Supplementary Figures (doc 928K)
... The clustering procedure for these samples is as follows: Sample NY278 (HCDR3 sequence CARGPDESGWCGFRYW) was connected to P2959 (HCDR3 sequence CARGPDISGWNGFEYW) by pattern ARGPD.SGW.GF.Y providing 78.57% identity, forming the level 0 cluster 0-0168. P2959 was then found to be connected to F73 (CARG ...
... The clustering procedure for these samples is as follows: Sample NY278 (HCDR3 sequence CARGPDESGWCGFRYW) was connected to P2959 (HCDR3 sequence CARGPDISGWNGFEYW) by pattern ARGPD.SGW.GF.Y providing 78.57% identity, forming the level 0 cluster 0-0168. P2959 was then found to be connected to F73 (CARG ...
Antibiotics involved in Clostridium difficile
... genes encoding known, or putative, colonization factors: three adhesins, P47 (one of the two Slayer proteins), Cwp66 and Fbp68, and a protease, Cwp84. The conditions studied included hyperosmolarity, iron depletion and exposure to several antibiotics (ampicillin, clindamycin, ofloxacin, moxifloxacin ...
... genes encoding known, or putative, colonization factors: three adhesins, P47 (one of the two Slayer proteins), Cwp66 and Fbp68, and a protease, Cwp84. The conditions studied included hyperosmolarity, iron depletion and exposure to several antibiotics (ampicillin, clindamycin, ofloxacin, moxifloxacin ...
transgenic canola - Australian Oilseeds Federation
... being tested include those encoding novel antimicrobial peptides derived from Australian native plants and from macadamia in particular. So far, transgenic plants expressing three peptides have been developed and advanced lines expressing one peptide at high levels are under evaluation for improved ...
... being tested include those encoding novel antimicrobial peptides derived from Australian native plants and from macadamia in particular. So far, transgenic plants expressing three peptides have been developed and advanced lines expressing one peptide at high levels are under evaluation for improved ...
A genome-wide association scan in pig identifies novel regions
... the tests conducted here were not independent and were linked because of linkage disequilibrium (/') between markers. The Bonferroni correction may result in too stringent a threshold and hence many false-negative UHVXOWV 7KHUHIRUH ZH DOVR FRQVLGHUHG D OLEHUDO VLJQL¿cant threshold, and a SN ...
... the tests conducted here were not independent and were linked because of linkage disequilibrium (/') between markers. The Bonferroni correction may result in too stringent a threshold and hence many false-negative UHVXOWV 7KHUHIRUH ZH DOVR FRQVLGHUHG D OLEHUDO VLJQL¿cant threshold, and a SN ...
XASH genes promote neurogenesis in Xenopus embryos
... probably not acting as a switch, causing cells that express it transiently to become neural. In this sense, the injection of XASH-3/XE12 RNA does not mimic the normal events of neural induction. This result also agrees with our whole embryo misexpression studies (see below), and indicates that XASH- ...
... probably not acting as a switch, causing cells that express it transiently to become neural. In this sense, the injection of XASH-3/XE12 RNA does not mimic the normal events of neural induction. This result also agrees with our whole embryo misexpression studies (see below), and indicates that XASH- ...
Imprinting in the endosperm: a possible role in preventing wide
... placenta, are regulated by a range of epigenetic mechanisms that are globally termed imprinting. Imprinted genes are characterized by their uniparental expression, the other parental allele being silenced. Normal development of the endosperm thus requires a highly specific balance of gene expression ...
... placenta, are regulated by a range of epigenetic mechanisms that are globally termed imprinting. Imprinted genes are characterized by their uniparental expression, the other parental allele being silenced. Normal development of the endosperm thus requires a highly specific balance of gene expression ...
Plasmid replication and control
... general rule that small plasmids tend to have a high copy number, sometimes over 100 copies per cell, whereas larger plasmids may be present in one or a few copies per cell. Certain classes of plasmids are capable of horizontal transmission from one bacterium to another. In most cases the recipient ...
... general rule that small plasmids tend to have a high copy number, sometimes over 100 copies per cell, whereas larger plasmids may be present in one or a few copies per cell. Certain classes of plasmids are capable of horizontal transmission from one bacterium to another. In most cases the recipient ...
Genetic tools for manipulating Acinetobacter baumannii genome: an
... carry a selectable marker, usually an antibiotic resistance gene. Sometimes integration vectors also contain oriT so that the construct can be transferred to other bacteria by conjugation. This is especially helpful when the other transfer methods, such as natural transformation or electroporation, ...
... carry a selectable marker, usually an antibiotic resistance gene. Sometimes integration vectors also contain oriT so that the construct can be transferred to other bacteria by conjugation. This is especially helpful when the other transfer methods, such as natural transformation or electroporation, ...
