NeuroGeM, a knowledgebase of genetic modifiers
... TVP15 and HSP104) are modifiers that are shared by two different ND models. Genes that were identified as modifiers in more than one disease model in D. melanogaster and C. elegans are shown in Figure S7. Similar to S. cerevisiae, there are no genes in C. elegans that are modifiers in more than 3 di ...
... TVP15 and HSP104) are modifiers that are shared by two different ND models. Genes that were identified as modifiers in more than one disease model in D. melanogaster and C. elegans are shown in Figure S7. Similar to S. cerevisiae, there are no genes in C. elegans that are modifiers in more than 3 di ...
Neonatal Hyperbilirubinemia and Organic Anion Transporting
... NY), kernicterus still occurs; these cases highlight the need for continued study of the etiology of hyperbilirubinemia.19 Neither hyperbilirubinemia nor kernicterus are reportable diseases, and there are no reliable sources of information providing national annual estimates.19 The primary risk fact ...
... NY), kernicterus still occurs; these cases highlight the need for continued study of the etiology of hyperbilirubinemia.19 Neither hyperbilirubinemia nor kernicterus are reportable diseases, and there are no reliable sources of information providing national annual estimates.19 The primary risk fact ...
Chromatin Evolution and Molecular Drive in Speciation
... carry expanded satellite DNAs, the gene centromere identifier (cid) has evolved rapidly in diverse organisms including Drosophila [127, 128]. cid encodes centromeric histone H3like, a homologue of human Centromere protein A (CENPA). Examples of centromeric repeats affecting meiotic drive include the ...
... carry expanded satellite DNAs, the gene centromere identifier (cid) has evolved rapidly in diverse organisms including Drosophila [127, 128]. cid encodes centromeric histone H3like, a homologue of human Centromere protein A (CENPA). Examples of centromeric repeats affecting meiotic drive include the ...
Genetics and heritability of coronary artery disease and myocardial
... that increase or decrease the risk of disease manifestation. These genes may or may not contribute to the variability of the disease in the context of other genetic and environmental factors. Genetic variants of these genes are present, albeit with different frequency, in both, apparently healthy an ...
... that increase or decrease the risk of disease manifestation. These genes may or may not contribute to the variability of the disease in the context of other genetic and environmental factors. Genetic variants of these genes are present, albeit with different frequency, in both, apparently healthy an ...
Patterns of Inheritance
... during the eukaryotic cell cycle, and from one generation to the next during eukaryotic life cycles. Since chromosomes contain the hereditary information, this shows us how the hereditary information is transmitted from one generation to the next. ...
... during the eukaryotic cell cycle, and from one generation to the next during eukaryotic life cycles. Since chromosomes contain the hereditary information, this shows us how the hereditary information is transmitted from one generation to the next. ...
Costimulatory receptors in jawed vertebrates: Conserved
... (Tetraodon nigroviridis) and zebrafish (Danio rerio). In zebrafish, it was not possible to find sequences corresponding to exons 3 and 4 (encoding transmembrane and intracytoplasmic region) from the available genome assembly. The Ensembl zebrafish genome assembly (v36) had two copies of CD28 exons 1 and ...
... (Tetraodon nigroviridis) and zebrafish (Danio rerio). In zebrafish, it was not possible to find sequences corresponding to exons 3 and 4 (encoding transmembrane and intracytoplasmic region) from the available genome assembly. The Ensembl zebrafish genome assembly (v36) had two copies of CD28 exons 1 and ...
Case Report Novel Sonic Hedgehog Mutation in a Couple
... substitution of tryptophan (TGG) for a stop codon (TGA) in exon 2 (c.384 G → A). The mother’s SHH ORF had a normal sequence. We were not able to perform molecular analysis in the miscarriages or previous child of the couple. ...
... substitution of tryptophan (TGG) for a stop codon (TGA) in exon 2 (c.384 G → A). The mother’s SHH ORF had a normal sequence. We were not able to perform molecular analysis in the miscarriages or previous child of the couple. ...
Loss-of-function of a Rice Gibberellin Biosynthetic Gene, GA20
... Molecular cloning, mapping and DNA sequencing Degenerate primers were designed from the consensus sequences of the GA20 oxidase gene (GA20ox) (Toyomasu et al. 1997) from rice and Arabidopsis (GA5) (Xu et al. 1995) (sense: 5′YTNCCNTGGAAYGARACNYT3′ and antisense: 5′GTNGGRTCRCARTGNGG3′). The DNA fragme ...
... Molecular cloning, mapping and DNA sequencing Degenerate primers were designed from the consensus sequences of the GA20 oxidase gene (GA20ox) (Toyomasu et al. 1997) from rice and Arabidopsis (GA5) (Xu et al. 1995) (sense: 5′YTNCCNTGGAAYGARACNYT3′ and antisense: 5′GTNGGRTCRCARTGNGG3′). The DNA fragme ...
