Supplementary Material for Autozygome Sequencing Expands the
... underlying biological issue whereby in some cases, two adjacent SNPs in the same codon are always coupled (become an MNP) and their combined impact on the ORF is usually different from what is predicted if each SNP was evaluated independently. Even though we were aware of the MNP issue, the preproc ...
... underlying biological issue whereby in some cases, two adjacent SNPs in the same codon are always coupled (become an MNP) and their combined impact on the ORF is usually different from what is predicted if each SNP was evaluated independently. Even though we were aware of the MNP issue, the preproc ...
Etiology : cytogenetics and microdeletions - HAL
... show decreased levels of expression [Merla and others 2006]. Therefore, genes flanking a genomic rearrangement should be considered as possible contributors to the phenotype. In addition, the interpretation of these observations is not obvious, as most of the chromosomal aberrations are large. One s ...
... show decreased levels of expression [Merla and others 2006]. Therefore, genes flanking a genomic rearrangement should be considered as possible contributors to the phenotype. In addition, the interpretation of these observations is not obvious, as most of the chromosomal aberrations are large. One s ...
Evidence for autosomal recessive inheritance in SPG3A
... Figure 1 Pedigree of the family segregating HSP and analysis of the ATL1 mutation. (a) The consanguineous family consists of two loops with two firstcousin marriages and six male individuals affected by pure HSP (filled symbols). The genotype at cDNA position 353 of ATL1 is shown below each symbol. ...
... Figure 1 Pedigree of the family segregating HSP and analysis of the ATL1 mutation. (a) The consanguineous family consists of two loops with two firstcousin marriages and six male individuals affected by pure HSP (filled symbols). The genotype at cDNA position 353 of ATL1 is shown below each symbol. ...
Divergence with Gene Flow: Models and Data
... each other, but that overlap or abut each other and that exchange genes with each other. Although the BDM model does not apply directly to this case, we learn from the BDM model that if the two populations are to diverge in the face of gene exchange, then (a) there must be forces acting against the ...
... each other, but that overlap or abut each other and that exchange genes with each other. Although the BDM model does not apply directly to this case, we learn from the BDM model that if the two populations are to diverge in the face of gene exchange, then (a) there must be forces acting against the ...
Yan D et al., 2014 - Drosophila RNAi Screening Center
... phenotypic data are available to date. For example, knockdown of CG11266 (referred to as igru thereafter (see Experimental Procedures for details)), a proposed splicing factor, resulted in an almost complete depletion of germline cells (Figure 3E) suggesting a role for igru in GSC maintenance. We se ...
... phenotypic data are available to date. For example, knockdown of CG11266 (referred to as igru thereafter (see Experimental Procedures for details)), a proposed splicing factor, resulted in an almost complete depletion of germline cells (Figure 3E) suggesting a role for igru in GSC maintenance. We se ...
Gene targeting by hybridization-hydrolysis process
... A new technology used to specifically target any transcript from a complex population of single-strand cDNA molecules was applied to dramatically decrease the abundance of selected genes in cDNA libraries. This innovative procedure offers new alternatives to previous efforts focused on normalizing t ...
... A new technology used to specifically target any transcript from a complex population of single-strand cDNA molecules was applied to dramatically decrease the abundance of selected genes in cDNA libraries. This innovative procedure offers new alternatives to previous efforts focused on normalizing t ...
How Biologists Conceptualize Genes: An empirical study
... hoped to avoid the inevitable biases that come from having worked in one particular biological field before becoming a philosopher, from collaborating with some particular research group or simply from having a particular interest in one or more fields of research. Although this can only be regarded ...
... hoped to avoid the inevitable biases that come from having worked in one particular biological field before becoming a philosopher, from collaborating with some particular research group or simply from having a particular interest in one or more fields of research. Although this can only be regarded ...
Genome-Wide Association Studies
... moderately common variants had been associated with IBD. These were found by association studies that focused on genes within regions highlighted by linkage studies or by large-scale studies of nonsynonymous coding variants (see 16, 57 and references therein). Subsequent GWA studies identified 32 loc ...
... moderately common variants had been associated with IBD. These were found by association studies that focused on genes within regions highlighted by linkage studies or by large-scale studies of nonsynonymous coding variants (see 16, 57 and references therein). Subsequent GWA studies identified 32 loc ...
