Anti-IgE: Beyond Asthma
... Atopic Dermatitis Various antigen-presenting cells are also involved in this immunologic process Langerhans cells, dendritic cells, and macrophages Langerhans cells are increased in number in chronic AD lesions, express FcRII and FcRI (high affinity) IgE receptors, and have been found to be carryin ...
... Atopic Dermatitis Various antigen-presenting cells are also involved in this immunologic process Langerhans cells, dendritic cells, and macrophages Langerhans cells are increased in number in chronic AD lesions, express FcRII and FcRI (high affinity) IgE receptors, and have been found to be carryin ...
Genetic variation in HLA and susceptibility to acute myeloid
... groove, varying the amino acids that can be housed within the peptide-binding pockets. Thus, different HLA alleles possess different peptide-binding repertoires. HLA class I proteins present peptides from intra-cellular proteins (including invasive viruses) to TCR on CD8 (cytotoxic) T cells leading ...
... groove, varying the amino acids that can be housed within the peptide-binding pockets. Thus, different HLA alleles possess different peptide-binding repertoires. HLA class I proteins present peptides from intra-cellular proteins (including invasive viruses) to TCR on CD8 (cytotoxic) T cells leading ...
Single Nucleotide Polymorphisms (SNPs) in the C5 gene affect
... Previously, it has been shown that mice deficient for C5 are resistant to K/BxN serum induced arthritis17. Moreover, anti-C5 monoclonal antibody treatment prevents arthritis in mice6, indicating that C5 is crucially involved in the process that contributes to arthritis. In this study, we investigate ...
... Previously, it has been shown that mice deficient for C5 are resistant to K/BxN serum induced arthritis17. Moreover, anti-C5 monoclonal antibody treatment prevents arthritis in mice6, indicating that C5 is crucially involved in the process that contributes to arthritis. In this study, we investigate ...
Type-I hypersensitivity
... Ag /hapten intradermally or with Freund’s adjuvant or by skin contact Circulating Ab may be absent and not responsible for reaction. “Cell mediated reaction” ...
... Ag /hapten intradermally or with Freund’s adjuvant or by skin contact Circulating Ab may be absent and not responsible for reaction. “Cell mediated reaction” ...
Early-life social adversity and developmental processes in
... [3,8]. Increased rates of distress calls are also observed in infant macaques that experienced abuse compared to infants who were not abused [9]. Despite the increased anxiety phenotype exhibited by ELSA-exposed animals in social contexts, ELSA may lead to decreased distress and increased novelty se ...
... [3,8]. Increased rates of distress calls are also observed in infant macaques that experienced abuse compared to infants who were not abused [9]. Despite the increased anxiety phenotype exhibited by ELSA-exposed animals in social contexts, ELSA may lead to decreased distress and increased novelty se ...
Aisha Bano - The Role of KCNQ (Kv7) - e
... The disease is characterized by the three facets – positive, negative and cognitive symptoms. Population, families and twin studies indicate that schizophrenia is “highly heritable”; however, no single gene can induce such effects. Rather, the disease is byproduct of synergistic interactions of vari ...
... The disease is characterized by the three facets – positive, negative and cognitive symptoms. Population, families and twin studies indicate that schizophrenia is “highly heritable”; however, no single gene can induce such effects. Rather, the disease is byproduct of synergistic interactions of vari ...
Mucosal Immunity in Mycobacterial Infections Anna Tjärnlund
... through the modification of bacterial DNA, proteins and lipids (reviewed in Chan et al., 2001). NO can deaminate, as well as directly damage bacterial DNA, and has been demonstrated to induce apoptosis. RNIs also have the potential to disrupt signalling pathways, ...
... through the modification of bacterial DNA, proteins and lipids (reviewed in Chan et al., 2001). NO can deaminate, as well as directly damage bacterial DNA, and has been demonstrated to induce apoptosis. RNIs also have the potential to disrupt signalling pathways, ...
Common Genetic Variants Found in HLA and KIR Immune Genes in
... ligands (Parham and Moffett, 2013). HLA class I A, B, C alleles all behave as antigen presenting ligands for self and nonselfpeptides; however, only certain HLA-A, B, C alleles are ligands for KIR cell surface proteins. Although the HLA cognate ligand site slightly overlaps the peptide binding site, ...
