Antoine Roquilly, MD (1-2), Alexis Broquet, PhD (1), Cedric Jacqueline,... Gautreau, PhD (3-4), Jean Pierre Segain, PhD (5), Pierre de... TLR-4 agonist in post-haemorrhage pneumonia: role of dendritic and natural...
... pneumonia (HP group) than in the P group and in treated mice (HP-MPLA group) [11]. We first assessed whether MPLA injection alters lung response to post-haemorrhage pneumonia. Lungs and spleen were harvested 24 hours after S. aureus intra-tracheal instillation. Haemorrhage did not modify the bacteri ...
... pneumonia (HP group) than in the P group and in treated mice (HP-MPLA group) [11]. We first assessed whether MPLA injection alters lung response to post-haemorrhage pneumonia. Lungs and spleen were harvested 24 hours after S. aureus intra-tracheal instillation. Haemorrhage did not modify the bacteri ...
chapter 1
... response towards a balanced Th1/Th2 response.25 In a murine asthma model, Ko et al. found that systemic glutamine administration suppressed the key features of asthma, such as airway eosinophilia, mucus formation, and airway type 2 cytokine production, as well as late airway hyperresponsiveness, by ...
... response towards a balanced Th1/Th2 response.25 In a murine asthma model, Ko et al. found that systemic glutamine administration suppressed the key features of asthma, such as airway eosinophilia, mucus formation, and airway type 2 cytokine production, as well as late airway hyperresponsiveness, by ...
Activators - U of M wiki
... Learning Objectives Explain the importance of the complement system in host defense and inflammation and the clinical consequences of complement deficiencies. Describe the biochemistry of activation of the three different pathways including the initiators, sequence of reactions, important enzym ...
... Learning Objectives Explain the importance of the complement system in host defense and inflammation and the clinical consequences of complement deficiencies. Describe the biochemistry of activation of the three different pathways including the initiators, sequence of reactions, important enzym ...
IMAC response to “Just a Little Prick” by Peter and Hilary Butler
... Hilary Butler also states that “it has long been proven that bad nutrition and environmental toxicities can be the cause of a malfunctioning immune system”. Exactly what does orthodox medical literature say on this topic? Studies of the effects of particulate air pollution on children and infants do ...
... Hilary Butler also states that “it has long been proven that bad nutrition and environmental toxicities can be the cause of a malfunctioning immune system”. Exactly what does orthodox medical literature say on this topic? Studies of the effects of particulate air pollution on children and infants do ...
Emerging Concepts in the Management of Skin Cancer
... in the survival curve beginning around year 3 Schadendorf D, et al. J Clin Oncol. 2015;33:1889-1894.[20] ...
... in the survival curve beginning around year 3 Schadendorf D, et al. J Clin Oncol. 2015;33:1889-1894.[20] ...
Anti–4-1BB Monoclonal Antibodies Abrogate T Cell
... The 4-1BB receptor (CDw137), a member of the tumor necrosis factor receptor superfamily, has been shown to costimulate the activation of T cells. Here we show that anti–mouse 4-1BB monoclonal antibodies (mAbs) inhibit thymus-dependent antibody production by B cells. Injection of anti–4-1BB mAbs into ...
... The 4-1BB receptor (CDw137), a member of the tumor necrosis factor receptor superfamily, has been shown to costimulate the activation of T cells. Here we show that anti–mouse 4-1BB monoclonal antibodies (mAbs) inhibit thymus-dependent antibody production by B cells. Injection of anti–4-1BB mAbs into ...
The gut microbiota and immune-regulation: the fate of
... and type 2 diabetes. In this review, Richards et al.2 explain that, from fiber fermentation, gut microbiota produce high concentrations of dietary metabolites or short-chain fatty acids (SCFAs) such as acetate, propionate and butyrate that keep the gut healthy, but also have beneficial anti-inflammator ...
... and type 2 diabetes. In this review, Richards et al.2 explain that, from fiber fermentation, gut microbiota produce high concentrations of dietary metabolites or short-chain fatty acids (SCFAs) such as acetate, propionate and butyrate that keep the gut healthy, but also have beneficial anti-inflammator ...
Fungal Keratitis
... • In zoster ophthalmicus the chief focus of infection is the Gasserian ganglion from where the virus travels down one or more of the branches of the ophthalmic division of the tiigeminal nerve, so that its area of distribution is marked out by rows of vesicles or the scars left by them. ...
... • In zoster ophthalmicus the chief focus of infection is the Gasserian ganglion from where the virus travels down one or more of the branches of the ophthalmic division of the tiigeminal nerve, so that its area of distribution is marked out by rows of vesicles or the scars left by them. ...
Commensal-Specific CD4+ Cells From Patients
... accepted that T cells, and more specifically CD4þ T cells, play a pathogenic role in CD because they heavily infiltrate involved areas of the intestinal mucosa and extensive data from experimental models support this.17 These cells show T-helper (Th)1 and Th17 proinflammatory profiles.18–22 Despite bein ...
... accepted that T cells, and more specifically CD4þ T cells, play a pathogenic role in CD because they heavily infiltrate involved areas of the intestinal mucosa and extensive data from experimental models support this.17 These cells show T-helper (Th)1 and Th17 proinflammatory profiles.18–22 Despite bein ...
3 Anatomy of the Nervous System
... The vertebrate nervous system is composed of two divisions: the central nervous system and the peripheral nervous system (see Figure 3.1). Roughly speaking, the central nervous system (CNS) is the division of the nervous system that is located within the skull and spine; the peripheral nervous syste ...
