Supplementary Material (doc 858K)
... Subjects from both samples were recruited using advertisements in local newspapers, by word-of mouth, and from local treatment facilities. All were fully informed of all study procedures and risks, and provided written consent in accordance with the local Institutional Review Board. Subjects were he ...
... Subjects from both samples were recruited using advertisements in local newspapers, by word-of mouth, and from local treatment facilities. All were fully informed of all study procedures and risks, and provided written consent in accordance with the local Institutional Review Board. Subjects were he ...
Section 3: Antiallergics and Medicines Used in Anaphylaxis
... qualified prescribers may be limited. Table 1 summarizes the medications under review. Appendix 6 on page 54 contains a list of EML application questions with section by section references to this review. ...
... qualified prescribers may be limited. Table 1 summarizes the medications under review. Appendix 6 on page 54 contains a list of EML application questions with section by section references to this review. ...
The Carroll Depression scale is a 21 item scale which asks
... and smoke from burning oil fields, have all been investigated inconclusively. Stress plays a likely role in the etiology of other multisymptom illnesses, such as irritable bowel syndrome (IBS), multiple chemical sensitivity and chronic headache (10 p. 73). It is likely that veterans of the current w ...
... and smoke from burning oil fields, have all been investigated inconclusively. Stress plays a likely role in the etiology of other multisymptom illnesses, such as irritable bowel syndrome (IBS), multiple chemical sensitivity and chronic headache (10 p. 73). It is likely that veterans of the current w ...
Cost-Effectiveness of Catheter Ablation Treatment for Patients with
... ness of breath due to the disturbed heart rhythm. Pulmonary vein isolation using radiofrequency catheter ablation (RFA) is aimed at maintaining sinus rhythm. Randomized clinical trials have shown that RFA is more effective than antiarrhythmic drug treatment (AAD) in maintaining sinus rhythm, but its ...
... ness of breath due to the disturbed heart rhythm. Pulmonary vein isolation using radiofrequency catheter ablation (RFA) is aimed at maintaining sinus rhythm. Randomized clinical trials have shown that RFA is more effective than antiarrhythmic drug treatment (AAD) in maintaining sinus rhythm, but its ...
FF Principal Investigator/Program Director (Last, first, middle): Orban
... hypoglycemia) is impaired, and therefore, hypoglycemia is a frequent complication of the disease. The occurrence of hypoglycemia limits the ability to achieve near normal glucose control. The Diabetes Control and Complications study (DCCT) showed that the long term complications could be reduced wit ...
... hypoglycemia) is impaired, and therefore, hypoglycemia is a frequent complication of the disease. The occurrence of hypoglycemia limits the ability to achieve near normal glucose control. The Diabetes Control and Complications study (DCCT) showed that the long term complications could be reduced wit ...
B (BLISTER)
... A randomised controlled trial to compare the safety and effectiveness of doxycycline (200 mg/day) with prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid ...
... A randomised controlled trial to compare the safety and effectiveness of doxycycline (200 mg/day) with prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid ...
AusPAR: Dulaglutide rch - Therapeutic Goods Administration
... hyperglycaemia which, if left untreated, can increase the risk of microvascular and macrovascular complications. For many years, there have been several classes of antihyperglycaemic agents available that target one or more of the pathophysiologic deficiencies associated with T2DM, including metform ...
... hyperglycaemia which, if left untreated, can increase the risk of microvascular and macrovascular complications. For many years, there have been several classes of antihyperglycaemic agents available that target one or more of the pathophysiologic deficiencies associated with T2DM, including metform ...
Combatting underarm odor by the means of microbial
... The structure of the skin (Figure 1) reflects the complexity of its functions as a protective barrier, in maintaining the body temperature, in gathering sensory information from the environment and in having an active role in the immune system (Nestle et al., 2009). The human skin forms the first co ...
... The structure of the skin (Figure 1) reflects the complexity of its functions as a protective barrier, in maintaining the body temperature, in gathering sensory information from the environment and in having an active role in the immune system (Nestle et al., 2009). The human skin forms the first co ...
The World Federation of Societies of Biological Psychiatry
... and appropriate statistical tests, fulfilment of good clinical practice (GCP) criteria, and approval by properly-constituted ethics committee. Unfortunately, abstracts of some recent key studies which have been presented as posters so far do not supply all these information. In these instances, addi ...
... and appropriate statistical tests, fulfilment of good clinical practice (GCP) criteria, and approval by properly-constituted ethics committee. Unfortunately, abstracts of some recent key studies which have been presented as posters so far do not supply all these information. In these instances, addi ...
Evidence-based clinical practice guideline on the nonsurgical
... to reflect changes in individual tooth attachment measurement experienced in the clinical setting but are statistical calculations used for comparison of overall performance of treatment options. Because we did not include baseline levels of disease in the assessment of mean change in CAL, the values ...
... to reflect changes in individual tooth attachment measurement experienced in the clinical setting but are statistical calculations used for comparison of overall performance of treatment options. Because we did not include baseline levels of disease in the assessment of mean change in CAL, the values ...