... ligands (Parham and Moffett, 2013). HLA class I A, B, C alleles all behave as antigen presenting ligands for self and nonselfpeptides; however, only certain HLA-A, B, C alleles are ligands for KIR cell surface proteins. Although the HLA cognate ligand site slightly overlaps the peptide binding site, ...
Pathological pain and the neuroimmune interface
... channel opening time, increasing burst firing, removing the Mg 2+-mediated channel blockade at the NMDA receptor, and promoting trafficking of receptors to the synaptic membrane15. Under such circumstances, low-threshold sensory (Aβ) fibres that are activated by innocuous stimuli are able to activat ...
... channel opening time, increasing burst firing, removing the Mg 2+-mediated channel blockade at the NMDA receptor, and promoting trafficking of receptors to the synaptic membrane15. Under such circumstances, low-threshold sensory (Aβ) fibres that are activated by innocuous stimuli are able to activat ...
Chapter 15 The Lymphatic System and Immunity
... • There are over 80 known types of disorders, affecting different areas of the body – from joints and muscles to skin and blood and organs. Among the most common autoimmune conditions are type 1 diabetes, multiple sclerosis, Crohn's disease, rheumatoid arthritis and psoriasis. There is no cure, but ...
... • There are over 80 known types of disorders, affecting different areas of the body – from joints and muscles to skin and blood and organs. Among the most common autoimmune conditions are type 1 diabetes, multiple sclerosis, Crohn's disease, rheumatoid arthritis and psoriasis. There is no cure, but ...
gastrointestinal (GI) tract
... microbial and nonmicrobial. Immune inductive sites are comprised of Peyer’s patches (pps) and mesenteric lymph nodes (mlns). Peyer’s patches have the anatomic appearance of secondary lymphoid organs, with clearly defined T- and B-cell–dependent areas. A single layer of epithelial cells separates the ...
... microbial and nonmicrobial. Immune inductive sites are comprised of Peyer’s patches (pps) and mesenteric lymph nodes (mlns). Peyer’s patches have the anatomic appearance of secondary lymphoid organs, with clearly defined T- and B-cell–dependent areas. A single layer of epithelial cells separates the ...
Chapter 1: General introduction - UvA-DARE
... of mycorrhiza, in which nutrients are shared among the partners [3]. Selected fungi are also appreciated for their industrial potential, especially baker’s yeast, Saccharomyces cerevisiae, and some filamentous fungi such as Aspergillus niger. Fermentation carried out by S. cerevisiae is essential fo ...
... of mycorrhiza, in which nutrients are shared among the partners [3]. Selected fungi are also appreciated for their industrial potential, especially baker’s yeast, Saccharomyces cerevisiae, and some filamentous fungi such as Aspergillus niger. Fermentation carried out by S. cerevisiae is essential fo ...
viruses
... occurs, vaccines are only approximately 50% effective [6]. Moreover, in the eventuality of a pandemic infection with a new strain, antiviral drugs represent the first line of defense [7]. Due to their metabolic properties, viruses are difficult to control, and there are relatively few drugs for the ...
... occurs, vaccines are only approximately 50% effective [6]. Moreover, in the eventuality of a pandemic infection with a new strain, antiviral drugs represent the first line of defense [7]. Due to their metabolic properties, viruses are difficult to control, and there are relatively few drugs for the ...
Nerve activates contraction
... by binding selectively to specific receptors, activates a tiny fraction of cells from the body’s diverse pool of lymphocytes. • This relatively small number of selected cells gives rise to clones of thousands of cells, all specific for and dedicated to eliminating that antigen. ...
... by binding selectively to specific receptors, activates a tiny fraction of cells from the body’s diverse pool of lymphocytes. • This relatively small number of selected cells gives rise to clones of thousands of cells, all specific for and dedicated to eliminating that antigen. ...