... The vertebrate nervous system is composed of two divisions: the central nervous system and the peripheral nervous system (see Figure 3.1). Roughly speaking, the central nervous system (CNS) is the division of the nervous system that is located within the skull and spine; the peripheral nervous syste ...
Vitamin D and ist meaning for pharmacologists - cfs
... Dermal mast cells (protection against UV-B radiation) Yu C, et al. Int J Biochem Cell Biol 2011;43(1):41-6. ...
... Dermal mast cells (protection against UV-B radiation) Yu C, et al. Int J Biochem Cell Biol 2011;43(1):41-6. ...
Examples of Supervisors and Research Projects (Wellcome)
... Transcriptional regulation of IL-10 versus proinflammatory cytokine production in myeloid cells via type I IFN dependent and independent mechanisms in mouse models and human disease including infection and allergy Immune regulation of B cells in RSV infection of human volunteers Immunity to cancer i ...
... Transcriptional regulation of IL-10 versus proinflammatory cytokine production in myeloid cells via type I IFN dependent and independent mechanisms in mouse models and human disease including infection and allergy Immune regulation of B cells in RSV infection of human volunteers Immunity to cancer i ...
Xenopus laevis Antiviral Immunity in the Amphibian Innate T Cells
... are inherently more resistant to FV3 infection and mount effective anti-FV3 responses. The antiviral response is initiated by a robust recruitment of mononuclear and polymorphonuclear phagocytes to the peritoneal cavity as early as 1 d postinfection (dpi), followed by an increase in NK cells at 3 dp ...
... are inherently more resistant to FV3 infection and mount effective anti-FV3 responses. The antiviral response is initiated by a robust recruitment of mononuclear and polymorphonuclear phagocytes to the peritoneal cavity as early as 1 d postinfection (dpi), followed by an increase in NK cells at 3 dp ...
chapter 20-the lymphatic system
... C. The Thymus Gland-located in the inferior neck and extending into the superior thorax. 1. This gland secretes the hormones thymosin and thymopoietin. These two hormones force T Lymphocytes to fight specific pathogens in the immune response (a property known as immunocompetence). 2. The thymus glan ...
... C. The Thymus Gland-located in the inferior neck and extending into the superior thorax. 1. This gland secretes the hormones thymosin and thymopoietin. These two hormones force T Lymphocytes to fight specific pathogens in the immune response (a property known as immunocompetence). 2. The thymus glan ...
S6 Table.
... Unexposed comparison cohort (n=39): vaccinated and nonvaccinated (seropositives without clinical history AQF). Occurrence infection not noted ...
... Unexposed comparison cohort (n=39): vaccinated and nonvaccinated (seropositives without clinical history AQF). Occurrence infection not noted ...
acute phase response
... structurally related peptides: interleukin-la (IL-1a); interleukin-lp (IL-β) receptor antagonist for IL1. The two known IL-1 forms (a and P) - the products of different genes. They differ in their amino acid sequence, but have a similar three-dimensional structure. Interleukins interact with the sam ...
... structurally related peptides: interleukin-la (IL-1a); interleukin-lp (IL-β) receptor antagonist for IL1. The two known IL-1 forms (a and P) - the products of different genes. They differ in their amino acid sequence, but have a similar three-dimensional structure. Interleukins interact with the sam ...
Primary immune responses to human CMV
... differentiation processes, first lose CD28 and then CD27.17 In latently infected persons, memory CD8⫹ T cells specific for asymptomatic latent viruses as such as Epstein-Barr virus (EBV) and cytomegalovirus (CMV) show phenotypic and functional heterogeneity,18-20 and the factors determining the phen ...
... differentiation processes, first lose CD28 and then CD27.17 In latently infected persons, memory CD8⫹ T cells specific for asymptomatic latent viruses as such as Epstein-Barr virus (EBV) and cytomegalovirus (CMV) show phenotypic and functional heterogeneity,18-20 and the factors determining the phen ...
Full-Text PDF
... persist in Peyer’s patch DCs in low quantities and contribute to the induction of local specific immune responses that limit dissemination beyond the MLNs, ultimately preventing systemic spread. The results of locally controlled IgA production are to create a simple feedback loop where DCs and epith ...
... persist in Peyer’s patch DCs in low quantities and contribute to the induction of local specific immune responses that limit dissemination beyond the MLNs, ultimately preventing systemic spread. The results of locally controlled IgA production are to create a simple feedback loop where DCs and epith ...
Fat Soluble Vitamins
... • Dietary Vitamin D is absorbed from a micelle, along with other fats. • About 50% of dietary D3 is absorbed. Most absorbed in distal small intestine. • Incorporated into chylomicrons • Cholecalciferol from the skin is bound to DBP and travels primarily to the liver, but can be picked up by other t ...
... • Dietary Vitamin D is absorbed from a micelle, along with other fats. • About 50% of dietary D3 is absorbed. Most absorbed in distal small intestine. • Incorporated into chylomicrons • Cholecalciferol from the skin is bound to DBP and travels primarily to the liver, but can be picked up by other t ...
Measles infection of the central nervous system
... of the viral H protein for neurovirulence was investigated using a recombinant MV in which the H gene of MV Edmonston had been replaced by the H gene of the neurovirulent strain CAM/RB. After intracerebral injection into suckling C57BL/6 mice, this recombinant virus induced neurological disease, and ...
... of the viral H protein for neurovirulence was investigated using a recombinant MV in which the H gene of MV Edmonston had been replaced by the H gene of the neurovirulent strain CAM/RB. After intracerebral injection into suckling C57BL/6 mice, this recombinant virus induced neurological disease, and ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.