Definition of historical models of gene function and their relation to
... explanations of the phenomenon. The entities from which the model is constructed are concrete or abstract and related within systems or processes. In science education there is an extensive literature about models and modeling (Gilbert 1991; Van Driel and Verloop 1999; Boulter and Buckley 2000; Gilb ...
... explanations of the phenomenon. The entities from which the model is constructed are concrete or abstract and related within systems or processes. In science education there is an extensive literature about models and modeling (Gilbert 1991; Van Driel and Verloop 1999; Boulter and Buckley 2000; Gilb ...
Simplified global gene expression profiling
... matched FFPE and fresh-frozen lung tissue RNA were >0.9. Inter-platform concordance for gene-level transcript detection and differentially expressed genes Inter-platform concordance was used to illustrate the sensitivity of gene expression profiling data obtained using the Ion S5 XL System and Ion A ...
... matched FFPE and fresh-frozen lung tissue RNA were >0.9. Inter-platform concordance for gene-level transcript detection and differentially expressed genes Inter-platform concordance was used to illustrate the sensitivity of gene expression profiling data obtained using the Ion S5 XL System and Ion A ...
Directions for Use Ready One-Step RT-PCR Kit
... performing RT-PCR reactions. Subsequent loading and visualization of RT-PCR products are streamlined since the loading buffer and visualization dye are included. The user supplies the primers and DNase-treated template RNA. Ready One-Step RT-PCR Kit includes 1 tube each of Ready One-Step Reverse Tra ...
... performing RT-PCR reactions. Subsequent loading and visualization of RT-PCR products are streamlined since the loading buffer and visualization dye are included. The user supplies the primers and DNase-treated template RNA. Ready One-Step RT-PCR Kit includes 1 tube each of Ready One-Step Reverse Tra ...
TBK1 Gene Duplication and Normal
... causes 0.4% to 1.3% of NTG cases.18,19 However, animal and/or functional studies will be required to definitively prove that chromosome 12q14 duplications cause NTG by altering the function of TBK1 rather than through effects on other neighboring genes. The discovery that TBK1 is a glaucoma gene sug ...
... causes 0.4% to 1.3% of NTG cases.18,19 However, animal and/or functional studies will be required to definitively prove that chromosome 12q14 duplications cause NTG by altering the function of TBK1 rather than through effects on other neighboring genes. The discovery that TBK1 is a glaucoma gene sug ...
Acute stress and hippocampal histone H3 lysine 9 trimethylation, a
... Our findings raise the question of why the hippocampus shows such a selective H3K9me3 response to stress. Indeed, the absence of an H3K9me3 stress response in the cerebellum is associated with a significant increase in retrotransposon expression (Fig. 5C); interestingly, this brain region is the only ...
... Our findings raise the question of why the hippocampus shows such a selective H3K9me3 response to stress. Indeed, the absence of an H3K9me3 stress response in the cerebellum is associated with a significant increase in retrotransposon expression (Fig. 5C); interestingly, this brain region is the only ...
Polyploidy Enhances F Pollen Sterility Loci
... ubiquitin-proteasome pathway. These results suggest that polyploidy enhances epistatic interactions between alleles of pollen sterility loci, thereby altering the expression profiles of important meiosis-related or meiosis stage-specific genes and resulting in high pollen sterility. ...
... ubiquitin-proteasome pathway. These results suggest that polyploidy enhances epistatic interactions between alleles of pollen sterility loci, thereby altering the expression profiles of important meiosis-related or meiosis stage-specific genes and resulting in high pollen sterility. ...
PDF-729K - ScienceCentral
... showed that this was a founder mutation with an estimated age of about 572 generations or 14,300 years old [20]. Two other proteins, GlcNAc-1-phosphotransferase γ (encoded by GNPTG ) and GlcNAc-1-phosphodiester α-Nacetylglucosaminidase (encoded by NAGPA ) were regarded as potential candidate genes f ...
... showed that this was a founder mutation with an estimated age of about 572 generations or 14,300 years old [20]. Two other proteins, GlcNAc-1-phosphotransferase γ (encoded by GNPTG ) and GlcNAc-1-phosphodiester α-Nacetylglucosaminidase (encoded by NAGPA ) were regarded as potential candidate genes f ...
AA - Virginia Institute for Psychiatric and Behavioral Genetics
... Mendel’s Experiments in Plant Hybridization, showed how discrete particles (particulate theory of inheritance) behaved mathematically: all or nothing states (round/wrinkled, green/yellow), “Mendelian” disease How do these particles produce a continuous trait like stature or liability to a complex di ...