Epithelial microRNAs regulate gut mucosal immunity via epithelium
... layer of epithelial cells forms a barrier that separates the host from luminal microflora. Unexpectedly, this abundant microflora does not elicit overt inflammation in the intestinal mucosa under normal physiological conditions. Whereas many of the microflora-tolerance mechanisms are yet to be ide ...
... layer of epithelial cells forms a barrier that separates the host from luminal microflora. Unexpectedly, this abundant microflora does not elicit overt inflammation in the intestinal mucosa under normal physiological conditions. Whereas many of the microflora-tolerance mechanisms are yet to be ide ...
A two-step model of T cell subset commitment: antigen
... stimulated with a mixture of APC from uninfected and Lminfected mice. As shown in Fig. 1(B), addition of a small fraction of Lm-infected APC to uninfected APC rendered T cells to shift to type 1 T cells. The results suggest that the Lm-infected APC render the function of uninfected APC to induce typ ...
... stimulated with a mixture of APC from uninfected and Lminfected mice. As shown in Fig. 1(B), addition of a small fraction of Lm-infected APC to uninfected APC rendered T cells to shift to type 1 T cells. The results suggest that the Lm-infected APC render the function of uninfected APC to induce typ ...
The ADP-ribose-10-monophosphatase domains of severe acute
... virus in the host organism (reviewed by Thiel & Weber, 2008). To investigate potential effects of ADRP activity on cellular cytokine profiles during virus infection, 293lp cells were infected for 16 h and expression of cellular cytokines and IFN-stimulated genes (ISGs) was determined by realtime RT- ...
... virus in the host organism (reviewed by Thiel & Weber, 2008). To investigate potential effects of ADRP activity on cellular cytokine profiles during virus infection, 293lp cells were infected for 16 h and expression of cellular cytokines and IFN-stimulated genes (ISGs) was determined by realtime RT- ...
Structural and functional aspects of factor viii in the initiation of the
... primary goal in managing patients with a bleeding disorder. The current treatment of hemorrhages is FVIII replacement therapy using plasma-derived or recombinant FVIII. The treatment regimen can be prophylactic (i.e. given at 25-50 IU/kg every 48 hours to maintain physiological levels of circulating ...
... primary goal in managing patients with a bleeding disorder. The current treatment of hemorrhages is FVIII replacement therapy using plasma-derived or recombinant FVIII. The treatment regimen can be prophylactic (i.e. given at 25-50 IU/kg every 48 hours to maintain physiological levels of circulating ...
VACCINOLOGY
... • These vaccines are produced by growing the bacteria or virus in culture media then inactivating it with heat and/or chemicals (usually in formalin). • Inactivated vaccines are not alive and cannot replicate. The entire dose of antigen is administered in the injection. These vaccines cannot cause d ...
... • These vaccines are produced by growing the bacteria or virus in culture media then inactivating it with heat and/or chemicals (usually in formalin). • Inactivated vaccines are not alive and cannot replicate. The entire dose of antigen is administered in the injection. These vaccines cannot cause d ...
Toll-like receptor-4 agonist in post-haemorrhage pneumonia: role
... Trauma is a major risk factor for nosocomial pneumonia in critically ill patients. Nosocomial pneumonia develops in 30–50% of trauma patients, mainly within the first week, and increases both the length of stay in the intensive care unit and the risk of death [1]. Methicillin-susceptible Staphylococ ...
... Trauma is a major risk factor for nosocomial pneumonia in critically ill patients. Nosocomial pneumonia develops in 30–50% of trauma patients, mainly within the first week, and increases both the length of stay in the intensive care unit and the risk of death [1]. Methicillin-susceptible Staphylococ ...
O A RIGINAL RTICLE
... Successful host defence and pathogenicity in leishmaniasis depends on T-cell polarization. Resistance to the Leishmania infection in the murine model is based on the activation of the cellular immune responses organized by the Th1 cells, making special cytokins including IFN-γ that recruits CMI. Lei ...
... Successful host defence and pathogenicity in leishmaniasis depends on T-cell polarization. Resistance to the Leishmania infection in the murine model is based on the activation of the cellular immune responses organized by the Th1 cells, making special cytokins including IFN-γ that recruits CMI. Lei ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.