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Lymphatic/Immune Power Point
Lymphatic/Immune Power Point

... • T cells: cell-mediated immunity – Killer T cells: punch holes in pathogen’s cell membrane and secrete lymphokines that enhance phagocytic activity – Helper T cells: secrete a lymphokine that stimulates T cells and B cells and enhances immune response – Suppressor T cells: inhibit immune response w ...
Prezentacja programu PowerPoint
Prezentacja programu PowerPoint

... Lymphoid neoplasms - a diverse group of entities In many but not all instances, the phenotype of the neoplastic cell closely resembles that of a particular stage of normal lymphocyte differentiation, a feature that is used in the diagnosis and classification of these disorders. ...
Sept15_lecture8a_immunology
Sept15_lecture8a_immunology

... Lymphocytes, like wasps, are genetically programmed for exploration, but each of them seems to be permitted a different, solitary idea. They roam through the tissues, sensing and monitoring. Since there are so many of them, they can make collective guesses at almost anything antigenic on the surface ...
Document
Document

... the thyroid in adulthood or increased secretion of sex steroids The immune system produces most of its T cells during childhood and requires very few new T cells after puberty. ...
Human Immunodeficiency Virus (HIV) VACCINE
Human Immunodeficiency Virus (HIV) VACCINE

... formulated the “target” so that instead of producing an antibody response, the “target” would activate the cytotoxic T cells (CD8). This trial became known as the STEP trial and the target included several recombinant HIV proteins, including the surface proteins of the virus, gag, nef and pol, all p ...
Data supplement 6
Data supplement 6

... baseline. These panels show the changes separately in those with normal baseline levels and those with an abnormal baseline values. C) In the absolute numbers of CD27- IgD+ antigen inexperienced B cell, the absolute numbers of CD38low mature naive B cell subset trend toward increasing with tocilizum ...
The Immune System, part I - University of Washington
The Immune System, part I - University of Washington

... Cytokines: A large family of low-molecular-weight soluble proteins involved in regulating cellular activity, particularly (but by no means exclusively) within the immune system. Cytotoxic T cell: A T lymphocyte (which usually expresses CD8) that kills its target cell on recognizing complexes of pept ...
Document
Document

... your own cells. When these agglutinins attack foreign RBC they bind to them and clump in a process called agglutination People w/out the Rh antigen (Rh-) don’t necessarily carry an antibody against Rh. This antibody is produced when a person is exposed to Rh. ...
BIMM 122 Dr. Milton Saier The CRISPR
BIMM 122 Dr. Milton Saier The CRISPR

... 8. The CRISPR and cas genes appear to evolve rapidly, accounting for their tremendous sequence divergence. 9. The process is sequence-specific, involving a variable cassette of CRISPRassociated (cas) genes. 10. There are at least four cas genes that are unique to and may be conserved in microorganis ...
Case 34: Hereditary Periodic Fever Syndromes Summary
Case 34: Hereditary Periodic Fever Syndromes Summary

... inflammation, they also induce fever. Fever is generally beneficial to the host defense because most pathogens grow better at lower temperatures and adaptive immune responses are more intense at elevated temperatures. IL1 and IL6 also enhance the production of innate proteins call acute phase reacta ...
Graves` Disease - The Interaction of Lymphocytes and Thyroid Cells
Graves` Disease - The Interaction of Lymphocytes and Thyroid Cells

... both cell proliferation and cytotoxicity; they have observed that glucocorticoid–induced TNF-like receptor (GITR) is expressed on such CD8 T suppressor cells. The papers of Nakano et al. [Nakano et al., 2006] and Nagayama [Nagayama et al., 2007] suggest a preventive role of Tregs in autoimmune react ...
Cavanaugh, V. J., D. H. Raulet, and A. E. Campbell. 2007. Upregulation of CD94/NKG2A receptors and Qa-1b ligand during murine cytomegalovirus infection of salivary glands. J Gen Virol 88:1440-1445.
Cavanaugh, V. J., D. H. Raulet, and A. E. Campbell. 2007. Upregulation of CD94/NKG2A receptors and Qa-1b ligand during murine cytomegalovirus infection of salivary glands. J Gen Virol 88:1440-1445.

