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Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12.
Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12.

... The analyzed family sample consisted of 573 interviewed and genotyped subjects ascertained through 65 BPI probands. Among the 508 relatives, 64 were diagnosed with BPI, 97 with BPII, 69 with RUP, and seven with SAM. The mean age of onset for the BPI subjects (including probands) was 21.6711.9 years, ...
Probable presence of an ubiquitous cryptic mitochondrial gene on
Probable presence of an ubiquitous cryptic mitochondrial gene on

... forming cloverleaf secondary structures, which suggests activity in protein synthesis [24]. For example, the usage frequencies of amino acid cognates in regular primate mitochondrial ORFs coevolve with various antisense tRNA properties that are required for proper activity in translation [24]. These ...
DNA
DNA

... information located on the chromosomes and consisting of DNA. • Genotype: The genetic makeup of an organism • Phenotype: the physical expressed traits of an organism • Nucleic acids: Biological molecules (RNA and DNA) that allow organisms to reproduce ...
Nadal_et_al_final
Nadal_et_al_final

... of diacetyl/acetoin, resulting in increased diacetyl formation [2]. In an attempt to ...
understanding heredity
understanding heredity

... facts easily accessible to the beginner, perrhitting him to see the great outlines of our science not blurred by unending details. The best success this little book could lilttain would be to make its student desirous of attacking one of the more advanced treatises. At the present time there is not ...
C. neoformans
C. neoformans

... C. elegans can utilize the non-pathogenic yeasts C. laurentii and C. kuetzingii as a sole source of food The human pathogenic yeast C. neoformans kills C. elegans Several C. neoformans genes, previously shown to be involved in mammalian virulence, also play a role in C. elegans killing The nematode ...
Polygenes and Modifier Genes for Tetracycline and
Polygenes and Modifier Genes for Tetracycline and

... As a result of transformation experiments using SDS-extracted DNA, three phenotypic classes of Pen-resistant transformants were observed by Maier et al. (19756). The representative strains 4B10, 7P16 and MP81 are listed in Table 1. Identical transformants were also obtained when phenol-extracted DNA ...
Plant speciation through chromosome instability and ploidy change
Plant speciation through chromosome instability and ploidy change

... Flowering plants (angiosperms) show a high level of biodiversity, comprising an estimated number of 352,000 species subdivided in 14,559 genera and 405 families [1]. From an evolutionary perspective, this high level of variability indicates that plants have undergone extensive diversification and ada ...
Full-Text PDF
Full-Text PDF

... E. coli, which is one of the main community-acquired human pathogen. As carbapenems are the last resort for a number of multidrug resistant Gram-negative bacteria [7], a major cause of nosocomial and community bacterial infections, new methods are needed to maintain and extend the useful working lif ...
Read here - Protect the White Deer
Read here - Protect the White Deer

... harmful or defective. A 2010 outdoorlife.com reader ("bigshed") makes the point: "I like all the discussion about the recessive genes being inferior. I have been telling people for years we need to eliminate left-handed people to help improve our species. This also goes for baldness and color blindn ...
marker assisted selection in disease resistance breeding
marker assisted selection in disease resistance breeding

... response by affecting efficiency and accuracy of selection. Even though marker-assisted selection now plays a prominent role in the field of plant breeding, examples of successful, practical outcomes are rare. MAS, with few exceptions, has not yet delivered its expected benefits in commercial breedi ...
Wisconsin`s White Deer: Separating Science and Myth by MaLenna
Wisconsin`s White Deer: Separating Science and Myth by MaLenna

... years and can tell anyone that they live long and healthy lives, and the does we have observed have had healthy fawns at 8 and 9 years of age..." A "New York Antler Outdoors" writer comments: “The albino deer, other than their color difference, are in every other way the same as regular colored deer ...
Genetics
Genetics

... II. Spinach Association analysis and SNP markers for leaf traits in spinach Association analysis and SNP markers for mineral components in spinach SNP discovery and genetic diversity in spinach SSR discovery and genetic diversity in spinach Slowing-booting and QTL mapping in spinach QTL mapping and ...
Stage- and Tissue-Specific Expression of Ethylene Receptor
Stage- and Tissue-Specific Expression of Ethylene Receptor

... ETR1 and ERS1 are expressed ubiquitously in Arabidopsis plants, but each gene has its particular expression pattern in each tissue (Hua et al., 1998). Three genes in tomato are also differentially regulated throughout plant development (Lashbrook et al., 1998). The expression of ERS1 (Hua et al., 19 ...


