A CLINICAL STUDY REPORT VIGRX PLUS In Male Sexual Health
... sperm motility between the two treatment groups. Serum Testosterone levels did not change significantly in any of the study groups. At the end of study, global assessment of therapy by investigator clearly saw a superiority of outcomes in subjects receiving VigRX Plus as compared to those receiving ...
... sperm motility between the two treatment groups. Serum Testosterone levels did not change significantly in any of the study groups. At the end of study, global assessment of therapy by investigator clearly saw a superiority of outcomes in subjects receiving VigRX Plus as compared to those receiving ...
Effects of candesartan in patients with chronic heart failure and
... group than in the placebo group, including previous percutaneous coronary intervention, and use of lipidlowering drugs, aspirin, and spironolactone (table 1). At baseline 296 (20%) in the candesartan group and 280 (19%) in the placebo group were taking angiotensinconverting-enzyme inhibitors, and 84 ...
... group than in the placebo group, including previous percutaneous coronary intervention, and use of lipidlowering drugs, aspirin, and spironolactone (table 1). At baseline 296 (20%) in the candesartan group and 280 (19%) in the placebo group were taking angiotensinconverting-enzyme inhibitors, and 84 ...
Best Ways to Beat Cold Symptoms
... vessels, which will help you breathe easier. Sprays used short-term are also a better first choice because they cause fewer side effects than oral decongestants – if you stick to the recommended dose – since they’re usually not absorbed into your bloodstream in significant amounts like oral deconges ...
... vessels, which will help you breathe easier. Sprays used short-term are also a better first choice because they cause fewer side effects than oral decongestants – if you stick to the recommended dose – since they’re usually not absorbed into your bloodstream in significant amounts like oral deconges ...
(vestibular neuritis).
... measures (generic, or disease specific, or both). Patient-reported adverse events: severe and minor. A severe adverse event is defined as resulting in a patient discontinuing the medication and withdrawing from the study. A minor adverse event is defined as a side effect experienced by the patie ...
... measures (generic, or disease specific, or both). Patient-reported adverse events: severe and minor. A severe adverse event is defined as resulting in a patient discontinuing the medication and withdrawing from the study. A minor adverse event is defined as a side effect experienced by the patie ...
Efficacy and Safety of Meriva®, a Curcumin
... the management of osteoarthritis, a condition in registry for the complementary management of need of novel therapeutic options.9 osteoarthritis. Patients were informed about the Osteoarthritis is the leading cause of physical aim of the study and treatment procedure accorddisability and impairment ...
... the management of osteoarthritis, a condition in registry for the complementary management of need of novel therapeutic options.9 osteoarthritis. Patients were informed about the Osteoarthritis is the leading cause of physical aim of the study and treatment procedure accorddisability and impairment ...
Intravenous N-acetylcysteine in Pediatric Patients
... for ineligibility were not recorded on the initial case report form for 165 participants and are shown as ‘‘reason unknown.’’ Of the remaining 171, reasons for ineligibility were recorded. In addition to those who failed to meet inclusion criteria, or who met at least one exclusion criterion, five d ...
... for ineligibility were not recorded on the initial case report form for 165 participants and are shown as ‘‘reason unknown.’’ Of the remaining 171, reasons for ineligibility were recorded. In addition to those who failed to meet inclusion criteria, or who met at least one exclusion criterion, five d ...
LDR Easypine ST
... The Mobi-C IDE trial was multi-centered, prospective, and controlled. The trial tested Mobi-C for non-inferiority to the current standard of care, ACDF. The trial planned for the testing of superiority in the event that non‑inferiority was established. The primary trial endpoint analysis was based u ...
... The Mobi-C IDE trial was multi-centered, prospective, and controlled. The trial tested Mobi-C for non-inferiority to the current standard of care, ACDF. The trial planned for the testing of superiority in the event that non‑inferiority was established. The primary trial endpoint analysis was based u ...
