Mutations in a member of the ADAMTS gene family cause
... (Fig. 3b). Analysis of RT-PCR and cloned cDNA sequences provided evidence for alternative splicing of exon 17 (GenBank accession number AF414400), resulting in a frameshift that predicts a truncated 842-amino-acid form of the protein lacking the six C-terminal TSP1 repeats. Comparative analysis with ...
... (Fig. 3b). Analysis of RT-PCR and cloned cDNA sequences provided evidence for alternative splicing of exon 17 (GenBank accession number AF414400), resulting in a frameshift that predicts a truncated 842-amino-acid form of the protein lacking the six C-terminal TSP1 repeats. Comparative analysis with ...
1. The PERL script to
... Introduction Microarray results were analysed for pathway information in the KEGG database using gene names of genes on the microarray. Genes may be known with different names. Therefore, the Gene Ontology database was searched before the KEGG database to collect all possible synonyms of gene names. ...
... Introduction Microarray results were analysed for pathway information in the KEGG database using gene names of genes on the microarray. Genes may be known with different names. Therefore, the Gene Ontology database was searched before the KEGG database to collect all possible synonyms of gene names. ...
Depth-stratified functional and taxonomic niche
... This might best be exemplified by cyanophages and ‘phage photosynthesis’ (Mann et al., 2003). Briefly, cyanophage genomes nearly universally contain the core photosystem II gene psbA (Sullivan et al., 2006) that is expressed during infection (Lindell et al., 2005; Clokie et al., 2006). This gene has ...
... This might best be exemplified by cyanophages and ‘phage photosynthesis’ (Mann et al., 2003). Briefly, cyanophage genomes nearly universally contain the core photosystem II gene psbA (Sullivan et al., 2006) that is expressed during infection (Lindell et al., 2005; Clokie et al., 2006). This gene has ...
• Autosomal dominant • autosomal recessive • X
... noticeable in middle age. It is the most common genetic cause of abnormal involuntary writhing movements called chorea. It is much more common in people of Western Europe descent than in those from Asia or Africa. The disease is caused by a dominant mutation on either of the two copies of a specific ...
... noticeable in middle age. It is the most common genetic cause of abnormal involuntary writhing movements called chorea. It is much more common in people of Western Europe descent than in those from Asia or Africa. The disease is caused by a dominant mutation on either of the two copies of a specific ...
Identification of Genetic Loci Associated With Helicobacter
... From: Identification of Genetic Loci Associated With Helicobacter pylori Serologic Status JAMA. 2013;309(18):1912-1920. doi:10.1001/jama.2013.4350 ...
... From: Identification of Genetic Loci Associated With Helicobacter pylori Serologic Status JAMA. 2013;309(18):1912-1920. doi:10.1001/jama.2013.4350 ...
Meiosis II
... egg) • Gametes have half the number of chromosomes • Occurs in the gonads (testes or ovaries) – Male: spermatogenesis – Female: oogenesis ...
... egg) • Gametes have half the number of chromosomes • Occurs in the gonads (testes or ovaries) – Male: spermatogenesis – Female: oogenesis ...
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... on different chromosomes). The second part of the activity looks at genes on the same chromosome, and how Dragon Genetics -linkage plays a part in allele assortment. It can be used to show how crossing over allows increased variation when Independent Assortment and involving linked genes. Gene Linka ...
... on different chromosomes). The second part of the activity looks at genes on the same chromosome, and how Dragon Genetics -linkage plays a part in allele assortment. It can be used to show how crossing over allows increased variation when Independent Assortment and involving linked genes. Gene Linka ...
sex reduces genetic variation: a multidisciplinary review
... additive genetic variance, providing the fodder by which natural selection can increase fitness of populations. Fisher’s (1930) fundamental theorem states that rates of change of fitness are proportional to additive genetic variance. Although mutation is the ultimate source of genetic variation, Fis ...
... additive genetic variance, providing the fodder by which natural selection can increase fitness of populations. Fisher’s (1930) fundamental theorem states that rates of change of fitness are proportional to additive genetic variance. Although mutation is the ultimate source of genetic variation, Fis ...