Common Ancestry
... The theory that all organisms descended from a single ancestor. Support for this idea is found in: • Fossil Record – shows the variety of organisms that have existed over time, going from very simple to more complex organisms over billions of years ...
... The theory that all organisms descended from a single ancestor. Support for this idea is found in: • Fossil Record – shows the variety of organisms that have existed over time, going from very simple to more complex organisms over billions of years ...
A/a · B/b
... In nature means that the variants did not appear in laboratory stock and, instead, were found growing wild. ...
... In nature means that the variants did not appear in laboratory stock and, instead, were found growing wild. ...
simple patterns of inheritance
... or crossed to each other, this is called a hybridization experiment, and the offspring are referred to as hybrids. For example, a hybridization experiment could involve a cross between a purple-flowered plant and a white-flowered plant. Mendel was particularly intrigued by the consistency with which ...
... or crossed to each other, this is called a hybridization experiment, and the offspring are referred to as hybrids. For example, a hybridization experiment could involve a cross between a purple-flowered plant and a white-flowered plant. Mendel was particularly intrigued by the consistency with which ...
Leukaemia Section 11q23 rearrangements in leukaemia Atlas of Genetics and Cytogenetics
... MLL; visible dup(11q) also occur. - inv(11)(p15q23): rare; ANLL and MDS. - t(X;11)(q13;q23): rare; ANLL; the gene involved in Xq13 is AFX1, a transcription regulator. - t(1;11)(p32;q23): rare; ALL and ANLL; the gene involved in 1p32 is AF1P. - t(1;11)(q21;q23): rare; mostly M4 ANLL; the gene involve ...
... MLL; visible dup(11q) also occur. - inv(11)(p15q23): rare; ANLL and MDS. - t(X;11)(q13;q23): rare; ANLL; the gene involved in Xq13 is AFX1, a transcription regulator. - t(1;11)(p32;q23): rare; ALL and ANLL; the gene involved in 1p32 is AF1P. - t(1;11)(q21;q23): rare; mostly M4 ANLL; the gene involve ...
The Frequency Distribution of Nucleotide Variation in Drosophila
... However, frequencies of neutral alleles might be reduced compared with equilibrium expectations if a population is rapidly expanding (Maruyama and Fuerst 1984). Positive selection is expected to cause frequencies of beneficial alleles to be higher than expected for neutral alleles in equilibrium pop ...
... However, frequencies of neutral alleles might be reduced compared with equilibrium expectations if a population is rapidly expanding (Maruyama and Fuerst 1984). Positive selection is expected to cause frequencies of beneficial alleles to be higher than expected for neutral alleles in equilibrium pop ...
Gene mapping and medical genetics Human chromosome 8
... use in cardiac disease. Since chromosome 8 represents about 5% of the human genome, we may expect it to carry about 5% of human gene loci. This would correspond to about 90 of the fully validated phenotypes in the MIM7 catalogue.' The 27 genes assigned to chromosome 8 at the Ninth Human Gene Mapping ...
... use in cardiac disease. Since chromosome 8 represents about 5% of the human genome, we may expect it to carry about 5% of human gene loci. This would correspond to about 90 of the fully validated phenotypes in the MIM7 catalogue.' The 27 genes assigned to chromosome 8 at the Ninth Human Gene Mapping ...
Natural Variation in Sensitivity to a Loss of Chloroplast Translation in
... in embryo lethality (Lin et al., 2003; Bryant et al., 2011; Muralla et al., 2011). Embryo lethality is also encountered in auxotrophic mutants unable to produce biotin, an essential vitamin required for ACCase function (Schneider et al., 1989; Patton et al., 1998; Muralla et al., 2008). The conversi ...
... in embryo lethality (Lin et al., 2003; Bryant et al., 2011; Muralla et al., 2011). Embryo lethality is also encountered in auxotrophic mutants unable to produce biotin, an essential vitamin required for ACCase function (Schneider et al., 1989; Patton et al., 1998; Muralla et al., 2008). The conversi ...
View PDF - G3: Genes | Genomes | Genetics
... them. Notably, the mat1 marker in this cross was recorded by the replica-plating and iodine-staining procedure employed for research with S. pombe. Nuclei orientation is indeterminate in the S. japonicus meiosis Interestingly, the two spores at each end of the ascus are “sisters” in the linear four- ...
... them. Notably, the mat1 marker in this cross was recorded by the replica-plating and iodine-staining procedure employed for research with S. pombe. Nuclei orientation is indeterminate in the S. japonicus meiosis Interestingly, the two spores at each end of the ascus are “sisters” in the linear four- ...
