the contribution of gene movement to the two rules of speciation
... contribute to hybrid dysfunction and the Large X-effect depends upon the specific mechanism of gene movement and on details of developmental and reproductive biology of the X. We briefly introduce these mechanisms below, returning to the evidence for each in the next section. There are three mechani ...
... contribute to hybrid dysfunction and the Large X-effect depends upon the specific mechanism of gene movement and on details of developmental and reproductive biology of the X. We briefly introduce these mechanisms below, returning to the evidence for each in the next section. There are three mechani ...
Compound heterozygosity of novel missense
... Mutations associated with hereditary combined VKD coagulation factor deficiency are rare. The carboxylase is encoded by a single gene,29 and only 3 naturally occurring missense mutations have previously been identified: Leu394Arg,10 which is impaired in both Glu binding and propeptide binding,30 Trp ...
... Mutations associated with hereditary combined VKD coagulation factor deficiency are rare. The carboxylase is encoded by a single gene,29 and only 3 naturally occurring missense mutations have previously been identified: Leu394Arg,10 which is impaired in both Glu binding and propeptide binding,30 Trp ...
INTEGRATING MULTIPLE EVOLUTIONARY
... adapted to a benign captive environment were exposed to a more competitive, crowded ...
... adapted to a benign captive environment were exposed to a more competitive, crowded ...
Evolution at the Subgene Level: Domain Rearrangements in
... are available, they tend to keep functional domains as a single unit. • We develop a model for gene evolution that captures architecture rearrangements, which we define as module generation, duplication, loss, merge (fusion), and split (fission) events (fig. 1D ). In contrast to many previous phylog ...
... are available, they tend to keep functional domains as a single unit. • We develop a model for gene evolution that captures architecture rearrangements, which we define as module generation, duplication, loss, merge (fusion), and split (fission) events (fig. 1D ). In contrast to many previous phylog ...
Control of the acetamidase gene of Mycobacterium smegmatis by
... Much interest has been focussed on this system for its potential use in mycobacterial genetic studies. The availability of an inducible promoter which functions well in mycobacteria including the important human pathogen Mycobacterium tuberculosis would be extremely useful. The acetamidase system ha ...
... Much interest has been focussed on this system for its potential use in mycobacterial genetic studies. The availability of an inducible promoter which functions well in mycobacteria including the important human pathogen Mycobacterium tuberculosis would be extremely useful. The acetamidase system ha ...
Acriflavine -resistant Mutants of Aspergillus nidulans
... Various mutant types have been used in genetic investigations with Aspergillus nidulans. Such types include those differing from wild type in conidial colour, colony morphology, nutritional requirements and ability to secrete certain enzymes (Pontecorvo, 1953). The present paper reports the extensio ...
... Various mutant types have been used in genetic investigations with Aspergillus nidulans. Such types include those differing from wild type in conidial colour, colony morphology, nutritional requirements and ability to secrete certain enzymes (Pontecorvo, 1953). The present paper reports the extensio ...
AnsteadSeniorHonorsThesis
... markers affecting adult and larval morphology; and having recessive mutations that cause lethality or reduced fertility in heterozygotes (Casso, D. 1999). These properties allow for the maintenance and stability of populations of mutants as balanced heterozygotes. A genetic screen can be performed m ...
... markers affecting adult and larval morphology; and having recessive mutations that cause lethality or reduced fertility in heterozygotes (Casso, D. 1999). These properties allow for the maintenance and stability of populations of mutants as balanced heterozygotes. A genetic screen can be performed m ...
Unit 4 - Purdue Agriculture
... inheritance in pea plants. He observed that many traits, from height to flower color, seemed to be controlled by these factors. In 1903, researcher William Sutton made the connection between Mendels factors and chromosomesmicroscopic structures in the cell nucleus that carry genetic material. The ...
