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Molecular Evolution of Two Linked Genes, Est-6 and Sod, in
Molecular Evolution of Two Linked Genes, Est-6 and Sod, in

... similar synonymous variability in these coding regions. In the intron and 3’-flanking regions of lb, divergence between D. melanogaster and D. simulans or D. sechellia was less than half that between D. melanogaster and D. yakuba. In the coding region divergence between species was less pronounced, ...
Dissecting Gene Expression Changes Accompanying a Ploidy
Dissecting Gene Expression Changes Accompanying a Ploidy

... We previously isolated several disomic derivatives of the strain F45, including one harboring an extra copy of chromosome XV and another harboring an extra copy of chromosome XVI (TAN et al. 2013). Because these disomies arose by mitotic missegregation, the two copies of the disomic chromosomes are ...
Investigation 1: Identify the Transcriptional Unit
Investigation 1: Identify the Transcriptional Unit

... tracks and then click on the “go” button. As you learned in the previous module, you can also use the buttons in the navigation controls section to zoom in, zoom out, and use the arrows to move to different parts of the contig. In addition, you can place your cursor on the "Scale" or the "Base Posit ...
Ensembl Compara Perl API
Ensembl Compara Perl API

... foreach my $this_synteny_region (@$synteny_regions) { my $these_dnafrag_regions = $this_synteny_region->get_all_DnaFragRegions(); ...
The 2013 Thomas Hunt Morgan Medal Thomas Douglas
The 2013 Thomas Hunt Morgan Medal Thomas Douglas

... Following a productive postdoctorate with Botstein, Tom began his independent career in 1977 as an assistant professor in the Department of Microbiology at the University of Chicago. He spent 12 very productive years at the University of Chicago, rapidly rising to the rank of full professor. During ...
Chapter 6: Cancer - Mendelian and Quantitative Genetics
Chapter 6: Cancer - Mendelian and Quantitative Genetics

... Copyright © 2010 Pearson Education, Inc. ...
Embryo Genome Profiling by Single-Cell
Embryo Genome Profiling by Single-Cell

... Traditionally, multiplex PCR has been used to detect the pathogenic variants of an embryo with short tandem repeat markers in close proximity to the causative gene as a diagnosis backup. With the introduction of whole-genome amplification (WGA) to amplify the biopsied embryonic single cell, the comp ...
Genome-Wide Gene Expression Effects of Sex Chromosome
Genome-Wide Gene Expression Effects of Sex Chromosome

... and histone modifications established during oogenesis and spermatogenesis (Sha 2008). In mammals, gynogenetic offspring are inviable (McGrath and Solter 1984; Thomson and Solter 1988), indicating that a balanced contribution of chromosomes of paternal and maternal origin is required for development ...
Structure, expression differentiation and evolution of duplicated fiber
Structure, expression differentiation and evolution of duplicated fiber

Walk-thru of CAGE exercise
Walk-thru of CAGE exercise

... – Etc What if we want to compare two experiments? ...
Chromosome Theory of Inheritance -States that genes or alleles
Chromosome Theory of Inheritance -States that genes or alleles

... -Down Syndrome: Aneuploid condition also known as trisomy 21, three copies of chromosome 21 -Turner Syndrome: Monosomic condition where females have one sex chromosome x. Are females but sterile. Is the only monosomic condition in humans -Klinefelter Syndrome: Aneuploid condition in which a male pos ...
Article Purifying Selection Maintains Dosage
Article Purifying Selection Maintains Dosage

... 2004). However, it remains unknown whether there are evolutionary strata correlated with the chromosomal rearrangements that have occurred on the Y chromosome. Similar to other young sex chromosome systems, female-biased expression ratios across the sex chromosomes suggest that there are incomplete ...
CRISPR: The Last Piece of the Genetic Puzzle
CRISPR: The Last Piece of the Genetic Puzzle

... What are CRISPR and Cas9? In 1987, researchers studying the bacteria E. coli noticed short repeated segments in the bacteria’s DNA. The repeated segments were grouped near each other on the bacteria’s chromosome separated by unique DNA sequences called spacers.2 This group of repeated segments and s ...
module 2: transcription part i
module 2: transcription part i

... tracks and then click on the “go” button. As you learned in the previous module, you can also use the buttons in the navigation controls section to zoom in, zoom out, and use the arrows to move to different parts of the contig. In addition, you can place your cursor on the "Scale" or the "Base Posit ...
Transposons ※ Transposons are DNA elements that can hop, or
Transposons ※ Transposons are DNA elements that can hop, or

