Latanoprostene Bunod, a Dual-acting Nitric Oxide Donating
... Topical ocular hypertensive medications which lower IOP have been the mainstay for first-line treatment of OHT and OAG to even before large, population-based clinical studies identified IOP as a modifiable risk factor. The Ocular Hypertension Treatment Study evaluated 1,636 individuals with an IOP o ...
... Topical ocular hypertensive medications which lower IOP have been the mainstay for first-line treatment of OHT and OAG to even before large, population-based clinical studies identified IOP as a modifiable risk factor. The Ocular Hypertension Treatment Study evaluated 1,636 individuals with an IOP o ...
Current management
... extensive,1 and pattern of disease (relapse frequency, course of disease, response to previous medications, side-effect profile of medication, extra-intestinal manifestation), before treatment decisions are made in conjunction with the patient. 5.1.1. Disease activity The principal scoring systems u ...
... extensive,1 and pattern of disease (relapse frequency, course of disease, response to previous medications, side-effect profile of medication, extra-intestinal manifestation), before treatment decisions are made in conjunction with the patient. 5.1.1. Disease activity The principal scoring systems u ...
Proof-of-Concept Trial with the Neurosteroid Pregnenolone
... METHODS This pilot investigation was a placebo-controlled, doubleblind, parallel group, randomized trial of adjunctive pregnenolone for the treatment of cognitive and negative symptoms in patients with schizophrenia or schizoaffective disorder. Following a single-blind 2-week placebo lead-in phase ( ...
... METHODS This pilot investigation was a placebo-controlled, doubleblind, parallel group, randomized trial of adjunctive pregnenolone for the treatment of cognitive and negative symptoms in patients with schizophrenia or schizoaffective disorder. Following a single-blind 2-week placebo lead-in phase ( ...
Treatment for Central-Involved Diabetic Macular Edema in Eyes with
... than 5% in any group). The mean change (+ standard deviation) in visual acuity letter score at one year from baseline was significantly greater in the ranibizumab+prompt laser group (+9 ± 11) and the ranibizumab+deferred laser group (+9 ± 12) as compared with the control laser group (+3 ± 13, P < 0. ...
... than 5% in any group). The mean change (+ standard deviation) in visual acuity letter score at one year from baseline was significantly greater in the ranibizumab+prompt laser group (+9 ± 11) and the ranibizumab+deferred laser group (+9 ± 12) as compared with the control laser group (+3 ± 13, P < 0. ...
highlights of prescribing information
... to treat psychiatric disorders is also contraindicated [see Dosage and Administration (2.5), and Warnings and Precautions (5.2)]. Starting Lexapro in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue is also contraindicated because of an increased risk of sero ...
... to treat psychiatric disorders is also contraindicated [see Dosage and Administration (2.5), and Warnings and Precautions (5.2)]. Starting Lexapro in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue is also contraindicated because of an increased risk of sero ...
- White Rose Research Online
... Newer AEDs, used as monotherapy, may be costeffective for the treatment of patients who have experienced adverse events with older AEDs, who have failed to respond to the older drugs, or where such drugs are contraindicated. The integrated economic analysis also suggested that newer AEDs used as adj ...
... Newer AEDs, used as monotherapy, may be costeffective for the treatment of patients who have experienced adverse events with older AEDs, who have failed to respond to the older drugs, or where such drugs are contraindicated. The integrated economic analysis also suggested that newer AEDs used as adj ...
Phase II clinical trial testing the safety and efficacy
... promising, the data gathered will be used to inform the design of two large (N= at least 280) multi-site Phase III studies of MDMA-assisted psychotherapy as a treatment for PTSD. MAPS' Clinical Plan (Doblin 2002) will require at least 5 years and will involve at least 600 subjects. Specific Hypothes ...
... promising, the data gathered will be used to inform the design of two large (N= at least 280) multi-site Phase III studies of MDMA-assisted psychotherapy as a treatment for PTSD. MAPS' Clinical Plan (Doblin 2002) will require at least 5 years and will involve at least 600 subjects. Specific Hypothes ...
