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Developing a New View of Evolution
Developing a New View of Evolution

... The approach is starting to pay off. Scientists had already discovered that many of the genes that shape development are similar in animals from fruit flies to people, implying previously unsuspected connections between groups of organisms. Now, they are realizing how these genes may be put to use i ...
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12885_2015_1934_MOESM1_ESM

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Kevin Ann Hunt Term paper

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Lesson 13: Polygenic Inheritance Lecture unit3Lesson13
Lesson 13: Polygenic Inheritance Lecture unit3Lesson13

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... variable genes), Spearman rank correlations were computed between the copy number ratios for 88 genes and 600 phenotypes. Because the phenotypes are highly correlated, and the number of individuals was too small to have statistical power, we explored this data using cluster analysis, rather than sim ...
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Epistasis



Epistasis is a phenomenon that consists of the effect of one gene being dependent on the presence of one or more 'modifier genes' (genetic background). Similarly, epistatic mutations have different effects in combination than individually. It was originally a concept from genetics but is now used in biochemistry, population genetics, computational biology and evolutionary biology. It arises due to interactions, either between genes, or within them leading to non-additive effects. Epistasis has a large influence on the shape of evolutionary landscapes which leads to profound consequences for evolution and evolvability of traits.
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