Eds., N. Hamamura, S. Suzuki, S. Mendo, C. M. Barroso,... © by TERRAPUB, 2010.
... mercury contaminated environments, and they are often found on plasmids or other mobile genetic elements such as transposons (Rochelle et al., 1991; Osborn et al., 1997; Bogdanova et al., 1998; Narita et al., 2004). Since the transposons that carry mer operons have been identified from both clinical ...
... mercury contaminated environments, and they are often found on plasmids or other mobile genetic elements such as transposons (Rochelle et al., 1991; Osborn et al., 1997; Bogdanova et al., 1998; Narita et al., 2004). Since the transposons that carry mer operons have been identified from both clinical ...
Network properties of human disease genes with pleiotropic effects
... profiles with their interactors could be explained by different biological functions. Hence, we used Gene Ontology (GO) to functionally characterize the essential and phenodiv genes for their cellular component, molecular function and biological process (Additional files 1 and 2). GO analysis of ess ...
... profiles with their interactors could be explained by different biological functions. Hence, we used Gene Ontology (GO) to functionally characterize the essential and phenodiv genes for their cellular component, molecular function and biological process (Additional files 1 and 2). GO analysis of ess ...
PopGen2: Linkage Disequilibrium
... Identification of disease genes generally fall into one of two broad categories of methods. The traditional method uses family pedigrees. This method, called a FAMILY STUDY, looks for polymorphic markers that cosegregate on the family pedigree with the disease. Such co-segregation occurs when the ma ...
... Identification of disease genes generally fall into one of two broad categories of methods. The traditional method uses family pedigrees. This method, called a FAMILY STUDY, looks for polymorphic markers that cosegregate on the family pedigree with the disease. Such co-segregation occurs when the ma ...
A novel mutation in the short-wavelength-sensitive
... amplified region. For all subjects whose DNA showed heteroduplexes, the amplicons were sequenced on the ABI Prism 310 with primers Sx1mAA56F and Sx1mAA56R. Direct sequencing of exon 1 was also done for 18 control subjects who gave ambiguous results in the heteroduplex analysis. Subjects homozygous f ...
... amplified region. For all subjects whose DNA showed heteroduplexes, the amplicons were sequenced on the ABI Prism 310 with primers Sx1mAA56F and Sx1mAA56R. Direct sequencing of exon 1 was also done for 18 control subjects who gave ambiguous results in the heteroduplex analysis. Subjects homozygous f ...
Further genetic evidence suggesting a role for the
... Discussion The results presented here suggest that genetic variation in the RHOA gene as well as the ARHGEF3 gene may influence BMD in women. These genes are both situated in the 3p14-p21 region of the genome, an area that has been linked with BMD in multiple studies [19,21]. Other genes from this ch ...
... Discussion The results presented here suggest that genetic variation in the RHOA gene as well as the ARHGEF3 gene may influence BMD in women. These genes are both situated in the 3p14-p21 region of the genome, an area that has been linked with BMD in multiple studies [19,21]. Other genes from this ch ...
MAK, a computational tool kit for automated MITE
... retrieved. The results for all the significant hits can be exported as a table. Implementation of MAK MAK runs on UNIX, Linux and Win32 platforms on which Perl 5.6.1 (http://www.perl.com) and Bioperl 1.0.2 releases (http://www.bioperl.org) are installed. The web-based software (http://perl.idmb.tamu ...
... retrieved. The results for all the significant hits can be exported as a table. Implementation of MAK MAK runs on UNIX, Linux and Win32 platforms on which Perl 5.6.1 (http://www.perl.com) and Bioperl 1.0.2 releases (http://www.bioperl.org) are installed. The web-based software (http://perl.idmb.tamu ...
Optimizing Restriction Site Placement for Synthetic
... synthesis technology enables us to refactor biological organisms: we seek to restructure the genome of an organism into a sequence which is functionally equivalent (meaning behaves the same in its natural environment) while being easier to manipulate. The redundancy of the genetic code (64 three-bas ...
... synthesis technology enables us to refactor biological organisms: we seek to restructure the genome of an organism into a sequence which is functionally equivalent (meaning behaves the same in its natural environment) while being easier to manipulate. The redundancy of the genetic code (64 three-bas ...
Leukaemia Section t(3;12)(q26;p13) ETV6/MECOM / t(3;12)(q26;p13) ETV6/EVI1 Atlas of Genetics and Cytogenetics
... The ETV6 protein (452 amino acids) contains two major domains, the HLH (helix-loop-helix) and ETS domains. The HLH domain, also referred to as the pointed or sterile alpha motif domain, is encoded by exons 3 and 4 and functions as a homooligodimerization domain. The ETS domain, encoded by exons 6 th ...
