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Identifying Mutations Responsible for Rare Disorders Using New
Identifying Mutations Responsible for Rare Disorders Using New

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... In some cases, a dominant allele at one locus may if function of either of these genes is lost in a homozymask the phenotype of a second locus. This produces gous mutant (e.g. in either a/a;B/- or A/-;b/b). Only a segregation ratio of 12:3:1, which can be viewed as the doubly recessive mutant (a/a;b ...
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... 1. A gene is a section of DNA, with many bases that code for a protein. This results in a trait. 2. Traits are controlled by genes. Genes are found on chromosomes and have a genetic code for a protein. The position of the gene on the chromosome is called the locus. 3. Different versions of a gene fo ...
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Epistasis



Epistasis is a phenomenon that consists of the effect of one gene being dependent on the presence of one or more 'modifier genes' (genetic background). Similarly, epistatic mutations have different effects in combination than individually. It was originally a concept from genetics but is now used in biochemistry, population genetics, computational biology and evolutionary biology. It arises due to interactions, either between genes, or within them leading to non-additive effects. Epistasis has a large influence on the shape of evolutionary landscapes which leads to profound consequences for evolution and evolvability of traits.
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