Part 4 Student Handout - URMC
... Narrator: Jenny, Jeremy, and their father have decided to undergo genetic testing for Huntington’s disease. Today, our lab groups will act as gene testing laboratory technicians. We will use the gel electrophoresis laboratory procedure to analyze the results of the simulated DNA samples from Jenny, ...
... Narrator: Jenny, Jeremy, and their father have decided to undergo genetic testing for Huntington’s disease. Today, our lab groups will act as gene testing laboratory technicians. We will use the gel electrophoresis laboratory procedure to analyze the results of the simulated DNA samples from Jenny, ...
Intellectual property rights and innovation: Evidence from
... From this empirical context, I construct three research designs to test for the effects of Celera’s IP on subsequent scientific research and product development outcomes. The first research design tests whether genes that ever had Celera’s IP differ in subsequent innovation, as of 2009, from genes ...
... From this empirical context, I construct three research designs to test for the effects of Celera’s IP on subsequent scientific research and product development outcomes. The first research design tests whether genes that ever had Celera’s IP differ in subsequent innovation, as of 2009, from genes ...
PERSPECTIVES IN HUMAN GENETICS Mendelian Inheritance in
... each AV consists of the title of the trait (phenotype) determined by the mutation, the gene symbol and the shorthand description of the mutation,10–12 text providing a varying amount of information on the family(ies) or population(s) studied, the details of the specific DNA change, and peculiarities ...
... each AV consists of the title of the trait (phenotype) determined by the mutation, the gene symbol and the shorthand description of the mutation,10–12 text providing a varying amount of information on the family(ies) or population(s) studied, the details of the specific DNA change, and peculiarities ...
Genome-wide search for asthma susceptibility loci in a founder
... of molecular biological techniques and the initiation of the Human Genome Project (4–6). The relatively small number of founders and recent ancestries that are characteristic of these populations facilitate the search for human disease genes and make them particularly amenable to novel analytical st ...
... of molecular biological techniques and the initiation of the Human Genome Project (4–6). The relatively small number of founders and recent ancestries that are characteristic of these populations facilitate the search for human disease genes and make them particularly amenable to novel analytical st ...
Genetic mapping of mutations using phenotypic pools and
... comprising a diploid genome is selected at random and the first element (locus) of the array is copied to an empty destination array, which will become the gamete. Before copying the next element from source to destination array, a random number between 1 and 100 is obtained. Only if the number is 1 ...
... comprising a diploid genome is selected at random and the first element (locus) of the array is copied to an empty destination array, which will become the gamete. Before copying the next element from source to destination array, a random number between 1 and 100 is obtained. Only if the number is 1 ...
Definition of historical models of gene function and their relation to
... 1993). Research and applications in genetics has in various degrees focused on the different aspects during history. Scientists have come up with different answers and hypotheses to explain these phenomena and their interrelations. Like in science generally it has led to a change in different scient ...
... 1993). Research and applications in genetics has in various degrees focused on the different aspects during history. Scientists have come up with different answers and hypotheses to explain these phenomena and their interrelations. Like in science generally it has led to a change in different scient ...
Recombination and epistasis facilitate introgressive hybridization
... incomplete for the species pairs that result from anthropogenic transplantation. In contrast, the post-zygotic isolating mechanism is likely to function as the final check against introgressive hybridization, because post-zygotic isolation is formed by a stochastic process and/or local adaptation, b ...
... incomplete for the species pairs that result from anthropogenic transplantation. In contrast, the post-zygotic isolating mechanism is likely to function as the final check against introgressive hybridization, because post-zygotic isolation is formed by a stochastic process and/or local adaptation, b ...
Gibberellin Signaling: Biosynthesis, Catabolism, and
... 20-oxidases (GA20ox), and GA 3-oxidases (GA3ox; Figure 1). Although 126 GAs have been identified in higher plants, fungi, and bacteria (http://www.plant-hormones.bbsrc.ac. uk/gibberellin_information2.htm), only a small number are biologically active (e.g., GA1, GA3, GA4, and GA7) (Hedden and Phillip ...
... 20-oxidases (GA20ox), and GA 3-oxidases (GA3ox; Figure 1). Although 126 GAs have been identified in higher plants, fungi, and bacteria (http://www.plant-hormones.bbsrc.ac. uk/gibberellin_information2.htm), only a small number are biologically active (e.g., GA1, GA3, GA4, and GA7) (Hedden and Phillip ...
Genome-Wide Copy Number Variation in Epilepsy: Novel
... in two probands with IGE. All other single-gene CNVs were seen only once. Seventeen events involved multiple genes, one of which was observed in two different individuals with JME (duplication of 18q11, Table 2). ...
... in two probands with IGE. All other single-gene CNVs were seen only once. Seventeen events involved multiple genes, one of which was observed in two different individuals with JME (duplication of 18q11, Table 2). ...
Genome evolution
Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.