Fifth NSI Newsletter
... Dear Friends! it’s time for yet another issue of ONYCHOSCOPE. This is the 5th issue with all its educative content centered on the nail. The issue features invited faculty article by Dr Vineet Relhan (founder treasurer of NSI) on paronychia, a common yet perplexing disorder. The article demystifies ...
... Dear Friends! it’s time for yet another issue of ONYCHOSCOPE. This is the 5th issue with all its educative content centered on the nail. The issue features invited faculty article by Dr Vineet Relhan (founder treasurer of NSI) on paronychia, a common yet perplexing disorder. The article demystifies ...
Peripheral Neuropathy
... Peripheral Neuropathy group of 75 type 1 diabetics, those with hyperhomocysteinemia had significantly higher plasma thrombomodulin levels (a sign of endothelial damage; 62.2 ng/mL versus 38.2 ng/mL) and higher prevalence of neuropathy (57% versus 41%).30 Not all studies have found a correlation betw ...
... Peripheral Neuropathy group of 75 type 1 diabetics, those with hyperhomocysteinemia had significantly higher plasma thrombomodulin levels (a sign of endothelial damage; 62.2 ng/mL versus 38.2 ng/mL) and higher prevalence of neuropathy (57% versus 41%).30 Not all studies have found a correlation betw ...
Treatment of Hyperhidrosis
... Hyperhidrosis may be defined as excessive sweating, beyond a level required to maintain normal body temperature in response to heat exposure or exercise. It can be classified as either primary or secondary. Primary focal hyperhidrosis is idiopathic in nature, typically involving the hands (palmar), ...
... Hyperhidrosis may be defined as excessive sweating, beyond a level required to maintain normal body temperature in response to heat exposure or exercise. It can be classified as either primary or secondary. Primary focal hyperhidrosis is idiopathic in nature, typically involving the hands (palmar), ...
AusPAR Attachment 2: Extract from the Clinical Evaluation Report
... gene mutation. In Australia, the standard treatment for patients with haemophilia A is substitution therapy including intravenous (iv) administration of high-purity, plasma-derived FVIII concentrates or recombinant FVIII. Replacement therapy can be provided either as prophylaxis to prevent bleeding ...
... gene mutation. In Australia, the standard treatment for patients with haemophilia A is substitution therapy including intravenous (iv) administration of high-purity, plasma-derived FVIII concentrates or recombinant FVIII. Replacement therapy can be provided either as prophylaxis to prevent bleeding ...
Foods and Supplements in the Management of Migraine
... observed when patients on monoamine oxidase inhibitors developed headaches and hypertensive crises after eating aged cheese, which has a high tyramine content.24 ...
... observed when patients on monoamine oxidase inhibitors developed headaches and hypertensive crises after eating aged cheese, which has a high tyramine content.24 ...
Document
... c. Always have a first line medication to take at onset and a second line to take 2 hours later for persistent headache d. First line therapy should not contain a sedating medication and child can return back to school work e. Second line therapy may contain a sedating medication and child should re ...
... c. Always have a first line medication to take at onset and a second line to take 2 hours later for persistent headache d. First line therapy should not contain a sedating medication and child can return back to school work e. Second line therapy may contain a sedating medication and child should re ...
Assessment and management of agitation in psychiatry
... addition, psychomotor agitation has been also described as a possible predictor of suicide behaviour (Sani et al. 2011; McClure et al. 2015). In fact, an ineffective management of agitation can result in an unnecessary use of coercive measures (involuntary medication, restraint, and seclusion), esca ...
... addition, psychomotor agitation has been also described as a possible predictor of suicide behaviour (Sani et al. 2011; McClure et al. 2015). In fact, an ineffective management of agitation can result in an unnecessary use of coercive measures (involuntary medication, restraint, and seclusion), esca ...
