Investigating the functional significance of evolutionarily conserved
... and hypomorphic-antimorph. Null alleles were nonsense mutations resulting in truncation and loss of highly conserved protein domains. Hypomorphic alleles were missense and small deletion mutations in highly conserved protein domains, including the DYTQL motif, YPWM motif and C-terminal domain (CTD). ...
... and hypomorphic-antimorph. Null alleles were nonsense mutations resulting in truncation and loss of highly conserved protein domains. Hypomorphic alleles were missense and small deletion mutations in highly conserved protein domains, including the DYTQL motif, YPWM motif and C-terminal domain (CTD). ...
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... distribution in any manner. This document may not be copied, scanned, duplicated, forwarded, distributed, or posted on a website, in whole or part. ...
... distribution in any manner. This document may not be copied, scanned, duplicated, forwarded, distributed, or posted on a website, in whole or part. ...
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... About Chromosome Penalties---------------------------------------------------------------------------------------39 About PSoup’s Energy Systems ------------------------------------------------------------------------------------41 About Combat Profiles ---------------------------------------------- ...
... About Chromosome Penalties---------------------------------------------------------------------------------------39 About PSoup’s Energy Systems ------------------------------------------------------------------------------------41 About Combat Profiles ---------------------------------------------- ...
VAAST 2 User`s Guide
... line. This header line begins with the ‘>’ character. The first contiguous set of non-‐ whitespace characters after the ‘>’ are used as the ID of that sequence. This ID must match EXACTLY wi ...
... line. This header line begins with the ‘>’ character. The first contiguous set of non-‐ whitespace characters after the ‘>’ are used as the ID of that sequence. This ID must match EXACTLY wi ...
The genetics of Caenorhabditis elegans.
... is a major unsolved problem in biology. Many of the molecular mechanisms involved in gene expression in prokaryotic microorganisms have already been found to exist in a relatively unmodified form in eukaryotic cells. The genetic code is universal and the mechanism of protein synthesis is much the sa ...
... is a major unsolved problem in biology. Many of the molecular mechanisms involved in gene expression in prokaryotic microorganisms have already been found to exist in a relatively unmodified form in eukaryotic cells. The genetic code is universal and the mechanism of protein synthesis is much the sa ...
EXCHANGE OF GENETIC MATERIAL BETWEEN
... that even in a mut+ strain the change from infertility to fertility can occur, with very low frequency. Transfer of the Hfr character from E. coli to Salmonella: It is known that the Hfr character, unlike the F+ character, is not transferable to F- cells by infection but can be transferred by conjug ...
... that even in a mut+ strain the change from infertility to fertility can occur, with very low frequency. Transfer of the Hfr character from E. coli to Salmonella: It is known that the Hfr character, unlike the F+ character, is not transferable to F- cells by infection but can be transferred by conjug ...
Further manipulation by centric misdivision of the 1RS.1BL
... The experiments with repeated centric fissionfusion cycles demonstrate that chromosome arms can be transferred from one translocation to another until the most suitable location is found. As a result of the manipulations described here, translocations of the same rye chromosome arm 1RS to all three ...
... The experiments with repeated centric fissionfusion cycles demonstrate that chromosome arms can be transferred from one translocation to another until the most suitable location is found. As a result of the manipulations described here, translocations of the same rye chromosome arm 1RS to all three ...
New variants of the tet(M) gene in Clostridium
... Sequence analysis revealed that except for tet(M)1, which was 100% identical to the tet(M) gene found in Streptococcus agalactiae 2603V/R (GenBank accession no. AE014233), the other alleles did not show complete identity with other tet(M) genes. The phylogenetic tree obtained by nucleotide sequence ...
... Sequence analysis revealed that except for tet(M)1, which was 100% identical to the tet(M) gene found in Streptococcus agalactiae 2603V/R (GenBank accession no. AE014233), the other alleles did not show complete identity with other tet(M) genes. The phylogenetic tree obtained by nucleotide sequence ...
PROGRAM PROGRAM
... mutations in livestock. (K. Flisikowski) – 25 min • Novel candidates for host response to BLV infection in Holstein cattle based on genome-wide association study (P. Brym) – 12 min • Comparing gene expression profiles in the mammary glands of high- and low-milkyield Holstein Friesian cows (M. Mill ...
