Immunolocalization of surfactant protein A and D in
... Pseudomonas produces proteases known to degrade SPs (Malloy et al). SP-B upregulated in response to degradation of SP-B and surfactant by Pseudomonas. Alternatively, increased submucosal glands in CF mucosa contribute more mRNA transcripts to sample ...
... Pseudomonas produces proteases known to degrade SPs (Malloy et al). SP-B upregulated in response to degradation of SP-B and surfactant by Pseudomonas. Alternatively, increased submucosal glands in CF mucosa contribute more mRNA transcripts to sample ...
The role of lymph node sinus macrophages in host defense
... of SCS and medullary macrophages could explain their different permissivity to VSV infection. First, when compared to SCS macrophages, medullary macrophages are more phagocytic and express higher levels of endosomal degradative enzymes.17,67,68 Second, the two subsets of macrophages differ in expres ...
... of SCS and medullary macrophages could explain their different permissivity to VSV infection. First, when compared to SCS macrophages, medullary macrophages are more phagocytic and express higher levels of endosomal degradative enzymes.17,67,68 Second, the two subsets of macrophages differ in expres ...
Stem Cell-Based Cell Carrier for Targeted Oncolytic Virotherapy
... the cell carrier types via their homing patterns as well as to predict their distinct migratory behaviors once they are in the circulatory system (Table 1). ...
... the cell carrier types via their homing patterns as well as to predict their distinct migratory behaviors once they are in the circulatory system (Table 1). ...
HMGB1 Mediates Endogenous TLR2 Activation and
... death to release tumor antigens. Our approach consists of expressing Fms-like tyrosine kinase 3 ligand (Flt3L), which induces DC infiltration into the brain parenchyma [7], in combination with the conditional cytotoxic gene thymidine kinase (TK) [8]. Cell death can trigger antigen-specific immune re ...
... death to release tumor antigens. Our approach consists of expressing Fms-like tyrosine kinase 3 ligand (Flt3L), which induces DC infiltration into the brain parenchyma [7], in combination with the conditional cytotoxic gene thymidine kinase (TK) [8]. Cell death can trigger antigen-specific immune re ...
... CN polysaccharide capsule-specific mAb 18B7 with alphaparticle emitting 213-Bismuth (213 Bi) or the beta-particle emitting 188-Rhenium (188 Re). Mice treated with radiolabeled 18B7 mAb lived significantly longer than mice given irrelevant labeled IgG1 or PBS. We used a labeled irrelevant mAb (213 Bi ...
as a PDF
... mechanisms underlying the relationship between zinc and immunity are still open to speculation. Several hypotheses can be made: (1) Zinc is an essential factor for the activity of many enzymes — it is known to form part of more than 300 metalloenzymes which cannot function in its absence. Thus, zinc ...
... mechanisms underlying the relationship between zinc and immunity are still open to speculation. Several hypotheses can be made: (1) Zinc is an essential factor for the activity of many enzymes — it is known to form part of more than 300 metalloenzymes which cannot function in its absence. Thus, zinc ...
Exploring S-Shaped Growth
... classic examples of S-shaped behavior. The cellular growth of a plant and physical and intellectual development in small children, along with the body's immune response, are all subject to S-shaped growth. This paper will begin by exploring population dynamics, taking as an example Jean's population ...
... classic examples of S-shaped behavior. The cellular growth of a plant and physical and intellectual development in small children, along with the body's immune response, are all subject to S-shaped growth. This paper will begin by exploring population dynamics, taking as an example Jean's population ...
Dermal Toxicology
... blood or extracellular fluid by one cell that affect the functioning of other cells Endocrine action – distribution in blood and binding to a distant target ...
... blood or extracellular fluid by one cell that affect the functioning of other cells Endocrine action – distribution in blood and binding to a distant target ...
Infection T Cell Response during Chronic Viral +CD8 Exhaustion
... underlying mechanism, the CD8⫹ T cell effector response in single-epitope-vaccinated and control mice was analyzed by intracellular cytokine staining for IFN-␥ in the early (days 10 and 20 p.i.) as well as in the late (2–3 mo p.i.) phase of infection. To evaluate the breadth of the antiviral CD8⫹ T ...