Xq28 duplications
... How common are Xq28 duplications? Duplications of Xq28 are considered quite rare but now that more specific laboratory techniques are available, the frequency of diagnoses is increasing. At the time of updating this booklet in 2015, over 100 male and almost 100 female cases of Xq28 duplication had b ...
... How common are Xq28 duplications? Duplications of Xq28 are considered quite rare but now that more specific laboratory techniques are available, the frequency of diagnoses is increasing. At the time of updating this booklet in 2015, over 100 male and almost 100 female cases of Xq28 duplication had b ...
Genetics of mammalian meiosis: regulation, dynamics and impact
... (SMC1B)) and synaptonemal complex (SC)-specific proteins, such as SYCP3 and SYCP2. The chromatids experience genetically programmed double-strand DNA breaks (induced by SPO11), which provide the substrate for recombination (the two chromatids of the upper homologue are depicted by a turquoise line, ...
... (SMC1B)) and synaptonemal complex (SC)-specific proteins, such as SYCP3 and SYCP2. The chromatids experience genetically programmed double-strand DNA breaks (induced by SPO11), which provide the substrate for recombination (the two chromatids of the upper homologue are depicted by a turquoise line, ...
X r Y
... – The factors separated when the gametes were formed during meiosis, each gamete would get either the tall or short gene. – When random fusion of the gametes occurred during fertilization, the combinations were brought together in a 3:1 ratio, as indicated by the Punnett square. ...
... – The factors separated when the gametes were formed during meiosis, each gamete would get either the tall or short gene. – When random fusion of the gametes occurred during fertilization, the combinations were brought together in a 3:1 ratio, as indicated by the Punnett square. ...
Reebops: A "Model" Organism for Teaching Genetic Concepts
... uncoiled and spread over the entire cell nucleus. But when a cell is preparing to divide, each long DNA strand will coil tightly to form a chromosome. When this happens, the chromosomes can be seen using a microscope. Since there are 46 strands of DNA Chromosome in the nucleus of most human cells, ...
... uncoiled and spread over the entire cell nucleus. But when a cell is preparing to divide, each long DNA strand will coil tightly to form a chromosome. When this happens, the chromosomes can be seen using a microscope. Since there are 46 strands of DNA Chromosome in the nucleus of most human cells, ...
Scientific background report AMFLORA potato
... construct that expresses GBSS for this purpose. In other words: they have introduced an extra gbss gene, of which one would logically assume that it would rather lead to enhanced production of amylose than of reduced production. However, the additional copy suppresses the expression of the natural g ...
... construct that expresses GBSS for this purpose. In other words: they have introduced an extra gbss gene, of which one would logically assume that it would rather lead to enhanced production of amylose than of reduced production. However, the additional copy suppresses the expression of the natural g ...
Myb genes enhance tobacco trichome production
... hair-like shape suggested by the term. Trichomes may be composed of one or more cells, may be unbranched or branched, and may or may not possess glands which accumulate or secrete alkaloids like nicotine, terpenoids such as menthol and camphor, or other compounds repellent or toxic to phytophagous i ...
... hair-like shape suggested by the term. Trichomes may be composed of one or more cells, may be unbranched or branched, and may or may not possess glands which accumulate or secrete alkaloids like nicotine, terpenoids such as menthol and camphor, or other compounds repellent or toxic to phytophagous i ...
Evaluation of genomic DNA from paraffin
... polymorphism. Single nucleotide polymorphisms (SNPs) and microsatellites are examples of such genetic polymorphism. These can be used as genetic markers to create a haplotype, which can be used to determine association between a haplotype and a phenotype. A haplotype covers a genomic region that is ...
... polymorphism. Single nucleotide polymorphisms (SNPs) and microsatellites are examples of such genetic polymorphism. These can be used as genetic markers to create a haplotype, which can be used to determine association between a haplotype and a phenotype. A haplotype covers a genomic region that is ...
Gene Section SIX1 (sine oculis homeobox homolog 1) (mammalian)
... 60 amino acid six-type homeodomain (HD). The SD is important for the interaction of Six1 with cofactors and also contributes to DNA binding along with the homeodomain. View of the SIX1 gene which is composed of 2 exons that are 833 and 543 bps respectively, and a single 2,052 bp intron. Start and st ...
... 60 amino acid six-type homeodomain (HD). The SD is important for the interaction of Six1 with cofactors and also contributes to DNA binding along with the homeodomain. View of the SIX1 gene which is composed of 2 exons that are 833 and 543 bps respectively, and a single 2,052 bp intron. Start and st ...
Single-Gene Inheritance Single-Gene Inheritance
... wild,” or in nature. The genetic modus operandi is to mate an individual showing the property in its wild-type form (for example, a plant with red flowers) to an individual showing a mutated form of the property (for example, a plant with white flowers). The progeny of this cross are interbred and, ...