Lactobacillus GG - Oxford Academic
... diarrhoea of these Thai children when compared to placebo. However, in those presenting with acute watery non-bloody diarrhoea, the use of LactobacUlus GG was associated with a significantly shorter duration of diarrhoea and reduction in stool frequency on the second day. These findings resemble tho ...
... diarrhoea of these Thai children when compared to placebo. However, in those presenting with acute watery non-bloody diarrhoea, the use of LactobacUlus GG was associated with a significantly shorter duration of diarrhoea and reduction in stool frequency on the second day. These findings resemble tho ...
Placebo effects: clinical aspects and neurobiology
... matched well for expectancy, the overall effect—the combination of the non-specific and specific effects—may be reasonably high with only a small specific effect. This may be the case for surgical procedures where non-specific beneficial effects may be very prominent but sham surgery is not often us ...
... matched well for expectancy, the overall effect—the combination of the non-specific and specific effects—may be reasonably high with only a small specific effect. This may be the case for surgical procedures where non-specific beneficial effects may be very prominent but sham surgery is not often us ...
Treatment of Intractable Hiccups
... However, the studies were weak with high degree of bias. The randomization was poorly performed, the groups were not well matched, the intervention was not compared to placebo, and the acupuncture was varied from patient to patient with no one protocol. Therefore, no real conclusions can be drawn fr ...
... However, the studies were weak with high degree of bias. The randomization was poorly performed, the groups were not well matched, the intervention was not compared to placebo, and the acupuncture was varied from patient to patient with no one protocol. Therefore, no real conclusions can be drawn fr ...
Experience of an Ibogaine treatment provider
... that an echo cardiogram must be given to determine cardiac health deficits that would not show up on a normal EKG or EKG stress test. NIDA in their Ibogaine protocol set the exclusion criteria at 400% of normal liver enzyme values. However, the core safety issue is cardiac health. Further, patients ...
... that an echo cardiogram must be given to determine cardiac health deficits that would not show up on a normal EKG or EKG stress test. NIDA in their Ibogaine protocol set the exclusion criteria at 400% of normal liver enzyme values. However, the core safety issue is cardiac health. Further, patients ...
and treatment outcome definitions
... has at least five consecutive negative cultures from samples collected at least 30 days apart in the final 12 months of treatment. If only one positive culture is reported during that time, and there is no concomitant clinical evidence of deterioration, a patient may still be considered cured, provi ...
... has at least five consecutive negative cultures from samples collected at least 30 days apart in the final 12 months of treatment. If only one positive culture is reported during that time, and there is no concomitant clinical evidence of deterioration, a patient may still be considered cured, provi ...
Bias Reduction in Observational Cohort Studies - Obtaining Matched Cohorts Using Propensity Scores
... The propensity score was defined as the probability of the patient being prescribed treatment B and the scores estimated in SAS® using a multivariate logistic regression model with PROC LOGISTIC. The covariates for the propensity score model were all based on the results of an exploratory analysis o ...
... The propensity score was defined as the probability of the patient being prescribed treatment B and the scores estimated in SAS® using a multivariate logistic regression model with PROC LOGISTIC. The covariates for the propensity score model were all based on the results of an exploratory analysis o ...
Nova Southeastern University Institutional Review Board Policies and Procedures
... Even for an emergency use, the investigator is required to obtain informed consent of the subject or the subject's legally authorized representative unless both the investigator and a physician who is not otherwise participating in the clinical investigation certify in writing all of the following: ...
... Even for an emergency use, the investigator is required to obtain informed consent of the subject or the subject's legally authorized representative unless both the investigator and a physician who is not otherwise participating in the clinical investigation certify in writing all of the following: ...
Original Research
... moderate-to-severe COPD exacerbation or lower respiratory tract infection during the run-in period; and any significant medical condition or disease that would place the patient at risk or interfere with the study evaluation. This study was conducted in compliance with the protocol and principles of ...
... moderate-to-severe COPD exacerbation or lower respiratory tract infection during the run-in period; and any significant medical condition or disease that would place the patient at risk or interfere with the study evaluation. This study was conducted in compliance with the protocol and principles of ...