Assessment and management of agitation in psychiatry
... addition, psychomotor agitation has been also described as a possible predictor of suicide behaviour (Sani et al. 2011; McClure et al. 2015). In fact, an ineffective management of agitation can result in an unnecessary use of coercive measures (involuntary medication, restraint, and seclusion), esca ...
... addition, psychomotor agitation has been also described as a possible predictor of suicide behaviour (Sani et al. 2011; McClure et al. 2015). In fact, an ineffective management of agitation can result in an unnecessary use of coercive measures (involuntary medication, restraint, and seclusion), esca ...
Stinging Nettle: the Bad, the Good, the Unknown
... or muscular pain by use of nettle, mostly by rubbing, beating or touching (apparently) fresh nettle leaves to the affected area (i.e. counterirritation).12 The only significant side effect was transient urticarial rash. Two underpowered randomized trials of thumb pain,13 and knee pain,14 respectivel ...
... or muscular pain by use of nettle, mostly by rubbing, beating or touching (apparently) fresh nettle leaves to the affected area (i.e. counterirritation).12 The only significant side effect was transient urticarial rash. Two underpowered randomized trials of thumb pain,13 and knee pain,14 respectivel ...
M P I. P
... from a therapist reduced distress (greater than 50% on the tinnitus reaction questionnaire) in 32% of subjects compared with 5% of the waiting-list control group. (5) Analysis of follow-up data suggested that a self-help book alone (provided to the control group after the study period) without thera ...
... from a therapist reduced distress (greater than 50% on the tinnitus reaction questionnaire) in 32% of subjects compared with 5% of the waiting-list control group. (5) Analysis of follow-up data suggested that a self-help book alone (provided to the control group after the study period) without thera ...
1: Introduction and Summary
... understanding of reasons for its efficacy. * As a result, much of the existing literature on the effectiveness of apheresis is not of very good methodological quality. The great majority of the reported studies are case reports without any conclusive control groups, blinding, randomization, or other ...
... understanding of reasons for its efficacy. * As a result, much of the existing literature on the effectiveness of apheresis is not of very good methodological quality. The great majority of the reported studies are case reports without any conclusive control groups, blinding, randomization, or other ...
Evidence-based practice guideline: Disease
... disease course and disease activity). It is sometimes unclear when or whether therapy should be ...
... disease course and disease activity). It is sometimes unclear when or whether therapy should be ...
COPD
... • Increased concentrations of inflammatory mediators, including TNF-, IL-6, and oxygen-derived free radicals, may mediate some of these systemic effects. • There is an increase in the risk of cardiovascular diseases, which is correlated with an increase in C-reactive protein (CRP)21. ...
... • Increased concentrations of inflammatory mediators, including TNF-, IL-6, and oxygen-derived free radicals, may mediate some of these systemic effects. • There is an increase in the risk of cardiovascular diseases, which is correlated with an increase in C-reactive protein (CRP)21. ...
Table of Contents
... The time to the first COPD exacerbation and time to first COPD exacerbation leading to hospitalization were identified by the Applicant as key secondary endpoints in UPLIFT. From a statistical standpoint, the primary endpoints did not win and with a step-down approach, secondary endpoints should not ...
... The time to the first COPD exacerbation and time to first COPD exacerbation leading to hospitalization were identified by the Applicant as key secondary endpoints in UPLIFT. From a statistical standpoint, the primary endpoints did not win and with a step-down approach, secondary endpoints should not ...
A comparative study for the topical treatment of Aloe ferox Balb/c mice.
... Topical corticosteroids is used in the treatment of AD to relieve itching and ease scaling but these topical treatments come with varies side effects such as skin thinning and stretch marks, skin irritation, discoloration and skin infection that in turn need to be treated with antibiotics. Oral or i ...