... frei von jeder Hypothese”--“the word ‘gene’ is completely free from every hypothesis !” It was this completely non-committal quality of JOHANNSEN’S proposed terms that impressed me, since they harmonized with the complete openmindedness that I have always considered essential in scientific research. ...
Finding New Clock Components: Past and Future
Finding New Clock Components: Past and Future

... impossible,” when told of Konopka’s results. Benzer’s reply: “But Max, you don’t understand. They’ve already been found” (Greenspan, 1990). Much has changed since the golden age of phage genetics, but much has also stayed the same. Thirty-three years later, we have dozens of examples of single genes ...
Genome Biology - Department of Computer Science and
Genome Biology - Department of Computer Science and

... regions from ChIP-chip experiments [23]. Since TFs bind to the upstream sequence of ORFs, we focused on histone modification signals 1kb flanking translation start sites (ATGs), because TFBSs were enriched in these regions. For TF PSSMs, 2 independent sets were obtained from previous studies. One se ...
PHI-Canto video tutorial text - PHI-base
PHI-Canto video tutorial text - PHI-base

... visible for quick access. It is important to note that PHI-Canto can only have 1 assigned curator per PubMed ID to prevent duplication however each author can several papers under curation at the same time. ...
Mol Microbiol. Jun 21. [Epub ahead of print]
Mol Microbiol. Jun 21. [Epub ahead of print]

... temporal or functional distribution within the family of GGDEF-EAL proteins, but the processes that they regulate generally lead to an effect on the transition between the biofilm-associated state of a bacterial cell and the planktonic or virulent state (Tamayo et al., 2007; Hengge, ...
PHANTASTICA Regulates Development of the Adaxial Mesophyll in
PHANTASTICA Regulates Development of the Adaxial Mesophyll in

... for PHAN orthologs in negative regulation of class I KNOX genes. The leaf phenotypes of the rs2 mutant in maize and the as1 mutant in Arabidopsis in fact have a striking resemblance to those resulting from KNOX overexpression in those species (Lincoln et al., 1994; Schneeberger et al., 1995; Chuck e ...
PDF
PDF

... into the correct chromosomal var upstream region. This design enables rapid positive selection for integration into the desired locus as described by Wang et al. [18]. The constructs, cloning strategy, and expression patterns are shown in Figures 1–5. var loci are found in both subtelomeric and inte ...
Genes involved in asexual sporophyte development in Ceratopteris
Genes involved in asexual sporophyte development in Ceratopteris

... lethality contribute to a small seed set in these plants. However, reciprocal crosses indicate that the mutant allele does not affect gametophyte function. Instead, it appears to be a failure of the maternal plant to sustain the life of a percentage of the gametophytes that it produces. Thus, the At ...
Exploratory data analysis for microarray data
Exploratory data analysis for microarray data

... Extend a distance measure d to a measure of distance between clusters. ❍ Single linkage The distance between two clusters is the minimal distance between two objects, one from each cluster. ❍ Average linkage The distance between two clusters is the average of the pairwise distance between members of ...
Hailey Spelman - Determining Cellular Fate: Pre- and Postnatal Methylation Effects on Gene Expression
Hailey Spelman - Determining Cellular Fate: Pre- and Postnatal Methylation Effects on Gene Expression

... the hypermethylation of the CpGIS of anti-oncogenes, thereby causing the repression of tumor suppressors and the possibility of cancer development (Bird). At the same time, developmentally programmed CpGI methylation (that is not seen in the germ line but is expressed in somatic cells) is involved i ...
Parasitism and Mutualism in Wolbachia: What the
Parasitism and Mutualism in Wolbachia: What the

... at bacterial protein-coding genes and typically adhere to the criteria of greater than 3% divergence at the 16S rDNA gene (Lo et al. 2007). Thus, these lifestyle transitions within the Wolbachia-invertebrate endosymbiosis have occurred in a time frame potentially amenable to assessing the evolutiona ...
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Minimal genome

The concept of minimal genome assumes that genomes can be reduced to a bare minimum, given that they contain many non-essential genes of limited or situational importance to the organism. Therefore, if a collection of all the essential genes were put together, a minimum genome could be created artificially in a stable environment. By adding more genes, the creation of an organism of desired properties is possible. The concept of minimal genome arose from the observations that many genes do not appear to be necessary for survival. In order to create a new organism a scientist must determine the minimal set of genes required for metabolism and replication. This can be achieved by experimental and computational analysis of the biochemical pathways needed to carry out basic metabolism and reproduction. A good model for a minimal genome is Mycoplasma genitalium, the organism with the smallest known genome. Most genes that are used by this organism are usually considered essential for survival; based on this concept a minimal set of 256 genes has been proposed.
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