The World Federation of Societies of Biological Psychiatry (WFSBP)
... and appropriate statistical tests, fulfilment of good clinical practice (GCP) criteria, and approval by properly-constituted ethics committee. Unfortunately, abstracts of some recent key studies which have been presented as posters so far do not supply all these information. In these instances, addi ...
... and appropriate statistical tests, fulfilment of good clinical practice (GCP) criteria, and approval by properly-constituted ethics committee. Unfortunately, abstracts of some recent key studies which have been presented as posters so far do not supply all these information. In these instances, addi ...
Evening Primrose Oil - American Botanical Council
... In 22 clinical studies on evening primrose with a total of 1,154 participants, all but six demonstrated positive effects for indications including PMS, dermatological conditions, diabetic neuropathy, and arthritis. Seven double-blind, placebo-controlled (DB, PC) studies investigated the use of EPO i ...
... In 22 clinical studies on evening primrose with a total of 1,154 participants, all but six demonstrated positive effects for indications including PMS, dermatological conditions, diabetic neuropathy, and arthritis. Seven double-blind, placebo-controlled (DB, PC) studies investigated the use of EPO i ...
Terlipressin acetate - Therapeutic Goods Administration
... Powder for injection and diluent Two sites of manufacture are proposed for the powder for injection. The process is similar at both sites. The sterility aspects of the manufacture are controlled to the satisfaction of the Microbiology Section of OLSS (Office of Laboratories and Scientific Services). ...
... Powder for injection and diluent Two sites of manufacture are proposed for the powder for injection. The process is similar at both sites. The sterility aspects of the manufacture are controlled to the satisfaction of the Microbiology Section of OLSS (Office of Laboratories and Scientific Services). ...
Extract from the Clinical Evaluation Report for Bortezomib
... 2. Clinical rationale MCL is an uncommon type of B cell non Hodgkin Lymphoma (NHL) characterised by the t(11;14) chromosomal translocation and overexpression of cyclin D1. It accounts for 2-10% of all B-NHL and occurs most often in older people (median age at diagnosis 65 years). Although the diseas ...
... 2. Clinical rationale MCL is an uncommon type of B cell non Hodgkin Lymphoma (NHL) characterised by the t(11;14) chromosomal translocation and overexpression of cyclin D1. It accounts for 2-10% of all B-NHL and occurs most often in older people (median age at diagnosis 65 years). Although the diseas ...
Efficacy and safety of repeated use of ulipristal acetate in uterine
... analysis. However, if 3 consecutive days or less of the daily bleeding pattern were missing, the missing values were imputed with the greatest strength of bleeding immediately before or after the period of missing days. The results for binary end points (including the primary efficacy end point) for ...
... analysis. However, if 3 consecutive days or less of the daily bleeding pattern were missing, the missing values were imputed with the greatest strength of bleeding immediately before or after the period of missing days. The results for binary end points (including the primary efficacy end point) for ...
Efficacy and safety of repeated use of ulipristal acetate in uterine
... analysis. However, if 3 consecutive days or less of the daily bleeding pattern were missing, the missing values were imputed with the greatest strength of bleeding immediately before or after the period of missing days. The results for binary end points (including the primary efficacy end point) for ...
... analysis. However, if 3 consecutive days or less of the daily bleeding pattern were missing, the missing values were imputed with the greatest strength of bleeding immediately before or after the period of missing days. The results for binary end points (including the primary efficacy end point) for ...
Zhongzhou Ointment
... New Drug Application Materials (13th) Experiment & Literature Materials of General Pharmacology Research: In recent years, based on the medical research, it has been demonstrated that rosacea is a kind of human facial skin lesion and inflammation, which is caused by a high degree of demodex infectio ...
... New Drug Application Materials (13th) Experiment & Literature Materials of General Pharmacology Research: In recent years, based on the medical research, it has been demonstrated that rosacea is a kind of human facial skin lesion and inflammation, which is caused by a high degree of demodex infectio ...
Is Afrin - DigitalCommons@PCOM
... the CON AUC showed significant differences between the Oxymetazoline and placebo groups, P< 0.001 and P= 0.012 respectively.4 Watanabe et al5 is a randomized double-blind, placebo-controlled continuous study in which its data is capable of being converted into dichotomous format (see Table 4). The t ...
... the CON AUC showed significant differences between the Oxymetazoline and placebo groups, P< 0.001 and P= 0.012 respectively.4 Watanabe et al5 is a randomized double-blind, placebo-controlled continuous study in which its data is capable of being converted into dichotomous format (see Table 4). The t ...
Guideline on the Clinical Development of Products for Specific
... are mono-sensitised, the majority is sensitised to more than one allergen group and multiple sensitisations can occur at the high end of the spectrum. As a consequence it is difficult to include only mono-sensitised patients in specific immunotherapy studies. However, preferably patients with sensit ...
... are mono-sensitised, the majority is sensitised to more than one allergen group and multiple sensitisations can occur at the high end of the spectrum. As a consequence it is difficult to include only mono-sensitised patients in specific immunotherapy studies. However, preferably patients with sensit ...
Protocol Template
... State the secondary OBJECTIVE. The secondary is usually one of the other items listed above or may be research related, etc. ...