... Topical corticosteroids is used in the treatment of AD to relieve itching and ease scaling but these topical treatments come with varies side effects such as skin thinning and stretch marks, skin irritation, discoloration and skin infection that in turn need to be treated with antibiotics. Oral or i ...
full prescribing information: contents
... Patients with left ventricular outflow obstruction, (e.g., aortic stenosis and idiopathic hypertrophic subaortic stenosis) can be sensitive to the action of vasodilators, including PDE5 inhibitors. The following groups of patients with cardiovascular disease were not included in clinical safety and ...
... Patients with left ventricular outflow obstruction, (e.g., aortic stenosis and idiopathic hypertrophic subaortic stenosis) can be sensitive to the action of vasodilators, including PDE5 inhibitors. The following groups of patients with cardiovascular disease were not included in clinical safety and ...
Product Monograph
... MI-CP124), SYNAGIS® solution for injection was used as an active control (3918 pediatric subjects) to evaluate an investigational monoclonal antibody for prophylaxis of serious RSV disease in premature infants or children with BPD or hemodynamically significant CHD. The overall rate and pattern of a ...
... MI-CP124), SYNAGIS® solution for injection was used as an active control (3918 pediatric subjects) to evaluate an investigational monoclonal antibody for prophylaxis of serious RSV disease in premature infants or children with BPD or hemodynamically significant CHD. The overall rate and pattern of a ...
Guidelines for the diagnosis and management of migraine in clinical practice
... comparison of alternative clinical pathways and the description of how published data were analysed; the definition of the level of evidence for data in each case; the evaluation and revision of guidelines (at a consensus conference involving neurologists, specialists in emergency medicine, psycholo ...
... comparison of alternative clinical pathways and the description of how published data were analysed; the definition of the level of evidence for data in each case; the evaluation and revision of guidelines (at a consensus conference involving neurologists, specialists in emergency medicine, psycholo ...
Placebo-controlled study
Placebo-controlled studies are a way of testing a medical therapy in which, in addition to a group of subjects that receives the treatment to be evaluated, a separate control group receives a sham ""placebo"" treatment which is specifically designed to have no real effect. Placebos are most commonly used in blinded trials, where subjects do not know whether they are receiving real or placebo treatment. Often, there is also a further ""natural history"" group that does not receive any treatment at all.The purpose of the placebo group is to account for the placebo effect, that is, effects from treatment that do not depend on the treatment itself. Such factors include knowing one is receiving a treatment, attention from health care professionals, and the expectations of a treatment's effectiveness by those running the research study. Without a placebo group to compare against, it is not possible to know whether the treatment itself had any effect.Patients frequently show improvement even when given a sham or ""fake"" treatment. Such intentionally inert placebo treatments can take many forms, such as a pill containing only sugar, a surgery where nothing efficacious is actually done (just an incision and sometimes some minor touching or handling of the underlying structures), or a medical device (such as an ultrasound machine) that is not actually turned on. Also, due to the body's natural healing ability and statistical effects such as regression to the mean, many patients will get better even when given no treatment at all. Thus, the relevant question when assessing a treatment is not ""does the treatment work?"" but ""does the treatment work better than a placebo treatment, or no treatment at all?"" As one early clinical trial researcher wrote, ""the first object of a therapeutic trial is to discover whether the patients who receive the treatment under investigation are cured more rapidly, more completely or more frequently, than they would have been without it.""p.195 More broadly, the aim of a clinical trial is to determine what treatments, delivered in what circumstances, to which patients, in what conditions, are the most effective.Therefore, the use of placebos is a standard control component of most clinical trials, which attempt to make some sort of quantitative assessment of the efficacy of medicinal drugs or treatments. Such a test or clinical trial is called a placebo-controlled study, and its control is of the negative type. A study whose control is a previously tested treatment, rather than no treatment, is called a positive-control study, because its control is of the positive type.Government regulatory agencies approve new drugs only after tests establish not only that patients respond to them, but also that their effect is greater than that of a placebo (by way of affecting more patients, by affecting responders more strongly, or both). As a result, ""placebo-controlled studies often are designed in such a way that disadvantages the placebo condition"".