Profiling adaptive immune repertoires across multiple human tissues
... Assay-based approaches provide a detailed view of the adaptive immune system by profiling T and B cell receptor repertoires. However, these methods carry a high cost and lack the scale of standard RNA sequencing (RNA-Seq). Here we report the development of ImReP, a novel computational ...
... Assay-based approaches provide a detailed view of the adaptive immune system by profiling T and B cell receptor repertoires. However, these methods carry a high cost and lack the scale of standard RNA sequencing (RNA-Seq). Here we report the development of ImReP, a novel computational ...
Tartrate‐Resistant Acid Phosphatase Deficiency in the
... patients also manifest a variable neurologic and autoimmune phenotype. These autoimmune features include antinuclear antibody (ANA) and anti–double-stranded DNA (anti-dsDNA) antibody, autoimmune thrombocytopenic purpura, and systemic lupus erythematosus (SLE). Patients with SPENCD consistently show ...
... patients also manifest a variable neurologic and autoimmune phenotype. These autoimmune features include antinuclear antibody (ANA) and anti–double-stranded DNA (anti-dsDNA) antibody, autoimmune thrombocytopenic purpura, and systemic lupus erythematosus (SLE). Patients with SPENCD consistently show ...
Characterization of cell-mediated immune responses elicited
... of T cells activated (or not) by orthotopic corneal grafts, the authors examined the development of delayed hypersensitivity (DH) to donor-specific alloantigens. Methods. Recipient BALB/c mice received orthotopic corneal allografts from donor mice that were MHC incompatible at MHC loci only, multipl ...
... of T cells activated (or not) by orthotopic corneal grafts, the authors examined the development of delayed hypersensitivity (DH) to donor-specific alloantigens. Methods. Recipient BALB/c mice received orthotopic corneal allografts from donor mice that were MHC incompatible at MHC loci only, multipl ...
Cell Systems to Investigate the Impact of Polyphenols on
... if the bioavailability of a certain polyphenol is poor, it would have a limited effect on health [10]. The term “bioavailability” is defined as the fraction of an ingested nutrient or compound that reaches the systemic circulation and the specific sites where it can exert its biological action [1]. ...
... if the bioavailability of a certain polyphenol is poor, it would have a limited effect on health [10]. The term “bioavailability” is defined as the fraction of an ingested nutrient or compound that reaches the systemic circulation and the specific sites where it can exert its biological action [1]. ...
Hutchinson JF ARA2001
... nucleotide bases, integrase, a protease, ribonuclease, and two other proteins, p6 and p7, fit inside the viral core (Greene 1993, Stine 2000, Fauci 1988). Retroviruses like HIV reverse the usual direction of genetic information within the host cell to produce protein. The process of protein synthesi ...
... nucleotide bases, integrase, a protease, ribonuclease, and two other proteins, p6 and p7, fit inside the viral core (Greene 1993, Stine 2000, Fauci 1988). Retroviruses like HIV reverse the usual direction of genetic information within the host cell to produce protein. The process of protein synthesi ...
Welcome to the Nature Immunology Immune Evasion Web Focus
... spots. Some organisms have evolved to occupy special niches where immunity may not penetrate or is frustrated. Malarial parasites have an asexual phase within red blood cells. These complex organisms pay the price of adaptation to life in a biochemically simple environment; the lack of major histoco ...
... spots. Some organisms have evolved to occupy special niches where immunity may not penetrate or is frustrated. Malarial parasites have an asexual phase within red blood cells. These complex organisms pay the price of adaptation to life in a biochemically simple environment; the lack of major histoco ...
Potential use of probiotics
... used as effective probiotic organisms. These features are as follows: i) efficient adherence to intestinal epithelial cells to reduce or prevent colonisation of pathogens (Reid et al., 1993; Bernet et al., 1994; Sarem-Damerdjii et al., 1995; Kirjavainen et al., 1998; Ouwehand et al., 1999); ii) comp ...
... used as effective probiotic organisms. These features are as follows: i) efficient adherence to intestinal epithelial cells to reduce or prevent colonisation of pathogens (Reid et al., 1993; Bernet et al., 1994; Sarem-Damerdjii et al., 1995; Kirjavainen et al., 1998; Ouwehand et al., 1999); ii) comp ...
Killed but metabolically active microbes: a new vaccine paradigm for
... test this vaccine concept. L. monocytogenes is a Gram-positive facultative intracellular pathogen of animals and humans that has been studied for decades as a model to understand basic aspects of cellular immunology and microbial pathogenesis4–6. L. monocytogenes is a powerful inducer of innate immu ...
... test this vaccine concept. L. monocytogenes is a Gram-positive facultative intracellular pathogen of animals and humans that has been studied for decades as a model to understand basic aspects of cellular immunology and microbial pathogenesis4–6. L. monocytogenes is a powerful inducer of innate immu ...
THE ROLE OF MICROGLIA AS PRIME COMPONENT OF CNS
... (Ghinikar et al. 1998; Lenzlinger et al. 2001; Smith et al. 2003; Sroga et al. 2003; Streit et al. 2004; Yang et al. 2004), because it produces wide variety of protein such as beta amyloid precursor protein and its products and amyloid beta (Aβ) peptides neurofilament protein (Babcock et al. 2003; S ...
... (Ghinikar et al. 1998; Lenzlinger et al. 2001; Smith et al. 2003; Sroga et al. 2003; Streit et al. 2004; Yang et al. 2004), because it produces wide variety of protein such as beta amyloid precursor protein and its products and amyloid beta (Aβ) peptides neurofilament protein (Babcock et al. 2003; S ...
