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1 - Lone Star College
1 - Lone Star College

... Chains have constant regions at the trunk of the Y The class of antibody is determined by the structure of the constant region Monomers – single Y-shaped molecules Dimers – paired Y-shaped molecules Pentamers – clusters of 5 Y-shaped molecules linked ...
Immune System Review Sheet
Immune System Review Sheet

... 2. What are antigens and antibodies? Relate the two terms. 3. What are lymphocytes? Difference between B and T cells? 5. Outline the steps of humoral immunity. Include the terms antibody, macrophage, T cell, B cell, helper T cells, plasma cells, memory cells. 6. Outline the steps of cell-mediated im ...
7-Organ
7-Organ

... Thymocytes Dendritic cell ...
Something that makes us sick, causes disease
Something that makes us sick, causes disease

... Something that makes us sick, causes disease -Use your phone to find 5 pathogens, quick description and an example of a disease they cause. If you know one from memory you can write that down. ...
2nd seminar - Innate immunity, inflammation 2015
2nd seminar - Innate immunity, inflammation 2015

... Symbiotic, non-pathogenic microbes, living in „peaceful” commensalisms Beneficial features: • Digesting non absorbable food compounds e.g. cellulose • Producing vitamines, antimicrobial molecules, regulating pH • Compete with pathogenic microbes – survival of the fittest • Providing constant low-dos ...
Specific Immune Defense
Specific Immune Defense

Topic 6.3 Defence against infectious disease
Topic 6.3 Defence against infectious disease

... Killer (Cytotoxic) cells attack with perforin or nitric oxide. T memory cells remember the antigen for a later attack. T suppressor cells switch off T and B cells after attack over. ...
The Immune System
The Immune System

B cell - International Consortium Of Gene Therapy
B cell - International Consortium Of Gene Therapy

... Humans harbor memory CD8+ T cells to AAV capsid, and human hepatocytes present input capsid on their surface Multiple CD8+ capsid epitopes have been mapped in humans Several epitopes are highly conserved between serotypes AAV vectors can also activate a primary T cell response to capsid AAV capsids ...
Historical Perspectives (cont.)
Historical Perspectives (cont.)

... In 1975 demonstrated the need for self recognition in effector role of cell mediated immunity (CMI). Received the Nobel Prize in 1997 for this work which was carried out in the John Curtin School for Medical Research at the Australian National University in Canberra. ...
CLASS REVIEW...in the form of Jeopardy!
CLASS REVIEW...in the form of Jeopardy!

... Lymphocytes that persistently receive a primary stimulatory signal without a costimulatory signal are likely to end up in this inactive state. ...
VCE BIOLOGY 2011 LARA SECONDARY COLLEGE COURSE
VCE BIOLOGY 2011 LARA SECONDARY COLLEGE COURSE

... This unit explores evidence for the evolution of life over time. Observable differences, DNA and the conservation of genes are presented as markers of ancestral lines which lead to the diversity of life today. Genomics and the relationship between species is examined, as are patterns of inheritance ...
T cell
T cell

... Thymocytes Dendritic cell ...
t lyphocyte
t lyphocyte

... HIV virus destroys these cells & hence both the types of immunity are lost. ...
immune complex-mediated (type iii) hypersensitivity
immune complex-mediated (type iii) hypersensitivity

... - antigen-antibody complexes produce tissue damage by eliciting inflammation at site of deposition - reaction initiated when antigen combines with antibody in circulation and these are deposited, typically in vessel walls, or the complexes are formed at extravascular sites where antigen may have bee ...
Unit 4 Mind Maps
Unit 4 Mind Maps

... Describe the role of cytokines Damage to connective tissue causes, __________ cells to release a chemical ...
Slide 1
Slide 1

... • Cytotoxic T-cells: “killer” white blood cells • Helper T-cells: present antigens so that good “match” can be found among antibody-making cells • B-cells: recognize antigens and make antibodies • MHC: Major Histocompatiblity Complex—allows body to recognize own cells so that their proteins don’t tr ...
Nertila_Ujkaj:Littin_Kandoth_Sandra
Nertila_Ujkaj:Littin_Kandoth_Sandra

... Gliadin Peptide ...
EasySep™ Release - STEMCELL Technologies
EasySep™ Release - STEMCELL Technologies

F13Lect21Cancer
F13Lect21Cancer

... constitutively active (human) (3) Loss of extracellular domain: constitutively active (mice.) ...
Humoral Immune Effector Mechanisms
Humoral Immune Effector Mechanisms

... proliferative response only when F(ab)’2 is used. Fc gRII provides the inhibitory signal in this (by binding the Fc of the intact antibody). Indeed in FcgRII knock-out mice there was a significantly higher antibody response to both thymus independent and thymus dependent antigens. Therefore FcgRII a ...
Peripheral tolerance in T cells
Peripheral tolerance in T cells

... Immune responses are the outcome of a balance between the need to make a protective response and the need to maintain self-tolerance ...
The host defense system
The host defense system

... – “Functional” names like tumor necrosis factor, macrophage inhibitory peptide – CC, CXC, etc chemokines ...
17. The Immune Response
17. The Immune Response

... 3. Some attach to the invader, making the microbe less soluble and more attractive to leukocytes (Fig. 2c) Another group of WBCs, called lymphocytes, produces antibodies Antibodies are protein molecules that protect the body from invaders All cells have special markers on their cell membranes, but t ...
Immune System Overview
Immune System Overview

... Binds to allergens and triggers histamine release from mast cells, eosinophils and basophils, and is involved in allergy. Also protects against parasitic worms. In its four forms, provides the majority of antibody-based immunity against invading pathogens. The only antibody capable of crossing the p ...
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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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