... inheritance in pea plants. He observed that many traits, from height to flower color, seemed to be controlled by these factors. In 1903, researcher William Sutton made the connection between Mendels factors and chromosomesmicroscopic structures in the cell nucleus that carry genetic material. The ...
lecture 02 - selection on the gene, genome, trait and phenotype
... Alleles or allele combinations, and the traits they produce, determine fitness of an individual: # of offspring that survive to reproduce - if you live forever but produce no offspring, your fitness = 0 Allele combinations resulting in higher fitness are passed to more offspring, and thus those alle ...
... Alleles or allele combinations, and the traits they produce, determine fitness of an individual: # of offspring that survive to reproduce - if you live forever but produce no offspring, your fitness = 0 Allele combinations resulting in higher fitness are passed to more offspring, and thus those alle ...
A genetic screen in zebrafish identifies the mutants
... The hepatomegaly screen Our laboratory has used viral insertional mutagenesis to generate a collection of over 400 zebrafish lines that are mutated in 315 recessive embryonic lethal genes. The gene bearing the mutagenic insert has been cloned for each line and we estimate that we have achieved ~22% ...
... The hepatomegaly screen Our laboratory has used viral insertional mutagenesis to generate a collection of over 400 zebrafish lines that are mutated in 315 recessive embryonic lethal genes. The gene bearing the mutagenic insert has been cloned for each line and we estimate that we have achieved ~22% ...
Divinyl Chlorophyll(ide) a Can Be Converted to Monovinyl
... the green sulfur bacterium Chlorobium tepidum TLS. They also considered that BchJ, which had been reported to be a vinyl reductase (Suzuki and Bauer, 1995), is not the enzyme, but it may play an important role in substrate channeling and/or regulation of bacteriochlorophyll biosynthesis. Islam et al ...
... the green sulfur bacterium Chlorobium tepidum TLS. They also considered that BchJ, which had been reported to be a vinyl reductase (Suzuki and Bauer, 1995), is not the enzyme, but it may play an important role in substrate channeling and/or regulation of bacteriochlorophyll biosynthesis. Islam et al ...
Familial Malignant Melanoma Approved by the Cancer.Net Editorial
... forming a mass called a tumor. Overall, about 8% of people newly diagnosed with melanoma have a first-degree relative with melanoma. A much smaller percentage, about 1% to 2%, has two or more close relatives with melanoma. Dysplastic nevi are large, flat, irregular, asymmetric, variably pigmented mo ...
... forming a mass called a tumor. Overall, about 8% of people newly diagnosed with melanoma have a first-degree relative with melanoma. A much smaller percentage, about 1% to 2%, has two or more close relatives with melanoma. Dysplastic nevi are large, flat, irregular, asymmetric, variably pigmented mo ...
Genetic mapping and manipulation: Chapter 2-Two
... chromosome (0.5 × 0.5 = 0.25). The overall percentage of animals with an Unc phenotype will therefore be 4.5 + 20.25 = 24.75%. Finally, the percentage of Unc animals with a ste unc/unc genotype will be 4.5/24.75 = 18.2%. The above determination tells us that if our mutation and marker(s) are 10.0 ma ...
... chromosome (0.5 × 0.5 = 0.25). The overall percentage of animals with an Unc phenotype will therefore be 4.5 + 20.25 = 24.75%. Finally, the percentage of Unc animals with a ste unc/unc genotype will be 4.5/24.75 = 18.2%. The above determination tells us that if our mutation and marker(s) are 10.0 ma ...
The ara Operon - University of Pennsylvania
... This model assumes that two molecules of AraC are always joined together as a dimer. Further, this dimer can exist in two different states: active (P1) and inactive (P2). When arabinose is absent, AraC dimer is in the P1 state but when arabinose is present, it can react with AraC and change its conf ...
... This model assumes that two molecules of AraC are always joined together as a dimer. Further, this dimer can exist in two different states: active (P1) and inactive (P2). When arabinose is absent, AraC dimer is in the P1 state but when arabinose is present, it can react with AraC and change its conf ...
