research infrastructure - The American Society of Hematology
... Several cytokines, including granulocyte colonystimulating factor, erythropoietin, and thrombopoietin mimetics, are now part of the standard therapeutic armamentarium for the hematologist. A better understanding of how erythropoietin acts in non-hematopoietic tissues is required to optimize the use ...
... Several cytokines, including granulocyte colonystimulating factor, erythropoietin, and thrombopoietin mimetics, are now part of the standard therapeutic armamentarium for the hematologist. A better understanding of how erythropoietin acts in non-hematopoietic tissues is required to optimize the use ...
Lymphatics and Immunity
... functions and ultimately destroyed. The medulla also has thymic (Hassalls’s) corpuscles which are concentric layers of five or six epithelial cells. Their role is currently unknown. During the involution, or shrinking, of the thymus after puberty, the cortex becomes thin. Lymphocytes disappear and a ...
... functions and ultimately destroyed. The medulla also has thymic (Hassalls’s) corpuscles which are concentric layers of five or six epithelial cells. Their role is currently unknown. During the involution, or shrinking, of the thymus after puberty, the cortex becomes thin. Lymphocytes disappear and a ...
Respiratory syncytial virus infection in Fischer 344 rats is attenuated
... or siRNA can be adsorbed to the nanoparticles through interaction with the positively charged amine groups on chitosan, and the complex can be instilled intranasally into mice or other animals [21,22]. Chitosan has mucoadhesive properties that serve to target intranasally administered chitosan-plasm ...
... or siRNA can be adsorbed to the nanoparticles through interaction with the positively charged amine groups on chitosan, and the complex can be instilled intranasally into mice or other animals [21,22]. Chitosan has mucoadhesive properties that serve to target intranasally administered chitosan-plasm ...
A Possible Link Between Autoimmunity and Cancer
... immune response in cancer, immature pDCs are activated by Toll-like receptors, which lead to B- and T-cell immune responses in autoimmune disease (Lang et al., 2005). The immunological tolerance is produced by tumour-derived soluble factors (TDSFs) and immature dendritic cells (iDCs), which inhibit ...
... immune response in cancer, immature pDCs are activated by Toll-like receptors, which lead to B- and T-cell immune responses in autoimmune disease (Lang et al., 2005). The immunological tolerance is produced by tumour-derived soluble factors (TDSFs) and immature dendritic cells (iDCs), which inhibit ...
Association of innate immune activation with latent Epstein-Barr virus in active Objective:
... disease.4,5 Furthermore, EBV infection was found to be a characteristic feature of the MS brain6; however, these findings were countered by other studies.7–9 EBV infects predominantly B lymphocytes and persists in the blood in rare memory B cells. The gold standard for detecting EBV in tissue is in ...
... disease.4,5 Furthermore, EBV infection was found to be a characteristic feature of the MS brain6; however, these findings were countered by other studies.7–9 EBV infects predominantly B lymphocytes and persists in the blood in rare memory B cells. The gold standard for detecting EBV in tissue is in ...
Licentiate thesis from the Department of Immunology, Wenner-Gren Institute,
... at risk of infection and the infection claims a million lives each year. A vast majority of the deaths occur in children below the age of 5 in sub-Saharan Africa. Survivors typically acquire immunity only after long time of repeated exposure and immunity is rapidly lost. Immunity is created by the a ...
... at risk of infection and the infection claims a million lives each year. A vast majority of the deaths occur in children below the age of 5 in sub-Saharan Africa. Survivors typically acquire immunity only after long time of repeated exposure and immunity is rapidly lost. Immunity is created by the a ...
Methods. Anti-LFA-1 mAb was used in a multiple minor
... heart transplantation because the murine minor H antigen is well characterized, and recently developed MHC multimers allow us to track the donor specific CD8 T cells. In addition, the BALB to C57BL/6 combination models acute and chronic rejection without any immunosuppressive manipulation, thus pr ...
... heart transplantation because the murine minor H antigen is well characterized, and recently developed MHC multimers allow us to track the donor specific CD8 T cells. In addition, the BALB to C57BL/6 combination models acute and chronic rejection without any immunosuppressive manipulation, thus pr ...
Main Differences Between IgE and IgG Allergies
... symptoms vary because of the genetic makeup of the individual. The complete elimination of IgG positive foods may bring about important improvements in symptoms of irritable bowel syndrome, autism, AD(H)D, cystic fibrosis, rheumatoid arthritis, and epilepsy as demonstrated in numerous clinical studi ...