The Human Chromosome
... hair and eyes due to absence or defect of an enzyme involved in the production of ...
... hair and eyes due to absence or defect of an enzyme involved in the production of ...
Duplication of an approximately 1.5 Mb DNA segment
... Hosoe et al. (1994) determined the most common region of deletions at loci D5S141 and D5S81, which is approximately the same region found to be duplicated in nonpapillary RCCs in this study. No mutations of the APC and MCC genes have been detected neither in the aforementioned tumours nor in RCCs (H ...
... Hosoe et al. (1994) determined the most common region of deletions at loci D5S141 and D5S81, which is approximately the same region found to be duplicated in nonpapillary RCCs in this study. No mutations of the APC and MCC genes have been detected neither in the aforementioned tumours nor in RCCs (H ...
Ali J. Berens
... Identified which global populations have the greatest genetic risk of prostate cancer and classified alleles and adapted regions of the human genome based on contributions to prostate cancer health disparities Assessed health of ancient hominids based on estimated genetic risk at known disease a ...
... Identified which global populations have the greatest genetic risk of prostate cancer and classified alleles and adapted regions of the human genome based on contributions to prostate cancer health disparities Assessed health of ancient hominids based on estimated genetic risk at known disease a ...
induction of instability at selected loci in maize
... 1:3 ratio will occur if the plants are not homozygous for the mutation (i.e. there is only one a1m‐4). 1/2 of gametes wil posses Ac, while only 1/4 of the gametes will possess the mutation. Therefore, less kernels will the mutation in which Ds can "jump out" of, producing less variegated kernels. 2 ...
... 1:3 ratio will occur if the plants are not homozygous for the mutation (i.e. there is only one a1m‐4). 1/2 of gametes wil posses Ac, while only 1/4 of the gametes will possess the mutation. Therefore, less kernels will the mutation in which Ds can "jump out" of, producing less variegated kernels. 2 ...
High-resolution haplotype structure in the human genome
... association to Crohn disease1. Because this structure is the same in both groups, we present combined data from all chromosomes (transmitted and untransmitted). The haplotype blocks span up to 100 kb and contain multiple (five or more) common SNPs. The blocks have only a few (2–4) haplotypes, which ...
... association to Crohn disease1. Because this structure is the same in both groups, we present combined data from all chromosomes (transmitted and untransmitted). The haplotype blocks span up to 100 kb and contain multiple (five or more) common SNPs. The blocks have only a few (2–4) haplotypes, which ...
Genes underlying altruism
... yolk precursor protein vitellogenin is synthesized by the reproductive queen and invested directly into her developing offspring (eggs). Workers, by contrast, are functionally sterile but nonetheless synthesize this protein for a different reason: they incorporate it into royal jelly and feed it to ...
... yolk precursor protein vitellogenin is synthesized by the reproductive queen and invested directly into her developing offspring (eggs). Workers, by contrast, are functionally sterile but nonetheless synthesize this protein for a different reason: they incorporate it into royal jelly and feed it to ...
Genetic Algorithms
... Basic genetic algorithms Step 1: Represent the problem variable domain as a chromosome of a fixed length, choose the size of a chromosome population N, the crossover probability pc and the mutation probability pm. Step 2: Define a fitness function to measure the performance, or fitness, of an indiv ...
... Basic genetic algorithms Step 1: Represent the problem variable domain as a chromosome of a fixed length, choose the size of a chromosome population N, the crossover probability pc and the mutation probability pm. Step 2: Define a fitness function to measure the performance, or fitness, of an indiv ...
How to determine whether a strain will undergo senescence. Background
... Occasional outcrossing can purge the genome of the accumulated defective genes, but in the absence of genetic recombination, deleterious mutations are expected ultimately to result in death of a serially propogated normal culture. Exceptions are known, however, where the potential for unlimited grow ...
... Occasional outcrossing can purge the genome of the accumulated defective genes, but in the absence of genetic recombination, deleterious mutations are expected ultimately to result in death of a serially propogated normal culture. Exceptions are known, however, where the potential for unlimited grow ...
