Gaucher iPSC-Derived Macrophages Produce Elevated Levels of
... form of the disease, while type 3 GD is a subacute form. The serum of patients with GD has elevated levels of inflammatory mediators including tumor necrosis factor a (TNF-a), IL-6, and IL-1b, and it is believed that these cytokines are produced by Gaucher macrophages [5]. These cells may also be the ...
... form of the disease, while type 3 GD is a subacute form. The serum of patients with GD has elevated levels of inflammatory mediators including tumor necrosis factor a (TNF-a), IL-6, and IL-1b, and it is believed that these cytokines are produced by Gaucher macrophages [5]. These cells may also be the ...
Cnidarian-Microbe Interactions and the Origin of Innate Immunity in
... For analytical purposes, Hydra is a premier model organism, which in the laboratory is propagated and cultured in plastic or glass dishes at 18◦ C in Hydra medium with an artificial day-night rhythm of 12 hours and larval stages of Artemia salina as food source. With a 3.5-day life cycle, each animal ...
... For analytical purposes, Hydra is a premier model organism, which in the laboratory is propagated and cultured in plastic or glass dishes at 18◦ C in Hydra medium with an artificial day-night rhythm of 12 hours and larval stages of Artemia salina as food source. With a 3.5-day life cycle, each animal ...
R E V I E W S
... granzymes in viral immunity has emerged only in the past few years, with the finding that mice that lack both granzyme A and the ‘granzyme B cluster’ are as susceptible as perforin-deficient animals to ectromelia virus19. Most of the important progress with granzyme-deficient mice and viral infectio ...
... granzymes in viral immunity has emerged only in the past few years, with the finding that mice that lack both granzyme A and the ‘granzyme B cluster’ are as susceptible as perforin-deficient animals to ectromelia virus19. Most of the important progress with granzyme-deficient mice and viral infectio ...
PROBING IMMUNE FUNCTION DURING AGING IN ADULT DROSOPHILA MELANOGASTER
... An immune system is universal and necessary for all organisms to defend themselves from foreign invaders. Two different forms of immunity exist, adaptive immunity, and innate immunity. However, it is only in higher organisms, such as mammals, that an adaptive, antigen specific immune system has evol ...
... An immune system is universal and necessary for all organisms to defend themselves from foreign invaders. Two different forms of immunity exist, adaptive immunity, and innate immunity. However, it is only in higher organisms, such as mammals, that an adaptive, antigen specific immune system has evol ...
Modulation of interferon gamma response
... Bovine colostrum has been shown to possess some potential activity in enhancing specific immune responses in humans [2,12]. Some studies have reported that BC supplementation can protect children and adults against infectious diseases and diarrhoea [13,14]. Several cytokines have been found in BC, i ...
... Bovine colostrum has been shown to possess some potential activity in enhancing specific immune responses in humans [2,12]. Some studies have reported that BC supplementation can protect children and adults against infectious diseases and diarrhoea [13,14]. Several cytokines have been found in BC, i ...
All Activated CD8 T Cells A Transgenic Mouse Model Genetically Tags
... response, or immune memory, is a central concept in immunology, and it forms the basis of vaccination against infectious disease. Immune memory is mediated, in part, by memory CD4 and CD8⫹ T lymphocytes that persist in the host long after resolution of the antigenic insult or infection. Following vi ...
... response, or immune memory, is a central concept in immunology, and it forms the basis of vaccination against infectious disease. Immune memory is mediated, in part, by memory CD4 and CD8⫹ T lymphocytes that persist in the host long after resolution of the antigenic insult or infection. Following vi ...
Award Recipients 2015
... demonstrating a need to understand the relationship between adipose tissue, lymphatic capability, and immune function at a basic science level to catalyze more effective therapies. Studies exploring this relationship will be performed in lean mice and mice with increased adiposity (obese). Lymphatic ...
... demonstrating a need to understand the relationship between adipose tissue, lymphatic capability, and immune function at a basic science level to catalyze more effective therapies. Studies exploring this relationship will be performed in lean mice and mice with increased adiposity (obese). Lymphatic ...