... wild,” or in nature. The genetic modus operandi is to mate an individual showing the property in its wild-type form (for example, a plant with red flowers) to an individual showing a mutated form of the property (for example, a plant with white flowers). The progeny of this cross are interbred and, ...
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... medium. For TUNEL analysis, aged brains were dissected and fixed (PBS, 4% paraformaldehyde) for 20 minutes at room temperature. Tissues were washed twice in PBS, once in H2O plus 0.1% Triton X-100 and 0.1% sodium citrate for 10 minutes, and then twice in PBS. TUNEL analysis was performed by followin ...
... medium. For TUNEL analysis, aged brains were dissected and fixed (PBS, 4% paraformaldehyde) for 20 minutes at room temperature. Tissues were washed twice in PBS, once in H2O plus 0.1% Triton X-100 and 0.1% sodium citrate for 10 minutes, and then twice in PBS. TUNEL analysis was performed by followin ...
1q21 microdeletions
... segments. To pair up precisely, each chromosome ‘recognises’ matching or nearmatching DNA sequences on its partner chromosome. However, throughout the chromosomes there are many DNA sequences that are so similar that it is thought that mispairing can occur. The 1q21.1 region has an extremely complex ...
... segments. To pair up precisely, each chromosome ‘recognises’ matching or nearmatching DNA sequences on its partner chromosome. However, throughout the chromosomes there are many DNA sequences that are so similar that it is thought that mispairing can occur. The 1q21.1 region has an extremely complex ...
1q21 microdeletions
... million base pairs, or one so-called megabase (Mb) of DNA. Base pairs are the chemicals in DNA that form the ends of the ‘rungs’ of its ladder-like structure. Chromosome 1 has around 247 Mb in total and band 1q21.1 alone contains around 5.4 Mb. In a class 1 deletion, DNA is typically missing between ...
... million base pairs, or one so-called megabase (Mb) of DNA. Base pairs are the chemicals in DNA that form the ends of the ‘rungs’ of its ladder-like structure. Chromosome 1 has around 247 Mb in total and band 1q21.1 alone contains around 5.4 Mb. In a class 1 deletion, DNA is typically missing between ...
Genetic code redundancy and its influence on the encoded
... transcribed from DNA, is translated into protein by a template driven process. The template is composed of a specific combination of 61 trinucleotide codons which encode 20 amino acids. This genetic code is common to most organisms and is referred to as redundant because all amino acids, with the ex ...
... transcribed from DNA, is translated into protein by a template driven process. The template is composed of a specific combination of 61 trinucleotide codons which encode 20 amino acids. This genetic code is common to most organisms and is referred to as redundant because all amino acids, with the ex ...
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... results provide strong support for the view that all melanoblasts are affected and the host tissue plays an important role in determining the pattern of spotting. However, there appear to be some indications that all melanoblasts may not be affected to the same degree. INTRODUCTION ...
... results provide strong support for the view that all melanoblasts are affected and the host tissue plays an important role in determining the pattern of spotting. However, there appear to be some indications that all melanoblasts may not be affected to the same degree. INTRODUCTION ...
Characterization of chaperonin 10 (Cpn10)
... but harbours mitochondrial remnant organelles called mitosomes. These organelles are characterized by the presence of mitochondrial chaperonin Cpn60, but little else is known about the functions and molecular composition of mitosomes. In this study, a gene encoding molecular chaperonin Cpn10 – the f ...
... but harbours mitochondrial remnant organelles called mitosomes. These organelles are characterized by the presence of mitochondrial chaperonin Cpn60, but little else is known about the functions and molecular composition of mitosomes. In this study, a gene encoding molecular chaperonin Cpn10 – the f ...
chromosomes
... If the centromere is very near the end, the chromosome is telocentric. The centromere divides the chromosome into two arms, so that, for example, an acrocentric chromosome has one short and one long arm, While, a metacentric chromosome has arms of equal length. All house mouse chromosomes are teloce ...
... If the centromere is very near the end, the chromosome is telocentric. The centromere divides the chromosome into two arms, so that, for example, an acrocentric chromosome has one short and one long arm, While, a metacentric chromosome has arms of equal length. All house mouse chromosomes are teloce ...
New and Redesigned pRS Plasmid Shuttle Vectors for Genetic
... plasmids includes new shuttle vectors that can be used with histidine and adenine auxotrophic laboratory yeast strains carrying mutations in the genes HIS2 and ADE1, respectively. Our pRSII plasmids also include updated versions of commonly used pRS plasmids from which common restriction sites that ...
... plasmids includes new shuttle vectors that can be used with histidine and adenine auxotrophic laboratory yeast strains carrying mutations in the genes HIS2 and ADE1, respectively. Our pRSII plasmids also include updated versions of commonly used pRS plasmids from which common restriction sites that ...
Genome evolution
Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.