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Module 50 / Homeostasis and Homeostatic Imbalances
Module 50 / Homeostasis and Homeostatic Imbalances

Cytokines
Cytokines

Chapter 51
Chapter 51

... Innate immune components recognize markers found on a variety of “nonself” invaders, adaptive immune components recognize specific markers ...
Teaching Slides
Teaching Slides

... Humoral response: B cells Stimulated by an antigen-presenting macrophage (WBC w/ a germ on it) Activates Helper T cells T cells secrete cytokine chemicals that activate B cells B cells differentiate into memory B cells and antibody-producing plasma cells ...
Poster - IRMACS Centre - Simon Fraser University
Poster - IRMACS Centre - Simon Fraser University

... Fig. 3. Proposed configuration of iReceptor environment. Data migration services facilitate input of data into nodes of receptor databases (e.g., VDJServer data commons, BC Genome Sciences Centre, SFU, etc.). iReceptor database service authenticates access at 3 levels: public data “commons”; sharing ...
Viruses
Viruses

... There are many cells that are responsible for the specific immune response: Macrophages/Phagocytes- Large cells that ‘eat’ the virus/bacteria and show the T Cells and B Cells the antigen to target Helper T Cells – Cells that tell B Cells, Cytotoxic T Cells, and Natural Killer Cells what to do B Cell ...
Slide 1
Slide 1

... A set of physiological reactions to damage of tissue integrity, leading to protection against infection, localization and restriction of the damaged site and finally to healing. ...
The Basics of Cancer Biology
The Basics of Cancer Biology

... cytokines that suppress CD8 and CD4 Th1 cells) – CD4 T-cells of the Th2 variety (produce cytokines that stimulate B-cells and drive an antibody response rather than a cytotoxic response) – CD4 T-cells of the Th17 variety (produce IL-17 and are stimulated by IL-23). These cells drive chronic inflamma ...
Immunological Methods and their Application
Immunological Methods and their Application

... Antigenic determinants epitopes (linear and confromational epitopes) Antibodies or immunoglobulins, classes and subclasses, Ig-superfamily, structure of Ig molecule, biological/physiological functions of antibodies. Ig-genes, generation and antibody diversity Major histocompatibility complex (MHC) o ...
The Immune System
The Immune System

... • They kill infected body cells (present foreign antigens on major histocompatability complex (MHC) or other cells that don’t belong (like tumors) at the cell membrane • Class I MHCs = on almost all body cells except RBCs. • Class II MHCs= made by dendritic cells, macrophages, & B cells. ...
Athlete`s Foot, Ringworm, Yeast Infection
Athlete`s Foot, Ringworm, Yeast Infection

... II. Immune System- a network of cells, tissues, organs and chemicals that fights off pathogens A. Inflammatory ___________-reaction to tissue damage caused by injury or infection 1. Phagocyte- a white blood cell that attacks invading pathogens a. pus- dead white blood cells that collect at the infla ...
in this issue - The Journal of Immunology
in this issue - The Journal of Immunology

... mouse splenocytes. They found that administration of the adjuvant resulted in an enhanced Ag-specific CD8⫹ T cell response. In addition, the mice that received the adjuvant exhibited increased protection against subsequent infection with live P. yoelii sporozoites. DC-CK1 may therefore be an effecti ...
Presentation
Presentation

... • CD8+ T cells may expand >50,000-fold within a week after an acute viral infection with minimal expansion of cells not specific for the virus (up to 10% of all CD8+ T cells in the blood may be specific for the pathogen) • Some of the progeny of the expanded clone differentiate into effector and mem ...
Antigens
Antigens

... A certain amount of chemical complexity is required, for example, amino acid homopolymers are less immunogenic than heteropolymers containing two or three different amino acids. ...
Chapter_01_Haz4 - Welcome to people.pharmacy.purdue.edu!
Chapter_01_Haz4 - Welcome to people.pharmacy.purdue.edu!

... What components make up the immune system? Cells, organs, cytokines and other molecules involved in the immune system What is the goal of the immune system? To clear pathogens in our body How do we classify immune responses? Innate and adaptive immune responses What are the side effects of the immun ...
Notes on Immunodeficiency
Notes on Immunodeficiency

... o Heart defects are the immediate concern when the child is born; during surgery, doctors notice no thymus is present and send for immunological consult (flow cytometry with anti-CD3 Ab to check for T cells) o Children with DiGeorge have NO T CELLS Facial Characteristics: fish shaped mouth; low set ...
Physiology of foodborne bacterial pathogens and the effects of food
Physiology of foodborne bacterial pathogens and the effects of food

... tetracyclines, R-type ACSSuT) S. Typhimurium DT104 strains have emerged as a specific problem in the pig sector and so alternative intervention strategies are urgently required. Probiotics have been shown to be effective in reducing Salmonella colonisation in a number of farm animal species. One of ...
The life of a B cell - Blueprint Epigenome
The life of a B cell - Blueprint Epigenome

... during B cell development but provide general new insights into mechanisms that define cell fate in the human body. The project focused on an epigenetic mechanism called DNA methylation. Enzymes in cells attach small chemical tags called methyl groups to specific DNA sequences. These tags are import ...
Haemopoiesis Clinical application
Haemopoiesis Clinical application

...  Liver and spleen  Bone marrow  Gradual replacement of active (red) marrow by inactive (fatty) tissue  Expansion can occur during increased need for cell production ...
Disease Prevention
Disease Prevention

...  Phagocytes engulf pathogens and then destroy them with chemicals  Pus may collect at the site ...
Chapter 20-22 Lymphatic System
Chapter 20-22 Lymphatic System

... No irritant remains ...
IN THIS ISSUE Improving survival after sepsis Outgrowing
IN THIS ISSUE Improving survival after sepsis Outgrowing

... 2407). The kinase helps protect young children from specific pathogens but is expendable in adults. The TLRs are part of an early infection warning system that recognizes microbial intrusion. Many activated TLRs recruit a kinase called IRAK-4, which switches on immune-boosting transcription pathways ...
insights - The Journal of Experimental Medicine
insights - The Journal of Experimental Medicine

... In their study, Zenonos et al. generated recombinant chimeric antibodies with high affinity for the human Insight from erythrocyte surface receptor basigin. P. falciparum parasites bind to basigin as they invade erythrocytes, and Kirk Deitsch this binding appears to be essential for parasite prolife ...
Viral immunology: reunion of the conjoined twins disciplines
Viral immunology: reunion of the conjoined twins disciplines

... and the mode of action of these emerging ISGs is useful for the identification of novel cellular targets against which effective HCV therapeutics can be developed. Wong and Chen also discussed the functions of several cellular determinants critical for regulating host immunity. In the second review, ...
Document
Document

... immunological memory from either exposure and recovery from an infectious disease, or from vaccination with an inactivated pathogen. • Passive Immunity: antibodies are supplied through the placenta to a fetus, to milk to a nursing infant, or by antibody injection providing temporal immunity ...
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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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