... Mendel’s Experiments in Plant Hybridization, showed how discrete particles (particulate theory of inheritance) behaved mathematically: all or nothing states (round/wrinkled, green/yellow), “Mendelian” disease How do these particles produce a continuous trait like stature or liability to a complex di ...
ACMG Standards and Guidelines for constitutional cytogenomic
... samples, each run multiple times in separate experiments. The concordance of the repeated runs should be documented, and any alterations should be considered (variability of breakpoints, calls, and potential reasons for variation, i.e., segmental duplication-rich region) as they pertain to the repor ...
... samples, each run multiple times in separate experiments. The concordance of the repeated runs should be documented, and any alterations should be considered (variability of breakpoints, calls, and potential reasons for variation, i.e., segmental duplication-rich region) as they pertain to the repor ...
Exam 2
... 4. It is possible to eliminate the tetracycline resistant (TetR) plasmid pLAFR from a bacterial strain by mating in the gentamycin resistant (GenR) plasmid pPH1JI. a. What does this suggest about the properties of these two plasmids? ANSWER: The two plasmids are probably incompatible. This means tha ...
... 4. It is possible to eliminate the tetracycline resistant (TetR) plasmid pLAFR from a bacterial strain by mating in the gentamycin resistant (GenR) plasmid pPH1JI. a. What does this suggest about the properties of these two plasmids? ANSWER: The two plasmids are probably incompatible. This means tha ...
Towards Programmable Molecular Machines
... machine can switch between two states “open” and “close” controlled using the strand invasion mechanism. This machine makes one state change every time a specific DNA strand is added. Later on, this construction was modified by Bishop et al. [2] into a DNA tweezer powered by enzymes; the operation o ...
... machine can switch between two states “open” and “close” controlled using the strand invasion mechanism. This machine makes one state change every time a specific DNA strand is added. Later on, this construction was modified by Bishop et al. [2] into a DNA tweezer powered by enzymes; the operation o ...
Caffeine overrides S. pombe SM checkpoint
... (Hartwell and Weinert, 1989). These checkpoints can be disrupted by a variety of drugs or genetic lesions. In mammalian cells, loss of checkpoint control results in DNA rearrangements, amplification and chromosome loss, events that are causally associated with cancer (Hartwell and Kastan, 1994; Lehm ...
... (Hartwell and Weinert, 1989). These checkpoints can be disrupted by a variety of drugs or genetic lesions. In mammalian cells, loss of checkpoint control results in DNA rearrangements, amplification and chromosome loss, events that are causally associated with cancer (Hartwell and Kastan, 1994; Lehm ...
Chapter 2
... susceptible cv. Saluda can be 17% when disease severity reaches 19% on the flag leaf by the time of head emergence (Leath et al. 1989, 1990). Losses of 10-15% can occure from natural inoculum in winter wheat due to powdery mildew (Bowen et al. 1991). Fried et al (1981) reviewed previous work and rep ...
... susceptible cv. Saluda can be 17% when disease severity reaches 19% on the flag leaf by the time of head emergence (Leath et al. 1989, 1990). Losses of 10-15% can occure from natural inoculum in winter wheat due to powdery mildew (Bowen et al. 1991). Fried et al (1981) reviewed previous work and rep ...
The full-length HIV-1 molecular clone pLAI 61 was used to produce
... the SalI and HindIII sites of pBluescript SK- (Stratagene) to yield pBlue-LTR and pBlue7tetO, respectively. To create the lhRNA tat and nef1, approximately 300 nt as-tat and as-nef1 fragments were PCR amplified from pEF1α-tat and pEF1α-nef1 with primers HindIII-PKF4 and NotI-PKR2, and cloned into t ...
... the SalI and HindIII sites of pBluescript SK- (Stratagene) to yield pBlue-LTR and pBlue7tetO, respectively. To create the lhRNA tat and nef1, approximately 300 nt as-tat and as-nef1 fragments were PCR amplified from pEF1α-tat and pEF1α-nef1 with primers HindIII-PKF4 and NotI-PKR2, and cloned into t ...
Giant viruses, giant chimeras: The multiple evolutionary histories of
... analyses for each marker. In fact, when independent phylogenetic trees of the proteins used by Raoult et al. were carried out with a rich taxonomic sampling, the results were completely different [18]. Not only HGT events were detected, but Mimivirus did no longer form an independent branch at the b ...
... analyses for each marker. In fact, when independent phylogenetic trees of the proteins used by Raoult et al. were carried out with a rich taxonomic sampling, the results were completely different [18]. Not only HGT events were detected, but Mimivirus did no longer form an independent branch at the b ...