PDF
... blasts themselves, which affected their division, migration, differentiation or viability; or some abnormality of their host tissue which affected the entry, division, differentiation or viability of these cells. For long it was not possible to say which type of explanation applied to which gene, bu ...
... blasts themselves, which affected their division, migration, differentiation or viability; or some abnormality of their host tissue which affected the entry, division, differentiation or viability of these cells. For long it was not possible to say which type of explanation applied to which gene, bu ...
Specification of floral organs in Arabidopsis
... several studies showing that AP1 and AP2 indeed play important roles in the specification of floral meristems (Okamuro et al., 1997; Ferrandiz et al., 2000). Furthermore, it has been shown that while AP2 represses AG expression in the outer two floral whorls (thus fulfilling one of the proposed role ...
... several studies showing that AP1 and AP2 indeed play important roles in the specification of floral meristems (Okamuro et al., 1997; Ferrandiz et al., 2000). Furthermore, it has been shown that while AP2 represses AG expression in the outer two floral whorls (thus fulfilling one of the proposed role ...
Practice Questions, Lectures 6-13 (259 KB pdf file)
... Answers to Practice questions lectures 5-12 Question 1 Let allele A represent the dominant allele, with frequency p in both males and females, and a the recessive allele, with frequency q, with p + q =1. We are given the information that in females 84% have the dominant phenotype. This means that 1 ...
... Answers to Practice questions lectures 5-12 Question 1 Let allele A represent the dominant allele, with frequency p in both males and females, and a the recessive allele, with frequency q, with p + q =1. We are given the information that in females 84% have the dominant phenotype. This means that 1 ...
Meristematic sculpting in fruit development
... are mechanistically similar (Pautot et al., 2001). At stage 8, the presumptive repla give rise to two medial ridges on their adaxial side (i.e. inside the tube) flanked on both sides by placental tissues. The medial ridges will grow towards each other and post-genitally fuse at stage 9 in the centre ...
... are mechanistically similar (Pautot et al., 2001). At stage 8, the presumptive repla give rise to two medial ridges on their adaxial side (i.e. inside the tube) flanked on both sides by placental tissues. The medial ridges will grow towards each other and post-genitally fuse at stage 9 in the centre ...
Unit 1 Study Guide: Ecology and the Nature of Science
... C. Describe the importance of genetic variation D. Distinguish between spermatogenesis and oogenesis. Illustrate these processes with diagrams. SG 3 – The Origin of Genetics (162-165) and Mendel’s Theory (166-169) [3b] A. What did Mendel already know about plant reproduction? How did Mendel produce ...
... C. Describe the importance of genetic variation D. Distinguish between spermatogenesis and oogenesis. Illustrate these processes with diagrams. SG 3 – The Origin of Genetics (162-165) and Mendel’s Theory (166-169) [3b] A. What did Mendel already know about plant reproduction? How did Mendel produce ...
Practice exam
... Oops, this was a trick question! Some of the crosses listed above are not feasible by conventional genetics. Which ones (circle them)? Why? ...
... Oops, this was a trick question! Some of the crosses listed above are not feasible by conventional genetics. Which ones (circle them)? Why? ...
Chapter 15 ppt
... Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
... Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
model for Escherichia coli chromosome packaging supports
... TF regulates, the higher is its need to be expressed in higher concentrations to regulate targets located dispersedly on the chromosome. In contrast, local or dedicated TFs were found to be expressed in much lower concentrations explaining the reasons for their proximity on the chromosome to their t ...
... TF regulates, the higher is its need to be expressed in higher concentrations to regulate targets located dispersedly on the chromosome. In contrast, local or dedicated TFs were found to be expressed in much lower concentrations explaining the reasons for their proximity on the chromosome to their t ...
Applied and Environmental Microbiology
... Archaeoglobus fulgidus (16). Form IV is designated a RubisCOlike protein, as its sequence is most closely related to RubisCO but it is not involved in the Calvin cycle. The large subunit of form I RubisCO is encoded by the cbbL gene (18). The cbbL gene is 1,400 bp long and thus is large enough for u ...