Lycopene in the management of oral lichen planus: A placebo
... the management of oral leukoplakia.[13] LP is a chronic condition and various studies have reported longer duration of treatment, ranging from 2 to 32 weeks, and most of the studies, using retinoids, have used the medications for 8 weeks.[1‑4] Therefore, we decided to use 8 mg/day of lycopene for a ...
... the management of oral leukoplakia.[13] LP is a chronic condition and various studies have reported longer duration of treatment, ranging from 2 to 32 weeks, and most of the studies, using retinoids, have used the medications for 8 weeks.[1‑4] Therefore, we decided to use 8 mg/day of lycopene for a ...
03-Loop-diuretics-in-the-management-of-acute-renal
... sodium than those who did not respond to the diuretic, implying they had less severe renal failure as renal tubular sodium reabsorption continued. This is in keeping with our observation that the patients who became non-oliguric after loop diuretics had significantly less severe organ failure and be ...
... sodium than those who did not respond to the diuretic, implying they had less severe renal failure as renal tubular sodium reabsorption continued. This is in keeping with our observation that the patients who became non-oliguric after loop diuretics had significantly less severe organ failure and be ...
does inhaling hot dry air reduce common cold symptoms?
... temperature to the throat of patients with a newly acquired common cold using a symptom severity score. Design, setting and participants: A randomised single-blind controlled trial with a treatment duration of 3 days and a follow-up period of 4 days was conducted at a sauna in Berlin, Germany. Betwe ...
... temperature to the throat of patients with a newly acquired common cold using a symptom severity score. Design, setting and participants: A randomised single-blind controlled trial with a treatment duration of 3 days and a follow-up period of 4 days was conducted at a sauna in Berlin, Germany. Betwe ...
White Paper Long-Acting Muscarinic Agents
... the highest fluticasone dose i.e. 500 μg twice daily, while some others got good asthma control after adding an oral corticosteroid, whilst others did not achieve control of their asthma at all. This finding is not surprising, since inhaled corticosteroids have a relatively flat dose response curve, ...
... the highest fluticasone dose i.e. 500 μg twice daily, while some others got good asthma control after adding an oral corticosteroid, whilst others did not achieve control of their asthma at all. This finding is not surprising, since inhaled corticosteroids have a relatively flat dose response curve, ...
Treatment of Relapsing Mild-to-Moderate Ulcerative
... Probiotics have proven to be effective in the management of pouchitis (3,4), and preliminary data are available for the treatment of UC (5,6), but strong data are still lacking in both UC and Crohn’s disease. In particular, there is limited evidence that probiotics, in addition to standard therapy, ...
... Probiotics have proven to be effective in the management of pouchitis (3,4), and preliminary data are available for the treatment of UC (5,6), but strong data are still lacking in both UC and Crohn’s disease. In particular, there is limited evidence that probiotics, in addition to standard therapy, ...
Treatment with inhaled steroids in patients with normal lung function
... ABSTRACT: A total of 144 patients with lower airway symptoms suggestive of asthma, but who did not fulfil the functional criteria of asthma, were included in a randomised, double-blind, placebo-controlled 8-week ‘‘proof-of-concept’’ study with mometasone furoate (MF), 400 mg once daily. The primary ...
... ABSTRACT: A total of 144 patients with lower airway symptoms suggestive of asthma, but who did not fulfil the functional criteria of asthma, were included in a randomised, double-blind, placebo-controlled 8-week ‘‘proof-of-concept’’ study with mometasone furoate (MF), 400 mg once daily. The primary ...
treatment of acute migraine headaches
... 6. Oral narcotic combination products (e.g. acetaminophen/ASA + codeine) are effective. 7. When narcotics are used alone or parenterally, morphine is the drug of choice. However, aside from meperidine there are few well-conducted trials of parenteral narcotics in acute migraine. 8. ASA 900 mg plus m ...
... 6. Oral narcotic combination products (e.g. acetaminophen/ASA + codeine) are effective. 7. When narcotics are used alone or parenterally, morphine is the drug of choice. However, aside from meperidine there are few well-conducted trials of parenteral narcotics in acute migraine. 8. ASA 900 mg plus m ...