Having it both ways: transcription factors that bind DNA and RNA
... participate in multiple, perhaps super®cially unrelated regulatory pathways. These multiple functions may be dif®cult to detect by traditional reductionist approaches. Nonetheless, macromolecules with multiple functions have been identi®ed, although such discoveries are typically unexpected. Multifu ...
... participate in multiple, perhaps super®cially unrelated regulatory pathways. These multiple functions may be dif®cult to detect by traditional reductionist approaches. Nonetheless, macromolecules with multiple functions have been identi®ed, although such discoveries are typically unexpected. Multifu ...
transposon
... dicentric chromosome : product of fusing two chromosome fragments, each of which has a centromere. It is unstable and may be broken when the two centromeres are pulled to opposite poles in mitosis. breakage-fusion-bridge cycle : chromosomal behavior in which a broken chromatid fuses to its siste ...
... dicentric chromosome : product of fusing two chromosome fragments, each of which has a centromere. It is unstable and may be broken when the two centromeres are pulled to opposite poles in mitosis. breakage-fusion-bridge cycle : chromosomal behavior in which a broken chromatid fuses to its siste ...
Functional variation of MC1R alleles from red
... for the recessive yellow (Mc1re) mutation. Nine positive transgenic founders gave rise to seven lines, all of which showed rescue of the coat colour from yellow to agouti or darker (Table 1). In addition to darkening of hair, the skin of the ear and tail was also rescued from pale to darkly pigmente ...
... for the recessive yellow (Mc1re) mutation. Nine positive transgenic founders gave rise to seven lines, all of which showed rescue of the coat colour from yellow to agouti or darker (Table 1). In addition to darkening of hair, the skin of the ear and tail was also rescued from pale to darkly pigmente ...
Diploidy and the selective advantage for sexual reproduction in
... organisms to survive in a co-evolutionary “genetic arms race” with quickly reproducing parasites. This theory derives its name from a character named the Red Queen in Lewis Carroll’s In the Looking Glass, who states, “It takes all the running you can do to stay in one place” (Hamilton et al. 1990). ...
... organisms to survive in a co-evolutionary “genetic arms race” with quickly reproducing parasites. This theory derives its name from a character named the Red Queen in Lewis Carroll’s In the Looking Glass, who states, “It takes all the running you can do to stay in one place” (Hamilton et al. 1990). ...
Time-shift and inverse clustering of expression data finds new
... more likely than random to have a known interaction or a similar cellular role. This suggests that local clustering may be useful in functional annotation of uncharacterized genes. We examined many of the new relationships in detail. Some of them were already well-documented examples of inhibition o ...
... more likely than random to have a known interaction or a similar cellular role. This suggests that local clustering may be useful in functional annotation of uncharacterized genes. We examined many of the new relationships in detail. Some of them were already well-documented examples of inhibition o ...
PHANTASTICA Regulates Development of the Adaxial Mesophyll in
... is shown in Figure 1 with identical residues shaded. All have a highly conserved MYB DNA binding domain at the N terminus, consisting of two imperfect repeats (55 and 51 residues), both of which are essential for sequence-specific DNA binding based on structural analysis of c-MYB (Jin and Martin, 19 ...
... is shown in Figure 1 with identical residues shaded. All have a highly conserved MYB DNA binding domain at the N terminus, consisting of two imperfect repeats (55 and 51 residues), both of which are essential for sequence-specific DNA binding based on structural analysis of c-MYB (Jin and Martin, 19 ...
1 Tall - (canvas.brown.edu).
... 1) Traits are inherited as genes, invisible, indivisible, characters passed from one generation to the next. 2) Some genes are dominant over others. 3) During gamete formation, the two copies of a gene are segregated from each other 4) The segregation of genes for different characters is independent ...
... 1) Traits are inherited as genes, invisible, indivisible, characters passed from one generation to the next. 2) Some genes are dominant over others. 3) During gamete formation, the two copies of a gene are segregated from each other 4) The segregation of genes for different characters is independent ...
perspectives - University of Arizona | Ecology and Evolutionary Biology
... natural selection, and how their evolution is influenced by sexual reproduction and population structure. His influence on genetics and evolution was therefore substantial and wideranging (for a book-length biography, see REF. 2; for excerpts from his collected papers, see REF. 3). In fact, Muller’s ...
... natural selection, and how their evolution is influenced by sexual reproduction and population structure. His influence on genetics and evolution was therefore substantial and wideranging (for a book-length biography, see REF. 2; for excerpts from his collected papers, see REF. 3). In fact, Muller’s ...