Cys mutation of fibroblast growth factor receptor 3 in mouse
... Figure 5. Effect of bFGF on the growth in culture of metatarsal bones isolated from E17.5 wild-type mice. (A–D) Bones before and after culture for 3 days in the absence (A and B) or presence (C and D) of bFGF (10 ng/ml), respectively. The dark area corresponds to the zone of mineralized hypertrophic ...
... Figure 5. Effect of bFGF on the growth in culture of metatarsal bones isolated from E17.5 wild-type mice. (A–D) Bones before and after culture for 3 days in the absence (A and B) or presence (C and D) of bFGF (10 ng/ml), respectively. The dark area corresponds to the zone of mineralized hypertrophic ...
i A Thesis Entitled A Visual Screen for Centriolar Mutants in
... needle-shaped at maturity (Fabian and Brill, 2012). Alongside nuclear morphogenesis, the mitochondria similarly change from an initial round shape to an elongated needle shape at maturity. Around the onset of nuclear and mitochondrial morphogenesis, the centriole migrates from the plasma membrane pu ...
... needle-shaped at maturity (Fabian and Brill, 2012). Alongside nuclear morphogenesis, the mitochondria similarly change from an initial round shape to an elongated needle shape at maturity. Around the onset of nuclear and mitochondrial morphogenesis, the centriole migrates from the plasma membrane pu ...
e-GRASP: an integrated evolutionary and GRASP
... with discovering genetic variation linked to phenotypic traits and diseases. Both discrete and continuous traits can be analyzed in GWAS to discover associations between single nucleotide polymorphisms (SNPs) and traits of interest. Associations are typically determined by estimating the significanc ...
... with discovering genetic variation linked to phenotypic traits and diseases. Both discrete and continuous traits can be analyzed in GWAS to discover associations between single nucleotide polymorphisms (SNPs) and traits of interest. Associations are typically determined by estimating the significanc ...
1999 paper
... (self-adaptation). Angeline's framework considers an EA as a whole, without dividing attention to its di erent components (e.g., mutation, recombination, selection, etc). The classication proposed by Hinterding, Michalewicz, and Eiben 65] extends that of 2] by considering an additional level of a ...
... (self-adaptation). Angeline's framework considers an EA as a whole, without dividing attention to its di erent components (e.g., mutation, recombination, selection, etc). The classication proposed by Hinterding, Michalewicz, and Eiben 65] extends that of 2] by considering an additional level of a ...
Title Changes in the Concept of "Fitness" in Evolutionary Biology
... influenced by social factors as Hull describes. Moreover, scientists might have "social" problems and strategies to solve them along with empirical and conceptual ones. Sometimes such social strategies may give us more plausible hypotheses about the methods scientists used. In such cases, Darden's a ...
... influenced by social factors as Hull describes. Moreover, scientists might have "social" problems and strategies to solve them along with empirical and conceptual ones. Sometimes such social strategies may give us more plausible hypotheses about the methods scientists used. In such cases, Darden's a ...
PDF + SI - Biology Open - The Company of Biologists
... conclude that Htt is dominant and 100% penetrant. Further crosses were performed with the wild-type strain of PS312 to prevent any effects caused by loci linked to the pdl-1 allele. Five independent crosses were performed with hermaphrodites of the wild-type strain PS312 and males of the Htt strain ...
... conclude that Htt is dominant and 100% penetrant. Further crosses were performed with the wild-type strain of PS312 to prevent any effects caused by loci linked to the pdl-1 allele. Five independent crosses were performed with hermaphrodites of the wild-type strain PS312 and males of the Htt strain ...
Epistasis
Epistasis is a phenomenon that consists of the effect of one gene being dependent on the presence of one or more 'modifier genes' (genetic background). Similarly, epistatic mutations have different effects in combination than individually. It was originally a concept from genetics but is now used in biochemistry, population genetics, computational biology and evolutionary biology. It arises due to interactions, either between genes, or within them leading to non-additive effects. Epistasis has a large influence on the shape of evolutionary landscapes which leads to profound consequences for evolution and evolvability of traits.