... Archaeoglobus fulgidus (16). Form IV is designated a RubisCOlike protein, as its sequence is most closely related to RubisCO but it is not involved in the Calvin cycle. The large subunit of form I RubisCO is encoded by the cbbL gene (18). The cbbL gene is 1,400 bp long and thus is large enough for u ...
Four types of controls were performed to support these
... (1:400). The relative densities of each competitor after 24 h of competition were ...
... (1:400). The relative densities of each competitor after 24 h of competition were ...
PHI-Canto video tutorial text - PHI-base
... Next to add in additional details about the annotation using the available extension options. In this case for ‘TRI5Delta’ ‘functional test in host organism’ with an annotated PHI phenotype of ‘unaffected pathogenicity’ we will add in information about the # Pathogen strain NCBI taxonomy ID, ...
... Next to add in additional details about the annotation using the available extension options. In this case for ‘TRI5Delta’ ‘functional test in host organism’ with an annotated PHI phenotype of ‘unaffected pathogenicity’ we will add in information about the # Pathogen strain NCBI taxonomy ID, ...
Genetics Part I
... We will begin by looking at a special kind of cell division called meiosis. Meiosis is from the Greek word for "diminution," which means to make smaller. This is the process that results in egg and sperm cells with one half of the normal number of chromosomes. Egg and sperm unite to form a new indiv ...
... We will begin by looking at a special kind of cell division called meiosis. Meiosis is from the Greek word for "diminution," which means to make smaller. This is the process that results in egg and sperm cells with one half of the normal number of chromosomes. Egg and sperm unite to form a new indiv ...
Unearthing the Roles of Imprinted Genes in the Placenta
... perturbations in gene expression because these processes depend on a complex cascade of events [12,13]. Any disruption to the wellorchestrated expression of these regulatory factors may lead to placental disorders, causing undesirable phenotypes or even precocious deaths in animals or humans [9]. Fo ...
... perturbations in gene expression because these processes depend on a complex cascade of events [12,13]. Any disruption to the wellorchestrated expression of these regulatory factors may lead to placental disorders, causing undesirable phenotypes or even precocious deaths in animals or humans [9]. Fo ...
Student Handout
... You will be working in groups of 6. Designate four group members as "parents" and two group members as "offspring." 1. Each parent takes two marbles of the same type (i.e. both soild or both clear). These marbles represent the parents' alleles for a trait. Record the "Marble Type", "Genotype", and " ...
... You will be working in groups of 6. Designate four group members as "parents" and two group members as "offspring." 1. Each parent takes two marbles of the same type (i.e. both soild or both clear). These marbles represent the parents' alleles for a trait. Record the "Marble Type", "Genotype", and " ...
The Informational Gene and the Substantial Body: On the
... can even come to replace the molecular concept of the gene altogether. The result is a theory that genes are evolutionary information. Hence if evolution occurs at other levels, there must be “genes” at those levels. As formal theory, this reflexive definition of the gene in terms of evolutionary th ...
... can even come to replace the molecular concept of the gene altogether. The result is a theory that genes are evolutionary information. Hence if evolution occurs at other levels, there must be “genes” at those levels. As formal theory, this reflexive definition of the gene in terms of evolutionary th ...
Genetic testinG
... genes in the human genome that are responsible for making proteins and contain 85 percent of all known disease-causing mutations. To begin the process, DNA is collected, typically by a blood draw. If a blood draw is difficult, DNA can also be extracted from saliva or a cheek swab. Prior to sample c ...
... genes in the human genome that are responsible for making proteins and contain 85 percent of all known disease-causing mutations. To begin the process, DNA is collected, typically by a blood draw. If a blood draw is difficult, DNA can also be extracted from saliva or a cheek swab. Prior to sample c ...
Molecular Evolution of the Endosperm Starch Synthesis Pathway
... the roles of various forces of evolution, such as selection and drift, in shaping patterns of genetic variation (Clegg 1997). Numerous studies have been conducted to understand their relative roles in evolution (Wright and Gaut 2005; Ramos-Onsins et al. 2008). However, most of this work focuses on i ...
... the roles of various forces of evolution, such as selection and drift, in shaping patterns of genetic variation (Clegg 1997). Numerous studies have been conducted to understand their relative roles in evolution (Wright and Gaut 2005; Ramos-Onsins et al. 2008). However, most of this work focuses on i ...