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MAGMA manual (version 1.05)
MAGMA manual (version 1.05)

... The p-value file must be a plain text data file with each row corresponding to a SNP. If MAGMA detects a header in the file it will look for SNP IDs and p-values in the SNP and P column respectively. If no header is found it will use the first column for SNP IDs and the second column for p-values. I ...
Global Transcriptional Profiling Reveals Distinct Functions of Thymic
Global Transcriptional Profiling Reveals Distinct Functions of Thymic

... regardless of age (Figure 1B), demonstrating that each stromal subset maintains its transcriptional identity during thymic involution. Stromal subsets at 6 months of age were further from their 1- and 3-month counterparts, indicative of age-related transcriptional changes in the data. Interestingly, ...
Extrapolation to the whole human genome
Extrapolation to the whole human genome

... human genome, with a little more than half of them processed. We have determined the main populations and clusters of pseudogenes on chromosomes 21 and 22. There are notable excesses of pseudogenes relative to genes near the centromeres of both chromosomes, suggesting the existence of pseudogenic 'h ...
MCB317 Topic 10, part 4, A Story of Txn Sp14
MCB317 Topic 10, part 4, A Story of Txn Sp14

... Which, if any encode txn factors? Secondary screen to identify possible txn factors ...
anterior olfactory nucleus (aon) - Dashboard
anterior olfactory nucleus (aon) - Dashboard

... can first be seen at the lateral aspect of the MOB bordering the subependymal zone/rhinocele (SEZ/ RC). Caudally, the AONe disappears and the internal areas spread medially until they fully surround the SEZ/RC. At its most caudal aspect, the AONl is no longer present, and only the AONm and AONpv sub ...
A nested deletion approach to generate Cre deleter mice with
A nested deletion approach to generate Cre deleter mice with

... 2000). Using this system, it is for instance possible to activate a given transgene at the desired time and position, or alternatively, to inactivate a gene, or group of genes, only in those organs where one would like to study the phenotype. Therefore, this system helps to overcome the difficulties ...
SARS Outbreaks in Ontario, Hong Kong and Singapore
SARS Outbreaks in Ontario, Hong Kong and Singapore

... • Diploid (2n): An organism or cell having two sets of chromosomes or twice the haploid number • Haploid (n): An organism or cell having only one complete set of chromosomes • Gamete: Reproductive cells involved in fertilization. The ovum is the female gamete; the spermatozoon is the male gamete. • ...
Sample 2
Sample 2

... When we tested for hair on the second digit of their finger, we concluded that almost every guy has hair there and barely and girls have hair on their fingers. Our family has the trait where they have lots of hair except for on their heads, so we predicted that it would turn out to be like that. As ...
AA - rfisd
AA - rfisd

...  The principals of probability can be used to predict the outcomes of genetic crosses.  Gene combinations (what allele you get from your mom and what allele you get from your dad) that might result from a genetic cross can be determined by drawing a diagram known as a Punnett square. ...
genetics - Krishikosh
genetics - Krishikosh

... -;eneticists who lectured in this series. For each of their lectures I have provided a chapter containing a ist of readings, a set of notes, and questions for discussion. At intervals a number of tests also are in~luded, each covering the material in a group of chapters. While these contents could f ...
Supplementary Legends - Word file
Supplementary Legends - Word file

... plane specification as analysed by asymmetric spindle severing (ASS): Shown are gene names, loci, knockout method and phenotypes after ASS. Gene knockout was performed using established protocols, either by using feeding clones obtained form the MRC Geneservice1 (labeled Ahringer) or injection of do ...
The Biology of Aging
The Biology of Aging

... Ashkenazi Jews •  Large genetic component •  Likely to be passed from generation to generation ...
What is learning? On the nature and merits of a... definition of learning THEORETICAL REVIEW
What is learning? On the nature and merits of a... definition of learning THEORETICAL REVIEW

... Although many of these alternative definitions of learning still refer to the impact of experience on behavior, they are no longer functional in a strict sense of the word, because they refer to the mechanism that mediates the impact of experience on behavior. Mechanistic approaches in psychology ai ...
Jigsaw handout - the Biology Scholars Program Wiki
Jigsaw handout - the Biology Scholars Program Wiki

... and the operon is not transcribed. When lactose is present, the gene products are needed and the operon is transcribed. The system is controlled by a protein call lac repressor. Lac repressor is a DNA binding protein that binds to a site on the DNA called the operator. The operator partially overlap ...
Mimicry: developmental genes that contribute to speciation
Mimicry: developmental genes that contribute to speciation

... and are often Müllerian mimics of other Heliconius or ithomiine butterflies (Turner 1984; Sheppard et al. 1985; Mallet et al. 1998). Extensive work has shown that major genes control color pattern differences between geographic races within species (Turner and Crane 1962; Sheppard et al. 1985; Malle ...
Mending Mendelism
Mending Mendelism

