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... Valacyclovir, a prodrug of acyclovir, is converted to acyclovir on first pass through the portal circulation, where its valine moiety is stripped off and metabolized as an amino ...
Ear Infections (Otitis Media) in Children
Ear Infections (Otitis Media) in Children

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... Received 15 April 1992/Accepted 3 November 1992 ...
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Hygiene hypothesis

In medicine, the hygiene hypothesis is a hypothesis that states that a lack of early childhood exposure to infectious agents, symbiotic microorganisms (e.g. gut flora or probiotics), and parasites increases susceptibility to allergic diseases by suppressing the natural development of the immune system. In particular, the lack of exposure is thought to lead to defects in the establishment of immune tolerance.The hygiene hypothesis has also been called the ""biome depletion theory"" and the ""lost friends theory"".
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