Uchanska-Ziegler, B., Loll, B., Fabian, H., Hee, CS, Saenger, W
... The possible consequences of carrying only MHC class I genes exhibiting a very low degree of polymorphism can be seen in the Tasmanian devil (Sarcophilus harrisii). The population of this carnivorous marsupial has declined by more than 50% due to the spread of a highly contagious clonal malignancy, ...
... The possible consequences of carrying only MHC class I genes exhibiting a very low degree of polymorphism can be seen in the Tasmanian devil (Sarcophilus harrisii). The population of this carnivorous marsupial has declined by more than 50% due to the spread of a highly contagious clonal malignancy, ...
Autophagy Delivers Viral Antigens for MHC Class II Presentation
... loading compartments (MIICs) by confocal and immuno-electron microscopy, suggesting that autophagosomes frequently fuse with MIICs. Furthermore, this pathway was of functional relevance, because targeting of influenza matrix protein 1 to autophagosomes via LC3 fusion led to strongly enhanced CD4+ T ...
... loading compartments (MIICs) by confocal and immuno-electron microscopy, suggesting that autophagosomes frequently fuse with MIICs. Furthermore, this pathway was of functional relevance, because targeting of influenza matrix protein 1 to autophagosomes via LC3 fusion led to strongly enhanced CD4+ T ...
Signaling pathways
... factor AP1, is activated by growth factors (GF), which bind to receptor tyrosine kinases (RTK). This pathway relies on activation of RAS and MAPK cascades. The second pathway is activated by the TNF-family receptor activator of NF-B ligand (RANKL), which binds to the receptor activator of NF-B ( ...
... factor AP1, is activated by growth factors (GF), which bind to receptor tyrosine kinases (RTK). This pathway relies on activation of RAS and MAPK cascades. The second pathway is activated by the TNF-family receptor activator of NF-B ligand (RANKL), which binds to the receptor activator of NF-B ( ...
Vitamin D and tuberculosis
... Even before the discovery of the etiologic cause of tuberculosis by Robert Koch in 1903, vitamin D from cod liver oil7 and from exposure to sun or radiation was used to treat tuberculosis.13,15 Several recent studies in different populations have associated a deficiency in vitamin D with increased ris ...
... Even before the discovery of the etiologic cause of tuberculosis by Robert Koch in 1903, vitamin D from cod liver oil7 and from exposure to sun or radiation was used to treat tuberculosis.13,15 Several recent studies in different populations have associated a deficiency in vitamin D with increased ris ...
Agglutination Reactions
... 1. Serial dilutions of serum from a patient suspected to be infected with a given bacterium in tubes. 2. Addition of bacteria to these tubes with constant concentration (same amount and concentration for all tubes). 3. If the person was infected with these bacteria, a visible agglutination will form ...
... 1. Serial dilutions of serum from a patient suspected to be infected with a given bacterium in tubes. 2. Addition of bacteria to these tubes with constant concentration (same amount and concentration for all tubes). 3. If the person was infected with these bacteria, a visible agglutination will form ...
Brock_Allison_David_2011
... complications including, cardiovascular disease, muscular atrophy, urinary tract infections, and pressure sores are not uncommon among this population. The role a loss of function plays in the development of many secondary health complications is quite clear, however, it is now becoming more evident ...
... complications including, cardiovascular disease, muscular atrophy, urinary tract infections, and pressure sores are not uncommon among this population. The role a loss of function plays in the development of many secondary health complications is quite clear, however, it is now becoming more evident ...
- Brain
... strategies. The clinical heterogeneity of multiple sclerosis has been recognized for many years, but it is now apparent that this heterogeneity extends to both the genetics of the disease and the pathomechanisms involved in lesion formation. Clinically the illness may present as a relapsing–remittin ...
... strategies. The clinical heterogeneity of multiple sclerosis has been recognized for many years, but it is now apparent that this heterogeneity extends to both the genetics of the disease and the pathomechanisms involved in lesion formation. Clinically the illness may present as a relapsing–remittin ...
Antimicrobial peptides: A natural alternative to chemical antibiotics
... most multi-cellular organisms ought to depend on a network of host defense mechanisms which in most cases, involves several levels of interacting systems. Since the initial contact of fastidious microorganismswith the host usually occurs at inner or outer body surfaces, they should be the primary si ...
... most multi-cellular organisms ought to depend on a network of host defense mechanisms which in most cases, involves several levels of interacting systems. Since the initial contact of fastidious microorganismswith the host usually occurs at inner or outer body surfaces, they should be the primary si ...
Ketamine and Peripheral Inflammation
... the region. In this regard, alterations of the vascular walls close to the site are of primary importance. Mediators such as histamine, prostaglandins and nitric oxide cause local vasodilation which increase blood flow and the amount of recruited leukocytes. Under the influence of histamine and leuk ...
... the region. In this regard, alterations of the vascular walls close to the site are of primary importance. Mediators such as histamine, prostaglandins and nitric oxide cause local vasodilation which increase blood flow and the amount of recruited leukocytes. Under the influence of histamine and leuk ...
Induction of Antiviral Response Against Avian Infectious
... GRADUATE PROGRAM IN VETERINARY MEDICAL SCIENCES ...
... GRADUATE PROGRAM IN VETERINARY MEDICAL SCIENCES ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