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Methylation Dynamics in the Early Mammalian Embryo: Implications
Methylation Dynamics in the Early Mammalian Embryo: Implications

... phenotypes increase after interfering with or bypassing essential steps of gametogenesis, early embryogenesis, or both. Nevertheless, it is plausible that normal fertilization, assisted reproduction, and embryo cloning are all susceptible to similar dysregulation of epigenetic components. Although t ...
Methylation Dynamics in the Early Mammalian Embryo - Beck-Shop
Methylation Dynamics in the Early Mammalian Embryo - Beck-Shop

... phenotypes increase after interfering with or bypassing essential steps of gametogenesis, early embryogenesis, or both. Nevertheless, it is plausible that normal fertilization, assisted reproduction, and embryo cloning are all susceptible to similar dysregulation of epigenetic components. Although t ...
However, if
However, if

... Theodor Boveri carried out experiments on sea urchin eggs, studying the behaviour of the cell nucleus and chromosomes during meiosis and fertilisation. Sea urchin eggs were ideally suited for stuffy because they could be easily fertilised in a laboratory and have a quick (48 hour) time frame for lar ...
Molecular biology of Ri-plasmid—A review
Molecular biology of Ri-plasmid—A review

... degree of the weakened response varied considerably among the mutants in this region and between inoculations. Since such results are possible if the insertions have affected expression of the adjacent loci, no rol locus has been assigned to this region. The rol mutations present a rather intriguing ...
Differential Network Analysis
Differential Network Analysis

... a tutorial to differential weighted gene co-expression network analysis. Some familiarity with the R software is desirable but the document is fairly self-contained. This document and data files can be found at the following webpage: http://www.genetics.ucla.edu/labs/horvath/CoexpressionNetwork/Diff ...
Deep Insight Section Common fragile sites and genomic instability
Deep Insight Section Common fragile sites and genomic instability

... do not incorporate in their models the different breakage frequencies of aCFSs. To better understand the relationship between aCFSs and their genomic contexts, Fungtammasan et al. built statistical models to explain the fragility of wellcharacterized aCFSs by considering their genomic neighborhoods ...
PDF
PDF

... polyA signal finder (Tabaska and Zhang, 1999). The background sequence statistics were worked out on a set of 764 high throughput genomic sequences of human genome. We considered only completed sequences with size larger than 100 kb. Total size of these genomic sequences is ∼100 Mb. The test set. Fo ...
Complementation
Complementation

... - = no complementation, blind fish += complementation, fish can see ...
REVIEW Pathways to understanding the extended phenotype of
REVIEW Pathways to understanding the extended phenotype of

... basis of manipulated behaviors would be to sequence the genomes of parasites that manipulate and do not manipulate their hosts and ask what is different between the two. This has not yet been done for any parasite known to affect behavior but it has intrinsic appeal due to the commonness of such an ...
Analyses of human–chimpanzee orthologous gene
Analyses of human–chimpanzee orthologous gene

... Because the dataset of the Chimpanzee Sequencing and Analysis Consortium (2005) is derived from a draft sequence of the chimpanzee genome, not all human genes have been matched to orthologs in the chimpanzee genome and so our results should not be considered as comprehensive. For instance, of GenAge ...
gene - Archbishop Ryan High School
gene - Archbishop Ryan High School

... • The varied patterns of stripes on zebras are due to differences in genetic makeup • No two zebras have identical stripe patterns ...
nature | methods Versatile P[acman] BAC libraries for transgenesis
nature | methods Versatile P[acman] BAC libraries for transgenesis

... DNA, isolated from the isogenized y1; cn1 bw1 sp1 strain, was partially digested with MboI and ligated into the BamHI site of the attB-P(acman)-CmR-BW plasmid. White recombinant clones ...
THE BITHORAX COMPLEX: THE FIRST FIFTY YEARS
THE BITHORAX COMPLEX: THE FIRST FIFTY YEARS

... the tradition of Morgan, Sturtevant allowed his students considerable freedom to choose their thesis research projects. Quite a risk was involved in choosing to work on S and its “alleles.” Crossovers between them would be rare if they were to occur at all. Even if the wild-type crossover could be r ...
Ch15ChromoBasisInheritance
Ch15ChromoBasisInheritance