Effects of Initiating Carvedilol in Patients With Severe Chronic Heart
... (n=1156), or placebo (n=1133), in addition to their usual medications for heart failure. Main Outcome Measures Death, hospitalization, or permanent withdrawal from study drug, as well as adverse events during the first 8 weeks of treatment. Results The carvedilol group experienced no increase in car ...
... (n=1156), or placebo (n=1133), in addition to their usual medications for heart failure. Main Outcome Measures Death, hospitalization, or permanent withdrawal from study drug, as well as adverse events during the first 8 weeks of treatment. Results The carvedilol group experienced no increase in car ...
Placebo effects in chronic pain conditions. Can placebo components
... treatment was administered, the heat pain intensity was surreptitiously decreased from 80 to 20 in half of the participants to give the participants an experience of pain relief (positive treatment history group), whereas it remained stable in the other half of the participants (negative treatment h ...
... treatment was administered, the heat pain intensity was surreptitiously decreased from 80 to 20 in half of the participants to give the participants an experience of pain relief (positive treatment history group), whereas it remained stable in the other half of the participants (negative treatment h ...
Presentation 1 ACK Tick Committee
... walk at least 100 meters, but not more than 450 meters. The baseline measurement for analysis will be performed at Visit 2 and repeated at 3 months on treatment (Visit 5) and at 6 months of treatment (Visit 7). The walking test will be performed based upon the guidelines of the American Thoracic Soc ...
... walk at least 100 meters, but not more than 450 meters. The baseline measurement for analysis will be performed at Visit 2 and repeated at 3 months on treatment (Visit 5) and at 6 months of treatment (Visit 7). The walking test will be performed based upon the guidelines of the American Thoracic Soc ...
Placebo-controlled study
Placebo-controlled studies are a way of testing a medical therapy in which, in addition to a group of subjects that receives the treatment to be evaluated, a separate control group receives a sham ""placebo"" treatment which is specifically designed to have no real effect. Placebos are most commonly used in blinded trials, where subjects do not know whether they are receiving real or placebo treatment. Often, there is also a further ""natural history"" group that does not receive any treatment at all.The purpose of the placebo group is to account for the placebo effect, that is, effects from treatment that do not depend on the treatment itself. Such factors include knowing one is receiving a treatment, attention from health care professionals, and the expectations of a treatment's effectiveness by those running the research study. Without a placebo group to compare against, it is not possible to know whether the treatment itself had any effect.Patients frequently show improvement even when given a sham or ""fake"" treatment. Such intentionally inert placebo treatments can take many forms, such as a pill containing only sugar, a surgery where nothing efficacious is actually done (just an incision and sometimes some minor touching or handling of the underlying structures), or a medical device (such as an ultrasound machine) that is not actually turned on. Also, due to the body's natural healing ability and statistical effects such as regression to the mean, many patients will get better even when given no treatment at all. Thus, the relevant question when assessing a treatment is not ""does the treatment work?"" but ""does the treatment work better than a placebo treatment, or no treatment at all?"" As one early clinical trial researcher wrote, ""the first object of a therapeutic trial is to discover whether the patients who receive the treatment under investigation are cured more rapidly, more completely or more frequently, than they would have been without it.""p.195 More broadly, the aim of a clinical trial is to determine what treatments, delivered in what circumstances, to which patients, in what conditions, are the most effective.Therefore, the use of placebos is a standard control component of most clinical trials, which attempt to make some sort of quantitative assessment of the efficacy of medicinal drugs or treatments. Such a test or clinical trial is called a placebo-controlled study, and its control is of the negative type. A study whose control is a previously tested treatment, rather than no treatment, is called a positive-control study, because its control is of the positive type.Government regulatory agencies approve new drugs only after tests establish not only that patients respond to them, but also that their effect is greater than that of a placebo (by way of affecting more patients, by affecting responders more strongly, or both). As a result, ""placebo-controlled studies often are designed in such a way that disadvantages the placebo condition"".