... The ETV6 protein (452 amino acids) contains two major domains, the HLH (helix-loop-helix) and ETS domains. The HLH domain, also referred to as the pointed or sterile alpha motif domain, is encoded by exons 3 and 4 and functions as a homooligodimerization domain. The ETS domain, encoded by exons 6 th ...
Chapter 27 Presentation
... “All the world’s bacteria essentially have access to a single gene pool and hence to the adaptive mechanisms of the entire bacterial kingdom. The speed of recombination over that of mutation is superior: it could take eukaryotic organisms a million years to adjust to a change on a worldwide scale th ...
... “All the world’s bacteria essentially have access to a single gene pool and hence to the adaptive mechanisms of the entire bacterial kingdom. The speed of recombination over that of mutation is superior: it could take eukaryotic organisms a million years to adjust to a change on a worldwide scale th ...
Bioinformatics: Bringing it all together
... Another trend is the increased integration of data analysis with experimental design. The needs of bench scientists don't always coincide with those of professional bioinformaticians producing tools for whole-genome analyses. Genome projects require programs that can efficiently, if not very accurat ...
... Another trend is the increased integration of data analysis with experimental design. The needs of bench scientists don't always coincide with those of professional bioinformaticians producing tools for whole-genome analyses. Genome projects require programs that can efficiently, if not very accurat ...
Trans-HHS Workshop: Diet, DNA Methylation
... nutrients have been associated with higher risk for developing cancer. Interestingly, many micronutrients and vitamins are indispensable in DNA metabolic pathways (1,11). Although most studies have been conducted in vitro and in animal models and there is no clear evidence for the optimal dietary ra ...
... nutrients have been associated with higher risk for developing cancer. Interestingly, many micronutrients and vitamins are indispensable in DNA metabolic pathways (1,11). Although most studies have been conducted in vitro and in animal models and there is no clear evidence for the optimal dietary ra ...
iGenetics: A Molecular Approach, 3e (Russell/Bose)
... study, their progeny would be as well, and it would be impossible to determine how the trait was being passed on to the offspring. Skill: Conceptual understanding 46) What characteristics does an organism have to possess to be a good genetic model? Answer: To be a good genetic model, an organism has ...
... study, their progeny would be as well, and it would be impossible to determine how the trait was being passed on to the offspring. Skill: Conceptual understanding 46) What characteristics does an organism have to possess to be a good genetic model? Answer: To be a good genetic model, an organism has ...
7.1 Chromosomes and Phenotype
... 7.1 Chromosomes and Phenotype • Gene expression is often related to whether a gene is located on an autosome or a sex chromosome – Sex chromosomes: determine gender – Autosomes: all other chromosomes- no relation to gender • All genes that Mendel studied were autosomes • Most traits are the result ...
... 7.1 Chromosomes and Phenotype • Gene expression is often related to whether a gene is located on an autosome or a sex chromosome – Sex chromosomes: determine gender – Autosomes: all other chromosomes- no relation to gender • All genes that Mendel studied were autosomes • Most traits are the result ...
Molecular markers located on the DGAT1, CAST, and - Funpec-RP
... between SNPs and the previously described traits. Sire was fitted in the model as a random effect. The pdiff function of LSMEANS was utilized to evaluate significant differences in the performance of genotypes for SNPs that were identified as significant. All statistical analyses were conducted usin ...
... between SNPs and the previously described traits. Sire was fitted in the model as a random effect. The pdiff function of LSMEANS was utilized to evaluate significant differences in the performance of genotypes for SNPs that were identified as significant. All statistical analyses were conducted usin ...
Estimates of DNA and Protein Sequence Divergence: An
... genes. These create a large amount of variability in the mutation rate among sites. The possibility that such variation may affect estimates of divergence has been recognized since the initial study of restriction patterns by Upholt (1977; see also Nei and Li 1979). These authors state that if such ...
... genes. These create a large amount of variability in the mutation rate among sites. The possibility that such variation may affect estimates of divergence has been recognized since the initial study of restriction patterns by Upholt (1977; see also Nei and Li 1979). These authors state that if such ...
1 Rapid evolution of phenotypic plasticity and shifting thresholds of
... pathogens, are clear, in some cases brief exposure to stress at one point in the life cycle can lead to increased resistance to stress at a later time period—a phenomenon known as hormesis (Gems and Partridge 2008; Le Bourg 2009). In general, it appears that protection via a hormetic response is gen ...