... symptoms vary because of the genetic makeup of the individual. The complete elimination of IgG positive foods may bring about important improvements in symptoms of irritable bowel syndrome, autism, AD(H)D, cystic fibrosis, rheumatoid arthritis, and epilepsy as demonstrated in numerous clinical studi ...
the innate immunity in bovine mastitis
... nucleus and bind to target promoters. A wealth of proinflammatory regulated genes feature NF-κB attachment sites in their promoter region and transcription factor complex act as a main switch to orchestrate immune defense genes against bacterial infection, as production of several pro-inflammatory c ...
... nucleus and bind to target promoters. A wealth of proinflammatory regulated genes feature NF-κB attachment sites in their promoter region and transcription factor complex act as a main switch to orchestrate immune defense genes against bacterial infection, as production of several pro-inflammatory c ...
Recognition of measles virus-infected cells by CD8MT cells
... only in vaccinia virus-infected cells (Fig. 3 b). To investigate the effect of MV replication on lysis by CD8+ T cells, we used the semi-permissive mouse neuroblastoma cell line NS20Y and a fully permissive human B cell line (C1R) transfected with the Kk molecule. After infection of NS20Y cells, no ...
... only in vaccinia virus-infected cells (Fig. 3 b). To investigate the effect of MV replication on lysis by CD8+ T cells, we used the semi-permissive mouse neuroblastoma cell line NS20Y and a fully permissive human B cell line (C1R) transfected with the Kk molecule. After infection of NS20Y cells, no ...
... cells, to inhibit the maturation of dendritic cells (DCs) and the proliferation of regulatory T cells [53]. It has been demonstrated that MSCs are also able to inhibit T lymphocyte pro-inflammatory cytokine production in vitro [54, 55], as well as in vivo [56]. Their ability to modulate the immune s ...
Cells Inhibits NK Cell Antitumor Activity GITR Ligand Provided by
... Thrombocytopenia inhibits tumor growth and especially metastasis in mice, whereas additional depletion of NK cells reverts this antimetastatic phenotype. It has therefore been speculated that platelets may protect hematogenously disseminating tumor cells from NK-dependent antitumor immunity. Tumor c ...
... Thrombocytopenia inhibits tumor growth and especially metastasis in mice, whereas additional depletion of NK cells reverts this antimetastatic phenotype. It has therefore been speculated that platelets may protect hematogenously disseminating tumor cells from NK-dependent antitumor immunity. Tumor c ...
Bet5 - Eubios Ethics Institute
... The therapy in 1989 involved the use of cells which attack cancer, called tumour-infiltrating lymphocytes (TILs). They are isolated from the patient's own tumour, then grown in large number in vitro. The cells are then given back to the patient, and stimulated by a naturally-occuring hormone, interl ...
... The therapy in 1989 involved the use of cells which attack cancer, called tumour-infiltrating lymphocytes (TILs). They are isolated from the patient's own tumour, then grown in large number in vitro. The cells are then given back to the patient, and stimulated by a naturally-occuring hormone, interl ...
Physiological & Clinical Changes of Aging
... Rate of Living Theory (Metabolic Rate Theory) • The higher the basal metabolic rate (the rate, at which the body at rest, uses energy), the shorter the life span ...
... Rate of Living Theory (Metabolic Rate Theory) • The higher the basal metabolic rate (the rate, at which the body at rest, uses energy), the shorter the life span ...
Aβ, tau, α-synuclein, huntingtin, TDP-43, PrP and AA are
... well-known members of the immune system, including the interferon- and TNF-families (36,37; discussed in 1), and newly discovered members such as mitochondrial antiviral signaling protein (MAVS) (38-40), assemble into pathogenlike amyloid aggregates in order to perform their innate immunity function ...
... well-known members of the immune system, including the interferon- and TNF-families (36,37; discussed in 1), and newly discovered members such as mitochondrial antiviral signaling protein (MAVS) (38-40), assemble into pathogenlike amyloid aggregates in order to perform their innate immunity function ...
The promise of cd T cells and the cd T cell receptor for cancer
... summarised in Table 2). Importantly, functional d/ab T cells comprise a high proportion of human CD1d-reactive T cells. aGalCer has been so far investigated only in context of boosting NK T cell anticancer activity,39 but it could potentially be used to activate aGalCer-reactive cd T cells, similarl ...
... summarised in Table 2). Importantly, functional d/ab T cells comprise a high proportion of human CD1d-reactive T cells. aGalCer has been so far investigated only in context of boosting NK T cell anticancer activity,39 but it could potentially be used to activate aGalCer-reactive cd T cells, similarl ...