... Inhibitory CD94/NKG2A receptors are expressed on the vast majority of at least IE1-specific CD8 T cells in the SMG during an acute primary immune response, and expression of its ligand, Qa-1b, is increased dramatically 1 week prior to the upregulation of activating H-2Dd molecules. However, at the p ...
PATHOPHYSIOLOGY OF THE IMMUNE SYSTEM
PATHOPHYSIOLOGY OF THE IMMUNE SYSTEM

... T lymphocytes develop in the fetal thymus. After maturation, T lymphocytes are distributed by the circulation to the T-cell domains of peripheral lymphoid tissue. T lymphocytes continuously and actively recirculate between the peripheral blood and peripheral lymphoid tissue T Cell Transformation Fo ...
As HIV viral load increases CD4 cell count decreases and vise
As HIV viral load increases CD4 cell count decreases and vise

... Subtypes (clades): M group (subtypes A-K) and Subtype O (55-70% homology with M subtypes), N (“new”) subtype Diagnostic tests may preferentially detect a specific type or subtype Vaccines may need to be subtype specific ...
Immuno-stimultory/regulatory gene expression
Immuno-stimultory/regulatory gene expression

... and tumor antigen genes were selected for analysis. We repeated our analysis in an independent validation study. Five genes showed stimulatory/regulatory patterns at a high level of confidence (Bonferroni p < 0.05). Three of these (MAGEA8, MPL, AMHR2) were validated and one (WT1) could not be evalua ...
Immunotherapy: Targeting Cancer with the Immune System
Immunotherapy: Targeting Cancer with the Immune System

... http://www.cancer.gov/aboutcancer/treatment/drugs/recombinant-interferon-alfa2b), promote the activation and activity of natural killer cells (with direct tumor-killing ability) and dendritic cells (which can promote additional patient-derived immunity to cancer). These agents have been in widesprea ...
Schedule for Lectures of the Summer School “Molecular Interactions
Schedule for Lectures of the Summer School “Molecular Interactions

... Rudolf Manz ...
The function of Fcγ receptors in dendritic cells and macrophages
The function of Fcγ receptors in dendritic cells and macrophages

... high expression levels of MHC class II molecules) in mixed bone-marrow chimeric mice that had been reconstituted with 50% bone marrow from wild-type mice and 50% bone marrow from CC‑chemokine receptor 2 (Ccr2)–/– mice. Bone marrow from Ccr2−/− mice was used because monocytes require CCR2 for their e ...
Whole Blood Count The full blood count (FBC) is one of the most
Whole Blood Count The full blood count (FBC) is one of the most

... The full blood count (FBC) is one of the most commonly ordered tests and provides important information about the kinds and numbers of cells in the blood: red blood cells, white blood cells and platelets. Abnormalities in any of these types of cells can indicate the presence of important medical dis ...
T and B cells
T and B cells

... • The macrophage's main role is to phagocytize bacteria and damaged tissue,[15] and they also debride damaged tissue by releasing proteases.[20] • Macrophages secrete a number of factors such as growth factors and other cytokines, especially during the third and fourth post-wounding days. These fact ...
Answers to WHAT DID YOU LEARN QUESTIONS
Answers to WHAT DID YOU LEARN QUESTIONS

... and may present antigens to the other lymphatic cells. Special epithelial cells (also called nurse cells) are found in the thymus and secrete thymic hormones. Dendritic cells are found in lymphatic nodules; they internalize antigens from the lymph and present them to other lymphatic cells. These cel ...
MOLECULAR MEDICINE 2013-2014  Module BI3805 Proteins &amp; Drugs (5 ECTs)
MOLECULAR MEDICINE 2013-2014 Module BI3805 Proteins & Drugs (5 ECTs)

... Describe the factors that determine the mobility of membrane proteins and explain the role their mobility has in signal and energy transduction. ...
22.4 How Does The Immune System Launch An Attack?
22.4 How Does The Immune System Launch An Attack?

... 22.3 How Does The Immune System Recognize Invaders?  The immune system distinguishes “self” from “non-self”. • It does so by destroying immune cells that respond to the body’s own molecules and retaining those that do not. • Some cell-surface proteins, called the major histocompatibility complex ( ...
Pathophysiology of Type 1 Diabetes
Pathophysiology of Type 1 Diabetes

... susceptible individuals – May be precipitated by environmental factors ...
Tumor immunology Dr Monem Alshok 20\12\2012 Tumor is
Tumor immunology Dr Monem Alshok 20\12\2012 Tumor is

... virally induced tumours show extensive cross reactivity; immunization of animals with any of these viruses provides protection against a variety of similar viruses. Common oncogenic RNA viruses are the human T cell leukaemia virus (HTLV) in man and the feline leukaemia virus (FeLV) in cats. In many ...
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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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