... mutations in livestock. (K. Flisikowski) – 25 min • Novel candidates for host response to BLV infection in Holstein cattle based on genome-wide association study (P. Brym) – 12 min • Comparing gene expression profiles in the mammary glands of high- and low-milkyield Holstein Friesian cows (M. Mill ...
C57BL/6 - Envigo
... degeneration mutants in the mouse. Vision Res 2002;42:517-525. Huang, T. T. et. al. (2006). Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase. Hum Mol Genet. 2006 Apr 1;15(7):1187-94. Mattapallil, Mary J. et al. The rd8 mutation of the Crb1 gene is present in ...
... degeneration mutants in the mouse. Vision Res 2002;42:517-525. Huang, T. T. et. al. (2006). Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase. Hum Mol Genet. 2006 Apr 1;15(7):1187-94. Mattapallil, Mary J. et al. The rd8 mutation of the Crb1 gene is present in ...
Perspectives in Diabetes Glucokinase Gene Structure
... glucokinase isoforms are generated through alternate splic- acids in a region of the protein situated between the putative ing of the glucokinase gene product. One of these isoforms ATP- and glucose-binding domains. There is no evidence is specific for the liver, whereas two others are specific for ...
... glucokinase isoforms are generated through alternate splic- acids in a region of the protein situated between the putative ing of the glucokinase gene product. One of these isoforms ATP- and glucose-binding domains. There is no evidence is specific for the liver, whereas two others are specific for ...
Selecting Degenerate Multiplex PCR Primers
... Single Nucleotide Polymorphisms (SNPs) are individual base differences in DNA sequences between individuals. It is estimated that there are roughly three million SNPs in the human genome [12]. Association studies between SNPs and various diseases, as well as differences in how individuals respond to ...
... Single Nucleotide Polymorphisms (SNPs) are individual base differences in DNA sequences between individuals. It is estimated that there are roughly three million SNPs in the human genome [12]. Association studies between SNPs and various diseases, as well as differences in how individuals respond to ...
MyGene.info Documentation
... “refseq” and “accession” fields now contain accession number including version. Data can be search with and without version. Version is available for “genomic”, “rna” and “protein” accession number keys. Note: “genomic” field is returned but is not searchable v2: http://mygene.info/v2/query?q=NM_052 ...
... “refseq” and “accession” fields now contain accession number including version. Data can be search with and without version. Version is available for “genomic”, “rna” and “protein” accession number keys. Note: “genomic” field is returned but is not searchable v2: http://mygene.info/v2/query?q=NM_052 ...
Imposition of Crossover Interference through the
... CO distribution is often assumed. Consistent with this view, large chromosomes display more interference than small ones (Kaback et al., 1999). CO interference is generally presumed to involve the transmission of an inhibitory signal from one CO site to nearby potential sites of crossing over. One l ...
... CO distribution is often assumed. Consistent with this view, large chromosomes display more interference than small ones (Kaback et al., 1999). CO interference is generally presumed to involve the transmission of an inhibitory signal from one CO site to nearby potential sites of crossing over. One l ...
Affymetrix Software User Manuals
... Subject to the Affymetrix terms and conditions that govern your use of Affymetrix products, Affymetrix grants you a nonexclusive, non-transferable, non-sublicensable license to use this Affymetrix product only in accordance with the manual and written instructions provided by Affymetrix. You underst ...
... Subject to the Affymetrix terms and conditions that govern your use of Affymetrix products, Affymetrix grants you a nonexclusive, non-transferable, non-sublicensable license to use this Affymetrix product only in accordance with the manual and written instructions provided by Affymetrix. You underst ...
PH4 of Petunia Is an R2R3 MYB Protein That Activates
... Mutations That Alter pH in Petals The petunia line R27 contains functional alleles for all of the regulatory anthocyanin genes that color the petal (AN1, AN2, and AN11) but contains mutations in the structural genes HYDROXYLATION AT FIVE (HF1) and HF2, both encoding FLAVONOID 3959 HYDROXYLASE (Holto ...
... Mutations That Alter pH in Petals The petunia line R27 contains functional alleles for all of the regulatory anthocyanin genes that color the petal (AN1, AN2, and AN11) but contains mutations in the structural genes HYDROXYLATION AT FIVE (HF1) and HF2, both encoding FLAVONOID 3959 HYDROXYLASE (Holto ...
univERsity oF copEnhAGEn
... gene expression polymorphisms between individuals is rapidly gaining popularity as a way to query the underlying mechanistic causes of variation between individuals. However, there is little direct evidence of a linkage between global gene expression polymorphisms and phenotypic consequences. In thi ...