... place in DNA to another. They are also called “jumping genes”. They carry the enzyme, transposase responsible for transposition, the movement by a transposon. ※ They are discovered by Barbara McClintock in the early 1950s. ※ The transposons now exist in all organisms on the earth, including human. ※ ...
Differential Regulation of Antagonistic Pleiotropy in Synthetic and
Differential Regulation of Antagonistic Pleiotropy in Synthetic and

... The existence of such trade-offs in multiple phenotypes results in a paradigm where no single ...
The faster-X effect: integrating theory and data
The faster-X effect: integrating theory and data

... mutations and the nature of genetic variation acted upon by natural selection. We also identify several aspects of disagreement between these empirical results and the population genetic models used to interpret them. However, there are clearly delineated aspects of the problem for which additional ...
sets of metaphors in multilevel cognitive models
sets of metaphors in multilevel cognitive models

... metaphorization (Sedov, 2000). These analogies are much deeper than the shallow similarities: as all the living beings as many of human-made creations, and also our thought and mind itself, are shown to be the self-referential informational systems with digital-analogic duality and interactions (Ho ...
Chapter 7
Chapter 7

... • When glucose levels increase, CAP detaches from the lac operon, and transcription returns to a normal rate • CAP helps regulate other operons that encode enzymes used in catabolic pathways ...
INTRODUCTOR Y BIOTECHNOLOGY (ABG 504) THEORETICAL MODULE  BY
INTRODUCTOR Y BIOTECHNOLOGY (ABG 504) THEORETICAL MODULE BY

... inheritance. In 1928, Frederick Griffith discovered the phenomenon of transformation in which he reported that dead bacteria could transfer genetic material to "transform" other still-living bacteria. Sixteen years later, in 1944, Oswald Theodore Avery, Colin M cLeod and M aclyn M cCarty identified ...
12859_2006_1447_MOESM4_ESM
12859_2006_1447_MOESM4_ESM

... The Xpro (http://origin.bic.nus.edu.sg/xpro/ ) database contains all eukaryotic proteinencoding DNA sequences contained in GenBank that have associated structural features listed in their records [12]. Xpro validates intron positions by re-alignment of a record’s sequence and EST sequences found in ...
Genetic Algorithms and the Evolution of Neural Networks for
Genetic Algorithms and the Evolution of Neural Networks for

... Figure 2: Input layer presentation of boy (not all input nodes are shown). The language used in this research is composed of ten nouns: boy, girl, john, mary, horse, duck, car, boat, park, river. Available semantic nodes are: human, animal, or mechanical (three mutually exclusive nodes); animate or ...
characters found in indica xjaponica
characters found in indica xjaponica

... controlling biochemical and morphological traits. The nature of associations between twelve alleles and phenotypes was studied in both a sample of varieties and hybrid populations derived from a single indica x japonica cross. Many of the associations found in varieties were not found in the F2 popu ...
The Arabidopsis RAD51 paralogs RAD51B, RAD51D and XRCC2
The Arabidopsis RAD51 paralogs RAD51B, RAD51D and XRCC2

... Three-week-old young plants grown without or with DNA damaging agent at a concentration of 23.5 lg ml 1 (in the same manner as for the phenotypic analyses) were collected and quickly frozen in liquid nitrogen. Total RNA was extracted using an RNeasy Plant Kit (Qiagen, Valencia, CA, USA) and its conc ...
Digenic inheritance in medical genetics
Digenic inheritance in medical genetics

... studies on genetics, the term ‘epistatis’ was used by some to describe some forms of digenic inheritance,1 but in recent decades ‘epistasis’ has been used to describe a much broader category of locus– locus interactions in polygenic diseases, including but not limited to interactions of loci identifi ...
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Minimal genome

The concept of minimal genome assumes that genomes can be reduced to a bare minimum, given that they contain many non-essential genes of limited or situational importance to the organism. Therefore, if a collection of all the essential genes were put together, a minimum genome could be created artificially in a stable environment. By adding more genes, the creation of an organism of desired properties is possible. The concept of minimal genome arose from the observations that many genes do not appear to be necessary for survival. In order to create a new organism a scientist must determine the minimal set of genes required for metabolism and replication. This can be achieved by experimental and computational analysis of the biochemical pathways needed to carry out basic metabolism and reproduction. A good model for a minimal genome is Mycoplasma genitalium, the organism with the smallest known genome. Most genes that are used by this organism are usually considered essential for survival; based on this concept a minimal set of 256 genes has been proposed.
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