A dissection of T cell receptor signaling pathways
... Figure 4.2. Flowchart of the procedure for stimulating T cells in the RWV. ............................................... 46 Figure 4.3. Site-specific tyrosine phosphorylation of select TCR signaling molecules. ............................... 53 Figure 4.4. Site-specific tyrosine phosphorylation of ...
... Figure 4.2. Flowchart of the procedure for stimulating T cells in the RWV. ............................................... 46 Figure 4.3. Site-specific tyrosine phosphorylation of select TCR signaling molecules. ............................... 53 Figure 4.4. Site-specific tyrosine phosphorylation of ...
Coinfections following Influenza Immune Dysfunction and Bacterial
... antibiotics were not available in 1918 and thus secondary bacterial infections would likely not represent a serious problem today. Nevertheless, most deaths in the 1957–58 “Asian influenza” pandemic were still due to secondary bacterial pneumonia, even with the availability of antibiotics (6). In on ...
... antibiotics were not available in 1918 and thus secondary bacterial infections would likely not represent a serious problem today. Nevertheless, most deaths in the 1957–58 “Asian influenza” pandemic were still due to secondary bacterial pneumonia, even with the availability of antibiotics (6). In on ...
REVIEWS - Advances in Clinical and Experimental Medicine
... as the organism ages [2]. The thymus grows from birth to 2–3 years of age, then it reaches its highest weight (30–40 g), and then begins to shrink in the period of adolescence (because of the influence of sex hormones present in the bloodstream). Its proper functioning during childhood ensures that ...
... as the organism ages [2]. The thymus grows from birth to 2–3 years of age, then it reaches its highest weight (30–40 g), and then begins to shrink in the period of adolescence (because of the influence of sex hormones present in the bloodstream). Its proper functioning during childhood ensures that ...
Naturally produced opsonizing antibodies restrict the survival of
... Nonetheless, the mechanism by which Abs confer protection against intracellular infections largely remains obscure. Phagosome acidification through fusion with lysosomes is critical for killing of the bacilli within macrophages and its inhibition is a major survival mechanism employed by Mtb [13]. A ...
... Nonetheless, the mechanism by which Abs confer protection against intracellular infections largely remains obscure. Phagosome acidification through fusion with lysosomes is critical for killing of the bacilli within macrophages and its inhibition is a major survival mechanism employed by Mtb [13]. A ...
Immune challenge induces DNA synthesis and nuclear
... Endoreplication, where a cell undergoes multiple rounds of S phase without entering mitosis, and gene amplification are well documented in Drosophila melanogaster [6-8]. Mosquitoes are vectors of a variety of infectious diseases; Aedes aegypti in particular, is competent for the transmission of viru ...
... Endoreplication, where a cell undergoes multiple rounds of S phase without entering mitosis, and gene amplification are well documented in Drosophila melanogaster [6-8]. Mosquitoes are vectors of a variety of infectious diseases; Aedes aegypti in particular, is competent for the transmission of viru ...
CD8 -Mediated Survival and Differentiation of CD8 Memory T Cell
... during the primary response. The LCMVspecific primary activated CD8␣␣⫹ T cells also displayed enhanced expression of IL7R␣ (also called CD127) and IL-15R (Fig. 2B), which are typically up-regulated on memory CD8 T cells (18, 19). Given the characteristics so far described for CD8␣␣⫹ activated lymph ...
... during the primary response. The LCMVspecific primary activated CD8␣␣⫹ T cells also displayed enhanced expression of IL7R␣ (also called CD127) and IL-15R (Fig. 2B), which are typically up-regulated on memory CD8 T cells (18, 19). Given the characteristics so far described for CD8␣␣⫹ activated lymph ...
Probiotics Applications in Autoimmune Diseases
... understand the mechanism by which gut microflora interacts with the epithelial mucosa lining up the intestinal tract. Over the last decade, there have been growing interests in studying the mechanism by which enterocytes interact with gut microflora. The epithelial mucosa is inhabited by significant ...
