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The GABAergic system in schizophrenia
The GABAergic system in schizophrenia

... results in excessive dopaminergic input into corticolimbic regions (also see Carlsson et al., 2001) with resultant further hypofunctioning of the glutamatergic system through feedback mechanisms. Several classes of compounds, including benzodiazepines (BZD), muscurinic receptor antagonist and halope ...
unit cover page - Bremen High School District 228
unit cover page - Bremen High School District 228

... individuals receive half of their genetic information from each parent; in cases in which two or more forms of the gene exist, some may be dominant and others are recessive. alleles for different genes segregate independently of each other. not all traits are inherited in a dominant/recessive patter ...
Dopamine in Schizophrenia
Dopamine in Schizophrenia

... Joyce et al. 1988, 1997). In any event, it should be evident that elevation/upregulation of D2 receptors is not indicative of higher DA activity but rather would be in agreement with DA hypoactivity (Grace 1991; Csernansky et al. ...
Molecular Genetics of Bipolar Disorder and Related Traits
Molecular Genetics of Bipolar Disorder and Related Traits

... worldwide population, and it seems to be equally frequent in both sexes and all ethnicities (1). Epidemiological studies, such as family, twin and adoption studies together with genome-wide scans and targeted DNA-studies indicate strong genetic predisposition in bipolar disorder. A strong genetic co ...
The Genetic Basis of Lateralization
The Genetic Basis of Lateralization

... females than males, and also under-reporting of left-handedness in mothers by righthanded children. Monozygotic (MZ) twins discordant for handedness have led to doubts about genetic influence but these doubts are misplaced if random asymmetry affects every individual, twin and singleborn. The simila ...
Mendel`s Principles of Heredity
Mendel`s Principles of Heredity

... • Artificial selection has been an important practice since before recorded history. ...
Dopaminergic and Glutamatergic Dysfunctions
Dopaminergic and Glutamatergic Dysfunctions

... unlikely to account for the majority of cases of schizophrenia. Instead, most of them are likely to be susceptibilities [64, 84, 85]. Of the ones that have been identified, some have already been tied to altered dopamine transmission, but the functional relevance of most of them to dopamine function ...
Introduction - Trimbos
Introduction - Trimbos

... Heritable traits that reflect the actions of genes predisposing an individual to a disorder ...
Anesthesia and Cognitive Performance in Children: No Evidence for
Anesthesia and Cognitive Performance in Children: No Evidence for

... The twin pairs for this study were born between 1986 and 1995. Of the total sample of 4142 twin-families with data on anesthesia and either educational achievement and/or cognitive problems, 1569 were families with a MZ twin pair (677 MZ male or MZM and 892 MZ female or MZF). Data from 25 families w ...
Smooth Pursuit Impairment in Schizophrenia— What Does It Mean?
Smooth Pursuit Impairment in Schizophrenia— What Does It Mean?

... manipulations, such as giving patients cigarettes or money for good performance, are similarly ineffective in improving tracking (May 1979). The findings that saccadic eye movements of schizophrenic patients are normal, and particularly saccadic reaction times, further weaken the proposition that ET ...
AA - Virginia Institute for Psychiatric and Behavioral Genetics
AA - Virginia Institute for Psychiatric and Behavioral Genetics

... genetic material ...
Meiosis - Aurora City Schools
Meiosis - Aurora City Schools

... this cat? What would it look like? What would the number of chromatids be in a cell in telophase 2 of meiosis in this cat? What would it look like? ...
Genetics, Genetics, and More Genetics
Genetics, Genetics, and More Genetics

... 2. Students will identify, analyze and predict traits caused by various modes of inheritance. 3. Students will predict the genotype and phenotype of P1 and F1 generations using Punnett squares. 4. Students will construct both a monohybrid and a dihybrid cross and interpret results . Prior Knowledge ...
Pedigrees
Pedigrees

... family over several generations.  Scientists or a genetic counselor would find out about your family history and make a pedigree chart to analyze and provide advice. ...
Oxidative stress-driven parvalbumin interneuron impairment as a
Oxidative stress-driven parvalbumin interneuron impairment as a

... synchronization. Their activity supports critical developmental trajectories, sensory and cognitive processing, and social behavior. Despite heterogeneity in the etiology across schizophrenia and autism spectrum disorder, PVI circuits are altered in these psychiatric disorders. Identifying mechanism ...
Genetic testing: What is your view?
Genetic testing: What is your view?