... pathogens, are clear, in some cases brief exposure to stress at one point in the life cycle can lead to increased resistance to stress at a later time period—a phenomenon known as hormesis (Gems and Partridge 2008; Le Bourg 2009). In general, it appears that protection via a hormetic response is gen ...
Van, C., Williams, J.S., Kunkel, T.A., and
... To our knowledge, this is the first demonstration that a defect in SWR-C-dependent chromatin remodeling reduces genome stability. This effect is specific for single base changes generated by L612M Pol δ. Hypothetically, these mutations could reflect a SWR-Cdependent defect in any of several cellular ...
... To our knowledge, this is the first demonstration that a defect in SWR-C-dependent chromatin remodeling reduces genome stability. This effect is specific for single base changes generated by L612M Pol δ. Hypothetically, these mutations could reflect a SWR-Cdependent defect in any of several cellular ...
mRNA Expression Analysis
... unique, positionally known 20- or 21-base pair cDNA tag. These tags are compared to a species’ reference genome to identify the genes expressed. Tag Profiling provides similar benefits to mRNA-Seq, such as digital data for tunable depth and coverage, no need for probe design to support unbiased disc ...
... unique, positionally known 20- or 21-base pair cDNA tag. These tags are compared to a species’ reference genome to identify the genes expressed. Tag Profiling provides similar benefits to mRNA-Seq, such as digital data for tunable depth and coverage, no need for probe design to support unbiased disc ...
Characterization of the metacaspase gene family in Arabidopsis
... fungi, chromista, and protozoa (Uren 2000). There are two types of MCs, MC type I and MC type II (Bonneau et al. 2008). MCs type I contain a proline rich prodomain which is structurally similar to the prodomain found in animal caspases involved in PCD initiation and inflammation. MC type I can be fo ...
... fungi, chromista, and protozoa (Uren 2000). There are two types of MCs, MC type I and MC type II (Bonneau et al. 2008). MCs type I contain a proline rich prodomain which is structurally similar to the prodomain found in animal caspases involved in PCD initiation and inflammation. MC type I can be fo ...
Dosyayı İndir
... Different studies have shown presence and absence of dosage compensation in birds May occur only on specific genes May be accomplished through histone modification Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ...
... Different studies have shown presence and absence of dosage compensation in birds May occur only on specific genes May be accomplished through histone modification Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ...
Imprinted gene expression in hybrids: perturbed
... of a developmental switch from mono- to biallelic expression was delayed in (C B)F1 hybrids compared with (B C)F1 hybrids. The strain-specific genetic factor involved (such as a cis-regulatory polymorphism, for example, affecting transcription factor binding) must be located on chromosome 7 beca ...
... of a developmental switch from mono- to biallelic expression was delayed in (C B)F1 hybrids compared with (B C)F1 hybrids. The strain-specific genetic factor involved (such as a cis-regulatory polymorphism, for example, affecting transcription factor binding) must be located on chromosome 7 beca ...
Involvement of HLS1 in Sugar and Auxin
... hls1 mutations cause defects in sugar-responsive gene expression In order to identify genes that are involved in sugar signaling, we screened our activation-tagged mutant populations (Suzuki et al. 2004) and isolated putative mutants with altered levels of amylase activity and/or anthocyanin accumul ...
... hls1 mutations cause defects in sugar-responsive gene expression In order to identify genes that are involved in sugar signaling, we screened our activation-tagged mutant populations (Suzuki et al. 2004) and isolated putative mutants with altered levels of amylase activity and/or anthocyanin accumul ...
Parental Genome Separation and Elimination of Cells and
... cells was proposed to occur under genetic control in intergeneric hybrids between cultivated Brassica species and Orychophragmus violaceus (2n = 24). To elucidate further the cytological and molecular mechanisms behind parental genome separation, Brassica carinata (2n = 34) · O. violaceus hybrids we ...
... cells was proposed to occur under genetic control in intergeneric hybrids between cultivated Brassica species and Orychophragmus violaceus (2n = 24). To elucidate further the cytological and molecular mechanisms behind parental genome separation, Brassica carinata (2n = 34) · O. violaceus hybrids we ...
Twin methodology in epigenetic studies
... the full ACE model can be compared with its nested models including the AE model (dropping the C component), the CE model (dropping the A component) and E model (dropping the A and C components). This enables selection of the best fitting and most parsimonious model for a given set of data. Instead ...
... the full ACE model can be compared with its nested models including the AE model (dropping the C component), the CE model (dropping the A component) and E model (dropping the A and C components). This enables selection of the best fitting and most parsimonious model for a given set of data. Instead ...
Genome evolution
Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.