... State the secondary OBJECTIVE. The secondary is usually one of the other items listed above or may be research related, etc. ...
Treatment-refractory obsessive
... or a 25% increase in Y-BOCS from the patient’s YBOCS score during response) should guide the practitioner toward defining a relapse, a term that corresponds with the return of symptoms satisfying the full syndrome during a remission period (return of the symptoms on an ongoing but sub-clinical disor ...
... or a 25% increase in Y-BOCS from the patient’s YBOCS score during response) should guide the practitioner toward defining a relapse, a term that corresponds with the return of symptoms satisfying the full syndrome during a remission period (return of the symptoms on an ongoing but sub-clinical disor ...
GenF20 Plus Study | The #1 Rated HGH (Human Growth Hormone
... was statistically significant (p = 0.02) in GenF20 Plus group [22.69] as compared to the placebo group [-4.31]. The percentage increase of the same subgroup was 28.57% in GenF20 plus group and -0.55% in the placebo group with statistical significance (p=0.017). However in the subgroup (age<40), the ...
... was statistically significant (p = 0.02) in GenF20 Plus group [22.69] as compared to the placebo group [-4.31]. The percentage increase of the same subgroup was 28.57% in GenF20 plus group and -0.55% in the placebo group with statistical significance (p=0.017). However in the subgroup (age<40), the ...
Efficacy of daily and alternate-day dosing regimens with the
... effective candidate for long term maintenance (Ling et al., 1996), compares favorably to other full-agonist alternatives such as levomethadyl acetate hydrochloride (LAAM; Chutuape et al., 1999), and produces significant and substantial improvements over time in psychosocial functioning (Strain et al ...
... effective candidate for long term maintenance (Ling et al., 1996), compares favorably to other full-agonist alternatives such as levomethadyl acetate hydrochloride (LAAM; Chutuape et al., 1999), and produces significant and substantial improvements over time in psychosocial functioning (Strain et al ...
Review on clinical studies with cannabis and cannabinoids 2005-2009
... States, the United Kingdom and Mexico, nabilone is marketed as Cesamet®. It is registered for treatment of chemotherapy-induced nausea and vomiting that has not responded to conventional antiemetics. It is also used for other medical conditions. Sativex® (GW Pharmaceuticals, UK) is a cannabisbased p ...
... States, the United Kingdom and Mexico, nabilone is marketed as Cesamet®. It is registered for treatment of chemotherapy-induced nausea and vomiting that has not responded to conventional antiemetics. It is also used for other medical conditions. Sativex® (GW Pharmaceuticals, UK) is a cannabisbased p ...
... Chronic prostatitis (CP) is a disabling condition affecting an untold number of men of all ages and ethnic origins. As early as 1980, the National Ambulatory Care Survey reported 20 office visits/1,000 men/year for symptoms compatible with prostatitis(1). Although by one estimate, 50% of men will su ...
Placebo-controlled study
Placebo-controlled studies are a way of testing a medical therapy in which, in addition to a group of subjects that receives the treatment to be evaluated, a separate control group receives a sham ""placebo"" treatment which is specifically designed to have no real effect. Placebos are most commonly used in blinded trials, where subjects do not know whether they are receiving real or placebo treatment. Often, there is also a further ""natural history"" group that does not receive any treatment at all.The purpose of the placebo group is to account for the placebo effect, that is, effects from treatment that do not depend on the treatment itself. Such factors include knowing one is receiving a treatment, attention from health care professionals, and the expectations of a treatment's effectiveness by those running the research study. Without a placebo group to compare against, it is not possible to know whether the treatment itself had any effect.Patients frequently show improvement even when given a sham or ""fake"" treatment. Such intentionally inert placebo treatments can take many forms, such as a pill containing only sugar, a surgery where nothing efficacious is actually done (just an incision and sometimes some minor touching or handling of the underlying structures), or a medical device (such as an ultrasound machine) that is not actually turned on. Also, due to the body's natural healing ability and statistical effects such as regression to the mean, many patients will get better even when given no treatment at all. Thus, the relevant question when assessing a treatment is not ""does the treatment work?"" but ""does the treatment work better than a placebo treatment, or no treatment at all?"" As one early clinical trial researcher wrote, ""the first object of a therapeutic trial is to discover whether the patients who receive the treatment under investigation are cured more rapidly, more completely or more frequently, than they would have been without it.""p.195 More broadly, the aim of a clinical trial is to determine what treatments, delivered in what circumstances, to which patients, in what conditions, are the most effective.Therefore, the use of placebos is a standard control component of most clinical trials, which attempt to make some sort of quantitative assessment of the efficacy of medicinal drugs or treatments. Such a test or clinical trial is called a placebo-controlled study, and its control is of the negative type. A study whose control is a previously tested treatment, rather than no treatment, is called a positive-control study, because its control is of the positive type.Government regulatory agencies approve new drugs only after tests establish not only that patients respond to them, but also that their effect is greater than that of a placebo (by way of affecting more patients, by affecting responders more strongly, or both). As a result, ""placebo-controlled studies often are designed in such a way that disadvantages the placebo condition"".