... • The antenatal screening programme identified a pregnancy where the fetus had multiple anomalies caused by a chromosomal imbalance. The otherwise healthy father was found to be a carrier of the chromosome rearrangement. The geneticist offered to test his relatives' chromosomes to see if they might ...
Comprehension Questions
Comprehension Questions

... biological parents of schizophrenic adoptees are far more likely to be schizophrenic than genetically unrelated individuals (the adoptive parents), despite the fact that the schizophrenic adoptees share the same environment as the adoptive parents. If environmental variables (such as chemicals in th ...
Aberrant Localization of Synchronous Hemodynamic
Aberrant Localization of Synchronous Hemodynamic

... by Leopold et al (2003) in monkey visual cortex suggests that these fMRI signals might be related to low-frequency fluctuations in local field potential. Recently, methods based on independent component analysis (ICA) have been applied to measure functional connectivity; they have the advantage of n ...
Dysregulation of Arousal and Amygdala
Dysregulation of Arousal and Amygdala

... men and eight women) took part. Diagnoses of schizophrenia were based on the Composite International Diagnostic Interview (22) and consensus by three psychiatrists (two independent from the study), according to DSM-IV criteria. Exclusion criteria for both groups were left-handedness, neurological di ...
genetics genetics - Cystic Fibrosis Association of New Zealand
genetics genetics - Cystic Fibrosis Association of New Zealand

... help clear the mucus from the lungs, antibiotics to fight infection, and enzyme supplements with food to help digestion. Although new treatments are being developed, which will undoubtedly improve the quality and length of life for people with CF, the condition remains serious. There is no cure at p ...
What is known about interactions between genes and the
What is known about interactions between genes and the

... influences of – and interplay between – nature and nurture for human development. Notably, findings from behaviour genetic research using twin and adoption designs have highlighted the prevalent role of genes in explanations of individual differences and provided an impetus to identify the relevant ...
Transdisciplinary Imaging Genetics Center
Transdisciplinary Imaging Genetics Center

... Subtle differences in structure and function; Must involve brain circuitry Challenges: Behavior and performance, cause and effect, medication, structure and/or function Genetic background influences brain development, function, and structure in both specific and non specific ways ...
Pedigrees - Newark City Schools
Pedigrees - Newark City Schools

...  Pedigrees are family trees that explain your genetic history.  Pedigrees are used to find out the probability of a child having a disorder in a particular family.  To begin to interpret a pedigree, determine if the disease or condition is autosomal or Xlinked and dominant or recessive. ...
Pedigree Charts
Pedigree Charts

... ♣ A pedigree is a chart of the genetic history of family over several generations. ♣ Scientists or a genetic counselor would find out about your family history and make this chart to analyze. ...
What is known about interactions between genes and the
What is known about interactions between genes and the

... influences of – and interplay between – nature and nurture for human development. Notably, findings from behaviour genetic research using twin and adoption designs have highlighted the prevalent role of genes in explanations of individual differences and provided an impetus to identify the relevant ...
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Irving Gottesman

Irving Isadore Gottesman (born December 29, 1930) is a professor of psychology who has devoted most of his career to the study of the genetics of schizophrenia. He has written 17 books and more than 290 other publications, mostly on schizophrenia and behavioral genetics, and created the first academic program on behavioral genetics in the United States. He has won awards such as the Hofheimer Prize for Research, the highest award from the American Psychiatric Association for psychiatric research. Gottesman is a professor in the psychology department at the University of Minnesota, where he received his Ph.D.A native of Ohio, Gottesman studied psychology for his undergraduate and graduate degrees, became a faculty member at various universities, and spent most of his career at the University of Virginia and the University of Minnesota. He is known for researching schizophrenia in identical twins to document the contributions of genetics and the family, social, cultural, and economic environment to the onset, progress, and inter-generational transmission of the disorder. Gottesman has worked with researchers to analyze hospital records and conduct follow-up interviews of twins where one or both were schizophrenic. He has also researched the effects of genetics and the environment on human violence and variations in human intelligence. Gottesman and co-researcher James Shields introduced the word epigenetics—the control of genes by biochemical signals modified by the environment from other parts of the genome—to the field of psychiatric genetics.Gottesman has written and co-written a series of books which summarize his work. These publications include raw data from various studies, their statistical interpretation, and possible conclusions presented with necessary background material. The books also include first-hand accounts of schizophrenic patients and relatives tending to them, giving an insight into jumbled thoughts, the disorder's primary symptom. Gottesman and Shields have built models to explain the cause, transmission, and progression of the disorder, which is controlled by many genes acting in concert with the environment, with no cause sufficient by itself.
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