Immune Deficiency AIDS
... • Occur more often in the elderly • Are more common in women than in men • May result when an individual begins to make autoantibodies or cytotoxic T cells against normal body components ...
... • Occur more often in the elderly • Are more common in women than in men • May result when an individual begins to make autoantibodies or cytotoxic T cells against normal body components ...
Chapter 5 Normal Histology of the Lymphoid Tissues
... the in vivo equivalent of thymic nurse cells, a cell population that has been extensively studied in vitro (8). The results of these in vitro experiments, using cell lines derived from murine thymic nurse cells, suggest that they could be involved in the negative selection process of thymocytes by i ...
... the in vivo equivalent of thymic nurse cells, a cell population that has been extensively studied in vitro (8). The results of these in vitro experiments, using cell lines derived from murine thymic nurse cells, suggest that they could be involved in the negative selection process of thymocytes by i ...
Innate immune responses in hepatitis B virus (HBV
... virus mediated, with CTLs also playing a central part in this process [8]. One way to overcome the inherent tolerance of HBVtransgenic mice to viral antigens was to use human hepatocyte chimeric mice, where human hepatocytes repopulated the liver of uPA/SCID mice, making it susceptible to HBV infect ...
... virus mediated, with CTLs also playing a central part in this process [8]. One way to overcome the inherent tolerance of HBVtransgenic mice to viral antigens was to use human hepatocyte chimeric mice, where human hepatocytes repopulated the liver of uPA/SCID mice, making it susceptible to HBV infect ...
Transcutaneous vaccination via laser microporation
... tuberculosis and rabies vaccine in developing countries are delivered intradermally [2,3]. For both, the Mantoux method is used, which employs a conventional hypodermic needle inserted at a shallow angle into the skin. Invented by Mendel & Mantoux in the early 1900s [4], this technique requires well ...
... tuberculosis and rabies vaccine in developing countries are delivered intradermally [2,3]. For both, the Mantoux method is used, which employs a conventional hypodermic needle inserted at a shallow angle into the skin. Invented by Mendel & Mantoux in the early 1900s [4], this technique requires well ...
Nutritional Strategies to Counter Stress to the Immune System In
... MHCII expression on monocytes were also lowest at the time when form (wins/losses ratio and league position) was at its lowest. Finally, Malm et al. (2004a) found that a 5 day football-training camp for Swedish Elite Junior Football players resulted in decreases in T and B lymphocytes, but no change ...
... MHCII expression on monocytes were also lowest at the time when form (wins/losses ratio and league position) was at its lowest. Finally, Malm et al. (2004a) found that a 5 day football-training camp for Swedish Elite Junior Football players resulted in decreases in T and B lymphocytes, but no change ...
Live attenuated vaccines - WHO Vaccine Safety Basics
... Immune response LAVs stimulate an excellent immune response Immune responseThe body's defense against foreign objects or organisms, such as bacteria, viruses or transplanted organs or tissue. that is nearly as good as compared to an infection with the wild-type pathogen. Live microorganisms Microorg ...
... Immune response LAVs stimulate an excellent immune response Immune responseThe body's defense against foreign objects or organisms, such as bacteria, viruses or transplanted organs or tissue. that is nearly as good as compared to an infection with the wild-type pathogen. Live microorganisms Microorg ...
Immunity to brucellosis
... antigen-presenting cells (APCs). Upon activation, they perform pathogen uptake and process the antigenic material into peptides, presenting them in association with major histocompatibility (MHC) class II and I molecules to CD4+ T helper (Th) lymphocytes and CD8+ cytotoxic T lymphocytes (CTLs), resp ...
... antigen-presenting cells (APCs). Upon activation, they perform pathogen uptake and process the antigenic material into peptides, presenting them in association with major histocompatibility (MHC) class II and I molecules to CD4+ T helper (Th) lymphocytes and CD8+ cytotoxic T lymphocytes (CTLs), resp ...
Autoimmunity and pulmonary hypertension: a perspective REVIEW
... development of severe PAH [2]. It is also known that certain viral infections, e.g. HIV and human herpes virus (HHV)-8, can be associated with the development of severe PAH [3–6]. Of great interest, is that all of these conditions are either characterised by, or have a propensity to, autoimmunity. A ...
... development of severe PAH [2]. It is also known that certain viral infections, e.g. HIV and human herpes virus (HHV)-8, can be associated with the development of severe PAH [3–6]. Of great interest, is that all of these conditions are either characterised by, or have a propensity to, autoimmunity. A ...