Univ.-Prof. Dr. med. Britta Siegmund
... to the bench and vice versa with the ultimate goal to contribute to the understanding of the disease pathways as well as to identify possible novel therapeutic targets. Two main directions build the current focus of our group. First, the biological and clinical significance of „creeping fat“, a path ...
... to the bench and vice versa with the ultimate goal to contribute to the understanding of the disease pathways as well as to identify possible novel therapeutic targets. Two main directions build the current focus of our group. First, the biological and clinical significance of „creeping fat“, a path ...
Hypersensitivity
... Immune complexes activate the complement system, neutrophils, basophils and thrombocytes ...
... Immune complexes activate the complement system, neutrophils, basophils and thrombocytes ...
Document
... • Described once by de la Rubia et al in 2001, in a transplant cohort of 217 transplant patients, of whom 8 had developed non-ABO RBC antibodies – ABO blood group incompatibility (p = 0.005) and patient's age (p = 0.02) were the only two variables significantly associated with the development of RBC ...
... • Described once by de la Rubia et al in 2001, in a transplant cohort of 217 transplant patients, of whom 8 had developed non-ABO RBC antibodies – ABO blood group incompatibility (p = 0.005) and patient's age (p = 0.02) were the only two variables significantly associated with the development of RBC ...
Stem Cell Research - Evidence for God from Science
... Cancer is caused by cells of the body multiplying uncontrollably due to genetic mutation or viral infection, in some cases. ...
... Cancer is caused by cells of the body multiplying uncontrollably due to genetic mutation or viral infection, in some cases. ...
Xenopus laevis Antiviral Immunity in the Amphibian Innate T Cells
... are inherently more resistant to FV3 infection and mount effective anti-FV3 responses. The antiviral response is initiated by a robust recruitment of mononuclear and polymorphonuclear phagocytes to the peritoneal cavity as early as 1 d postinfection (dpi), followed by an increase in NK cells at 3 dp ...
... are inherently more resistant to FV3 infection and mount effective anti-FV3 responses. The antiviral response is initiated by a robust recruitment of mononuclear and polymorphonuclear phagocytes to the peritoneal cavity as early as 1 d postinfection (dpi), followed by an increase in NK cells at 3 dp ...
Slide 1
... The degree of immune response to a graft varies with the type of graft. The following terms are used to denote different types of transplants: Auto graft: is self-tissue transferred from one body site to another in the same individual. Transferring healthy skin to a burned area in burn patients and ...
... The degree of immune response to a graft varies with the type of graft. The following terms are used to denote different types of transplants: Auto graft: is self-tissue transferred from one body site to another in the same individual. Transferring healthy skin to a burned area in burn patients and ...
X Tumor Immunity (Clynes) Cross-presentation The Good News/Bad News Story
... eradicate cancer cells? Is there any evidence for immunological surveillance (Burnett and Thomas)? • How can the immune system recognize cancer if it is essentially self-tissue? (Tolerance) • If it does not- can it be made to do so? (Immunization designed to Break Tolerance) Where is the danger-th ...
... eradicate cancer cells? Is there any evidence for immunological surveillance (Burnett and Thomas)? • How can the immune system recognize cancer if it is essentially self-tissue? (Tolerance) • If it does not- can it be made to do so? (Immunization designed to Break Tolerance) Where is the danger-th ...
Sepsis
... culture, tissue stain or PCR test) infection caused by any pathogen OR a clinical syndrome associated with a high probability of infection ...
... culture, tissue stain or PCR test) infection caused by any pathogen OR a clinical syndrome associated with a high probability of infection ...
1 Leukocyte Membrane Molecules—An Introduction
... markers of differentiation on leukocyte membranes are glycoproteins. There is enormous variation of structure, but there are also recognizable themes and motifs. Structural features of proteins are summarized in Boxes 1.1 to 1.4. Function depends on structure, so structure can predict function to a ...
... markers of differentiation on leukocyte membranes are glycoproteins. There is enormous variation of structure, but there are also recognizable themes and motifs. Structural features of proteins are summarized in Boxes 1.1 to 1.4. Function depends on structure, so structure can predict function to a ...
The challenge of multiple sclerosis: How do we cure a chronic
... EAE models,49,50 and we have found that a carbonbased fullerene linked to an NMDA receptor with antiexcitotoxic properties slows progression and prevents axonal damage in the spinal cord in a model of chronic progressive EAE.48 Although the compound is not an immune compound, it reduces infiltration ...