... understand the mechanism by which gut microflora interacts with the epithelial mucosa lining up the intestinal tract. Over the last decade, there have been growing interests in studying the mechanism by which enterocytes interact with gut microflora. The epithelial mucosa is inhabited by significant ...
Lecture_5
... The TCR repertoire differs from individual to individual • The specificity of self/non-self peptide binding to MHC molecules determined by pockets that only bind certain amino acid side chains • MHC genes are extremely polymorphic and alleles encode pockets with specificities for different amino ac ...
... The TCR repertoire differs from individual to individual • The specificity of self/non-self peptide binding to MHC molecules determined by pockets that only bind certain amino acid side chains • MHC genes are extremely polymorphic and alleles encode pockets with specificities for different amino ac ...
Aging of the hematopoietic system
... accumulating damaged cells. Summary We argue that age-related changes in HSCs and in the hematopoietic system may not entirely be due to a degenerative aging process, but are the result of developmental and stem cell-protective mechanisms aimed at maximizing fitness during reproductive life. These m ...
... accumulating damaged cells. Summary We argue that age-related changes in HSCs and in the hematopoietic system may not entirely be due to a degenerative aging process, but are the result of developmental and stem cell-protective mechanisms aimed at maximizing fitness during reproductive life. These m ...
The Role of Intracellular Neutral Lipid Hydrolases in Immune Cell
... the last and hopefully upcoming years. Thanks for being such an unbelievable source of energy and for your infectious motivation concerning science and life overall. It is beautiful and comforting to know, that certain things in life persist, while other things are changing. Therefore I want to than ...
... the last and hopefully upcoming years. Thanks for being such an unbelievable source of energy and for your infectious motivation concerning science and life overall. It is beautiful and comforting to know, that certain things in life persist, while other things are changing. Therefore I want to than ...
Global Proteomic Analyses of Macrophage Response to
... Alveolar macrophages serve as the first line of defence against microbial infection, yet provide a unique niche for the growth of Mycobacterium tuberculosis. To better understand the evasive nature of the tubercle bacilli and its molecular manifest on the macrophage response to infection, we conduct ...
... Alveolar macrophages serve as the first line of defence against microbial infection, yet provide a unique niche for the growth of Mycobacterium tuberculosis. To better understand the evasive nature of the tubercle bacilli and its molecular manifest on the macrophage response to infection, we conduct ...
Publications by Bart Lambrecht, incl. "extra muros" papers
... muros" papers This page shows "extra muros" publications from Bart Lambrecht (without IRC as affiliation). For copyright reasons, PDF-versions of our publications are available on the intranet only (login required ...
... muros" papers This page shows "extra muros" publications from Bart Lambrecht (without IRC as affiliation). For copyright reasons, PDF-versions of our publications are available on the intranet only (login required ...
anterior uveitis in cats
... Infectious—fungal or mycotic infections (such as Blastomyces, Cryptococcus neoformans, Coccidiodes immitis, Histoplasma capsulatum); protozoal infection (Toxoplasma gondii); bacterial infection (any generalized disease caused by the spread of bacteria in the blood [known as “septicemia” or “blood ...
... Infectious—fungal or mycotic infections (such as Blastomyces, Cryptococcus neoformans, Coccidiodes immitis, Histoplasma capsulatum); protozoal infection (Toxoplasma gondii); bacterial infection (any generalized disease caused by the spread of bacteria in the blood [known as “septicemia” or “blood ...
The Role of Staphylococcus aureus Virulence Factors in Skin
... response. They produce large quantities of IL-1α, tumour-necrosis factor α (TNFα) and antimicrobial peptides such as β-defensins in response to various stimuli, including the presence of bacteria [26]. Keratinocytes also produce a large number of chemokines and other immunoregulatory cytokines in re ...
... response. They produce large quantities of IL-1α, tumour-necrosis factor α (TNFα) and antimicrobial peptides such as β-defensins in response to various stimuli, including the presence of bacteria [26]. Keratinocytes also produce a large number of chemokines and other immunoregulatory cytokines in re ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