... instruction. Such notions as: some traits are inherently more likely to be inherited than others; dominant traits are more prevalent in the population; adaptive traits eventually become dominant through natural selection; mutations or "abnormal" genes are recessive; dominant alleles subdue or contro ...
Role of 1-aminocyclopropane-1-carboxylate (ACC) Synthases
Role of 1-aminocyclopropane-1-carboxylate (ACC) Synthases

... ‘Vanilla’ has long lasting flowers and was compared with ‘Bronze’, which has a shorter flower life, for levels of RhETR1 (similar to AtERS1) transcripts. Results showed that expression levels of RhETR1 were distinctly higher in ‘Bronze’, suggesting that modulation of receptor levels may contribute t ...
Mary Ann Osley*, Alastair Fleming, and Cheng
Mary Ann Osley*, Alastair Fleming, and Cheng

... 2000 #1}{Hochstrasser, 1995 #38}{Wilkinson, 1997 #109}. These proteases act by hydrolyzing the linkage between ubiquitin and the target protein or between individual ubiquitin molecules in the case of polyubiquitylation. The large family of Ubps suggests that, like E3s, Ubps have significant specifi ...
Handout 1
Handout 1

... textual stimuli is sufficient to explain both looking at the list and taking appropriate action. We are in no such position with respect to our nervous system. The relevant physiological changes are not stimuli; we cannot respond to them as we can to items on a grocery list. Stored changes are of no ...
Open Access
Open Access

... phenotypic changes is evolutionary developmental biology (also called Evo-Devo) [1]. As most of our knowledge is based on a few well-characterized model systems that are separated by large evolutionary distances, evolutionary comparisons are often descriptive and have little functional depth. Typica ...
Chapter 3 Clustering Microarray Data
Chapter 3 Clustering Microarray Data

... genes may be represented by a gene cluster and an associated subset of the samples which distinguishes the cluster. If the samples in the data set were taken over time, then gene clusters should be based on all the samples, but it may be more appropriate to use a clustering method that is designed f ...
Evolutionary dynamics of nematode operons
Evolutionary dynamics of nematode operons

... genes reside in over 1100 operons in the model organism Caenorhabditis elegans. It is unclear how operons have become abundant in nematode genomes. The “one-way street” hypothesis asserts that once formed by chance, operons are very difficult to break, because the breakage would leave downstream gen ...
Applet for calculating heritability for threshold traits
Applet for calculating heritability for threshold traits

... Most quantitative traits exhibit some degree of heritability. The heritability is evident when individuals, deviating positively or negatively from the average, also become offspring with deviation in the same trait in the same direction as their parents. There is a continuum of some traits, which i ...
Biol 208/308 Quick Program Reference Course Descriptions:
Biol 208/308 Quick Program Reference Course Descriptions:

... BIOL 208 LEC,TUT Analytical Methods in Molecular Biology An introduction to molecular methods used to analyze the structure of genes and genomes, including DNA sequencing, cloning, restriction mapping and bioinformatic tools. Techniques to monitor transcript and protein abundance, protein-protein an ...
Intervention, integration and translation in obesity research: Genetic
Intervention, integration and translation in obesity research: Genetic

... especially in groups with high rates of obesity or in less obesogenic environments [58]. Subsequent efforts to identify mechanisms and biochemical pathways between genes and obesity phenotypes have, however, been slow and halting [59]. The FTO gene is the most robust finding of genome-wide approache ...
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Biology and consumer behaviour

Consumer behaviour is the study of the motivations surrounding a purchase of a product or service. It has been linked to the field of psychology, sociology and economics in attempts to analyse when, why, where and how people purchase in the way that they do. However, little literature has considered the link between our consumption behaviour and the basics of our being, our biology. Segmentation by biological driven demographics such as sex and age are already popular and pervasive in marketing. As more knowledge and research is known, targeting based on a consumers biology is of growing interest and use to marketers.As human machines being made up of cells controlled by our brain to influence aspects of our behaviour, there must be some influence of biology on our consumer behaviour and how we purchase as well. The nature versus nurture debate is at the core of how much biology influences these buying decisions, because it argues the extent to which biological factors influence what we do, and how much is reflected through environmental factors. Neuromarketing is of interest to marketers in measuring the reaction of stimulus to marketing. Even though we know there is a reaction, the question of why we consume the way we do still lingers, but it is a step in the right direction. Biology helps to understand consumer behaviour as it influences consumption and aids in the measurement of it.Lawson and Wooliscroft (2004) drew the link between human nature and the marketing concept, not explicitly biology, where they considered the contrasting views of Hobbes and Rousseau on mankind. Hobbes believed man had a self-serving nature whereas Rousseau was more forgiving towards the nature of man, suggesting them to be noble and dignified. Hobbes saw the need for a governing intermediary to control this selfish nature which provided a basis for the exchange theory, and also links to Mcgregor’s Theory of X and Y, relevant to management literature. He also considered cooperation and competition, relevant to game theory as an explanation of man’s motives and can be used for understanding the exercising of power in marketing channels. Pinker outlines why the nature debate has been suppressed by the nurture debate in his book The Blank Slate.
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