... EAE models,49,50 and we have found that a carbonbased fullerene linked to an NMDA receptor with antiexcitotoxic properties slows progression and prevents axonal damage in the spinal cord in a model of chronic progressive EAE.48 Although the compound is not an immune compound, it reduces infiltration ...
Infectious disease - Journal of Biomedical Research
... Abstract: A cross-sectional study using the snowball sampling method was conducted in May 2008 to investigate human immunodeficiency virus (HIV) infection status and related high risk factors among men who have sex with men (MSM) in Suzhou city of Jiangsu province. The researchers carried out a face ...
... Abstract: A cross-sectional study using the snowball sampling method was conducted in May 2008 to investigate human immunodeficiency virus (HIV) infection status and related high risk factors among men who have sex with men (MSM) in Suzhou city of Jiangsu province. The researchers carried out a face ...
Apoptosis and the immune system
... The pro B cell joins the DH to JH regions and then subsequently joins the VH to the now joined DH gene. In later stages of development, light chain rearrangements occur such as at the pre BII stage. Many rearrangements produce genes in a reading frame that cannot be translated into functional protei ...
... The pro B cell joins the DH to JH regions and then subsequently joins the VH to the now joined DH gene. In later stages of development, light chain rearrangements occur such as at the pre BII stage. Many rearrangements produce genes in a reading frame that cannot be translated into functional protei ...
This work has led to an increased understanding not only of
... Lactobacillus casei is a species naturally found in the gastrointestinal and genital tracts of animals and humans. It has been traditionally employed in the production of fermented foods and recent studies have demonstrated the probiotic properties of certain strains of this species, as L. casei BL2 ...
... Lactobacillus casei is a species naturally found in the gastrointestinal and genital tracts of animals and humans. It has been traditionally employed in the production of fermented foods and recent studies have demonstrated the probiotic properties of certain strains of this species, as L. casei BL2 ...
Document
... disease. Although animal models are informative, there are in fact few models of spontaneous autoimmunity that reliably mimic the human disorders. Nevertheless, studies using existing models, as well as genetic and other analyses, are beginning to reveal some of the abnormalities that account for th ...
... disease. Although animal models are informative, there are in fact few models of spontaneous autoimmunity that reliably mimic the human disorders. Nevertheless, studies using existing models, as well as genetic and other analyses, are beginning to reveal some of the abnormalities that account for th ...
Maternal Obesity - Specializzazione Pediatria
... Challenges in Neonatal Drug Development • Most drugs used in newborn infants not ...
... Challenges in Neonatal Drug Development • Most drugs used in newborn infants not ...
Characterization of hTERT-immortalized Prostate-derived
... changed, although prostate cancer animal models are available for use to aid in development of new treatments. In fact, a comprehensive analysis of genetically engineered mouse models identified that invasive prostate cancers are associated with the presence of fibroblast or myofibroblast cells. Add ...
... changed, although prostate cancer animal models are available for use to aid in development of new treatments. In fact, a comprehensive analysis of genetically engineered mouse models identified that invasive prostate cancers are associated with the presence of fibroblast or myofibroblast cells. Add ...
Antigen
... Generalized Attack (Instant, innate defense) • The main cells involved in the generalized attack can be described as “on-the-ready” cells. They function in different ways: ...
... Generalized Attack (Instant, innate defense) • The main cells involved in the generalized attack can be described as “on-the-ready” cells. They function in different ways: ...
document
... Cytokine-mediated process – Tissue necrosis factor (TNF), IL-1, interferon 1. Shortened RBC survival Normal survival of patient’s cells in normal plasma Decreased survival of normal cells in patient’s plasma 2. Impaired marrow response Normal BM – 6-8x increase in red cell production rate ...
... Cytokine-mediated process – Tissue necrosis factor (TNF), IL-1, interferon 1. Shortened RBC survival Normal survival of patient’s cells in normal plasma Decreased survival of normal cells in patient’s plasma 2. Impaired marrow response Normal BM – 6-8x increase in red cell production rate ...
THE T CELL RECEPTOR (TCR)
... Intracellular microbes: antigens from cytoplasmic microbes are captured and presented on class I by all nucleated cells. CD8 T cells directly eliminate infected cells. Thus, CD8 T cells activate best defenses against ...
... Intracellular microbes: antigens from cytoplasmic microbes are captured and presented on class I by all nucleated cells. CD8 T cells directly eliminate infected cells. Thus, CD8 T cells activate best defenses against ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