk medications Parental hip fracture Vertebral # or osteopenia on X-ray Current smoking or high EtOH intake Low weight (< 60kg) or wt loss (>10% loss of weight at age 25 yr) • Rheumatoid arthritis • Other disorder strongly associated with osteoporosis CMAJ 2010 ...
... Use of other high-risk medications Parental hip fracture Vertebral # or osteopenia on X-ray Current smoking or high EtOH intake Low weight (< 60kg) or wt loss (>10% loss of weight at age 25 yr) • Rheumatoid arthritis • Other disorder strongly associated with osteoporosis CMAJ 2010 ...
(PTH), or parathormone, is secreted
... calciumin the blood, whereas calcitonin (a hormone produced by the parafollicular cells of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptorin three parts of the body: In the bones- It ...
... calciumin the blood, whereas calcitonin (a hormone produced by the parafollicular cells of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptorin three parts of the body: In the bones- It ...
Bone tissue
... Cartilage between shaft and epiphysis does not completely fill with bone because the epiphyseal plates (growth plate) on the ends continue to enlarge, increasing the length of developing bone. ...
... Cartilage between shaft and epiphysis does not completely fill with bone because the epiphyseal plates (growth plate) on the ends continue to enlarge, increasing the length of developing bone. ...
Calcium and vitamin D for osteoporotic fracture prevention
... reduces osteoporotic bone loss and fracture risk was a metaanalysis by Tang et al. [9]. It included 29 studies (n = 63,897) of calcium alone or calcium with vitamin D, but excluded vitamin D alone studies. Calcium alone (9 trials, n = 6517) provided a 10% reduction in fracture risk (RR 0.9), but the ...
... reduces osteoporotic bone loss and fracture risk was a metaanalysis by Tang et al. [9]. It included 29 studies (n = 63,897) of calcium alone or calcium with vitamin D, but excluded vitamin D alone studies. Calcium alone (9 trials, n = 6517) provided a 10% reduction in fracture risk (RR 0.9), but the ...
Case Study #1 - Osteoporosis Canada
... Vitamin D: Optimal Levels • To most consistently improve clinical outcomes such as fracture risk, an optimal serum level of 25hydroxy vitamin D is probably > 75 nmol/L – For most Canadians, supplementation is needed to achieve this level Hanley DA, et al. CMAJ 2010; 182:E610-E618. ...
... Vitamin D: Optimal Levels • To most consistently improve clinical outcomes such as fracture risk, an optimal serum level of 25hydroxy vitamin D is probably > 75 nmol/L – For most Canadians, supplementation is needed to achieve this level Hanley DA, et al. CMAJ 2010; 182:E610-E618. ...
Discussion Topics
... Aerobic exercise: this can be as simple as walking 10 minutes a day. This does not have to be high impact. Proper diet: protein and calcium are essential for bone growth. Protein should be eaten two to three times per week. Weight loss can decrease pressure on bones at rest. Hormone replacem ...
... Aerobic exercise: this can be as simple as walking 10 minutes a day. This does not have to be high impact. Proper diet: protein and calcium are essential for bone growth. Protein should be eaten two to three times per week. Weight loss can decrease pressure on bones at rest. Hormone replacem ...
OSTEOPOROSIS IN PATIENTS WITH HYPERTHYROIDISM
... hyperthyroid patients of all ages. The distal BMD was also lower for all hyperthyroid patients and for the young women group with hyperthyroidism….. Discussion Overt hyperthyroidism is an important risk factor for osteoporosis and fractures (3, 9). Thyroid hormones accelerate the rate of bone remode ...
... hyperthyroid patients of all ages. The distal BMD was also lower for all hyperthyroid patients and for the young women group with hyperthyroidism….. Discussion Overt hyperthyroidism is an important risk factor for osteoporosis and fractures (3, 9). Thyroid hormones accelerate the rate of bone remode ...
Reciprocal regulation of bone and energy metabolism
... inhibits RANKL expression. The notion that the brain regulate bone mass has now been verified experimentally in multiple laboratories. These studies immediately raised a second question: if fat and brain regulates bone remodeling by acting on osteoblasts, are osteoblasts in turn regulating any aspec ...
... inhibits RANKL expression. The notion that the brain regulate bone mass has now been verified experimentally in multiple laboratories. These studies immediately raised a second question: if fat and brain regulates bone remodeling by acting on osteoblasts, are osteoblasts in turn regulating any aspec ...
CLINICAL PHARMACY IN ENDOCRINOLOGY
... beyond age 60 which may come in the form of increased food calcium or from specific calcium and vitamin D supplements. For women at menopause, the appropriate administration of estrogen (or some of the new synthetic estrogens) is the most potent means by which bone mass may be preserved, thereby pre ...
... beyond age 60 which may come in the form of increased food calcium or from specific calcium and vitamin D supplements. For women at menopause, the appropriate administration of estrogen (or some of the new synthetic estrogens) is the most potent means by which bone mass may be preserved, thereby pre ...
PDF Booklet - Spine University
... Each of the iliac bones has projections called the pubic rami. They meet together in the front of the pelvis, forming a joint called the symphysis pubis. The iliac bones also contain the cup or socket for the hip joint. Nerves that leave the spine in the area of the sacrum help control the bowels an ...
... Each of the iliac bones has projections called the pubic rami. They meet together in the front of the pelvis, forming a joint called the symphysis pubis. The iliac bones also contain the cup or socket for the hip joint. Nerves that leave the spine in the area of the sacrum help control the bowels an ...
Osteoporosis
Osteoporosis is a disease where decreased bone strength increases the risk of a broken bone. It is the most common reason for a broken bone among people who are old. Bones that commonly break include the back bones, the bones of the forearm, and the hip. Until a broken bone occurs there are typically no symptoms. Bones may weaken to such a degree that a break may occur with minor stress or spontaneously. Chronic pain and a decreased ability to carry out normal activities may occur following a broken bone.Osteoporosis may be due to lower than normal peak bone mass and greater than normal bone loss. Bone loss increases after menopause due to lower levels of estrogen. Osteoporosis may also occur due to a number of diseases or treatments including alcoholism, anorexia, hyperthyroidism, surgical removal of the ovaries, and kidney disease. Certain medications increase the rate of bone loss including some antiseizure medications, chemotherapy, proton pump inhibitors, selective serotonin reuptake inhibitors and steroids. Not enough exercise and smoking are also risk factors. Osteoporosis is defined as a bone density of 2.5 standard deviations below that of a young adult. This is typically measured by dual-energy X-ray absorptiometry at the hip.Prevention of osteoporosis includes a proper diet during childhood and efforts to avoid medications that cause the condition. Efforts to prevent broken bones in those with osteoporosis include a good diet, exercise, and fall prevention. Lifestyle changes such as stopping smoking and not drinking alcohol may help. Medication of the bisphosphonate type are useful in those with previous broken bones due to osteoporosis. In those with osteoporosis but no previous broken bones they are less effective. A number of other medications may also be useful.Osteoporosis becomes more common with age. About 15% of white people in their 50s and 70% of those over 80 are affected. It is more common in women than men. In the developed world, depending on the method of diagnosis, 2% to 8% of males and 9% to 38% of females are affected. Rates of disease in the developing world are unclear. About 22 million women and 5.5 million men in the European Union had osteoporosis in 2010. In the United States in 2010 about eight million women and one to two million men had osteoporosis. White and Asian people are at greater risk. The word osteoporosis is from the Greek terms for ""porous bones"".