Gene Section myeloid leukemia 1; aml1 oncogene)) Atlas of Genetics and Cytogenetics
... AML1 and partners - recurrent translocations. Editor 02/2003; updated 08/2003. Note: cases of AML1 translocations with either 4q21, 4q27, 8q24 (not the TRPS1 one), 11q24,14q11, 16p13 hav e been prov ed to be cry ptic t(12;21) with ETV6/AML1 inv olv ement, and we hav e theref ore to be cautious with ...
... AML1 and partners - recurrent translocations. Editor 02/2003; updated 08/2003. Note: cases of AML1 translocations with either 4q21, 4q27, 8q24 (not the TRPS1 one), 11q24,14q11, 16p13 hav e been prov ed to be cry ptic t(12;21) with ETV6/AML1 inv olv ement, and we hav e theref ore to be cautious with ...
Nucleotide sequence changes in the MSX1 and IRF6 genes in
... sequence polymorphisms have already been reported by Jezewski et al. [24], registered in the online databases HGMD [28] and dbSNP [29]. The majority of such mutations have been found in the exon 1 of the gene, suggesting the presence of hidden regulatory elements in this exon thus causing conservati ...
... sequence polymorphisms have already been reported by Jezewski et al. [24], registered in the online databases HGMD [28] and dbSNP [29]. The majority of such mutations have been found in the exon 1 of the gene, suggesting the presence of hidden regulatory elements in this exon thus causing conservati ...
12.2: Mendel`s Theory
... inheritance. In these patterns, two of several versions of a gene combine and result in one of several possible traits. ...
... inheritance. In these patterns, two of several versions of a gene combine and result in one of several possible traits. ...
The Detection of Carbapenemases in Carbapenem
... prevalence worldwide and are associated with an increase in morbidity and mortality. The most prevalent resistance mechanisms are carbapenemases. The different carbapenemases have different epidemiology and therapeutic options. Therefore, it is important to understand the resistance mechanisms of ca ...
... prevalence worldwide and are associated with an increase in morbidity and mortality. The most prevalent resistance mechanisms are carbapenemases. The different carbapenemases have different epidemiology and therapeutic options. Therefore, it is important to understand the resistance mechanisms of ca ...
Genetic markers in beef and sheep breeding
... copy females in breeding populations. In contrast, the Booroola gene, which is not carried on the X chromosome, has additive effects which can increase ovulation rates from 1-2 eggs (non-carrier) to 2-3 eggs per ovulation (one copy of Booroola) to 4-5 eggs per ovulation in animals with 2 copies. ...
... copy females in breeding populations. In contrast, the Booroola gene, which is not carried on the X chromosome, has additive effects which can increase ovulation rates from 1-2 eggs (non-carrier) to 2-3 eggs per ovulation (one copy of Booroola) to 4-5 eggs per ovulation in animals with 2 copies. ...
Measuring the Rates of Transcriptional Elongation in the Female
... the nuclear run-on assay readily detected an approximately 1.5-fold change in the transcriptional rate of a housekeeping gene in D. melanogaster ovaries. A central assumption in this assay is that only transcripts initiated by RNA pol II prior to cell lysis are extended during the radiolabeling reac ...
... the nuclear run-on assay readily detected an approximately 1.5-fold change in the transcriptional rate of a housekeeping gene in D. melanogaster ovaries. A central assumption in this assay is that only transcripts initiated by RNA pol II prior to cell lysis are extended during the radiolabeling reac ...
Mate-pair, paired ends - molecularevolution.org
... • Read: segment of DNA (~30-1200 nt) read by a sequencer • Mate-pair, paired ends: pair of reads whose distance from each other within the genome is approximately known • Contig: contiguous segment of DNA reconstructed (unambiguously) from a set of reads • Scaffold: group of contigs that can be orde ...
... • Read: segment of DNA (~30-1200 nt) read by a sequencer • Mate-pair, paired ends: pair of reads whose distance from each other within the genome is approximately known • Contig: contiguous segment of DNA reconstructed (unambiguously) from a set of reads • Scaffold: group of contigs that can be orde ...
Genome evolution
Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.