... underlying mechanism, the CD8⫹ T cell effector response in single-epitope-vaccinated and control mice was analyzed by intracellular cytokine staining for IFN-␥ in the early (days 10 and 20 p.i.) as well as in the late (2–3 mo p.i.) phase of infection. To evaluate the breadth of the antiviral CD8⫹ T ...
Persistence T Cell Function during Viral + CD8 Memory Generation
... of latently infected cells (left y-axis) in the spleen of C57BL/6 (f) and BALB/c (䡺) mice was determined using LDA-PCR assay at 5 m.p.i. The number of lytically infected cells (ND, not detected, right y-axis) was determined using a modified plaque assay. Three individual mice were independently anal ...
... of latently infected cells (left y-axis) in the spleen of C57BL/6 (f) and BALB/c (䡺) mice was determined using LDA-PCR assay at 5 m.p.i. The number of lytically infected cells (ND, not detected, right y-axis) was determined using a modified plaque assay. Three individual mice were independently anal ...
ImmunoGrid – The virtual human immune system project
... ethical concerns (e.g. there are strict rules as what experiments can be performed in humans) ...
... ethical concerns (e.g. there are strict rules as what experiments can be performed in humans) ...
T Lymphocyte Responses + Despite Augmenting Antigen
... T cells play a critical role in cellular immunity against intracellular bacterial pathogens, such as Listeria monocytogenes and Mycobacterium tuberculosis (8). Effector CD4⫹ T cells act as Th cells during Listeria infection by the production of Th1-type cytokines, such as IFN-␥, which activate macro ...
... T cells play a critical role in cellular immunity against intracellular bacterial pathogens, such as Listeria monocytogenes and Mycobacterium tuberculosis (8). Effector CD4⫹ T cells act as Th cells during Listeria infection by the production of Th1-type cytokines, such as IFN-␥, which activate macro ...
CNS–Immune Reconstitution Inflammatory Syndrome in the Setting
... T-cells into the circulation and the second stage typified by a gradual rise in naïve T-cell production.1 More specifically within the first 2 weeks of HAART, during the first stage of immune restoration, there is a rapid decrease in the HIV viral load.1 The circulating CD8⫹ T-cells also rapidly inc ...
... T-cells into the circulation and the second stage typified by a gradual rise in naïve T-cell production.1 More specifically within the first 2 weeks of HAART, during the first stage of immune restoration, there is a rapid decrease in the HIV viral load.1 The circulating CD8⫹ T-cells also rapidly inc ...
Delayed acquisition of Plasmodium falciparum antigen
... prevents severe and life threatening illness [1, 2]. Evidence from mouse models and experimental human infections suggests that both CD4+ and CD8+ T cells play an important role in protective immunity to P. falciparum malaria [3–6]. T cells directly control the development of pre-erythrocytic Plasmo ...
... prevents severe and life threatening illness [1, 2]. Evidence from mouse models and experimental human infections suggests that both CD4+ and CD8+ T cells play an important role in protective immunity to P. falciparum malaria [3–6]. T cells directly control the development of pre-erythrocytic Plasmo ...
Papillitis as the prominent ocular sign in Acquired Immune
... system may produce third and sixth nerve palsies 5. It is important to note that fundus findings and the patient's general condition do not correlate 5 6. ...
... system may produce third and sixth nerve palsies 5. It is important to note that fundus findings and the patient's general condition do not correlate 5 6. ...
Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome
... 1 Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands, 2 Center for Infection and Immunity Amsterdam (CINIMA), University of Amsterdam, Amsterdam, The Netherlands, 3 Department of Molecular Cell Biology & Immunology, VU Medical Center, Amsterdam, The N ...
... 1 Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands, 2 Center for Infection and Immunity Amsterdam (CINIMA), University of Amsterdam, Amsterdam, The Netherlands, 3 Department of Molecular Cell Biology & Immunology, VU Medical Center, Amsterdam, The N ...
ABSTRACT - Johns Hopkins University
... divided into >3 year disease free survival (DFS) and < 3 year DFS groups for analysis. The 3 year cut off was chosen because patients surviving disease free after 3 years are likely to remain disease free. These experiments identified several protein bands that patients in the > 3 year DFS group dev ...
... divided into >3 year disease free survival (DFS) and < 3 year DFS groups for analysis. The 3 year cut off was chosen because patients surviving disease free after 3 years are likely to remain disease free. These experiments identified several protein bands that patients in the > 3 year DFS group dev ...