... small hands and feet. These individuals inherit the abnormal chromosome from their father. ...
Here - Personal Genome Project Study Guide
Here - Personal Genome Project Study Guide

... Lesson 1: Introduction to Cells, DNA, and Genes ...
1 Combining Gene Expression with Marker Genotypes in Poultry
1 Combining Gene Expression with Marker Genotypes in Poultry

... microarray data in an attempt to move from a functional QTL to the underlying gene(s) (Wayne & McIntyre 2002). Below, we outline a case study where detection of functional QTL was followed up by a gene expression analysis. In this example, microarray experiments were carried out on the founder lines ...
Cis-Regulatory Timers for Developmental Gene
Cis-Regulatory Timers for Developmental Gene

... [5,6]). By the early gastrula stage, the four cells have divided once to form eight cells that maintain expression of Ci-Bra whereas two more cells from a different origin also activate Ci-Bra to form the secondary notochord lineage. These ten initial notochord precursors become internalized, divide ...
BIOINFORMATICS
BIOINFORMATICS

... data of Shipp et al. (2002) produced at the Whitehead Institute (WI data), and validate our findings on a separate Affymetrix gene expression data produced by DallaFavera laboratory at Columbia University (CU data, see (Stolovitzky, 2005)). The WI and CU datasets report gene expression data for DLBC ...
Genomic disorders: structural features of the genome can lead to
Genomic disorders: structural features of the genome can lead to

... traits. The gene is still the key in mediating the phenotype, but is altered almost coincidentally by the rearrangement. I will refer to such conditions that result from genome architecture as genomic disorders. Genomic disorders are caused by an alteration of the genome that might lead to the compl ...
DNA-free CRISPR-Cas9 genome engineering in
DNA-free CRISPR-Cas9 genome engineering in

... The CRISPR-Cas9 system permits researchers to quickly edit genes for functional protein knockout in mammalian, fish and plant genomes, among others, and consequently has dramatically transformed biological research. The CRISPR-Cas9 system requires exogenous Cas9 nuclease to be delivered into the cel ...
FOXP2 in focus: what can genes tell us about speech and language?
FOXP2 in focus: what can genes tell us about speech and language?

Inflorescence Meristem Identity in Rice Is Specified
Inflorescence Meristem Identity in Rice Is Specified

... 1 online). PAP2 plays multiple roles, including the determination of spikelet meristem (SM) identity and the suppression of the extra growth of glumes (Gao et al., 2010; Kobayashi et al., 2010). To understand PAP2 function further, we analyzed its spatial and temporal expression throughout infloresce ...
MEIOSIS
MEIOSIS

... have 46 chromosomes) have to be copied so both DAUGHTER cells get the same 46 chromosomes that were in the parent cell. ...
Integrated genome sequence and linkage map of physic nut
Integrated genome sequence and linkage map of physic nut

... and 0.746 Mbp, respectively, which are approximately 1.8 and 46.8 times longer, respectively, than the reported physic nut genome (Hirakawa et al., 2012). As the result of short contigs and scaffolds, too many predicted genes in their study were fragmented. Only 17 Mbp (6%) of their assembly (but ab ...
Non-Mendelian inheritance
Non-Mendelian inheritance

... Division Ave. High School ...
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Minimal genome

The concept of minimal genome assumes that genomes can be reduced to a bare minimum, given that they contain many non-essential genes of limited or situational importance to the organism. Therefore, if a collection of all the essential genes were put together, a minimum genome could be created artificially in a stable environment. By adding more genes, the creation of an organism of desired properties is possible. The concept of minimal genome arose from the observations that many genes do not appear to be necessary for survival. In order to create a new organism a scientist must determine the minimal set of genes required for metabolism and replication. This can be achieved by experimental and computational analysis of the biochemical pathways needed to carry out basic metabolism and reproduction. A good model for a minimal genome is Mycoplasma genitalium, the organism with the smallest known genome. Most genes that are used by this organism are usually considered essential for survival; based on this concept a minimal set of 256 genes has been proposed.
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