... gene expression polymorphisms between individuals is rapidly gaining popularity as a way to query the underlying mechanistic causes of variation between individuals. However, there is little direct evidence of a linkage between global gene expression polymorphisms and phenotypic consequences. In thi ...
Persistence and Loss of Meiotic Recombination
... sometimes lower than its probability of doing harm. A previous model examining the loss of active hotspots (Boulton et al. 1997) found that recombination of deleterious mutations did not provide benefits large enough to prevent the rapid loss of an active hotspot allele or even to slow its rate of l ...
... sometimes lower than its probability of doing harm. A previous model examining the loss of active hotspots (Boulton et al. 1997) found that recombination of deleterious mutations did not provide benefits large enough to prevent the rapid loss of an active hotspot allele or even to slow its rate of l ...
A novel role for the floral homeotic gene APETALA2
... valves and replum, respectively. In ful rpl double mutants, the valve margin identity genes become ectopically expressed, and, as a result, the entire outer surface of the ovary takes on valve margin identity. We carried out a genetic screen in this sensitized genetic background and identified a sup ...
... valves and replum, respectively. In ful rpl double mutants, the valve margin identity genes become ectopically expressed, and, as a result, the entire outer surface of the ovary takes on valve margin identity. We carried out a genetic screen in this sensitized genetic background and identified a sup ...
Chromosome Variation
... How does a chromosome duplication alter the phenotype? After all, gene sequences are not altered by duplications, and no genetic information is missing; the only change is the presence of additional copies of normal sequences. The answer to this question is not well understood, but the effects are m ...
... How does a chromosome duplication alter the phenotype? After all, gene sequences are not altered by duplications, and no genetic information is missing; the only change is the presence of additional copies of normal sequences. The answer to this question is not well understood, but the effects are m ...
Pharmacogenetics of warfarin: current status and future
... S-warfarin may also be metabolized by CYP2C8, CYP2C18 and CYP2C19 to form 4-hydroxywarfarin, although these are minor pathways.28 The genes encoding these P450 isoforms contain many functional polymorphisms. Two studies have so far found no effect of the CYP2C19*2 variant allele on warfarin therapy. ...
... S-warfarin may also be metabolized by CYP2C8, CYP2C18 and CYP2C19 to form 4-hydroxywarfarin, although these are minor pathways.28 The genes encoding these P450 isoforms contain many functional polymorphisms. Two studies have so far found no effect of the CYP2C19*2 variant allele on warfarin therapy. ...
hermann joseph muller 1890—1967
... students, and Muller often was shunted to another room (to work with his lifelong friend and fellow high school alumnus, Edgar Altenburg, who was not accepted into Morgan’s laboratory), these budding geneticists engaged in numerous debates and discussions of all their experimental work.6 This makes ...
... students, and Muller often was shunted to another room (to work with his lifelong friend and fellow high school alumnus, Edgar Altenburg, who was not accepted into Morgan’s laboratory), these budding geneticists engaged in numerous debates and discussions of all their experimental work.6 This makes ...
Hermann Joseph Muller - National Academy of Sciences
... students, and Muller often was shunted to another room (to work with his lifelong friend and fellow high school alumnus, Edgar Altenburg, who was not accepted into Morgan’s laboratory), these budding geneticists engaged in numerous debates and discussions of all their experimental work.6 This makes ...
... students, and Muller often was shunted to another room (to work with his lifelong friend and fellow high school alumnus, Edgar Altenburg, who was not accepted into Morgan’s laboratory), these budding geneticists engaged in numerous debates and discussions of all their experimental work.6 This makes ...
Regulation of limb bud initiation and limbtype
... While the paired forelimb and hindlimb buds of vertebrates are initially morphologically homogeneous, as the limb progenitors differentiate, each individual tissue element attains a characteristic limb-type morphology that ultimately defines the constitution of the forelimb or hindlimb. This review f ...
... While the paired forelimb and hindlimb buds of vertebrates are initially morphologically homogeneous, as the limb progenitors differentiate, each individual tissue element attains a characteristic limb-type morphology that ultimately defines the constitution of the forelimb or hindlimb. This review f ...
Genome evolution
Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.